Señalización citoesquelética
Los inhibidores de la señalización del citoesqueleto son compuestos que interrumpen las vías de señalización que regulan el citoesqueleto, crucial para la forma celular, la motilidad, la división y el transporte intracelular. Estos inhibidores se utilizan para estudiar la dinámica de las proteínas del citoesqueleto, como la actina y la tubulina, y su papel en procesos como la migración celular, la adhesión y la metástasis del cáncer. Los inhibidores de la señalización del citoesqueleto son valiosos en la investigación sobre biología celular, cáncer y neurobiología. En CymitQuimica, ofrecemos una amplia gama de inhibidores de la señalización del citoesqueleto de alta calidad para apoyar su investigación en estas áreas.
Se han encontrado 1460 productos de "Señalización citoesquelética"
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Tau ligand-1
CAS:Tau ligand-1 (Compound 75) is a ligand of aggregated tau protein that can penetrate the blood-brain barrier. In tissues affected by Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 shows high affinity for aggregated tau protein, with equilibrium dissociation constants (KD) ranging from 1 to 3.8 nM. It holds potential as a positron emission tomography (PET) tracer for imaging studies of tau-related diseases within the central nervous system.Fórmula:C17H16FN3OForma y color:SolidPeso molecular:297.327RMS-07
CAS:RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.Fórmula:C35H40N8O2Forma y color:SolidPeso molecular:604.74DDO-6691
CAS:DDO-6691 is an inhibitor of heat shock protein 90 (HSP90). It exhibits antiproliferative effects against various tumor cells, with the highest sensitivity observed in HCT-116 colon cancer cells (IC50: 1.08 μM). DDO-6691 also demonstrates potent tumor growth inhibition in HCT-116 xenograft mouse models.Fórmula:C22H17N3O2SForma y color:SolidPeso molecular:387.45FAK-IN-21
CAS:<p>FAK-IN-21 (compound 9) is a FAK inhibitor with an IC50 value of 37.52 nM. It inhibits cell growth and the phosphorylation of FAK, making it useful for research into diffuse gastric cancer.</p>Fórmula:C22H22F2N8O3SForma y color:SolidPeso molecular:516.52GSD-11
GSD-11: Potent, selective anti-austerity agent; blocks Akt/mTOR pathway, hinders PANC-1 cell migration & colony growth. Promising for pancreatic cancer study.Fórmula:C20H28O2Forma y color:SolidPeso molecular:300.44Kolavenic acid analog
CAS:KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.Fórmula:C25H38O4Forma y color:SolidPeso molecular:402.57HSN748
CAS:<p>HSN748 is an analog of ponatinib and acts as a multi-kinase inhibitor. It exhibits inhibitory activity against kinases such as FLT3, ABL1, RET, PDGFRα/β, MNK1, and MNK2. HSN748 can suppress the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines, making it a useful compound in leukemia research.</p>Fórmula:C27H24F3N7OForma y color:SolidPeso molecular:519.521Alfalone
CAS:<p>Alfalone (compound 9ia) is an antimitotic agent. It induces cleavage arrest and initiates the formation of tubercular eggs.</p>Fórmula:C17H14O5Forma y color:SolidPeso molecular:298.29Tubulin inhibitor 15
<p>Tubulin inhibitor 15 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 15 exhibits cytotoxicity in HepG2 cells [1].</p>Fórmula:C16H12FNO2Forma y color:SolidPeso molecular:269.27Latrunculins A
CAS:Latrunculins A is a novel marine toxin, disrupts microfilament organization in cultured cells.Fórmula:C22H31NO6SForma y color:SolidPeso molecular:437.55TACC3 inhibitor 2
