Señalización citoesquelética
Los inhibidores de la señalización del citoesqueleto son compuestos que interrumpen las vías de señalización que regulan el citoesqueleto, crucial para la forma celular, la motilidad, la división y el transporte intracelular. Estos inhibidores se utilizan para estudiar la dinámica de las proteínas del citoesqueleto, como la actina y la tubulina, y su papel en procesos como la migración celular, la adhesión y la metástasis del cáncer. Los inhibidores de la señalización del citoesqueleto son valiosos en la investigación sobre biología celular, cáncer y neurobiología. En CymitQuimica, ofrecemos una amplia gama de inhibidores de la señalización del citoesqueleto de alta calidad para apoyar su investigación en estas áreas.
Se han encontrado 1586 productos para "Señalización citoesquelética".
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Sudocetaxel
CAS:Sudocetaxel is a compound that serves as a microtubule depolymerization inhibitor, specifically designed for the pH-sensitive delivery of docetaxel.Fórmula:C48H59NO16Forma y color:SolidPeso molecular:905.98PYRIB-SO 2
PYRIB-SO 2 is an effective antimitotic (mitotic) agent that exhibits antiproliferative activity and induces cell cycle arrest at the G2/M phase. It disrupts and reduces microtubule structures by binding to the colchicine-binding site (C-BS) on α, β-tubulin.Fórmula:C14H12ClN3O4SForma y color:SolidPeso molecular:353.0237MEK Inhibitor II
CAS:MEK Inhibitor II, Selective MEK1 inhibitor (IC50=0.38 μM), inhibits tubulin polymerization in T. cruzi, exhibits anti-trypanosome activity.Fórmula:C14H8ClNO4Pureza:99.40%Peso molecular:289.67AFM15
AFM15 is a humanized monoclonal antibody inhibitor that targets CD3E. It is useful for researching metabolic and immune system disorders, including type 1 diabetes and inflammatory bowel disease (IBD).Forma y color:Odour LiquidKatanin-IN-1
Katanin-IN-1 (122589735) is an effective inhibitor of katanin, and it holds potential for cancer research.Fórmula:C24H33N9O3Forma y color:SolidPeso molecular:495.58Chemerin-9 (149-157)
CAS:Chemerin-9, a nonapeptide C-terminal fragment of chemerin, retains full protein's activity as a ChemR23 agonist.Fórmula:C54H66N10O13Pureza:98%Forma y color:SolidPeso molecular:1063.16NMS-E973
CAS:NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.Fórmula:C22H22N4O7Pureza:99.84%Forma y color:Yellow SolidPeso molecular:454.43Ref: TM-T6609
2mg39,00€5mg60,00€1mL*10mM (DMSO)66,00€10mg92,00€25mg187,00€50mg294,00€100mg419,00€200mg590,00€(8R)-8-Hydroxyepoxyboetirane A
(8R)-8-Hydroxyepoxyboetirane A is a neuroactivating compound that interacts with PKCδ-C1B. This compound binds into the PKC enzyme pocket through hydrogen bonds with glycine-253, leucine-251, and threonine-242. It induces the release of NRG1 and promotes the differentiation of neural stem cells into neurons. (8R)-8-Hydroxyepoxyboetirane A holds potential for research into nervous system disorders.Forma y color:Odour SolidCYP51/Hsp90-IN-1
CYP51/Hsp90-IN-1 (Compound MM4) is a dual inhibitor of CYP51 and Hsp90. This compound exhibits antifungal activity against Candida albicans and effectively suppresses key fungal virulence factors. CYP51/Hsp90-IN-1 shows potential for research in treating invasive candidiasis.Fórmula:C38H40F2N6O4Forma y color:SolidPeso molecular:682.76JD-13
