Compuestos deuterados

<p>Applications Benzidine-d8 is involved in the enhancements in ion abundances in high-performance liquid chromatography, thus improving chromatography efficiency and particle-beam process.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bellar, T. A., et al.: J. Am. Soc. Mass. Spectrom., 1, 92-8 (1990)<br></p>

<p>Applications 2,5-Furandicarboxylic Acid-13C6 is isotopically labelled analogue of 2,5-Furandicarboxylic Acid (F863750), which is Furan (F863650) derivative that can be produced from biomass derived sugars using catalytic processes.<br>References Tong, X., et al.: Appl. Catal., A, 385, 1 (2010);<br></p>

<p>Applications 4-Hydroxychlorpropham-d7 is an intermediate in the synthesis of 4-Hydroxychlorpropham-d7 Sulfate Sodium Salt (H825077). 4-Hydroxychlorpropham-d7 Sulfate Sodium Salt is derived from Isopropanol-d7 (I822752), which is a deuterated alcohol used in the study of lignite liquefaction. 4-Hydroxychlorpropham-d7 is also the labelled analogue of 4-Hydroxychlorpropham (H825078). 4-Hydroxychlorpropham is an intermediate in synthesizing 4-Hydroxychlorpropham Sulfate Sodium Salt (H825075), which is a chemical herbicide used in the protection of crops. It also maintains the ability to induce mitochondrial dysfunction in rat hepatocytes.<br>References Kuznetov, P.N. et al.: Fuel, 70, 559 (1991); EPA.: Fed. Reg., 72, 37646 (2007); Nakagawa, Y. et al.: Toxicol., 200, 123 (2004)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Cyromazine (C989300). Insect growth regulator. Insecticide.<br>References Hall, R.D., et al.: J. Econ. Entomol., 73, 564 (1980), Hart, R.J., et al.: Aust. Vet. J., 59, 104 (1982),<br></p>

<p>Applications A labelled ethylene oxide-DNA adduct. Ethylene oxide (EtO) is classified as a known human carcinogen. The formation of EtO-DNA adducts is considered as an important early event in the EtO carcinogenic process.<br>References Walker, V., et al.: Cancer Res., 52, 4320 (1992), Wu, K., et al.: Chem. Res. Toxicol., 12, 722 (1999), van Sittert, N., et al.: Mutat. Res., 447, 27 (2000),<br></p>

<p>Applications An important isooptically labelled metabolite of benzene.<br>References Muller, G., et al. : Anal. Hazard. Sust. Biol. Mater., 5, 143 (1997)<br></p>

<p>Applications Labelled analogue of Phthalic Acid Anhydride, an organic reagent used to synthesize phthalates.<br></p>

<p>Applications Isotope labelled Hydrazine Sulfate, is a reagent used in the heterocyclization of primary amines and may be cyclized itself. It is also used in the synthesis of novel triazole corrosion inhibitors for mild steel.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bentiss, F. et al.: J. App. Electrochem., 29, 1073 (1999); Ju, Y. et al.: J. Org. Chem., 71, 135 (2006);<br></p>

<p>Applications Labelled Sulfanilic acid (S689095). Sulfanilic acid is a toxic metabolite of Tartrazine (T007700). Used as Ehrlich’s reagent, for detecting of nitrites. Antibacterial.<br>References Collins, T., et al.: Food Chem. Toxic., 28, 821 (1990), Levine, W., et al.: Drug Metab. Rev., 23, 235 (1991), Sasaki, Y., et al.: Mutat. .Res., 519, 103 (2002),<br></p>

<p>Applications N-Methyldiethanolamine-13C,d3 Hydrochloride is isotopically labelled salt form of N-Methyldiethanolamine (M301625), which is used as a reagent in the synthesis of broad-spectrum antimicrobial polycarbonate hydrogels with fast degradability. It is also used as a reagent in the synthesis of dihydroxy quaternary ammonium salts with long chain alkyl bromides that can exhibit antibacterial and antifungal activity.<br>References Pascual, A., et al.: Biomacromolecules, 16, 1169 (2015); Liu, W., et al.: Chem. Biol. Drug Des., 85, 91 (2015);<br></p>

