ATM / ATR
Los inhibidores de ATM (Ataxia Telangiectasia Mutada) y ATR (ATM y Rad3-relacionada) se dirigen a quinasas clave involucradas en la respuesta al daño del ADN (DDR) que se activan en respuesta a rupturas de doble hebra de ADN y estrés replicativo. Estos inhibidores interrumpen la capacidad de estas quinasas para detectar y reparar el daño del ADN, lo que puede llevar a una mayor inestabilidad genómica y muerte celular, particularmente en células cancerosas que dependen de mecanismos robustos de reparación del ADN para sobrevivir. Los inhibidores de ATM/ATR son herramientas cruciales en la investigación y terapia contra el cáncer, especialmente en combinación con agentes que dañan el ADN. En CymitQuimica, ofrecemos una amplia gama de inhibidores de ATM/ATR de alta calidad para apoyar su investigación en la respuesta al daño del ADN, biología del cáncer y desarrollo terapéutico.
Se han encontrado 77 productos para "ATM / ATR".
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ATR kinase-IN-3
CAS:ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.Fórmula:C24H27F2N9O2Forma y color:SolidPeso molecular:511.53ATR-IN-17
CAS:ATR-IN-17 is a potent inhibitor of ATR kinase with good anti-cancer effects in LoVo cells (IC50: 1 nM).Fórmula:C22H28N6O2SForma y color:SolidPeso molecular:440.56(S)-WSD0628
CAS:(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.Fórmula:C23H23F2N5O2Forma y color:SolidPeso molecular:439.458ATR-IN-19
CAS:ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].Fórmula:C18H19N7OSForma y color:SolidPeso molecular:381.45ATR-IN-12
ATR-IN-12, a potent ATR kinase inhibitor with IC50 of 0.007 μM, shows promise for drug development.Fórmula:C22H27N5O3SForma y color:SolidPeso molecular:441.55ATR-IN-11
ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.Fórmula:C25H30N6O2Forma y color:SolidPeso molecular:446.54XRD-0394
CAS:XRD-0394 is a highly effective and selective dual inhibitor of ATM and DNA-PKcs, exhibiting oral bioactivity. It notably increases tumor cell destruction both in vitro and in vivo when combined with therapeutic ionizing radiation. Furthermore, XRD-0394 enhances the efficacy of PARP and topoisomerase I inhibitors in vitro [1].Fórmula:C26H30FN5O4SPeso molecular:527.61Decarbamoylmitomycin C
CAS:Decarbamoylmitomycin C, an analog of Mitomycin C (MC), functions as a DNA alkylating agent. It is capable of activating chromatin relaxation by the ataxia-telangiectasia and Rad3-related protein (ATR) in a p53-independent manner.Fórmula:C14H17N3O4Forma y color:SolidPeso molecular:291.302ATR-IN-14
CAS:ATR-IN-14: potent ATR kinase inhibitor; 98.03% inhibition at 25 nM; IC50 of 64 nM in LoVo cells.Fórmula:C20H20FN7OForma y color:SolidPeso molecular:393.42ATM Inhibitor-1
CAS:ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity.Fórmula:C27H36N6O3Pureza:98%Forma y color:SolidPeso molecular:492.61KU 59403
CAS:KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).Fórmula:C29H32N4O4S2Pureza:99.10% - 99.79%Forma y color:SolidPeso molecular:564.719ATR-IN-32
CAS:ATR-IN-32 is an orally active ATR inhibitor that effectively suppresses the proliferation of MIA PaCa-2 cells. It significantly inhibits tumor growth in mice bearing LOVO and HT-29 xenografts. ATR-IN-32 is applicable for studying cancers mediated by the ATR protein kinase, such as colorectal cancer and pancreatic cancer.Fórmula:C22H24N6O2Peso molecular:404.47ATM-IN-13
CAS:ATM-IN-13 (A36) is an orally active selective ATM kinase inhibitor with a human IC50 of 0.3 nM. It disrupts the ATM-mediated DNA double-strand break repair signaling pathway, reduces phosphorylation levels of ATM and p53, and inhibits the ATM-dependent DNA damage response. ATM-IN-13 is applicable in colorectal cancer research.Fórmula:C27H33N5OPeso molecular:443.58WSD0628
CAS:WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].Fórmula:C23H23F2N5O2Forma y color:SolidPeso molecular:439.46ATM Inhibitor-3
ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.Fórmula:C25H29FN6O3Forma y color:SolidPeso molecular:480.53ATM Inhibitor-2
ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).Fórmula:C26H31N7O3Forma y color:SolidPeso molecular:489.57ATM Inhibitor-4
ATM Inhibitor -4: selective, potent (IC50: 0.32 nM), inhibits PI3K family, stable, stops mTOR at 1 μM.Fórmula:C26H29FN6O3Forma y color:SolidPeso molecular:492.55