CAS:<p>TACC3 inhibitor 2 (Compound 13b) is a TACC3 inhibitor with an IC50 of 200 nM. It induces mitotic arrest, apoptosis (Apoptosis), and DNA damage. TACC3 inhibitor 2 is applicable for research in the field of cancer.</p>Fórmula:C20H22FN5O2Forma y color:SolidPeso molecular:383.419XD23
CAS:XD23 is a potent osteosarcoma inhibitor that functions by downregulating DKK1 and activating the WNT/β-catenin signaling pathway.Fórmula:C22H26ClN7O3Forma y color:SolidPeso molecular:471.94AKT-IN-11
AKT-IN-11 is one of the most potent antibacterial agents against human hepatocellular carcinoma Bel-7402 cell line (IC50: 1.15 μM).Fórmula:C27H27ClF3NO4Forma y color:SolidPeso molecular:521.96Monomethyl auristatin E intermediate-17
CAS:<p>MonomethylauristatinE intermediate-17 is an intermediate compound used in the synthesis of MonomethylauristatinE. MonomethylauristatinE (MMAE) functions as a microtubule/tubulin inhibitor with anticancer properties. It is widely utilized as the cytotoxic component in antibody-drug conjugates (ADCs).</p>Fórmula:C27H35NO7SPeso molecular:517.63AS2521780
CAS:AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).Fórmula:C30H41N7OSPureza:98%Forma y color:SolidPeso molecular:547.76DCEM1
CAS:<p>DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction between HSP60 and ClpP, thereby blocking the mitochondrial unfolded protein response. Additionally, DCEM1 suppresses the expression of β-catenin and reduces ATP production in PC-3 and TKO cells. It is utilized in research related to prostate cancer.</p>Fórmula:C22H23N3O2SForma y color:SolidPeso molecular:393.50Isodienestrol
CAS:Isodienestrol, a derivative of Diethylstilbestrol, acts as a microtubule (Microtubule) inhibitor. It is utilized in cancer research.Fórmula:C18H18O2Forma y color:SolidPeso molecular:266.3316,16-Dimethyl prostaglandin E2
CAS:<p>16,16-Dimethyl prostaglandin E2 regulates hematopoietic stem cells via EP2/EP4 and Wnt, taken orally.</p>Fórmula:C22H36O5Pureza:98%Forma y color:SolidPeso molecular:380.52OPN expression inhibitor 1
CAS:OPN expression inhibitor 1 is an osteopontin expression inhibitor used in the study of breast cancer metastasis.Fórmula:C25H33N3O5Pureza:99.78%Forma y color:SolidPeso molecular:455.55G-9791
CAS:G-9791 is an effective and selective inhibitor of group-I PAK.Fórmula:C26H26ClFN6O2Pureza:98%Forma y color:SolidPeso molecular:508.98α5β1 integrin agonist-1
CAS:α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.Fórmula:C24H26FN5O9Forma y color:SolidPeso molecular:547.49GR 83895
CAS:GR 83895 is an antagonist of prototype fibrinogen receptor.Fórmula:C29H39N9O8SPureza:98%Forma y color:SolidPeso molecular:673.74FO-4-15
CAS:<p>FO-4-15 is an activator of mGluR1/CaMKIIα. It exhibits protective effects against H2O2 in human neuroblastoma (SH-SY5Y) cells. In mice with Alzheimer's disease, FO-4-15 enhances cognitive function by activating the mGluR1/CaMKIIα pathway, reducing Aβ accumulation, Tau hyperphosphorylation, and synaptic damage.</p>Fórmula:C18H20N4O4SForma y color:SolidPeso molecular:388.44Tasidotin hydrochloride
CAS:<p>Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.</p>Fórmula:C32H59ClN6O5Pureza:98%Forma y color:SolidPeso molecular:643.30AMXI-5001 hydrochloride
<p>AMXI-5001 hydrochloride, an oral inhibitor of PARP1/2 and microtubules, shows greater potency and selective anti-cancer effects.</p>Fórmula:C25H21ClFN5O3Forma y color:SolidPeso molecular:493.92Hsp110-STAT3 interaction-IN-1
CAS:Row174336 (compound 29) serves as an efficient inhibitor of the Hsp110-STAT3 interaction, exhibiting antiproliferative activity in the HPAEC cell line with an IC50 of 22.67 μM.Fórmula:C23H31N3O4SForma y color:SolidPeso molecular:445.58Lisavanbulin