CAS:JD-13 is a selective GPR119 agonist; promotes insulin and GLP-1 release; glucose homeostasis; diabetes research tool.Fórmula:C25H32N4O3Pureza:99.32% - 99.69%Forma y color:White SolidPeso molecular:436.56PKCiota-IN-2
CAS:PKCiota-IN-2 selectively inhibits PKC-ι (IC50=2.8nM) and also blocks PKC-α, ε (IC50s=71nM, 350nM).Fórmula:C24H21N5OPureza:98.86%Forma y color:SolidPeso molecular:395.46Ref: TM-T9863
1mg109,00€2mg163,00€5mg243,00€1mL*10mM (DMSO)264,00€10mg355,00€25mg532,00€50mg750,00€100mg1.009,00€AS-605240 potassium
AS-605240 (potassium) is an orally active PI3Kγ inhibitor with an IC50 of 8 nM and a Ki of 7.8 nM. It inhibits MCP-1 and CSF1-induced PKB phosphorylation with IC50 values of 0.181 µM and 0.550 µM, respectively. In mouse models of peritonitis induced by RANTES (CCL5) and thioglycolate, AS-605240 (potassium) reduces neutrophil recruitment, showing EC50 values of 9.1 mg/kg and 10 mg/kg. Additionally, AS-605240 (potassium) ameliorates arthritis induced by αCII-IA in mice.Fórmula:C12H6KN3O2SForma y color:SolidPeso molecular:294.981782-Methylthiophenothiazine
CAS:2-Methylthiophenothiazine, with CAS No. 7643-08-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Methylthiophenothiazine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Fórmula:C13H11NS2Pureza:99.89%Forma y color:SolidPeso molecular:245.362-Methylbutyrylcarnitine chloride
2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.Fórmula:C12H24ClNO4Forma y color:SolidPeso molecular:281.78Vinflunine Tartrate
CAS:Vinflunine Tartrate, a uniquely fluorinated vinca alkaloid, exhibits mitotic-arresting and tubulin-interacting properties.Fórmula:C45H54F2N4O8·xC4H6O6Pureza:98%Forma y color:SolidPeso molecular:967.02Ref: TM-T6722
2mgA consultar5mgA consultar10mgA consultar25mgA consultar50mgA consultar1mL*10mM (DMSO)A consultarαVβ8-IN-1
CAS:αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).Fórmula:C25H32ClN5O4Forma y color:White SolidPeso molecular:502.01Integrin Binding Peptide acetate
Integrin Binding Peptide acetate is a fibronectin-derived peptide that binds integrins, enabling PEG-hydrogel functionalization for cell adhesion.Fórmula:C42H63N15O16S·xC2H4O2Pureza:95.03%Forma y color:White SolidPeso molecular:1066.12 (free base)LY 379196
LY 379196, a potent PKC-β inhibitor (IC 50: 50 nM for PKC βI and 30 nM for PKC βII), effectively suppresses the proliferation of bovine retinal microvascular endothelial cells (BREC) induced by VEGF, IGF-1, and bFGF. This compound serves as an antiproliferative agent for proliferative retinopathy.Fórmula:C30H34N4O5SForma y color:SolidPeso molecular:562.68P259
P259 is a Drp1-Mff inhibitor that selectively impedes the interaction between Drp1 and Mff, thereby differentiating physiological fission from pathological fission. It leads to mitochondrial elongation and impairs mitochondrial function and motility. P259 reduces ATP levels in the brain, alters mitochondrial structure, induces behavioral defects in wild-type mice, and shortens the lifespan of Huntington's disease (HD) model mice.Forma y color:Odour SolidBimosiamose
CAS:Bimosiamose has anti-inflammatory effects[1].Fórmula:C46H54O16Pureza:98%Forma y color:SolidPeso molecular:862.91SMART1