<p>Applications 3,4-Diaminopyridine-d3 is the deuterium labelled analog of the drug 3,4-Diaminopyridine (D415950), which is used as a reagent in the preparation of 9-deazaxanthine derivatives which has activity as dual A2A antagonists/MAO-B inhibitors with potential as anti-Parkinson's agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rivara, S., et al.: J. Med. Chem., 56, 1247 (2013)<br></p>

<p>Applications 3-Fluoro-6-nitroanisole-d3 is a compound useful in organic synthesis.<br></p>

<p>Applications n-Dotriacontane-d66 (CAS# 62369-68-0) is a useful isotopically labelled research compound. It has been studied as a potential generator to supply charged particles to plastic nuclear track detectors for high-energy neutrons.<br>References Oda, K., et al.: Radiation Measurements, 36, 119 (2003)<br></p>

<p>Applications n-Hexyl 4-Hydroxybenzoate-2,3,5,6-d4 (CAS# 2241800-08-6) is a useful isotopically labeled research compound. This compound has been found to be an endocrine disruptor that was found in a study involving pantyhose.<br>References Li, A.,et.al., Environ.Sci.Technol., 52,10812-10819,(2018);<br></p>

<p>Applications AOZ-HN-d4 is the isotope labelled analog of AOZ-HN (A699000); a metabolite of 3-Amino-2-oxazolidinone (AOZ, A618570) and 1-Formylnaphthalen-2-ol (F700825) which is a novel fluorescence agent.<br>References Sheng, L., et al.: Food Addit. Contam., 30, 2114 (2013); Du, N., et al.: J. Chromatogr. A, 1327, 90 (2014)<br></p>

<p>Applications A labelled metabolite of Theophylline.<br>References ottrup, A., et al.: Pharmacol. Toxicol., 67, 340 (1990), El-Kadi, A., et al.: Drug Metab. Dispos., 28, 1112 (2000), Kim, S., et al.: J. Med. Chem., 45, 2131 ( 2002), Hansel, T., et al.: Drugs Today, 40, 55 (2004),<br></p>

<p>Applications 1-Pyren-2,3,4,5,6,7,8,9,10-d9-amine is derived from Pyrene-d10 (P849002), which is labelled Pyrene. Occurs in coal tar. Also obtained by the destructive hydrogenation of hard coal.<br>References Winterstein, et al.: Z. Physiol. Chem., 230, 162 (1934)<br></p>

<p>Applications Emamectin-d3 is deuterium labeled emamectin, a soluble derivative of avermectin and used as parasiticide and insecticide. Emamectin activates glutamate-gated chloride channels.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xu X., et al.: Biochem Biophys Res Commun 473, 795 (2016); Lumaret, J. P., et al.: Curr Pharm Biotechnol. 13, 1004 (2012)<br></p>

<p>Applications 2,3,4-Trihydroxybenzophenone-2’,3’,4’,5’,6’-d5 is the isotope labelled analog of 2,3,4-Trihydroxybenzophenone; a trihydroxy derivative of Benzophenone (B204980) which is a compound used in the manufacturing of antihistamines, hypnotics, and insecticides.<br>References Wallace, W., et al.: Environ. Toxicol. Chem., 19, 962 (2000); Hayashi, T., et al.: Toxicol. Lett., 167, 1 (2006); Bechard, K., et al.: Aquat. Toxicol., 90, 310 (2008)<br></p>

<p>Applications 2-Butoxyethanol-d4 is the isotope labelled analog of 2-Butoxyethanol; a reagent in the synthesis of 4-butoxyethoxy-N-octadecyl-1,8-naphthalimide as a new fluorescent probe for the determination of proteins. Also used as a reagent in the synthesis of 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors.<br>References Sun, Y., et al.: Bioorg. Med. Chem. Lett., 21, 3798 (2011); Yi, W., et al.: Eur. J. Med. Chem., 45, 639 (2010)<br></p>