CAS:<p>Lisavanbulin (BAL-101553) is a prodrug of Avanbulin (BAL 27862), a microtubule-targeting agent. It exhibits antitumor activity, particularly effective against tumors with high expression of end-binding protein 1.</p>Fórmula:C26H29N9O3Forma y color:SolidPeso molecular:515.57EX05
CAS:<p>EX05, an effective KIF18A inhibitor, exhibits an IC50 of 8.2 nM and holds potential for cancer research applications.</p>Fórmula:C26H30F2N4O5SForma y color:SolidPeso molecular:548.60Hsp90-IN-34
CAS:Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.Fórmula:C22H14F2N6OForma y color:SolidPeso molecular:416.38Zalunfiban dihydrochloride
<p>Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.</p>Fórmula:C16H20Cl2N8O2SForma y color:SolidPeso molecular:459.35Tubulin inhibitor 19
Tubulin inhibitor 19 (9b), a potent indole chalcone, strongly blocks tubulin, valuable in cancer studies.Fórmula:C21H23NO5Forma y color:SolidPeso molecular:369.41AMG28
CAS:AMG28 is an inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 805 nM and 988 nM, respectively. Additionally, AMG28 suppresses the phosphorylation of tau protein at the Ser422 site, with an IC50 of 1.85 μM.Fórmula:C20H20N4OForma y color:SolidPeso molecular:332.399Quinagolide hydrochloride
CAS:Quinagolide hydrochloride is a selective agonist of dopamine D2 receptor.Fórmula:C20H34ClN3O3SPureza:98%Forma y color:SolidPeso molecular:432.02Tubulin inhibitor 22
Compound 4c: Strong tubulin inhibitor with anti-cancer & anti-angiogenic effects; halts MGC-803 cells in G2/M, triggers Caspase-mediated apoptosis.Fórmula:C20H17BrFNO4Forma y color:SolidPeso molecular:434.26Dictyostatin
CAS:Dictyostatin: potent microtubule stabilizer & anticancer agent with antiproliferative effects; researched for tauopathies.Fórmula:C32H52O6Forma y color:SolidPeso molecular:532.75FPDT
FPDT combats glioblastoma by inhibiting the AKT pathway; IC50: >100 μM (astrocytes), 45-68 μM (GBM cells).Fórmula:C16H12FNO2SForma y color:SolidPeso molecular:301.34Tubulin polymerization-IN-34
"Tubulin-IN-34 inhibits oxazolylisoindole microtubule assembly, selective for VL51 lymphoma."Fórmula:C31H35N3O6Forma y color:SolidPeso molecular:545.63AKT-IN-10
CAS:AKT-IN-10, a potent AKT inhibitor, has potential for breast and prostate cancer research, impacting cell growth and survival pathways.Fórmula:C26H34ClN5O2Forma y color:SolidPeso molecular:484.03NRX-2663
CAS:NRX-2663 boosts β-catenin binding to E3 ligase SCFβ-TrCP (Kd: 54.8 nM, EC50: 22.9 nM).Fórmula:C20H13F3N2O5Forma y color:SolidPeso molecular:418.32Tubulin polymerization-IN-74
CAS:<p>Tubulin polymerization-IN-74 (compound 11) is an inhibitor of tubulin polymerization, with an IC50 value of 15 μM. It is applicable to cancer research.</p>Fórmula:C14H11NSForma y color:SolidPeso molecular:225.309TTBK1/2-IN-3
CAS:<p>TTBK1/2-IN-3 (compound 10) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 579 nM and 258 nM, respectively. TTBK1/2-IN-3 can reduce the expression of primary cilia on the surface of human induced pluripotent stem cells (iPSC).</p>Fórmula:C21H22N4OForma y color:SolidPeso molecular:346.426SF0166
CAS:SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.Fórmula:C23H27F2N5O4Forma y color:SolidPeso molecular:475.49Hsp90-IN-37
CAS:<p>Hsp90-IN-37 (Z-2) is an inhibitor of heat shock protein 90 (Hsp90), demonstrating a 69% inhibition rate on Hsp90 enzyme activity. It exhibits antitumor properties.</p>Fórmula:C12H15N3O2Forma y color:SolidPeso molecular:233.2666-B345TTQ
CAS:<p>6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.</p>Fórmula:C22H20BrNO4Forma y color:SolidPeso molecular:442.303NRX-103094
