Otros inhibidores

<p>OB-1 is a STOML3 inhibitor that interferes with the self-association of stomatin, inhibiting fat formation and blocking lipid droplet growth.</p>

<p>O-Propargyl-Puromycin (OP-puro) is a potent protein synthesis inhibitor, a puromycin acetylene analog.</p>

<p>NRX-1532 is a small molecule β-catenin:β-TrCP interaction enhancer.</p>

<p>Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor that reduces the cytotoxicity induced by statins in human skeletal muscle cells.</p>

<p>YTH-IN-1 is an inhibitor of the five YTH structural domains in the human.The YTH family of proteins is an N 6-methyladenosine (m6A) reader in gene expression.</p>

<p>ELOVL1-IN-2 weakly inhibits ELOVL1 enzyme (IC50: 21 μM) and shows moderate potency in HEK293 cells (IC50: 6.7 μM).</p>

<p>BLU2864: oral PRKACA inhibitor, IC50=0.3 nM, potential in cancer/poly. kidney disease research.</p>

<p>Skp2 inhibitor 1 is a Skp2-Cks1 interaction inhibitor (IC50: 2.8μM) with antitumor activity and can be used to study cancer.</p>

<p>PREP inhibitor-1 is a prolyl oligopeptidase (PREP) inhibitor for the study of Alzheimer's disease.</p>

<p>VCPIP1-IN-1 is a VCPIP1 inhibitor used in cancer research.</p>

<p>MV151 is a fluorescent proteasome inhibitor that targets all active subunits of the proteasome and immunoproteasome in living cells.</p>

<p>ARN19702: orally active, brain-penetrant, selective NAAA inhibitor, IC50 230 nM, broad analgesic profile.</p>

<p>Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.</p>

<p>Demethyl 8-Epidiosbulbin E acetate is a structural analog of 8-Epidiosbulbin E acetate, a furan analog found in Dioscorea bulbifera L. 8-Epidiosbulbin E acetate is a furan analog found in Dioscorea bulbifera L. It is a structural analog of 8-Epidiosbulbin E acetate.</p>

<p>BI-2545 is an autotaxin (ATX) inhibitor that significantly reduces LPA. For human ATX and rat ATX, the IC50s values are 2.2 nM and 3.4 nM , respectively.</p>

<p>CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK.</p>

β-Apo-13-carotenone is a naturally occurring β-apocarotenoid, and is a RXRα antagonist.

<p>BFCAs-1 is a polyamine polycarboxylic bifunctional chelating agent (BFCAs) with a broad range of applications in biology, chemistry, medicine and diagnostic imaging.</p>

<p>Umbellulone is a natural product isolated from Umbellularia californica, and stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism.</p>

N3PT is a potent and selective inhibitor of transketolase(TK) with IC50 of 22 nM for Apo-TK)

<p>Beraprost sodium is a stable and orally active prodrug of PGI2.</p>

<p>4',5'-Dibromofluorescein (Eosinic acid) is a fluorescent dye that can be used as a ligand for protein characterization by spectroscopic analysis.</p>

<p>Calcitriol Impurities A refers to the contaminants found in Calcitriol, the hormonally active metabolite of vitamin D3, which serves to activate the vitamin D receptor.</p>

<p>SPL-410 is a highly potent,selective and orally active inhibitor of hydroxyethylamine based SPPL2a (Signal Peptide Peptidase Like 2a)(IC50 of 9 nM).</p>

<p>sodium 4-pentynoate is a alkynylacetate analogue.</p>

<p>Endogenous fatty acid glycerol ester</p>

<p>L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 µM, and a Kinact of 0.15±0.03 min-1. L-Eflornithine monohydrochloride (L-DFMO monohydrochloride) is an enantiomer of Eflornithine.</p>

<p>Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) is a potent GABAA receptor orthosteric modulator (PAM) with neuroprotective activity that selectively inhibits neurosteroid-mediated enhancement of GABA-induced currents at the GABAA receptor, and can be used in the study of neurological disorders.</p>

<p>TCblR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 32-58 KDa and the accession number is Q9NPF0.</p>

<p>2-Selenouracil is a specialized photosensitizer for photodynamical therapy.</p>

<p>PF-06747711 is an effective and selective retinoic acid receptor-related orphan C2 inverse agonist (IC50: 4.1 nM). PF-06747711 also has anti-skin inflammatory activity.</p>

<p>TEM1/CD248 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 73.6 kDa and the accession number is Q91V98.</p>

<p>Haloxon is an organophosphorus anthelmintic. Haloxon is used against nematodes of the abomasum and small intestine in ruminants.</p>

