mTOR
Los inhibidores de mTOR son compuestos que inhiben la actividad de la Proteína diana de la rapamicina en mamíferos (mTOR), un regulador central del crecimiento celular, la proliferación, el metabolismo y la supervivencia. La vía de mTOR se altera con frecuencia en el cáncer y otras enfermedades, lo que convierte a mTOR en un objetivo crítico para la intervención terapéutica. Los inhibidores de mTOR se utilizan ampliamente en la investigación relacionada con el cáncer, el envejecimiento y los trastornos metabólicos. En CymitQuimica, ofrecemos una variedad de inhibidores de mTOR para apoyar su investigación en transducción de señales, oncología y desarrollo terapéutico.
Se han encontrado 163 productos de "mTOR"
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Dactolisib
CAS:Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).
Fórmula:C30H23N5OPureza:97.64% - 99.85%Forma y color:SolidPeso molecular:469.54PQR620
CAS:PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.Fórmula:C21H25F2N7O2Pureza:97.61%Forma y color:SolidPeso molecular:445.47CDC25B-IN-2
CAS:BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression.Fórmula:C15H12N2O3Pureza:99.12%Forma y color:SolidPeso molecular:268.27GNE-477
CAS:GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.Fórmula:C21H28N8O3S2Pureza:98.88% - 99.55%Forma y color:SolidPeso molecular:504.63Ref: TM-T3692
1mg44,00€2mg57,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg138,00€25mg286,00€50mg447,00€100mg677,00€Salidroside
CAS:Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola rosea and is a prolyl endopeptidase inhibitor.Cost-effective and quality-assured.Fórmula:C14H20O7Pureza:97.81%Forma y color:Red-Brown Fine PowderPeso molecular:300.30Ref: TM-T2717
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg81,00€25mg130,00€50mg178,00€100mg268,00€200mg408,00€Corynoxine
CAS:Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla.Fórmula:C22H28N2O4Pureza:96.83% - 99.93%Forma y color:SolidPeso molecular:384.47Mito-LND
CAS:Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.Fórmula:C43H45BrCl2N3OPPureza:97.25% - 98.34%Forma y color:SolidPeso molecular:801.62Rotundic acid
CAS:Rotundic acid fights various cancers: HepG2, A375, NCI-H446, MCF-7, and HT-29.Fórmula:C30H48O5Pureza:96.91% - 99.97%Forma y color:SolidPeso molecular:488.70Ref: TM-T5S0506
2mg34,00€5mg49,00€1mL*10mM (DMSO)49,00€10mg75,00€25mg137,00€50mg215,00€100mg319,00€200mg474,00€Lupiwighteone
CAS:Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.Fórmula:C20H18O5Pureza:98.92%Forma y color:SolidPeso molecular:338.35Serabelisib
CAS:Serabelisib (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).Fórmula:C19H17N5O3Pureza:98.41% - 99.5%Forma y color:SolidPeso molecular:363.373BDO
CAS:3BDO is a new mTOR activator. 3BDO inhibits autophagy.Fórmula:C18H17NO5Pureza:97.76%Forma y color:SolidPeso molecular:327.33Ref: TM-T14033
1mg34,00€2mg44,00€5mg64,00€1mL*10mM (DMSO)71,00€10mg92,00€25mg195,00€50mg313,00€100mg467,00€Temsirolimus
CAS:Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 μM), used in the treatment of advanced renal cell cancer.Fórmula:C56H87NO16Pureza:97.76% - >99.99%Forma y color:White Crystalline PowderPeso molecular:1030.29GNE-317
CAS:GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).Fórmula:C19H22N6O3SPureza:98.42% - 99.54%Forma y color:SolidPeso molecular:414.48Ref: TM-T6845
2mg43,00€5mg63,00€1mL*10mM (DMSO)70,00€10mg92,00€25mg192,00€50mg264,00€100mg339,00€200mg497,00€CH5132799