<p>Applications 4-Ethylphenyl-d4 Sulfate Potassium Salt is the isotope labelled analog of 4-Ethylphenyl Sulfate Potassium Salt (E925865); a newly identified uremic substance.<br>References Kaori, K., et al.: J. Chromatogr. B, 878, 2997 (2010)<br></p>

<p>Stability Hygroscopic<br>Applications Isotope labelled analog of α-D-Galactose 1-Phosphate, the phosphate conjugate of α-D-Galactose (G155260), a natural aldohexose which is ubiquitous in bacteria, plants, and animals, including human brains.<br>References Sang, J.L., et al.: J. Bacteriol., 190, 7932 (2008);<br></p>

<p>Applications 2,6-Dichloroaniline-3,4,5-d3 (CAS# 77435-48-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications tert-Butyl-d9 4-Nitrophenyl Carbonate (cas# 1190006-35-9) is a compound useful in organic synthesis.<br></p>

<p>Stability Light and temperature Sensitive<br>Applications 2,2-Dichloroacetic Acid-1-13C is derived from Barium Carbonate-13C (B118672), which is a stable Barium Carbonate isotope used for studies on drug metabolism.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Horie, M. et al.: Yakug. Zas., 97, 805 (1977);<br></p>

<p>Stability Hygroscopic<br>Applications 4,4'-Dipyridyl-d8 as a solid-solution approach to control the dynamics of molecular rotors in crystal solids.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Inukai, M., et al.: J. Amer. Chem. Soc., 137, 12183-12186 (2015)<br></p>

<p>Applications 2,2′,4,4′-Tetrahydroxybenzophenone-d4 is an isotopic analog of 2,2′,4,4′-Tetrahydroxybenzophenone (T295900), a benzophenone-type UV filter with known or suspected endocrine disrupting properties detected in surface waters, sunscreens, personal care products, clothing and food packaging. It is used to protect the skin and materials from the adverse effects of UV-radiation.<br>References Wu, M., et al.: Ecotoxicol. Environ. Saf., 141, 235-241 (2017); Krause, M., et al.: Environ. Int., 99, 177-184 (2017); Jimenez-Diaz, I., et al.: J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 1035, 57-66 (2016)<br></p>

<p>Applications Hexanoic-d11 Acid acts as a reagent in the synthesis of per-deuterated alkyl amines for preparation of deuterated organic pyromellitamide gelators.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yepuri, N. R.; Tetrahedron Lett., 54, 2538 (2013)<br></p>

<p>Applications Diphenyl-2,2',4,4',6,6'-d6-amine (CAS# 99234-91-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope Labelled 2,4,6-Trichloroanisole (T774085), which is considered the main compound responsible for the cork taint, a wine flavor defect usually perceived as a moldy off-flavor. Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Chatonnet P. et al.: J Agric Food Chem. 2004 Mar 10;52(5):1255-62. 2. Cserjesi, A. et al.: Can J Microbiol. 1972 Jan;18(1):45-9.<br></p>

<p>Applications Isotope labelled Urethane (U82500), which is a naturally occurring contaminant in fermented foods, particularly wine, stone-fruit brandies, and bread. This substance is reasonably anticipated to be a human carcinogen (1) despite being an additive in some alcoholic beverages and foods (2). It binds covalently with DNA however due to its low unavoidable daily intake, it is considered of negligible concern (3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>References 1. Mirvish, S. et al.: Adv. Cancer Res. 1968;11:1-42.2. Battaglia R. et al.: Food Addit Contam. 1990 Jul-Aug;7(4):477-96.3. Zimmerli B. et al.: Mutat Res. 1991 Mar-Apr;259(3-4):325-50.<br></p>

<p>Applications Labeled Chlorotriphenylstannane, which is used in the synthesis of nanoparticles which bear triamide ligands.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shariatinia, Z. et al.: Beil. J. Nanotech., 4, 94 (2013);<br></p>