<p>Metrizoic acid is an ionic contrast medium. Metrizoic acid displays high osmolality and has a risk of inducing allergic reactions.</p>

<p>A-887826 is a selective, orally bioavailable, and voltage-dependent Na(v1.8) channel blocker (IC50: 11 nM). It attenuates neuropathic tactile allodynia in vivo.</p>

<p>GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. GAS6 Protein, Human, Recombinant (His) is expressed in HEK293 cells.</p>

<p>Norbiotinamine, a biotin alternative, is a sulfur-containing organic compound with a structure similar to that of biotin.</p>

<p>(8R,9S)-Talazoparib is Talazoparib enantiomer , less active than Talazoparib on the inhibition of PARP1 (IC50: 144 nM).</p>

<p>(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid, a constrained phenylalanine (Phe) analogue, can adopt beta-bend and helical structures, thereby facilitating a preferred side-chain orientation within the peptide.</p>

<p>β-Zearalenol, a non-steroidal estrogenic mycotoxin synthesized by Fusarium species, potentially influences transcription and affects gene expression on the translational level.</p>

<p>Daphnin is one of the main coumarin bioactive ingredients with antibacterial activity. Daphnine is isolated from the entire Daphne fragrance, which is a folk medicine used in China to relieve fever.</p>

<p>3-Acetylcoumarin as a practical ligand for copper-catalyzed CN coupling reactions at room temperature. It has neuroprotective and acaricidal properties.</p>

<p>Anisylacetone (Anisylacetone) is an effective lure for the male melon fly.</p>

<p>4-Ethoxycoumarin has antimicrobial activity.</p>

<p>3-Methoxyphenylacetic acid belongs to the class of organic compounds known as anisoles. 3-Methoxyphenylacetic acid is slightly soluble (in water) and a weakly acidic compound (based on its pKa).3-Methoxyphenylacetic acid (m-Methoxyphenylacetic acid), a m-hydroxyphenylacetic acid (m-OHPAA) derivative, is a phytotoxin in Rhizoctonia solani. 3-Methoxyphenylacetic acid is used to develop a toxin-mediated bioassay for resistance to rhizoctonia root rot</p>

<p>Isopulegol has antioxidant, and neuroactive properties. It also has gastroprotective effects induced by isopulegol appear to be mediated, at least in part, by endogenous prostaglandins, K+ATP channel opening and antioxidant proprieties related to GSH increased.</p>

<p>PRGL493 blocks ACSL4, halts PC3/MDA-MB-231 cancer cell spread, and inhibits MA-10 tumor progesterone. Effective in mouse PC3 tumor model at 0.25 mg/kg.</p>

<p>Dextromethorphan is a noncompetitive NMDA receptor antagonist and sigma-1 agonist that was approved by the FDA in 1958 for use as a cough suppressant.Cost-effective and quality-assured.</p>

<p>(S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide is a useful organic compound for research related to life sciences. The catalog number is T65903 and the CAS number is 27262-40-4.</p>

<p>Carbonylchlorohydrido[bis(2-(diphenylphosphinoethyl)amino]ruthenium(II) is a useful organic compound for research related to life sciences. The catalog number is T67264 and the CAS number is 1295649-40-9.</p>

<p>Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65565 and the CAS number is 161798-01-2.</p>

<p>2-Isopropoxy-1,3-diisopropylbenzene is a useful organic compound for research related to life sciences and the catalog number is T66259.</p>

<p>THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a polyethylene glycol (PEG)-based PROteolysis TArgeting Chimera (PROTAC) linker used in synthesizing PROTAC K-Ras Degrader-1, as documented in reference [1].</p>

<p>m-PEG12-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].</p>

<p>Antiviral agent 5 is a crucial intermediate utilized in the development of antiviral agents that specifically target 3C and 3CL proteases, which includes the SARS-CoV-2 M pro enzyme.</p>

<p>(S)-4-Isobutylpyrrolidin-2-one is a useful organic compound for research related to life sciences and the catalog number is T67247.</p>

<p>Ganoderic acid I is a natural product from Ganoderma lucidum .</p>

<p>2,3-Dimethyl-4-nitropyridine 1-oxide is a useful organic compound for research related to life sciences. The catalog number is T65951 and the CAS number is 37699-43-7.</p>

<p>4-(2-Aminoethyl)-2-ethoxyphenol hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T67209 and the CAS number is 91252-20-9.</p>

<p>Gly m 4 Protein, soybean, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17 kDa.</p>

<p>11-Keto budesonide is a useful organic compound for research related to life sciences and the catalog number is T64448.</p>

