PI3K
Los inhibidores de PI3K son compuestos que bloquean la actividad de las fosfoinosítido 3-quinasas (PI3Ks), una familia de enzimas involucradas en una amplia gama de procesos celulares, incluidos el crecimiento, la proliferación, la supervivencia y el metabolismo. La vía PI3K/Akt/mTOR a menudo está desregulada en el cáncer, lo que convierte a PI3K en un objetivo clave para la terapia contra el cáncer. Los inhibidores de PI3K son herramientas fundamentales para estudiar la transducción de señales, la biología del cáncer y el desarrollo de terapias dirigidas. En CymitQuimica, ofrecemos una variedad de inhibidores de PI3K para apoyar su investigación en señalización celular, oncología y desarrollo terapéutico.
Se han encontrado 241 productos de "PI3K"
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Isorhamnetin
CAS:<p>Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin.</p>Fórmula:C16H12O7Pureza:99.20% - >99.99%Forma y color:SolidPeso molecular:316.26Pilaralisib
CAS:<p>Pilaralisib (XL-147) is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K).</p>Fórmula:C25H25ClN6O4SPureza:98.51% - 99.61%Forma y color:SolidPeso molecular:541.02SF2523
CAS:<p>SF2523 is a highly selective and potent inhibitor.</p>Fórmula:C19H17NO5SPureza:99.1% - 99.51%Forma y color:SolidPeso molecular:371.41LY-294002 hydrochloride
CAS:<p>LY-294002 HCl (NSC 697286) is a stable PI3K inhibitor (IC50: 0.5-0.97 µM) and prevents autophagosome formation.</p>Fórmula:C19H17NO3·HClPureza:99.95%Forma y color:SolidPeso molecular:343.81DS-7423
CAS:<p>DS-7423: a dual PI3K/mTOR inhibitor; IC50s—PI3Kα: 15.6 nM, mTOR: 34.9 nM, PI3Kβ: 1,143 nM, PI3Kγ: 249 nM, PI3Kδ: 262 nM.</p>Fórmula:C22H27F3N10O2Pureza:99.98%Forma y color:SolidPeso molecular:520.51Gedatolisib
CAS:<p>Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling</p>Fórmula:C32H41N9O4Pureza:98% - 99.36%Forma y color:SolidPeso molecular:615.73KU-0060648
CAS:<p>KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.</p>Fórmula:C33H34N4O4SPureza:98.75%Forma y color:SolidPeso molecular:582.71Desmethyl-VS-5584
CAS:Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.Fórmula:C16H20N8OPureza:>99.99%Forma y color:SolidPeso molecular:340.38Duvelisib
CAS:<p>Duvelisib (INK1197, IPI-145) is a selective inhibitor of phosphatidylinositol 3-kinase (PI3K) and p100δ.Cost-effective and quality-assured.</p>Fórmula:C22H17ClN6OPureza:98.87% - 99.74%Forma y color:SolidPeso molecular:416.86PIK-75
CAS:<p>PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).</p>Fórmula:C16H14BrN5O4SPureza:98.52% - >99.99%Forma y color:SolidPeso molecular:452.28Vacuolin-1
CAS:<p>Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane.</p>Fórmula:C26H24IN7OPureza:97.20% - 98.45%Forma y color:SolidPeso molecular:577.42CZC24832
CAS:<p>CZC24832 is a selective inhibitor of PI 3-kinase γ.</p>Fórmula:C15H17FN6O2SPureza:99.08% - 99.12%Forma y color:SolidPeso molecular:364.4Deoxyelephantopin
CAS:<p>Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.</p>Fórmula:C19H20O6Pureza:99.6% - 99.71%Forma y color:SolidPeso molecular:344.36Acalisib
CAS:Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.Fórmula:C21H16FN7OPureza:98.99% - ≥95%Forma y color:SolidPeso molecular:401.4Parsaclisib hydrochloride