<p>Applications Labelled Isoferulic Acid 3-O-β-D-Glucuronide, the glucuronide conjugate of Isoferulic Acid (H946180). Isoferulic Acid 3-O-β-D-Glucuronide is one of the circulating metabolites in human plasma after coffee consumption.<br>References Fumeaux, R. et al.: Org. Biomol. Chem., 8, 5199 (2010); Redeuil, K. et al.: J. Chrom. A, 1218, 4678 (2011);<br></p>

<p>Applications This compound is the labelled analog of a cresol metabolite.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dills, R.L. et al: J. Chrom. B. Biomed. Sci. App., 703, 105 (1997);<br></p>

<p>Applications Gefitinib-d6 is the labeled version of Gefitinib (G304000), which is an antineoplastic.<br>References Anderson, N.G., et al.: Int. J. Cancer, 94, 774 (2001), Hirata, A., et al.: Cancer Res., 62, 2554 (2002), Kris, M.G., et al.: J. Am. Med. Assoc., 290, 2149 (2003), Tamura, K., et al.: Expert Opin. Pharmacother., 6, 985 (2005)<br></p>

<p>Applications Isotope labelled Resiquimod (R144680) is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist.<br>References Wu, J.J. et al.: Antivir. Res., 64, 79 (2004); Fife, K.H. et al.: Antimicrob. Agents Chemother., 52, 477 (2008); Szeimies, R.M. et al.: Brit. J. Dermatol., 159, 205 (2008);<br></p>

<p>Stability Hygroscopic<br>Applications n-Heptyl 4-hydroxybenzoate-d4 is labelled n-Heptyl 4-hydroxybenzoate which is used to prepare sulfonylbenzoic acid esters as potential inhibitors of oestrone sulphatase with antitumor activities.<br>References Owen, C., et al.: J. Pharm. Pharmacol., 55, 85 (2002)<br></p>

<p>Applications Labelled p-Phenetidine (P296300). A toxic metabolite of Phenacetin (P294580) which exhibits high renal toxicity. p-Phenetidine also reduced COX-1 and COX-2 expression in neutrophils.<br>References Green, C., et al.: Br. Med. J., 1, 162 (1969), Nelson, S., et al.: J. Med. Chem., 25, 753 (1982), Nicholls, A., et al.: Xenobiotica, 27, 1175 (1997),<br></p>

<p>Stability Hygroscopic<br>Applications Guaiacol-beta-D-glucopyranoside-d3, is a labeled analogue of Guaiacol-beta-D-glucopyranoside (G245565), a Guaiacol Conjugate, that has shown to present in fermentation of grapes that had been exposed to bushfire smoke and can potentially yield unpalatable, smoke-affected wine.<br>References Hayasaka, Y.m et al.: J. Arg. Food Chem., Vol. 58, Issue 4, P: 2076; 2081 (2010);<br></p>

<p>Applications D-Phenylalanine, the stereoisomer of L-Phenylalanine (P319415) has been used in the synthesis of Schaeffer’s acid analogues as important structures in tuberculostatic design. They exhibit the ability to inhibit Mycobacterium tuberculosis type II dehydroquinase. This is the labeled analog.<br>References Schmidt, M. et al.: ChemMedChem., 8, 54 (2013);<br></p>

<p>Applications Octadecanoic-17,17,18,18,18-d5 Acid (CAS# 211443-83-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Octanal. Use of deuterium exchange in the column of a gas chromatograph-mass spectrometer in the study of aliphatic alcohols and carbonyl compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mikaya, A.I., et al.: Org. Mass Spectrometry, 19, 521 (1984),<br></p>

<p>Applications Isotope labelled D-Glucitol is a sugar alcohol obtained from the reduction of glucose and is naturally found in various fruits such as apples, pears and peaches. D-Glucitol has been widely used as a sweetener, laxative, various medical applications and in cosmetic products.<br>References Wang, Z.J., et al.: Anal. BIoanal. Chem., 405, 3899 (2013); Vinarta, S.C., et al.: Carb. Poly., 92, 1107 (2013); Kaumanu, M.L., et al.: Soil. Biol. Biochem., 57, 644 (2013); Hailu, T., et al.: Anal. Biochem., 434, 181 (2013);<br></p>