<p>4-Chlorophenylacetic acid is a useful organic compound for research related to life sciences. The catalog number is T65823 and the CAS number is 1878-66-6.</p>

<p>Cyclohexylamine Hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65093 and the CAS number is 4998-76-9.</p>

<p>Gly-AMC HCl is a useful organic compound for research related to life sciences and the catalog number is T64464.</p>

<p>Cyp c 1 Protein, Common carp, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 12.5 kDa.</p>

<p>Der f 2 Protein, Dermatophagoides farinae, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 15 kDa and the accession number is Q00855.1.</p>

<p>(R)-N-Dimethyl-[(R)-1,1'-spirobiindane-7,7'-diyl]phosphoramidite is a useful organic compound for research related to life sciences and the catalog number is T66953.</p>

<p>Glycine 7-amido-4-methylcoumarin hydrobromide is a useful organic compound for research related to life sciences. The catalog number is T65237 and the CAS number is 113728-13-5.</p>

<p>Sirtratumab vedotin (ASG15-ME) is an antibody-drug conjugate (ADC) that links a SLITRK6-specific human gamma 2 antibody (Igγ2) to the microtubule disruption agent monomethyl auristatin E (MMAE) through a protease-cleavable linker [1].</p>

<p>5-Phenyl-1H-pyrrole-3-carbaldehyde is a useful organic compound for research related to life sciences. The catalog number is T66775 and the CAS number is 56448-22-7.</p>

<p>SHP2 degrader-1: highly efficient, induces SHP2 degradation &amp; cell apoptosis, shows promise in SHP2-related disease research.</p>

<p>(R)-4-Propyldihydrofuran-2(3H)-one is a useful organic compound for research related to life sciences. The catalog number is T67182 and the CAS number is 63095-51-2.</p>

<p>Sodium pyrophosphate (Disodium pyrophosphate), an inorganic food additive, exhibits potential hematotoxic and immunotoxic effects [1].</p>

<p>SK-575-NEG is a methylated form of SK-575, binds PARP1 (IC50: 2.64 nM), but doesn't induce PARP1 degradation up to 1 μM in cells.</p>

<p>(S)-2-((4-Chlorophenyl)(piperidin-4-yloxy)methyl)pyridine (2R,3R)-2,3-dihydroxysuccinate is a useful organic compound for research related to life sciences. The catalog number is T67217 and the CAS number is 210095-58-2.</p>

<p>(2R,4S)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66599 and the CAS number is 149690-12-0.</p>

<p>Lauryl Glucose Neopentyl Glycol is a useful organic compound for research related to life sciences. The catalog number is TF0033 and the CAS number is 1423318-02-8.</p>

<p>CV 4388 is a useful organic compound for research related to life sciences. The catalog number is T68029 and the CAS number is 93943-87-4.</p>

<p>7-Amino-2H-chromen-2-one is a useful organic compound for research related to life sciences and the catalog number is T64948.</p>

<p>Ethyl 3-oxo-3-(2,3,4,5-tetrafluorophenyl)propanoate is a useful organic compound for research related to life sciences. The catalog number is T64869 and the CAS number is 94695-50-8.</p>

<p>4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T67079 and the CAS number is 139756-02-8.</p>

<p>Methyl 2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T67049 and the CAS number is 877997-99-4.</p>

<p>Alt a 1 Protein, Alternaria alternate, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 14.6 kDa and the accession number is P79085.</p>

<p>5,6-Dichloronicotinic acid (catalog number: T67674, CAS number: 41667-95-2) is a valuable organic compound for life sciences research.</p>

<p>Z-Gly-OMe is a useful organic compound for research related to life sciences. The catalog number is T66677 and the CAS number is 1212-53-9.</p>

<p>NH-bis(PEG4-C2-NH-Boc) is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.</p>

<p>H-Arg-OEt.2HCl is an amino acid derivative and has a wide range of applications in life science related research.</p>

<p>N-Fmoc-3-nitro-L-tyrosine is a useful organic compound for research related to life sciences. The catalog number is T65730 and the CAS number is 136590-09-5.</p>

<p>TRIA14 Protein, wheat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 9 kDa.</p>

<p>(1R,3S)-(+)-Camphoric acid is a useful organic compound for research related to life sciences. The catalog number is T66682 and the CAS number is 124-83-4.</p>

<p>N-(2,4-Dichloro-5-hydroxyphenyl)acetamide is a useful organic compound for research related to life sciences. The catalog number is T65326 and the CAS number is 67669-19-6.</p>

<p>Cyclofos-4 is a useful organic compound for research related to life sciences. The catalog number is TF0104 and the CAS number is 675126-15-5.</p>