SMART1 is a CRBN-dependent PROTAC with high specificity that effectively degrades Smurf1. It inhibits tumor growth in xenograft models of colorectal cancer (CRC) with KRAS mutations and blocks the PDK1-Akt signaling pathway in KRAS-mutated colorectal cancer.Fórmula:C40H35N9O7Forma y color:SolidPeso molecular:753.76AKT1-IN-9
AKT1-IN-9 (4) is a selective inhibitor of the AKT1(E17K) mutation, exhibiting EC50 values of 9 nM in LAPC4-CR cells and 995 nM in SkBr3 cells.Fórmula:C33H25FN6O4Forma y color:SolidPeso molecular:588.588AD57
CAS:AD57 is a potent inhibitor of both c-Src and Abl with IC50 of 0.025 μM and 0.041 μM, respectively.Fórmula:C22H20F3N7OPureza:99.05%Forma y color:SolidPeso molecular:455.44Ref: TM-T22552L
2mg38,00€5mg86,00€1mL*10mM (DMSO)88,00€10mg145,00€25mg236,00€50mg339,00€100mg460,00€200mg622,00€c(phg-isoDGR-(NMe)k) TFA
C(phg-isoDGR-(NMe)k) TFA is a selective and potent ligand for α5β1-integrin, exhibiting an IC50 of 2.9 nM [1].Fórmula:C29H42F3N9O9Forma y color:SolidPeso molecular:717.69Davunetide acetate
Davunetide acetate is derived from activity-dependent neuroprotective protein existing in the mammalian CNS.Fórmula:C38H64N10O14Pureza:99.52% - 99.78%Forma y color:SolidPeso molecular:884.97αvβ6-BP
αvβ6-BP is a selective αvβ6-binding peptide, useful for research in molecular imaging.Fórmula:C93H164N34O27Peso molecular:2189.25052STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Pureza:97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Forma y color:LiquidPeso molecular:145.12 kDaMicrotubule inhibitor 11
Microtubule inhibitor 11 (compound 33) is a tubulin inhibitor with a mechanism of action similar to that of colchicine. It is utilized in cancer-related research.Fórmula:C28H27N3O4Forma y color:SolidPeso molecular:469.20016SIAIS178
CAS:SIAIS178 is a potent and selective degrader of BCR-ABL based on PROTAC technology (IC50 of 24 nM).Fórmula:C50H62ClN11O6S2Pureza:98.07%Forma y color:SolidPeso molecular:1012.68Ref: TM-T12907
1mg152,00€5mg356,00€1mL*10mM (DMSO)393,00€10mg485,00€25mg888,00€50mg1.431,00€100mg2.052,00€200mg2.673,00€AKTide-2T
CAS:Peptide substrate for Akt/PKBFórmula:C74H114N28O20Pureza:98%Forma y color:SolidPeso molecular:1715.87DPH
CAS:DPH is a potent cell permeable activator of c-Abl. It shows potent enzymatic and cellular activity in stimulating c-Abl activation.Fórmula:C18H13FN4O2Pureza:99.65%Forma y color:SolidPeso molecular:336.32Anti-EMMPRIN/CD147 Antibody
Anti-EMMPRIN/CD147 Antibody is a mAb targeting CD147 used to study the inhibition mechanisms of viral infection by blocking receptor binding to viralForma y color:Odour LiquidSNIPER(ABL)-020
SNIPER(ABL)-020, a Dasatinib-Bestatin conjugate via linker, inhibits ABL and targets IAP, reducing BCR-ABL protein.Fórmula:C44H59ClN10O8SPureza:98%Forma y color:SolidPeso molecular:923.52huATN-658
huATN-658 (MNPR-101) is a humanized monoclonal antibody inhibitor targeting the urokinase-type plasminogen activator receptor (uPAR). It effectively disrupts the interaction between uPAR and integrins, thereby inhibiting tumor cell proliferation, invasion, and migration. huATN-658 shows potential for research in breast cancer, particularly in cases of triple-negative breast cancer.Forma y color:Odour LiquidKGP591
KGP591, a tubulin polymerization inhibitor with an IC50 of 0.57 µM, effectively induces G2/M arrest, inhibits cell migration, and disrupts microtubule structureFórmula:C24H21NO5Forma y color:SolidPeso molecular:403.43PROTAC BCR-ABL Degrader-1