CAS:Parsaclisib hydrochloride (INCB050465 HCl) is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity.Fórmula:C20H23Cl2FN6O2Pureza:98%Forma y color:SolidPeso molecular:469.34Eganelisib
CAS:<p>Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)</p>Fórmula:C30H24N8O2Pureza:99.04% - 99.28%Forma y color:SolidPeso molecular:528.56AMG 511
CAS:<p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>Fórmula:C22H28FN9O3SPureza:≥98%Forma y color:SolidPeso molecular:517.58(E)-Akt inhibitor-IV
CAS:<p>(E)-Akt inhibitor-IV ((E)-AKTIV) ((E)-AKTIV) is an inhibitor of PI3K-Akt.</p>Fórmula:C31H29IN4SPureza:99.74% - 99.9%Forma y color:SolidPeso molecular:616.56iMDK
CAS:<p>iMDK quarterhydrate, a PI3K inhibitor, blocks MDK growth factor and enhances NSCLC treatment with MEK inhibitors, sparing normal cells.</p>Fórmula:C21H13FN2O2SPureza:99.99%Forma y color:SolidPeso molecular:376.4Vps34-PIK-III
CAS:<p>Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.</p>Fórmula:C17H17N7Pureza:98.39% - 98.43%Forma y color:SolidPeso molecular:319.36GNE-477
CAS:<p>GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.</p>Fórmula:C21H28N8O3S2Pureza:98.88% - 99.55%Forma y color:SolidPeso molecular:504.63TG 100713
CAS:<p>TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.</p>Fórmula:C12H10N6OPureza:98.17%Forma y color:SolidPeso molecular:254.25BEBT-908
CAS:<p>BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 <0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).</p>Fórmula:C23H25N9O3SPureza:99.67%Forma y color:SolidPeso molecular:507.57PI3K-IN-1
CAS:<p>PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.</p>Fórmula:C31H29N5O6SPureza:97.03% - 98%Forma y color:SolidPeso molecular:599.661,3-Dicaffeoylquinic acid
CAS:<p>1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.</p>Fórmula:C25H24O12Pureza:98% - 98.81%Forma y color:SolidPeso molecular:516.45Euscaphic acid
CAS:<p>Euscaphic acid has anti-diabetic and anti-inflammatory effects, blocking IKK/MAPKs and NF-κB activation by disrupting TRAF6/IRAK1/TAK1 clustering.</p>Fórmula:C30H48O5Pureza:98.93%Forma y color:SolidPeso molecular:488.7AS-605240
CAS:<p>AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).</p>Fórmula:C12H7N3O2SPureza:97% - 99.91%Forma y color:SolidPeso molecular:257.27HS-173
CAS:<p>HS-173 is an effective PI3Kα inhibitor (IC50: 0.8 nM).</p>Fórmula:C21H18N4O4SPureza:99.33% - 99.64%Forma y color:SolidPeso molecular:422.46Serabelisib
CAS:<p>Serabelisib (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).</p>Fórmula:C19H17N5O3Pureza:98.41% - 99.5%Forma y color:SolidPeso molecular:363.37TG100-115
CAS:<p>TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.</p>Fórmula:C18H14N6O2Pureza:99.22% - 99.26%Forma y color:SolidPeso molecular:346.34Sophocarpine
CAS:<p>Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.</p>Fórmula:C15H22N2OPureza:99.89%Forma y color:SolidPeso molecular:246.35Quercetin Dihydrate
CAS:<p>Quercetin Dihydrate (Sophoretin) is a flavonoid natural product that activates or inhibits the activity of many proteins. It activates SIRT1 and inhibits PI3K.</p>Fórmula:C15H10O7·2H2OPureza:97.77%Forma y color:Yellow SolidPeso molecular:338.2725(R,S)-Ruscogenin
