ATM / ATR
Los inhibidores de ATM (Ataxia Telangiectasia Mutada) y ATR (ATM y Rad3-relacionada) se dirigen a quinasas clave involucradas en la respuesta al daño del ADN (DDR) que se activan en respuesta a rupturas de doble hebra de ADN y estrés replicativo. Estos inhibidores interrumpen la capacidad de estas quinasas para detectar y reparar el daño del ADN, lo que puede llevar a una mayor inestabilidad genómica y muerte celular, particularmente en células cancerosas que dependen de mecanismos robustos de reparación del ADN para sobrevivir. Los inhibidores de ATM/ATR son herramientas cruciales en la investigación y terapia contra el cáncer, especialmente en combinación con agentes que dañan el ADN. En CymitQuimica, ofrecemos una amplia gama de inhibidores de ATM/ATR de alta calidad para apoyar su investigación en la respuesta al daño del ADN, biología del cáncer y desarrollo terapéutico.
Se han encontrado 71 productos de "ATM / ATR"
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ATR-IN-14
CAS:<p>ATR-IN-14: potent ATR kinase inhibitor; 98.03% inhibition at 25 nM; IC50 of 64 nM in LoVo cells.</p>Fórmula:C20H20FN7OForma y color:SolidPeso molecular:393.42KU 59403
CAS:<p>KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).</p>Fórmula:C29H32N4O4S2Pureza:99.10%Forma y color:SolidPeso molecular:564.72ATR kinase-IN-2
CAS:<p>ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.</p>Fórmula:C24H29F2N9O2Forma y color:SolidPeso molecular:513.54ATM Inhibitor-11
CAS:<p>ATMInhibitor-11 (Compound 1) is an inhibitor of ATM with an IC50 of 0.32 nM. It also inhibits KAP1 phosphorylation with an IC50 of 0.97 nM. This compound exhibits high exposure in the brain, heart, and plasma of ICR mice. Furthermore, ATMInhibitor-11 demonstrates antitumor activity in the NCI-H441 xenograft mouse model.</p>Fórmula:C27H33FN6O2Forma y color:SolidPeso molecular:492.59ATR kinase-IN-3
CAS:<p>ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.</p>Fórmula:C24H27F2N9O2Forma y color:SolidPeso molecular:511.53ATR-IN-12
<p>ATR-IN-12, a potent ATR kinase inhibitor with IC50 of 0.007 μM, shows promise for drug development.</p>Fórmula:C22H27N5O3SForma y color:SolidPeso molecular:441.55ATR-IN-19
CAS:<p>ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].</p>Fórmula:C18H19N7OSForma y color:SolidPeso molecular:381.45(S)-WSD0628
CAS:<p>(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.</p>Fórmula:C23H23F2N5O2Forma y color:SolidPeso molecular:439.458ATR-IN-11
<p>ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.</p>Fórmula:C25H30N6O2Forma y color:SolidPeso molecular:446.54KU-60019
CAS:<p>KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).</p>Fórmula:C30H33N3O5SPureza:98.05% - 98.50%Forma y color:SolidPeso molecular:547.67ATR-IN-24
CAS:<p>ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].</p>Fórmula:C23H26N6O2Pureza:98%Forma y color:SolidPeso molecular:418.49Ref: TM-T79058
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