PROTAC BCR-ABL Degrader-1 (compound PROTAC 1), featuring a 2-oxoethyl linker, promotes Bcr-Abl degradation through the ubiquitin-proteasome pathway andFórmula:C43H40N10O6Pureza:98%Forma y color:SolidPeso molecular:792.84Pep2m, myristoylated
CAS:Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.Fórmula:C63H118N18O14SPureza:98%Forma y color:SolidPeso molecular:1383.8SNIPER(ABL)-039
CAS:SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 ofFórmula:C54H68ClN11O9S2Pureza:98%Forma y color:SolidPeso molecular:1114.77Gamitrinib TPP hexafluorophosphate
CAS:Gamitrinib TPP hexafluorophosphate is a mitochondrial-targeted HSP90 inhibitor with anticancer activity that can be used to study cancer and viral infection.Fórmula:C52H65F6N3O8P2Pureza:98.52% - 98.52%Forma y color:SolidPeso molecular:1036.03Chromeceptin
CAS:Chromeceptin is an inhibitor of the IGF signaling pathway, decreases the numbers of tumorsphere, and inhibits the AKT/mTOR pathway.Fórmula:C19H16F3N3OPureza:99.85%Forma y color:SoildPeso molecular:359.35Alvespimycin TFA
Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.Fórmula:C34H49F3N4O10Forma y color:SolidPeso molecular:730.34008ML-B01
ML-B01 is an orally active inhibitor targeting Akt and PKA, with IC50 values of 2 nM and 136 nM, respectively. It demonstrates good blood-brain barrier (BBB) permeability in mice.Fórmula:C24H31Cl2N5OForma y color:SolidPeso molecular:476.44Tubulin inhibitor 24
CAS:Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization.Fórmula:C22H21N3O3Pureza:99.99%Forma y color:SolidPeso molecular:375.42SQLE-IN-1
CAS:SQLE-IN-1 is a SQLE inhibitor with antitumor activity that inhibits the proliferation of Huh7 and the protein expression of PI3K and AKT.Fórmula:C24H21F2N5O2SPureza:99.89%Forma y color:SolidPeso molecular:481.52Ref: TM-T83658
1mL*10mM (DMSO)44,00€1mg96,00€5mg205,00€10mg334,00€25mg655,00€50mg1.044,00€100mg1.558,00€E7130
E7130 is a microtubule inhibitor that enhances the tumor microenvironment by inhibiting cancer-associated fibroblasts and facilitating the remodeling of the tumor vasculature system.Fórmula:C58H83NO17Forma y color:SolidPeso molecular:1065.566110-Oxo Docetaxel
CAS:10-Oxo Docetaxel is a Docetaxel intermediate having remarkable antitumor properties.Fórmula:C43H51NO14Pureza:98%Forma y color:SolidPeso molecular:805.874β-catenin-IN-7
β-Catenin-IN-7 (Compound 9) is an inhibitor of β-catenin that disrupts its interaction with Tcf-4, consequently impeding Wnt-dependent gene expression, andFórmula:C17H13BrN2O2SForma y color:SolidPeso molecular:389.27Cemdomespib
CAS:Cemdomespib (KU-596) is a potent Hsp90 modulator with neuroprotective effects and can improve diabetic neuropathy.Fórmula:C24H30FNO6Forma y color:SolidPeso molecular:447.5Sangivamycin
CAS:Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.Fórmula:C12H15N5O5Pureza:99.85%Forma y color:SolidPeso molecular:309.28Ref: TM-T9605
1mg119,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg394,00€25mg640,00€50mg893,00€100mg1.198,00€SNIPER(ABL)-050
SNIPER(ABL)-050 is a chemical compound that combines Imatinib, an ABL inhibitor, with MV-1, an IAP ligand, using a linker.Fórmula:C68H84N12O9Pureza:98%Forma y color:SolidPeso molecular:1213.47