CAS:<p>25(R,S)-Ruscogenin is able to regulate the PI3K/Akt/mTOR signalling pathway, and hinder the metastasis of hepatocellular carcinoma.</p>Fórmula:C27H42O4Pureza:99.32% - 99.89%Forma y color:SolidPeso molecular:430.62Buparlisib
CAS:<p>Buparlisib (BKM120) is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110α, p110β, and p110δ).</p>Fórmula:C18H21F3N6O2Pureza:95.32% - 98.45%Forma y color:SolidPeso molecular:410.39Quercetin
CAS:<p>Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1.</p>Fórmula:C15H10O7Pureza:96.29% - 98.05%Forma y color:Sensitive To Exposure To Air And Light Insoluble In Water Alcoholic Solutions Taste Very Bitter (Ntp 1992)Peso molecular:302.24RLY-2608
CAS:<p>RLY-2608 is a variant PI3Kalpha inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.</p>Fórmula:C29H14ClF5N6O2Pureza:98.62% - 98.7%Forma y color:SolidPeso molecular:608.91740 Y-P
CAS:740 Y-P (740YPDGFR) is a PI3K activator with cell permeability,binds GST fusion proteins containing the N-and C-terminal SH2 domains of p85. Low-Cost!Fórmula:C141H222N43O39PS3Pureza:98.3% - 99.87%Forma y color:SolidPeso molecular:3270.7BGT226 maleate
CAS:<p>BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .</p>Fórmula:C28H25F3N6O2·C4H4O4Pureza:97.75% - 98.78%Forma y color:SolidPeso molecular:650.6GSK2292767
CAS:<p>GSK2292767 is a potent and selective PI3Kδ inhibitor.</p>Fórmula:C24H28N6O5SPureza:98%Forma y color:SolidPeso molecular:512.58CNX-1351
CAS:<p>CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.</p>Fórmula:C30H35N7O3SPureza:99.66% - 99.83%Forma y color:SolidPeso molecular:573.71CAL-130 Hydrochloride
CAS:<p>CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).</p>Fórmula:C23H23ClN8OForma y color:SolidPeso molecular:462.94PI3K-IN-10
CAS:<p>PI3K-IN-10 is a potent inhibitor of pan-PI3K .</p>Fórmula:C23H19ClN6OPureza:98%Forma y color:SolidPeso molecular:430.89PI3Kdelta inhibitor 1
CAS:<p>PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM.</p>Fórmula:C27H38N6O5SPureza:98%Forma y color:SolidPeso molecular:558.69PI3Kδ-IN-3
CAS:<p>PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.</p>Fórmula:C28H24N6O3Pureza:98.43%Forma y color:SolidPeso molecular:492.53AZD3458
CAS:<p>AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5 , respectively).</p>Fórmula:C20H23N3O4S2Forma y color:SolidPeso molecular:433.54AZ2
CAS:<p>AZ2 is a highly selective, active PI3Kγ inhibitor (pIC50=9.3) for use in inflammatory and immune disorders.</p>Fórmula:C20H23N3O2SPureza:99.25%Forma y color:SolidPeso molecular:369.48Vps34-IN-2
CAS:<p>Vps34-IN-2 is a potent and selective Vps34 inhibitor (IC50s: 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively).</p>Fórmula:C18H25F3N4O3Pureza:98%Forma y color:SolidPeso molecular:402.41PI3K-IN-38
CAS:<p>PI3K-IN-38: oral PI3K inhibitor, IC50 of 0.541 µM, anticancer, anti-inflammatory, halts tumors in vivo.</p>Fórmula:C20H24N6O2Pureza:99.89%Forma y color:SolidPeso molecular:380.44PI3K-IN-6
CAS:<p>PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).</p>Fórmula:C17H14Cl2FN9OPureza:98%Forma y color:SolidPeso molecular:450.26PI3Kα-IN-13
CAS:<p>PI3Kα-IN-13 (Compound 18a), a PI3Kα inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines,</p>Fórmula:C21H19N5O3Pureza:98%Forma y color:SolidPeso molecular:389.41
