ATM / ATR

Elimusertib hydrochloride is a effective, orally available and selective ATR inhibitor with anti-tumor activity.

RP-3500 (ATR inhibitor 4) is a selective, orally active ATR kinase inhibitor (ATRi) with an …

KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).

VE-822 has been used in trials studying the treatment of Ovarian Neoplasms, Ovarian Serous Tumor, …

Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and …

CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK …

KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.

BAY 1895344 is a potent, highly selective and orally available ATR inhibitor with an IC50 …

AZD6738 is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM.

NU7026 is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for …

AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and …

Schisandrin B has an antioxidant effect on rodent liver and heart.

AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 …

AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold …

Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity.

GJ103 sodium salt is an active analog of GJ072, a read-through compound.

AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a …

NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 …

PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα …

AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM …

CGK 733 is a potent and selective inhibitor of ATM/ATR.

Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity …

Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity …

Dactolisib is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 …

VE-821 is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).

ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).

ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) …

Ro 90-7501 is an amyloid β42 fibril assembly inhibitor (EC50: 2 μM). Ro 90-7501 inhibits …

ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) …

KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM …