Compuestos policíclicos

<p>7-Chloro-2H-pyrido[3,2-B]-1,4-oxazin-3(4H)-one is a chemical which is used as a reagent and building block in the synthesis of more complex compounds. It has been reported to be an intermediate for the production of pharmaceuticals and agrochemicals. The compound can also be used as an intermediate for the synthesis of other valuable chemicals such as pesticides and dyes. 7-Chloro-2H-pyrido[3,2-B]-1,4-oxazin-3(4H)-one has a CAS number of 205748-05-6.</p>

<p>6-Bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one is a versatile building block that can be used in a variety of chemical reactions as an intermediate. It is also useful in the synthesis of a variety of compounds, such as pharmaceuticals and research chemicals. 6-Bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one is an organic compound with a molecular formula of C8H5BrN4O. It has an mp of 152°C and decomposes to form nitrogen gas and carbon monoxide at higher temperatures.</p>

<p>7-Hydroxycoumarin is a fluorescent compound, known as a coumarin derivative, which is a naturally occurring chemical found in many plants. Derived from the umbelliferone compound family, it exhibits strong blue fluorescence under UV light due to its unique structural properties. This fluorescence is a result of its molecular conjugation and the electron-donating nature of the hydroxyl group, allowing it to absorb and emit light efficiently.</p>

<p>Plant hormone; auxin; inducer of root development; used in plant rooting</p>

<p>1-Methyl-1H-indole-2,3-dione is a chemical compound that belongs to the class of indole derivatives. It can be synthesized by reacting 2,3-dihydroxybenzaldehyde with 2,2'-azobis(2-amidinopropane) dihydrochloride and methyl iodide in the presence of copper (II) acetate. This reaction mechanism is similar to that of other reactions involving an intramolecular hydrogen transfer. The binding constants for 1-methyl-1H-indole-2,3-dione are very high and this compound has been shown to inhibit herpes simplex virus replication in vitro. 1MIDD binds to the active site of tryptophan fluorescence and synchronous fluorescence proteins. 1MIDD also binds to copper ions in a coordination geometry that is similar to that found for other compounds containing a carbonyl group.</p>

<p>6-Chloro-3-indolyl 1,3-diacetate is an aglycone that is used as a chromogenic substrate for the detection of bacteria. It reacts with specific enzymes in the bacterial cell wall to produce a red or pink color. 6-Chloro-3-indolyl 1,3-diacetate is used as a diagnostic tool to identify bacteria and has been shown to be excreted in urine.</p>

<p>1,10-Phenanthroline·HCl·H2O is a chemical compound that has been used for the preparation of samples for spectroscopic analysis. The compound is chemically stable and resistant to hydrolysis, making it suitable for long-term storage. 1,10-Phenanthroline·HCl·H2O has an inhibitory effect on bitter taste receptors in the mouth. It also has a hydroxyl group and a carbonyl group, which can react with acid molecules to form hydrogen ions and water. 1,10-Phenanthroline·HCl·H2O belongs to the class of metal ion sequestrants and can be used to remove aluminium from solutions. The molecular formula of this compound is C14H12N2O4Cl2. The structural formula is shown below:<br><br>[[image:1,10-phenanthroline-hcl-h2o.png]]</p>

<p>5-Methylisatin is a reaction rate-limiting substrate in the conversion of pyridoxal 5'-phosphate to pyridoxamine 5'-phosphate. It is oxidized by hydroxyl radicals to form malonic acid and anhydrous acetonitrile. The reaction is catalyzed by an enzyme called tissue nonspecific alkaline phosphatase (TNAP). TNAP activity can be inhibited by test compounds, such as anthranilic acid and homogenates, which are substances that contain enzymes or cells from tissues. Hydroxyl groups on the 5-methylisatin molecule form hydrogen bonds with the nitrogen atoms of TNAP, which causes a conformational change in the enzyme. This change inhibits its ability to react with other substrates, resulting in decreased levels of 5-methylisatin and increased levels of pyridoxal 5'-phosphate. The inhibition can be reversed by adding hydroxide ions or increasing</p>

<p>Fraxidin is a naturally occurring compound, specifically an O-methylated coumarin, which is derived from certain plant sources such as the fruits of the ash tree. It is primarily obtained through the processing of various plant materials within the Rutaceae family. The mode of action of Fraxidin involves the inhibition of oxidative damage due to its capacity to scavenge free radicals, thus leading to potential antioxidant properties in biological systems.</p>

