PI3K
Los inhibidores de PI3K son compuestos que bloquean la actividad de las fosfoinosítido 3-quinasas (PI3Ks), una familia de enzimas involucradas en una amplia gama de procesos celulares, incluidos el crecimiento, la proliferación, la supervivencia y el metabolismo. La vía PI3K/Akt/mTOR a menudo está desregulada en el cáncer, lo que convierte a PI3K en un objetivo clave para la terapia contra el cáncer. Los inhibidores de PI3K son herramientas fundamentales para estudiar la transducción de señales, la biología del cáncer y el desarrollo de terapias dirigidas. En CymitQuimica, ofrecemos una variedad de inhibidores de PI3K para apoyar su investigación en señalización celular, oncología y desarrollo terapéutico.
Se han encontrado 231 productos de "PI3K"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
740 Y-P
CAS:740 Y-P (740YPDGFR) is a PI3K activator with cell permeability,binds GST fusion proteins containing the N-and C-terminal SH2 domains of p85. Low-Cost!Fórmula:C141H222N43O39PS3Pureza:98.3% - 99.87%Forma y color:SolidPeso molecular:3270.7BGT226 maleate
CAS:BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .
Fórmula:C28H25F3N6O2·C4H4O4Pureza:97.75% - 98.78%Forma y color:SolidPeso molecular:650.6GSK2292767
CAS:GSK2292767 is a potent and selective PI3Kδ inhibitor.Fórmula:C24H28N6O5SPureza:98%Forma y color:SolidPeso molecular:512.58CNX-1351
CAS:CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.
Fórmula:C30H35N7O3SPureza:99.66% - 99.83%Forma y color:SolidPeso molecular:573.71PI3Kdelta inhibitor 1
CAS:PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM.Fórmula:C27H38N6O5SPureza:98%Forma y color:SolidPeso molecular:558.69PI3Kγ inhibitor 1
CAS:PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.Fórmula:C32H26N8O2SPureza:98%Forma y color:SolidPeso molecular:586.67PI3Kγ inhibitor 7
CAS:PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1].Fórmula:C31H25N9O2Pureza:98%Forma y color:SolidPeso molecular:555.59FD2056
CAS:FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.Fórmula:C23H17ClN6O2SPureza:98%Forma y color:SolidPeso molecular:476.94AZ2
CAS:AZ2 is a highly selective, active PI3Kγ inhibitor (pIC50=9.3) for use in inflammatory and immune disorders.Fórmula:C20H23N3O2SPureza:99.25%Forma y color:SolidPeso molecular:369.48Nemiralisib
CAS:Nemiralisib (GSK-2269557) is an oral PI3Kδ inhibitor (pKi 9.9) for treating respiratory diseases like COPD.Fórmula:C26H28N6OPureza:99.91%Forma y color:SolidPeso molecular:440.54PI3K/mTOR Inhibitor-2
CAS:Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ & mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.Fórmula:C20H13ClF2N4O4SPureza:96.16%Forma y color:SolidPeso molecular:478.86Ref: TM-T12459
1mg55,00€5mg138,00€10mg215,00€25mg358,00€50mg512,00€100mg692,00€200mg888,00€1mL*10mM (DMSO)144,00€Vps34-IN-2
CAS:Vps34-IN-2 is a potent and selective Vps34 inhibitor (IC50s: 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively).Fórmula:C18H25F3N4O3Pureza:98%Forma y color:SolidPeso molecular:402.41PI3Kδ-IN-3
CAS:PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.Fórmula:C28H24N6O3Pureza:99.8%Forma y color:SolidPeso molecular:492.53PI3K-IN-6
CAS:PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).Fórmula:C17H14Cl2FN9OPureza:98%Forma y color:SolidPeso molecular:450.26PI3Kα-IN-13
CAS:PI3Kα-IN-13 (Compound 18a), a PI3Kα inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines,Fórmula:C21H19N5O3Pureza:98%Forma y color:SolidPeso molecular:389.41PI4KIII β inhibitor 3
CAS:PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).Fórmula:C22H22N8OSPureza:98%Forma y color:SolidPeso molecular:446.53CAL-130 Hydrochloride
CAS:CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).Fórmula:C23H23ClN8OForma y color:SolidPeso molecular:462.94AZD3458
CAS:AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5 , respectively).Fórmula:C20H23N3O4S2Forma y color:SolidPeso molecular:433.54PI3K-IN-10
CAS:PI3K-IN-10 is a potent inhibitor of pan-PI3K .Fórmula:C23H19ClN6OPureza:98%Forma y color:SolidPeso molecular:430.89CHMFL-PI3KD-317
CAS:CHMFL-PI3KD-317: potent PI3Kδ inhibitor, IC50=6 nM, orally active, >10x selective vs. PI3K isoforms, anti-cancer.Fórmula:C21H24ClN5O3S2Pureza:99.16%Forma y color:SolidPeso molecular:494.03Ref: TM-T10804
1mg92,00€5mg216,00€10mg329,00€25mg593,00€50mg893,00€100mg1.216,00€1mL*10mM (DMSO)235,00€