<p>Applications 16alpha-Hydroxy-17beta-estradiol-2,4-d2 (CAS# 53866-32-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-Methionine Sulfoxide 13C1 is a labelled analogue of L-Methionine Sulfoxide ( M260450). L-Methionine Sulfoxide ( M260450) an intermediate in the synthesis of the acyclic amino carboxylic acid L-Methionine sulfoximine.<br>References Lee, B., et al.: J. Biol. Chem., 283, 28361 (2008), Nordqvist, A., et al.: Bioorg. Med. Chem., 16, 5501 (2008);Balog, E., et al.: Biochem., 48, 3005 (2009);<br></p>

<p>Stability Toxic<br>Applications Isotopopically Labelled analogue of Captan (C175725), which is an acetylcholinesterase inhibitor acting as a fungicide (1), often added to pesticide mixtures to control diseases among fruits and vegetables. Detected through various analytical techniques involving pesticide residues such as MS-PD and GC-MS (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Also used in cannabis testing.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Afful, S. et al.: Res. J. App. Sci. Eng. Tech. (2010) 14 Jul:2(6) 592-52. Engelen, K. et al.: J. Proteome. Res. 2010 Oct 1;9(10):4919-263. Lagunas-Allue, L. et al.: Anal. Bioanal. Chem. 2010 Oct;398(3):1509-23<br></p>

<p>Applications Labelled N-Nitrosodiisobutylamine (N525610). N-Nitrosodiisobutylamine is a nitrosoamine compound that shows carcinogenic effect.<br>References Scanlan, R., et al.: Cancer Res., 43, 2435 (1983), Spiegelhalder, B., et al.: Carcinogenesis, 4, 1147 (1983), Lijinsky, W., et al.: Mutat. Res., 443, 129 (1999), Robichova, S., et al.: Chem. Biol. Interact., 148, 163 (2004),<br></p>

<p>Applications Glutaric Acid-1,5-13C2 (cas# 1185108-16-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Propoxyphenyl-​thiohydroxyhomosilde​nafil-d4 is labelled Propoxyphenyl-thiohydroxyhomosildenafil (P831630), an analogue of Hydroxythiohomo Sildenafil (H963150).<br>References Balayssac, S., et. al.: J. Pharmaceut. Biomed., 63, 135 (2012)<br></p>

<p>Stability Volatile<br>Applications Assignments of far-IR (FIR) laser lines have been found for optically pumped Methanol-13C.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Moraes, J.C.S., et. al.: J. Mol. Spec., 177, 302 (1996)<br></p>

<p>Applications Medetomidine-d5 (d5-Major) is an intermediate in the synthesis of Dexmedetomidine-d4 L-Tartrate (d4-Major) (D299006). Dexmedetomidine-d4 L-Tartrate is the labeled salt analogue of Dexmedetomidine (D299000), an α2-Adrenergic agonist; (+)-isomer of Medetomidine; sedative; analgesic.<br>References Rajala, R., et al.: Eur. J. Pharm. Sci., 1, 219 (1994); Jalonen, J., et al.: Anesthesiology, 86, 331 (1997); Talke, P., et al.: Anesth. Analg., 85, 1136 (1997); Bhana, N., et al.: Drugs, 59, 263 (2000)<br></p>

<p>Applications Labelled Mecoprop (M203052). Herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gagne, F., et al.: Environ. Res., 103, 238 (2007), LaChapelle, A., et al.: Reprod. Toxicol., 23, 20 (2007),<br></p>

<p>Applications A labelled active ingredient formulation to prepare agrochemicals and drugs in amorphous form.<br>References Blair, A.M., et al.: J. Agr. Sci., 139, 385 (2002),<br></p>