<p>4-Acetoxyindole is a chromophore that belongs to the pyrrole family of compounds. It has been shown to react with an ionic liquid under acidic conditions to form a protonated intermediate, which can be deprotonated by a nucleophile. This reaction yields an acetate anion and a fluorescing product. 4-Acetoxyindole also reacts with deuterium gas, yielding an acetate, a deuterium atom, and fluorescing product. The reaction is reversible and the yield of the product depends on the concentration of the reactants. 4-Acetoxyindole has strong carbonyl groups that make it reactive towards other functional groups. These reactions are useful for synthesizing heterocycles such as indoles and isoquinolines.</p>

<p>6,6'-Dimethyl-2,2'-bipyridine (DMBP) is a bidentate ligand that is used in the functional theory of antibacterial activity. The bond cleavage of DMBP is believed to be due to its high oxidation potential and its ability to form hydrogen bonds with the bacteria cell wall. DMBP has been shown to have an antibacterial effect on both Gram-positive and Gram-negative bacteria. The mechanism of action may be due to its ability to release hydroxyl radicals when exposed to ultraviolet light. This compound also has a boronic acid group that can form a complex with 4-methoxyphenylboronic acid (MPA) which can inhibit bacterial growth.</p>

<p>7-Benzyloxindole-3-carboxaldehyde (BXA) is an assembled molecule that can be synthesized in a scalable and catalytic manner. BXA is an unwanted product that arises from the reaction of 7-benzyloxyindole with adrenaline. The hydrogenolysis of BXA yields the enantiomeric 7-benzyloxyindole, which has been shown to possess anti-inflammatory properties. When debenzylated by hydrogenolysis, crystallization of the byproduct is observed.</p>

<p>4-Aminoindole hydrochloride is a white crystalline solid that can be used as a versatile building block in organic synthesis. It is also used as an intermediate in the production of various pharmaceuticals and other chemical compounds. 4-Aminoindole hydrochloride is soluble in most polar solvents, but insoluble in ethers and oils. This compound is also a useful reagent for the conversion of nitrobenzenes to aminobenzoic acids. CAS Number 174854-93-4</p>

<p>2,3,3-Trimethylindolenine is a reactive aromatic hydrocarbon that has been synthesized by the coordination complex of nitric acid and sodium carbonate. It has a hydroxyl group in the 2 position and is used as an intermediate for the synthesis of hemicyanine. 2,3,3-Trimethylindolenine is soluble in nonpolar solvents such as benzene or hexane. Its light exposure can cause it to react with oxygen to form nitro groups. The structure of 2,3,3-Trimethylindolenine includes two nitrogen atoms in the alpha position.</p>

<p>4'-Iodo-2,2':6',2''-terpyridine is a transoid that has two conformations: one with the pyridine ring in the cisoid position and one with the pyridine ring in the transoid position. It can form intermolecular interactions with other molecules of 4'-iodo-2,2':6',2''-terpyridine. These interactions may be due to stacking or planar interactions.</p>

<p>(-)-Oxypeucedanin is a natural furanocoumarin, which is a type of organic compound. Furanocoumarins are derived from specific plants and are known for their complex structures and biological activities. (-)-Oxypeucedanin is sourced primarily from plants belonging to the Apiaceae family, such as Peucedanum species.</p>

<p>4,4'-Bis(diethylmethylphosphonate)-2,2'-bipyridine is a molecule that is covalently tethered to the copper oxide surface. The coordination of the 4,4'-bis(diethylmethylphosphonate)-2,2'-bipyridine ligand with the copper oxide surface is catalytic and bifunctional. This molecule has been shown to be able to coordinate with two different metal ions as well as act as a ligand for other metal ions. It can also be functionalized in order to create new molecules with different properties.</p>

<p>Pyridoxamine dihydrochloride is a dinucleotide phosphate that is used as an antimicrobial agent. It has been shown to be toxic to certain bacteria, such as Staphylococcus aureus and Bacillus subtilis. Pyridoxamine dihydrochloride also has been shown to have inhibitory effects on the growth of yeast and fungi. This compound binds to calcium in the body, which may account for its observed toxicity to organisms that use this element for cellular processes. Pyridoxamine dihydrochloride has also been shown to have effects on the kidney and heart.</p>

<p>Benzo[c]phenanthrene is a polycyclic aromatic hydrocarbon that has been shown to have carcinogenic properties in rats. It is also a potential mutagen and can cause DNA damage by forming intramolecular hydrogen bonds with guanine residues in DNA duplexes. These adducts are detected in tumor cells of rats treated with benzo[c]phenanthrene, as well as in human liver cells and mouse liver tumor cells. Benzo[c]phenanthrene can be activated by cytochrome P450 enzymes to form reactive metabolites, which bind covalently to DNA, proteins, and other cellular macromolecules. Benzo[c]phenanthrene has been shown to cause cancer in mice when given orally or injected into the peritoneal cavity. This chemical has also been found to cause liver cell necrosis in rats, at doses of 25 mg/kg body weight.</p>