CAS:CH5132799 has been used in trials studying the treatment of Solid Tumors.Fórmula:C15H19N7O3SPureza:99.41% - 99.87%Forma y color:SolidPeso molecular:377.42Ref: TM-T2619
1mg60,00€2mg92,00€5mg137,00€10mg215,00€25mg399,00€50mg590,00€100mg838,00€500mg1.693,00€LY 303511 hydrochloride
CAS:LY 303511 hydrochloride is a potent mTOR inhibitorFórmula:C19H19ClN2O2Pureza:98.47%Forma y color:SolidPeso molecular:342.82BGT226 maleate
CAS:BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .Fórmula:C28H25F3N6O2·C4H4O4Pureza:97.75% - 98.77%Forma y color:SolidPeso molecular:650.6Ref: TM-T6072
1mg35,00€5mg73,00€1mL*10mM (DMSO)94,00€10mg108,00€25mg230,00€50mg339,00€100mg485,00€200mg665,00€LY 303511
CAS:LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.Fórmula:C19H18N2O2Pureza:98%Forma y color:SolidPeso molecular:306.36PKI-179
CAS:PKI-179: Dual PI3K/mTOR inhibitor, orally active, IC50s: 0.42-77 nM, targets E545K and H1047R, antitumor in vivo.Fórmula:C25H28N8O3Forma y color:SolidPeso molecular:488.54mTOR inhibitor-2
CAS:mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).Fórmula:C23H21N7OPureza:98%Forma y color:SolidPeso molecular:411.46PP30
CAS:PP30 is an inhibitor of mTORC1 and mTORC2. It is selective within the PI3K family, inhibiting other PI3Ks only at high concentrations.Fórmula:C18H19N7OSPureza:98%Forma y color:SolidPeso molecular:381.45PI3K/mTOR Inhibitor-4
CAS:Oral PI3K/mTOR Inhibitor-4 targets PI3Kα, γ, δ, mTOR; IC50s: 0.63, 22, 9.2, 13.85 nM. Used in cancer research.Fórmula:C27H22FN3O6SForma y color:SolidPeso molecular:535.54PI-540
CAS:PI-540 is a potent and selective inhibitor of class 1A phosphatidylinositide 3-kinases (PI3K).Fórmula:C22H27N5O2SForma y color:SolidPeso molecular:425.55PI3K/mTOR Inhibitor-3
CAS:PI3K/mTOR Inhibitor-3, a potent dual-action anti-cancer imidazoline, targets PI3K and mTOR.Fórmula:C22H23N5OForma y color:SolidPeso molecular:373.45PI3K/mTOR Inhibitor-9
CAS:PI3K/mTOR Inhibitor-9 acts on mTOR (38 nM IC50) and PI3Kα/γ (6.6 nM IC50), PI3Kδ (0.8 nM IC50).Fórmula:C23H27N7O2Forma y color:SolidPeso molecular:433.51PI3Ka-IN-5
CAS:PI3Ka-IN-5 is a potent PI3Kα/mTOR inhibitor, with an IC 50 of 0.7 nM and 3.3 nM, respectively. PI3Ka-IN-5 can be used for the research of colorectal cancer .Fórmula:C30H35N9O5Forma y color:SolidPeso molecular:601.66NVP-BBD130
CAS:NVP-BBD130 is a stable, ATP-competitive, potent, orally active inhibitor of PI3K and mTOR.Fórmula:C28H21N5OForma y color:SolidPeso molecular:443.5PKI-179 hydrochloride
CAS:PKI-179: oral PI3K/mTOR inhibitor; IC50: PI3Kα/β/δ/γ (8-74 nM), PI3Kα mutants (11-14 nM), mTOR (0.42 nM); selective; inhibits cancer cell growth.Fórmula:C25H29ClN8O3Forma y color:SolidPeso molecular:525PI3K/mTOR Inhibitor-8
CAS:PI3K/mTOR Inhibitor-8: Dual PI3Kα (IC50: 0.46 nM) & mTOR (IC50: 12 nM) inhibitor; blocks G1/S phase & induces apoptosis in HCT-116 cells.Fórmula:C23H22N8O4SForma y color:SolidPeso molecular:506.54eCF-309
CAS:eCF-309 is a potent mTOR inhibitor with IC50 value of 15 nM.Fórmula:C18H21N7O3Forma y color:SolidPeso molecular:383.4PI3K/mTOR Inhibitor-13
CAS:PI3K/mTOR Inhibitor-13, an oral dual blocker of PI3K and mTOR, may treat sexual diseases, solid tumors, and IPF.Fórmula:C20H13F2N5O3SForma y color:SolidPeso molecular:441.41PI3-Kinase α Inhibitor 2
CAS:Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 andFórmula:C16H15N3O2SForma y color:SolidPeso molecular:313.37OXA-01
