PI3K
Los inhibidores de PI3K son compuestos que bloquean la actividad de las fosfoinosítido 3-quinasas (PI3Ks), una familia de enzimas involucradas en una amplia gama de procesos celulares, incluidos el crecimiento, la proliferación, la supervivencia y el metabolismo. La vía PI3K/Akt/mTOR a menudo está desregulada en el cáncer, lo que convierte a PI3K en un objetivo clave para la terapia contra el cáncer. Los inhibidores de PI3K son herramientas fundamentales para estudiar la transducción de señales, la biología del cáncer y el desarrollo de terapias dirigidas. En CymitQuimica, ofrecemos una variedad de inhibidores de PI3K para apoyar su investigación en señalización celular, oncología y desarrollo terapéutico.
Se han encontrado 231 productos de "PI3K"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
ETP-46321
CAS:ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).Fórmula:C20H27N9O3SPureza:99.8%Forma y color:SolidPeso molecular:473.55Ref: TM-TQ0229
1mg39,00€5mg87,00€10mg123,00€25mg225,00€50mg314,00€100mg430,00€200mg582,00€1mL*10mM (DMSO)90,00€Autophinib
CAS:Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay andFórmula:C14H11ClN6O3Pureza:99.25% - 99.41%Forma y color:SolidPeso molecular:346.73Ref: TM-T4219
2mg39,00€5mg58,00€10mg88,00€25mg160,00€50mg215,00€100mg334,00€200mg494,00€1mL*10mM (DMSO)66,00€Taselisib
CAS:Taselisib (GDC-0032) is an oral PI3K alpha inhibitor with potential cancer-treating properties.Fórmula:C24H28N8O2Pureza:99.62% - 99.79%Forma y color:SolidPeso molecular:460.53Ref: TM-T1999
2mg46,00€5mg66,00€10mg92,00€25mg157,00€50mg197,00€100mg350,00€200mg522,00€500mg840,00€1mL*10mM (DMSO)66,00€IITZ-01
CAS:IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)Fórmula:C26H23FN8OPureza:99.31%Forma y color:SolidPeso molecular:482.51Lupiwighteone
CAS:Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.Fórmula:C20H18O5Pureza:98.92%Forma y color:SolidPeso molecular:338.35Leniolisib
CAS:Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).
Fórmula:C21H25F3N6O2Pureza:99.88%Forma y color:SolidPeso molecular:450.46Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Fórmula:C19H24O5Pureza:96.66% - 99.93%Forma y color:SolidPeso molecular:332.39BGT226
CAS:BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Fórmula:C28H25F3N6O2Pureza:95.74% - 99.78%Forma y color:SolidPeso molecular:534.53Ref: TM-T6072L
1mg47,00€2mg62,00€5mg92,00€10mg147,00€25mg295,00€50mg485,00€100mg737,00€1mL*10mM (DMSO)107,00€Heterophyllin B
CAS:Heterophyllin B hinders esophageal cancer cell adhesion/invasion via PI3K/AKT/β-catenin and gene regulation.Fórmula:C40H58N8O8Pureza:99.12% - 99.85%Forma y color:SolidPeso molecular:778.94AMG319
CAS:AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.Fórmula:C21H16FN7Pureza:98.9% - 99.24%Forma y color:Crystalline SolidPeso molecular:385.4P7C3-A20
CAS:P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity.Fórmula:C22H19Br2FN2OPureza:96.83% - ≥98%Forma y color:SolidPeso molecular:506.21Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Fórmula:C13H14N6OPureza:98.21% - 99.69%Forma y color:SolidPeso molecular:270.29Ref: TM-T7014
1mg35,00€2mg50,00€5mg74,00€10mg117,00€25mg226,00€50mg364,00€100mg532,00€1mL*10mM (DMSO)74,00€Umbralisib
CAS:Umbralisib (TGR 1202) is a PI3Kδ inhibitor.Fórmula:C31H24F3N5O3Pureza:99.56% - 99.56%Forma y color:White SolidPeso molecular:571.55Ref: TM-T4976
1mg48,00€2mg65,00€5mg96,00€10mg170,00€25mg343,00€50mg449,00€100mg658,00€1mL*10mM (DMSO)120,00€AZD-8835
CAS:AZD-8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).Fórmula:C22H31N9O3Pureza:98.22% - 99.88%Forma y color:SolidPeso molecular:469.54AS-604850
CAS:AS-604850: ATP-competitive PI3Kγ inhibitor, IC50 250 nM, 18x > PI3Kα, 80x > PI3Kδ/β.Fórmula:C11H5F2NO4SPureza:99.65%Forma y color:SolidPeso molecular:285.22PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Fórmula:C14H16ClN3O4S2Pureza:97.72%Forma y color:SolidPeso molecular:389.88Ref: TM-T2616
1mg42,00€5mg85,00€10mg105,00€25mg200,00€50mg305,00€100mg427,00€200mg613,00€1mL*10mM (DMSO)94,00€CH5132799
CAS:CH5132799 has been used in trials studying the treatment of Solid Tumors.Fórmula:C15H19N7O3SPureza:99.41% - 99.87%Forma y color:SolidPeso molecular:377.42Ref: TM-T2619
1mg64,00€2mg96,00€5mg144,00€10mg227,00€25mg420,00€50mg622,00€100mg885,00€500mg1.786,00€Seletalisib
CAS:Seletalisib (UCB5857) (UCB5857) is a potent and specific PI3Kδ inhibitor (IC50: 12 nM).Fórmula:C23H14ClF3N6OPureza:99.81%Forma y color:SolidPeso molecular:482.85Ref: TM-TQ0044
1mg54,00€2mg77,00€5mg114,00€10mg178,00€25mg313,00€50mg447,00€100mg625,00€1mL*10mM (DMSO)119,00€α-Linolenic acid
CAS:α-Linolenic Acid (ALA) is an essential fatty acid. α-Linolenic acid improves memory, inhibits thrombosis, and lowers blood lipids. Cost-effective and quality-assured.Fórmula:C18H30O2Pureza:97.05% - 99.81%Forma y color:Physical Description Clear Colorless Liquid (Ntp 1992)Peso molecular:278.43GSK2636771
CAS:GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, and
Fórmula:C22H22F3N3O3Pureza:98.58% - ≥95%Forma y color:SolidPeso molecular:433.42