<p>4,5,6-Trimethoxyindole is a chemical compound that is found in the plant Chinensis. This compound has been shown to have potent anticancer properties and can be used as a treatment for inflammatory diseases. 4,5,6-Trimethoxyindole has been shown to modulate the activity of some bacteria and it has been hypothesized that this may be due to its interaction with formylation. The acidic nature of 4,5,6-Trimethoxyindole makes it soluble in ethanol. It can also be synthesised from butyric acid and other chemicals.</p>

<p>Indole-7-carboxylic acid is a tetrahydropyridine that can be prepared by formylation of indole-7-carboxylic acid with formaldehyde and hydroxylamine. It is also the reaction product of dimethoxybenzene and cyanoindole in the presence of a base. Indole-7-carboxylic acid has been used in the synthesis of several drugs, including metronidazole and nitrofurantoin.</p>

<p>Umbelliferone-3-carboxylic acid is a coumarin derivative, which is a type of natural or synthetic organic compound often utilized in biochemical research. It is sourced from modifications of natural coumarins, which are typically isolated from plants belonging to the Apiaceae family, such as parsley, celery, and carrots. This compound functions by interacting with cellular enzymes, providing a fluorescent probe that aids in the investigation of enzymatic activities and pathways.</p>

<p>Indole-3-acetyl-L-valine (IAV) is a naturally occurring amino acid that binds to the surface glycoprotein of wild-type viruses. It inhibits viral replication by inhibiting the production of basic proteins, which are necessary for viral life. IAV also has inhibitory properties against the toll-like receptor, which may be due to its ability to inhibit growth factor signaling. IAV has been shown to decrease the number of opportunistic fungal and bacterial infections in humans, with no adverse effects on human health. This drug has no effect on healthy cells and can be used as an adjuvant for the treatment of HIV and other viral infections.</p>

<p>5-Bromoindole-2-carboxylic acid is an indole derivative that has been shown to inhibit the expression of MMP-13, a matrix metalloproteinase that is involved in tumor invasion and metastasis. This compound also inhibits the transcriptional activity of RNA polymerases I and II, which is important for preventing cancer cell proliferation. 5-Bromoindole-2-carboxylic acid may be used as a treatment for cancer by inhibiting collagen synthesis. This would reduce the size of a tumor by preventing it from expanding in size.</p>

<p>Oxypeucedanin is a furanocoumarin compound, which is derived from various plant sources, most notably those in the Apiaceae family such as Peucedanum and Angelica species. It functions primarily as a photoreactive agent, capable of interacting with DNA under ultraviolet (UV) light through a process called photoactivation. Upon UV exposure, it forms covalent bonds with DNA, leading to cross-linking that can disrupt cellular functions.</p>

<p>(+/-)-Heraclenin is a naturally occurring coumarin, which is a class of organic compounds notable for diverse biological activities. This compound is primarily sourced from various plant species belonging to the family Apiaceae, such as Heracleum species. Coumarins like (+/-)-heraclenin are known for their ability to modify biological responses due to their chemical structure.</p>

<p>2-Methylbenz[c,d]indole is an indole. It exhibits a number of spectroscopic properties including the presence of a strong absorption band at 290 nm and a weak one at 430 nm. 2-Methylbenz[c,d]indole is not active against bacteria.</p>

<p>Substrate for dealkylase.</p>

<p>6-Fluoro-2-methylindole is a member of the group of aromatic ketones. It is an organic compound that can be synthetized from 2,6-dichloroindole and methyl iodide. There are two types of photodimerization reactions for 6-fluoro-2-methylindole: one is an aerobic reaction and the other is an anaerobic reaction. The mechanistic study of 6-fluoro-2-methylindole has been investigated using bond cleavage and transformation reactions. This organic compound reacts with amines to form polycycles with high yields. It also undergoes Diastereomeric Control in chemistry.</p>

<p>Indole-3-acetyl-l-leucine is a homologous auxin. It is a conjugated acid that is found in plants and has been shown to be involved in postharvest physiology, growth regulation, and plant tissue culture. Indole-3-acetyl-l-leucine has been used as a model system for the study of plant physiology and tissue culture. The physiological function of indole-3-acetyl-l-leucine is not currently known. However, it has been shown to be converted into butyric acid by certain bacteria, which can lead to the formation of conjugates with carboxylic acids.</p>