CAS:NRX-103094 boosts β-catenin binding to SCFβ-TrCP ligase with EC50 62 nM and Kd 0.6 nM.Fórmula:C20H11Cl2F3N2O4SPureza:99.13%Forma y color:SolidPeso molecular:503.28NRX-252114
CAS:NRX-252114 promotes mutant β-catenin degradation, binding it to E3 ligase SCFβ-TrCP (EC50: 6.5 nM; Kd: 0.4 nM).Fórmula:C22H12Cl2F3N3O2SPureza:99.70%Forma y color:SolidPeso molecular:510.32AKT Kinase Inhibitor
CAS:AKT Kinase Inhibitor is an Akt inhibitor with antitumor activity that selectively inhibits cell proliferation in a dose-dependent manner.Cost-effective and quality-assured.Fórmula:C16H19N7O3Pureza:97.83% - 99.13%Forma y color:SolidPeso molecular:357.37Ombrabulin
CAS:<p>Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.</p>Fórmula:C21H26N2O6Pureza:98%Forma y color:SolidPeso molecular:402.44ZW4864
CAS:ZW4864 is a selective inhibitor of the β-catenin/B-Cell Lymphoma 9 protein (β-catenin/BCL9 PPI) interaction, demonstrating oral activity. It inhibits β-catenin/BCL9 PPI with a K_i value of 0.76 μM and an IC_50 value of 0.87 μM.Fórmula:C33H43ClN6O3Forma y color:SolidPeso molecular:607.2Cercosporin
CAS:<p>Cercosporin, produced by the plant pathogen Cercospora kikuchii and the elsinochromes, is a potent photosensitizer with a short activation wavelength. Cercosporin contains perylene quinone structural features essential for PKC activity (IC50: 0.6-1.3 μM).</p>Fórmula:C29H26O10Pureza:98%Forma y color:SolidPeso molecular:534.5120-HETE
CAS:<p>20-HETE is a CYP450 product, vasoconstrictor, modulates K+ channels, affects NADPH, ROS, NF-κB, NO synthase, and cell apoptosis/proliferation.</p>Fórmula:C20H32O3Pureza:99.79%Forma y color:SolidPeso molecular:320.4724-Methylenecycloartanyl ferulate
CAS:24-Methylenecycloartanyl ferulate, a compound belonging to the γ-oryzanol family, demonstrates the ability to enhance parvin-beta expression within human breast cancer cells. Furthermore, it exhibits potential as an ATP-competitive Akt1 inhibitor, with an EC 50 value of 33.3 μM.Fórmula:C41H60O4Forma y color:SolidPeso molecular:616.927Methyl (6-chloro-1H-benzo[d]imidazol-2-yl)carbamate
CAS:Methyl (6-chloro-1H-benzo[d]imidazol-2-yl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T65302 and the CAS number is 20367-38-8.Fórmula:C9H8ClN3O2Forma y color:SolidPeso molecular:225.63Sevasemten
CAS:<p>Sevasemten is an allosteric inhibitor that targets skeletal muscle myosin. It displays selectivity in its inhibition, demonstrated by IC50 values of ≤10 μM for skeletal muscle myosin and >100 μM for cardiac myosin, respectively.</p>Fórmula:C16H11F4N5O2Forma y color:SolidPeso molecular:381.28Tau tracer 2
CAS:Tau tracer 2 (Pl-2620) is a specific imaging agent designed to detect and visualize Tau protein aggregates, primarily used for diagnosing neurodegenerative diseases [1].Fórmula:C15H9FN4Forma y color:SolidPeso molecular:264.263PF-03814735
CAS:<p>PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.</p>Fórmula:C23H25F3N6O2Pureza:98%Forma y color:SolidPeso molecular:474.48Cevipabulin fumarate
CAS:Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).Fórmula:C22H22ClF5N6O5Pureza:98%Forma y color:SolidPeso molecular:580.89CMX-2043
CAS:<p>CMX-2043 is a drug potentially to block oxidative damage and activate cell survival pathways.</p>Fórmula:C16H26N2O6S2Pureza:98%Forma y color:SolidPeso molecular:406.52BCR-ABL-IN-8
CAS:<p>BCR-ABL-IN-8 (compound 26f) is a BCR-ABL inhibitor featuring a trimethoxy group [1].</p>Fórmula:C30H33N7O5Pureza:98%Forma y color:SolidPeso molecular:571.63
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