CAS:OXA-01 is a potent mTORC1 and mTORC2 inhibitor, with IC 50 values of 29 nM and 7 nM, respectively [1]. OXA-01 demonstrates broad anti-tumor activity.Fórmula:C21H20ClN5O2Forma y color:SolidPeso molecular:409.87P-2281
CAS:P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cellFórmula:C9H8ClN3OPureza:99.98%Forma y color:SolidPeso molecular:209.63PI3K/mTOR Inhibitor-2
CAS:Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ & mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.Fórmula:C20H13ClF2N4O4SPureza:96.16%Forma y color:SolidPeso molecular:478.86Ref: TM-T12459
1mg55,00€5mg138,00€1mL*10mM (DMSO)144,00€10mg215,00€25mg358,00€50mg512,00€100mg692,00€200mg888,00€QNN33358
CAS:QNN33358 is an alkylacylglycerol acts as a protein kinase C (PKC) inhibitor and diacylglycerol (DAG) antagonist.Fórmula:C21H42O4Forma y color:SolidPeso molecular:358.56WJD008
CAS:WJD008 inhibits PI3K/mTOR, blocks cancer cell growth, and has tumor-fighting properties.Fórmula:C19H21N5O2Forma y color:SolidPeso molecular:351.4AP1867
CAS:AP1867 (FK506-binding protein) is a synthetic FKBP12 F36V-directed ligand coupled to THOX derivatives, facilitating targeted protein interactions and intracellular modulation studies.Fórmula:C38H47NO11Pureza:99.86%Forma y color:SolidPeso molecular:693.78Ref: TM-T14297
1mg138,00€5mg334,00€10mg502,00€1mL*10mM (DMSO)512,00€25mg888,00€50mg1.395,00€100mg2.097,00€PI3Kα/mTOR-IN-1
CAS:PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR.Fórmula:C16H18N6OPureza:99.89%Forma y color:SolidPeso molecular:310.35JR-AB2-011
CAS:JR-AB2-011: selective mTORC2 inhibitor, IC50 = 0.36μM, blocks Rictor-mTOR, Ki = 0.19μM, cytotoxic in glioblastoma.Fórmula:C17H14Cl2FN3OSPureza:98.33% - 99.41%Forma y color:SolidPeso molecular:398.28Ref: TM-T11728
1mg90,00€5mg192,00€1mL*10mM (DMSO)212,00€10mg326,00€25mg597,00€50mg895,00€100mg1.198,00€FT-1518
CAS:FT-1518 is an orally available, selective and potent mTORC1 and mTORC2 inhibitor with anticancer and antitumor activity for cancer research.Fórmula:C20H26N8OPureza:98.34% - 98.80%Forma y color:SolidPeso molecular:394.47mTOR inhibitor-3
CAS:mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments.Fórmula:C25H30N8O2Pureza:99% - 99.64%Forma y color:SolidPeso molecular:474.56Ref: TM-T12123
1mg57,00€5mg120,00€1mL*10mM (DMSO)128,00€10mg170,00€25mg290,00€50mg439,00€100mg620,00€500mg1.288,00€PI3K/mTOR Inhibitor-1
CAS:PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM)Fórmula:C18H22FN5O3SPureza:98%Forma y color:SolidPeso molecular:407.46mTOR inhibitor 9d
CAS:mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia,Fórmula:C21H23N5O3SPureza:98.91%Forma y color:SoildPeso molecular:425.5GNE-490
CAS:GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.Fórmula:C18H22N6O2SPureza:99.77%Forma y color:SolidPeso molecular:386.47Ref: TM-T22339
1mg80,00€2mg109,00€5mg178,00€1mL*10mM (DMSO)193,00€10mg304,00€25mg482,00€50mg665,00€100mg883,00€200mg1.215,00€mTOR inhibitor 9b
CAS:mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTORFórmula:C21H23N5O2SPureza:99.89%Forma y color:SoildPeso molecular:409.5PI3K/mTOR Inhibitor-7
CAS:Potent PI3K/mTOR inhibitor, 4.7x stronger than gedatolisib; IC50: 1.4 μM (PI3K), 0.3 μM (mTOR); impacts PI3K/Akt/mTOR pathway; research in cancer.Fórmula:C29H33N9O4Forma y color:SolidPeso molecular:571.63PI3K/mTOR Inhibitor-5