<p>Please enquire for more information about 1-Methylindole-3-acetamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Indole-3-glyoxylamide is a synthetic compound that was originally developed as a potential anti-cancer drug. It has been shown to inhibit glycogen synthase kinase 3 (GSK-3) and thereby reduce the production of proinflammatory cytokines in bowel disease. Indole-3-glyoxylamide also inhibits inflammatory bowel disease by inhibiting secretory phospholipase A2, which prevents the release of arachidonic acid from phospholipids. This synthesis is required for the production of prostaglandins and leukotrienes, which are involved in the inflammatory process. The compound has been shown to have immunomodulatory effects in chronic bronchitis, with an inhibitory effect on neutrophil chemotaxis, macrophage activity, and cytokine production. Indole-3-glyoxylamide has also been shown to be effective against cancer cells in vitro and in vivo animal models. It is metabolized through</p>

<p>6-Trifluoromethylindole is a carbamic acid that can be synthesized with the help of a sulfoxides. Carbamic acid reacts with an aryl halide to form an unsymmetrical biaryl. 6-Trifluoromethylindole has been shown to act as a modulator in Friedel-Crafts reactions, which may be used for the synthesis of heterocycles. This chemical has also been shown to react with alkyl chlorides and sulfonium salts to form carbamic acids and sulfoxides, respectively.</p>

<p>5-Methyl-3-piperidin-4-yl-1H-indole hydrochloride is a synthetic chemical that is used as a building block for the synthesis of other compounds. It is a versatile intermediate, having been shown to react with amines, alcohols, phenols, and thiols. 5-Methyl-3-piperidin-4-yl-1H-indole hydrochloride can be used in the manufacture of pharmaceuticals and agrochemicals. This compound has been found to be an effective reagent for the preparation of cyclic peptides and can be used as a building block for the synthesis of other compounds. When reacted with 2-(trimethylsilyl)ethanol, it produces a high quality complex compound.</p>

<p>Reduces brain amyloid plaques; induces neprilysin expression</p>

<p>Daphnetin-8-glucoside is a natural phenolic glucoside compound derived from plants of the Thymelaeaceae family, specifically from the Daphne genus. This compound is produced by the glycosylation of daphnetin, a coumarin derivative found in various botanical sources. The glycoside linkage enhances its solubility and stability, facilitating its bioavailability. Daphnetin-8-glucoside exhibits potent antioxidant and anti-inflammatory activities, mediated through the scavenging of free radicals and inhibition of pro-inflammatory cytokine production. Additionally, it modulates signal transduction pathways involved in cellular oxidative stress responses.</p>

<p>Synthon for preparation of cholinergic receptor ligands; hypotensive</p>

<p>Isosibiricin is a naturally occurring lignan, which is extracted from certain plant sources. This compound is derived from the genus Daphne, traditionally known for its diverse range of biologically active constituents. Its mode of action is primarily through the modulation of key signaling pathways involved in cell proliferation and apoptosis. Isosibiricin exhibits notable inhibitory effects on specific enzymes and receptors implicated in oncogenic processes, making it a subject of interest for cancer research.</p>

<p>Methyl indole-5-carboxylate is a hdac inhibitor that has been shown to have anticancer activity. It has been shown to inhibit the growth of hCT116 cells and xenograft tumors in mice. Methyl indole-5-carboxylate is also an active analog for other anticancer agents, such as 5-azacytidine and 5-aza-2'-deoxycytidine. The drug is cytotoxic to L6 cells and increases the expression of p21 protein, which inhibits tumor cell proliferation. This compound is metabolized by cytochrome P450 enzymes into methyl indole carboxylate, which can be further converted into a reactive intermediate that binds DNA.</p>

<p>7-Methylindole-3-acetic acid is a metabolite of indomethacin. It is excreted in the urine and has been found to be present in the tissues of monkeys. 7-Methylindole-3-acetic acid is excreted by the kidneys and it is not known how much of this compound is reabsorbed into the body. 7-Methylindole-3-acetic acid can be metabolized to form other metabolites, including 2,4,5,6 tetrahydropyridine (2,4,5,6 THP), which has been shown to produce DNA damage in rats. The metabolites are then excreted from the body through urination and feces.</p>

<p>1H-Indoline-3-carboxylic acid is a molecule with the chemical formula C8H6N2O2. It is an aromatic carboxylic acid and one of the three enantiopure isomers of indoline. 1H-Indoline-3-carboxylic acid has two tautomers, cis (cis) and trans (trans). The stereoisomer cis is found in nature, while trans can be synthesized. 1H-Indoline-3-carboxylic acid can be cleaved to form phenylacetic acid and benzoic acid in reactions catalyzed by acids at high temperatures. Kinetic studies have shown that 1H-indoline-3-carboxylic acid undergoes biotransformation to form methylbenzene, ethylbenzene, propylbenzene, butylbenzene, pentylbenzene and hexylbenzene.</p>