<p>Applications N-Methyl-d3-formamide (CAS# 87955-92-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Fumaric Acid (F500380). Occurs in many plants. Essential to vegetable and tissue respiration. Used as an antioxidant.<br>References Jelitto, T., et al.: Planta, 188, 238 (1992), Son, H., et al.: J. Agric. Food Chem., 56, 8007 ( 2008),<br></p>

<p>Applications 2-Chloronaphthalene-d7 (CAS# 93951-84-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethanolamine-d7 (CAS# 1219802-89-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Oxaloacetic Acid-13C4 is labelled form of Oxaloacetic Acid (O845030) which is a four carbon dicarboxylic acid that is an intermediate in the citric acid cycle and glucogenesis. It has been shown to inhibit succinate dehydrogenase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zeylemaker, W.P. et al.: Biochim. Biophys. Acta Enzymol., 132, 210 (1967); Dalla-Betta, P. et al.: Int. J. Mol. Sci., 10, 2809 (2009);<br></p>

<p>Applications Betaine-d3 Hydrochloride is a useful gastric acidifier.<br>References Wilcken, D.E., et al.: N. Engl. J. Med., 309, 448 (1983),<br></p>

<p>Applications Vardenafil oxopiperazine-D6 is a labelled analogue of Vardenafil oxopiperazine (V098030)<br></p>

<p>Applications Bis(4-hydroxyphenyl) Sulfone is commonly used as a reactant in epoxy reactions and is also used as a latent thermal catalyst for epoxy resin.<br>References Fu, J.W., et al.: Adv. Mat. Rsch., 266, 1022 (2011); Li, J.X., et al.: Polymers. Adv. Tech., 23, 803 (2012);<br></p>

<p>Applications Griseofulvin-d3 is the labeled analogue of Griseofulvin (G787500), an antifungal drug. It is used both in animal and in humans, to treat rigworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum.Environmental contaminants; Food contaminants<br>References Oxford, et al.: Biochem. J., 33, 240 (1939); Townley, E.R., et al.: Anal. Profiles Drug Subs., 8, 219 (1979)<br></p>

<p>Applications (±)-Mianserin-d3 HCl (methyl-d3) (CAS# 1219804-97-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled O,O-Diethyl Dithiophosphate-d10 is used in the synthesis of novel phosphorothioates and phosphorodithioates as cholinesterase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Millard, C., et al.: J. Neurochem., 64, 1909 (1995), Nicolet, Y., et al.: J. Biol. Chem., 278, 41141 (2003), Casida, J., et al.: Chem. Res. Toxicol., 17, 983 (2004),<br></p>

<p>Applications Phenylglyoxylic Acid-d5 (cas# 1217089-53-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Labelled Hexanal. Used in the enzymic synthesis of (R)- and (S)-1-deuteriohexanol.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tsai, A., et al.: J. Biol. Chem., 267, 17753 (1992), Glickman, M., et al.: Biochemistry, 35, 12882 (1996),<br></p>

<p>Applications Labelled Coumarin (C755380). Pharmaceutic aid (flavor). Found in tonka beans, levender oil, woodruff, sweet clover.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hazleton, L., et al.: J. Pharmacol. Exp. Ther., 118, 348 (1956), Lake, B., et al.: Food Chem. Toxicol., 37, 423 (1999), Frerot, E., et al.: Flavour Fragrance J., 17, 218 (2002), Yang, Z., et al.: Food Chem., 114, 289 (2009),<br></p>

<p>Applications Cyclopropyl-d5-amine is labelled Cyclopopylamine (C989140) which can inactivate major human drug-metabolizing cytochromes P450 enzymes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shaffer C., et al.: J. Am. Chem. Soc., 123, 8502 (2001); Polasek, T., et al.: Brit. J. Clin. Pharmaco., 61, 570 (2006)<br></p>

<p>Stability Light Sensitive<br>Applications A labelled derivatized of 3-amino-2-oxazolidone (AOZ, A618570), a metabolite of Furazolidone and Nitrofuran.Environmental contaminants; Food contaminants; Heat processing contaminants<br>References Vroomen, L., et al.: Drug Metab. Rev., 22, 663 (1990), Hoogenboom, L., et al.: Food Chem. Toxicol., 29, 185 (1991), McCracken, R., et al.: Food Addit. Contam., 17, 75 (2000),<br></p>

