PI3K
Los inhibidores de PI3K son compuestos que bloquean la actividad de las fosfoinosítido 3-quinasas (PI3Ks), una familia de enzimas involucradas en una amplia gama de procesos celulares, incluidos el crecimiento, la proliferación, la supervivencia y el metabolismo. La vía PI3K/Akt/mTOR a menudo está desregulada en el cáncer, lo que convierte a PI3K en un objetivo clave para la terapia contra el cáncer. Los inhibidores de PI3K son herramientas fundamentales para estudiar la transducción de señales, la biología del cáncer y el desarrollo de terapias dirigidas. En CymitQuimica, ofrecemos una variedad de inhibidores de PI3K para apoyar su investigación en señalización celular, oncología y desarrollo terapéutico.
Se han encontrado 231 productos de "PI3K"
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Vps34-IN-1
CAS:Vps34-IN-1: potent, selective Vps34 inhibitor, 25 nM IC50, spares class I/II PI3Ks.Fórmula:C21H24ClN7OPureza:97.04%Forma y color:SolidPeso molecular:425.91Ref: TM-T7015
1mg43,00€2mg56,00€5mg88,00€10mg124,00€25mg207,00€50mg333,00€100mg477,00€1mL*10mM (DMSO)96,00€SAR405
CAS:SAR-405 inhibits PIK3C3/Vps34 (IC50: 1.2 nM, Kd: 1.5 nM), blocks autophagy, and enhances MTOR inhibitor effects on cancer cells.Fórmula:C19H21ClF3N5O2Pureza:99.42% - 99.79%Forma y color:SolidPeso molecular:443.85PIK-90
CAS:PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .
Fórmula:C18H17N5O3Pureza:98.25% - ≥95%Forma y color:SolidPeso molecular:351.36A66
CAS:A66 is a specific and effective p110α inhibitor(IC50=32 nM).Fórmula:C17H23N5O2S2Pureza:99.51% - ≥95%Forma y color:SolidPeso molecular:393.53Ref: TM-T2418
2mg34,00€5mg52,00€10mg79,00€25mg137,00€50mg234,00€100mg344,00€200mg485,00€1mL*10mM (DMSO)52,00€Linperlisib
CAS:Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3KδFórmula:C28H37FN6O5SPureza:99.01%Forma y color:SolidPeso molecular:588.69Ref: TM-T6330
1mg34,00€2mg46,00€5mg66,00€10mg90,00€25mg192,00€50mg295,00€100mg462,00€1mL*10mM (DMSO)87,00€Vps34-IN-4
CAS:VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)Fórmula:C21H25N7OPureza:98.6%Forma y color:SolidPeso molecular:391.47Ref: TM-T7944
1mg63,00€5mg137,00€10mg215,00€25mg378,00€50mg537,00€100mg713,00€200mg982,00€1mL*10mM (DMSO)150,00€CAY10505
CAS:CAY10505, a form of dehydroxyl of AS-252424, is a PI3Kγ inhibitor (IC50: 33 nM).Fórmula:C14H8FNO3SPureza:99.69% - 99.74%Forma y color:SolidPeso molecular:289.28Ref: TM-T6433
10mg35,00€25mg56,00€50mg92,00€100mg153,00€200mg216,00€500mg369,00€1mL*10mM (DMSO)40,00€GDC-0326
CAS:GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).Fórmula:C19H22N6O3Pureza:99.35% - >99.99%Forma y color:SolidPeso molecular:382.42Ref: TM-T3985
1mg35,00€2mg49,00€5mg95,00€10mg155,00€25mg255,00€50mg406,00€100mg592,00€1mL*10mM (DMSO)94,00€AZD8186
CAS:AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).Fórmula:C24H25F2N3O4Pureza:99.89% - 99.91%Forma y color:SolidPeso molecular:457.47Ref: TM-T6773
2mg43,00€5mg63,00€10mg94,00€25mg165,00€50mg289,00€100mg477,00€500mg1.063,00€1mL*10mM (DMSO)69,00€Selective PI3Kδ Inhibitor 1
CAS:Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).Fórmula:C23H20FN7OPureza:97.96%Forma y color:SolidPeso molecular:429.45Pilaralisib analogue
CAS:Pilaralisib analogue (XL147 analogue) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.Fórmula:C21H16N6O2S2Pureza:99.3% - 99.72%Forma y color:SolidPeso molecular:448.52Ref: TM-T2377
2mg35,00€5mg52,00€10mg84,00€25mg132,00€50mg205,00€100mg354,00€200mg460,00€1mL*10mM (DMSO)93,00€AZD 6482
CAS:AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.Fórmula:C22H24N4O4Pureza:99.87% - 99.95%Forma y color:SolidPeso molecular:408.45PIK-293
CAS:PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.Fórmula:C22H19N7OPureza:99.88%Forma y color:SolidPeso molecular:397.43Ref: TM-T3348
1mg46,00€2mg62,00€5mg90,00€10mg144,00€25mg260,00€50mg394,00€100mg572,00€1mL*10mM (DMSO)100,00€ETP-45658
CAS:ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).Fórmula:C16H17N5O2Pureza:99.14%Forma y color:SolidPeso molecular:311.34Ref: TM-T25399
1mg52,00€5mg111,00€10mg175,00€25mg316,00€50mg512,00€100mg747,00€1mL*10mM (DMSO)124,00€Dactolisib
CAS:Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).
Fórmula:C30H23N5OPureza:97.64% - 99.85%Forma y color:SolidPeso molecular:469.54Pectolinarin
CAS:Pectolinarin is a Cirsium isolate with anti-inflammatory activity.Fórmula:C29H34O15Pureza:98% - 99.79%Forma y color:SolidPeso molecular:622.57MTX-211
CAS:MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.Fórmula:C20H14Cl2FN5O2SPureza:97.6% - >99.99%Forma y color:SolidPeso molecular:478.33Ref: TM-T4296
1mg64,00€2mg95,00€5mg170,00€10mg274,00€25mg464,00€50mg640,00€100mg847,00€200mg1.159,00€1mL*10mM (DMSO)180,00€Pictilisib
CAS:Pictilisib (GDC-0941) (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3/33/3/75 nM for p110α/β/δ/γ).Fórmula:C23H27N7O3S2Pureza:98.69% - 99.97%Forma y color:SolidPeso molecular:513.64Sincalide
CAS:Sincalide (CCK-8) is an injectable drug used to diagnose gallbladder and pancreas disorders; it's a cholecystokinin fragment.Fórmula:C49H62N10O16S3Pureza:98.32%Forma y color:SolidPeso molecular:1143.27IC-87114
CAS:IC-87114 is a specific PI3Kδ inhibitor(IC50=0.5 μM).Fórmula:C22H19N7OPureza:99.30% - >99.99%Forma y color:SolidPeso molecular:397.43