<p>3,4-Dihydro-2(1H)-quinolinone is a potent inhibitor of dopamine β-hydroxylase and is used as a model system to study the pharmacokinetic properties of carbostyril. It has been shown that 3,4-dihydro-2(1H)-quinolinone binds to the chloride ion in the active site of dopamine β-hydroxylase. This binding prevents the formation of a complex with the enzyme's substrate, which is required for catalysis. 3,4-Dihydro-2(1H)-quinolinone also interacts with the alkynyl group on dopamine and competitively inhibits its metabolism by monoamine oxidase (MAO).</p>

<p>4,4'-Dinitro-2,2'-bipyridine is a dihedral molecule that is used in biosensors to detect nitro compounds. It is synthesized by the reaction of osmium tetroxide with pyridine. The transfer of electrons from the pyridine ring to the osmium atom results in an oriented molecule with a positive charge on one end and a negative charge on the other end. This orientation can be reversed by oxidation. 4,4'-Dinitro-2,2'-bipyridine has been shown to react with monoalcohols and nucleophiles such as water to form covalent bonds. It also reacts with radiation, which may account for its use in dosimeters for measuring radiation exposure.</p>

<p>6-Methylmercaptopurine is an important metabolite of 6-methylmercaptopurine, which is a vital component of the nucleotide synthesis pathway. It is used in analytical methods to determine levels of nucleotides, as well as in biological studies for its effect on autoimmune diseases. 6-Methylmercaptopurine can inhibit replication by inhibiting the methyltransferase enzyme.</p>

<p>8-Aminopurine is an aminopurine that is used as a research tool in magnetic resonance spectroscopy. The proton magnetic resonance spectrum of 8-aminopurine shows two characteristic peaks at 3.0 and 4.2 ppm, which are assigned to the aminopurine tautomers (3-HPA, 4-HPA). The kinetic stability of 8-aminopurine in water is pH dependent and has been shown to be strongly dependent on the presence of aldehyde oxidase (AO) activity. AO activity can be inhibited by the addition of dimethylformamide or other non-specific inhibitors such as 2,6-dichloroisonicotinic acid.</p>

<p>(8S,10S,11S,13S,14S,16S)-9-Fluoro-11-Hydroxy-10,13,16-Trimethyl-17-Methylsulfanylcarbonyl-3-Oxo-6,7,8,11,12,14,15,16-Octahydrocyclo penta[a]Phenanthren-17-Yl) Acetate is a fatty acid ester that is used as a pharmaceutical preparation. It has been shown to be an effective treatment for the muscle wasting disease myotonic dystrophy and has been approved by the FDA. (8S,10S,11S,13S,14S,, 16 S)-9 - Fluoro - 11 - Hydroxy - 10 , 13 , 16 - Trimethyl - 17 - Methylsulfanylcarbonyl - 3 - Oxo - 6 , 7 , 8 , 11</p>

<p>6-Methoxyindole is an acetate extract of the plant 5-methoxyindole. It has been shown to be a 5-HT1A receptor agonist in animals, and has been shown to have cardiac effects in rats. 6-Methoxyindole is also used as a precursor for the synthesis of diphenylacetylindoles. 6-Methoxyindole is one of the molecules that can be recombined to form a batcho-leimgruber indole (BLI).</p>

<p>8-Hydroxyquinoline-2-carboxylic acid is a 3-hydroxyanthranilic acid derivative that is often used as a biomarker of urine. The 8OHQA can be synthesized from 3-hydroxyanthranilic acid by the action of xanthine oxidase and hydrogen peroxide, and it has been shown to be an inhibitor of protein synthesis. This inhibition may be due to its ability to form hydrogen bonds with the hydroxyl group on the ribose side chain and its ability to coordinate with metals. 8OHQA has been shown to have anti-inflammatory effects in bladder cancer cells, which may be due to its ability to inhibit prostaglandin synthesis.</p>

<p>Byakangelicol is a naturally occurring furanocoumarin, which is a type of organic compound found predominantly in the roots of certain plants, such as Angelica dahurica. This compound is synthesized through the plant's secondary metabolic pathways, primarily as a defense mechanism against herbivores and pathogens. Byakangelicol exerts its biological effects primarily through the inhibition of various enzymatic pathways, such as cytochrome P450s and monoamine oxidase, which are key in processes like drug metabolism and neurotransmitter regulation.</p>

<p>Radiosensitiser in hypoxic tumours</p>