CAS:PI3K/mTOR Inhibitor-5 is a potent dual inhibitor of PI3K and mTOR, displaying IC50 values of 86.9 nM (for PI3K) and 14.6 nM (for mTOR), respectively.Fórmula:C32H40N10O3Forma y color:SolidPeso molecular:612.73mTOR inhibitor-11
CAS:mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6.Fórmula:C21H26N6O2Pureza:98%Forma y color:SolidPeso molecular:394.47WYE-23
CAS:WYE-23 is an inhibitor of mammalian target of rapamycin (mTOR).Fórmula:C26H32N8O4Forma y color:SolidPeso molecular:520.58PI3K/mTOR Inhibitor-12
CAS:PI3K/mTOR Inhibitor-12: oral, potent, selective; IC50: PI3Kα 0.06 nM, mTOR 3.12 nM; strong antitumor; less liver toxicity.Fórmula:C27H27F2N9O4SPureza:98%Forma y color:SolidPeso molecular:611.62WYE-132
CAS:WYE-125132: potent mTOR inhibitor, IC50 0.19 nM, selective over PI3Ks/hSMG1/ATR.Fórmula:C27H33N7O4Pureza:99.16%Forma y color:SolidPeso molecular:519.6MTI-31
CAS:MTI-31 (LXI-15029) is a potent oral mTORC1/2 inhibitor with a Kd of 0.20 nM, >5,000-fold selectivity, and an IC50 of 39 nM.Fórmula:C26H30N6O3Pureza:99.97%Forma y color:SolidPeso molecular:474.55PI3K/mTOR Inhibitor-14
CAS:PI3K/mTOR Inhibitor-14 (compound Y-2) serves as a dual inhibitor of PI3K and mTOR, exhibiting IC50 values of 171.4 nM and 10.1 nM , respectively, andFórmula:C28H30N8O3SPureza:98%Forma y color:SolidPeso molecular:558.66PI3K/mTOR Inhibitor-6
CAS:Potent, stable PI3K/mTOR Inhibitor-6 surpasses gedatolisib in gastric fluid; 10 μM hinders PI3K/Akt/mTOR pathway, aids cancer research.Fórmula:C30H34N10O4Forma y color:SolidPeso molecular:598.66WAY-600
CAS:WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308).Fórmula:C28H30N8OPureza:99.88%Forma y color:SolidPeso molecular:494.59Ref: TM-T6730
500mgA consultar1mg35,00€2mg60,00€5mg92,00€1mL*10mM (DMSO)105,00€10mg133,00€25mg233,00€50mg344,00€100mg480,00€Rheb inhibitor NR1
CAS:Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor that promotes phosphorylation of S473pAKT.Fórmula:C25H19BrCl2N2O3SPureza:99.72%Forma y color:SolidPeso molecular:578.3Ref: TM-T16741
1mL*10mM (DMSO)44,00€1mg87,00€5mg178,00€10mg295,00€25mg595,00€50mg895,00€100mg1.513,00€PKI-402
CAS:PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.Fórmula:C29H34N10O3Pureza:99.94%Forma y color:SolidPeso molecular:570.65PF-04979064
CAS:PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).
Fórmula:C24H26N6O3Pureza:98.20% - ≥98%Forma y color:SolidPeso molecular:446.5GDC-0349
CAS:GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.Fórmula:C24H32N6O3Pureza:96.00% - 98.49%Forma y color:SolidPeso molecular:452.55PD-M6
CAS:PD-M6 is an mTOR PROTAC degrader with a DC50 of 4.8 μM, which facilitates the ubiquitination and degradation of mTOR. It inhibits the proliferation of cancer cell lines HeLa, MCF-7, and HepG2 with IC50 values of 11.3, 2.58, and 3.23 μM, respectively, and induces autophagy. Additionally, PD-M6 specifically targets the degradation of the key protein LAMTOR1 in the mTOR signaling pathway.Fórmula:C30H39N9O6Forma y color:SolidPeso molecular:621.69PI3K-IN-37
CAS:PI3K-IN-37 inhibits PI3K α/β/δ (IC50: 6/8/4 nM) and mTOR (IC50: 4 nM).Fórmula:C25H26N6O2Forma y color:SolidPeso molecular:442.51AZD 3147
CAS:AZD 3147 inhibits mTORC1 (40.7 nM), mTORC2 (5.75 nM), and PI3Kα/β/δ/γ (912/5495/9333/6310 nM IC50s).
Fórmula:C24H31N5O4S2Pureza:99.99%Forma y color:SolidPeso molecular:517.66mTORC1-IN-1
mTORC1-IN-1 (T1), a rapamycin homologue (rapalog) and selective inhibitor of mTORC1, controls cell growth and metabolism, with implications in various diseases
Pureza:98%Forma y color:Odour Solid