<p>Applications 1-Bromonaphthalene-d7 (cas# 37621-57-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Eicosanoic-d39 Acid (CAS# 39756-32-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethylene Urea-d4 (cas# 62740-68-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Cefepime-D8 sulfate is a labelled analogue of Cefepine sulfate, a cephalosporin that has antibacterial effects against Gram-positive and Gram-negative bacteria. Cefepime sulfate is used to treat mild to severe bacterial infections.<br>References Neu, H.: Am. J. Med., 100, 68S (1996); Sanders, C.: Clin. Infect. Dis., 17, 369 (1993); Sanders, W., et al.: Clin. Infect. Dis., 23, 454 (1996); Yahav, D., et al.: Lancet Infect. Dis., 7, 338 (2007)<br></p>

<p>Applications DL-Histidine-alpha,beta,beta-d3 (CAS# 344299-50-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tralomethrin-d5, is the labeled analogue of Tralomethrin (T712400), which is a pyrethroid insecticide. It is effective against most members of class Arachnida as well as insects.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Laskowski, D.A., et al.: Review Env. Conatmin. Toxic., 174, 49 (2002); Tanaka, Y., et al.: Shokuhin Eiseigaku Zasshi, 41, 335 (200);<br></p>

<p>Stability Hygroscopic<br>Applications rac-Propranolol-d7, is the labeled analogue of Propranolol (P831800), a β−Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).<br>References Bond, et al.: Nature, 213, 721 (1967), Hansteen, V., et al.: Br. Med. J., 284, 155 (1982), Diamond, S., et al.: J. Clin. Pharmacol., 28, 193 (1988),<br></p>

<p>Applications Labelled Urea. Physiological regulator of nitrogen excretion in mammals; synthesized in the liver as an end-product of protein catabolism and excreted in urine. Also occurs normally in skin. Emollient; diuretic.<br>References Demetriou, A., et al.: Science, 233, 1190 (1986); Aebischer, P., et al.: Nat. Med., 2, 696(1996); Prakash, S., et al.: Biotechnol. Bioeng., 46, 621(1995);<br></p>

<p>Applications A labelled thioxanthone derivative useful as photoinitiators.<br>References le Fur, Y., et al.: J. Agric. Food Chem., 47, 2860 (1999), Sanz, M., et al.: Food Chem., 84, 133 (2004), Herent, M., et al.: J. Pharm. Biomed. Anal., 43, 886 (2007),<br></p>

<p>Applications 4-(2-(4-Chlorobenz-d4-amido)ethyl)phenyl 4-Chlorobenz-d4-oate is an intermediate in the synthesis of Bezafibrate-d4 (B341002), a labeled antilipemic agent.<br>References Zimmerman, R., et al.: Atherosclerosis 29, 477 (1978), Monk, J.P., et al.: Drugs, 33, 539 (1987)<br></p>

<p>Applications 1,3-Diphenyl-d10-urea is labelled 1,3-Diphenyl-urea which is a cytokinin compound present in fruit and vegetables. It is metabolized by a moderate halophilic Marinobacter sp.<br>References Sørensen, S., et al.: FEMS Microbiol. Lett., 213, 199 (2002); Campillo, N., et al.: Talanta, 116, 376 (2013)<br></p>

<p>Applications Glyburide-d3 (methoxy-d3) (CAS# 1219803-02-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled N-nitrosopiperazine derivative; shows strong nasal carcinogenicity and genotoxicity after low dose inhalation.<br>References Sabadie, N., et al.: Cancer Res., 40, 119 (1980), Kuchenmeister, F., et al.: Toxicol. Lett., 88, 29 (1996), Mathison, B., et al.: Mutat. Res., 380, 77 (1997),<br></p>

<p>Applications Cyclohexanol-d12 (CAS# 66522-78-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled O,O-Diethyl Dithiophosphate (D444265). Used in the synthesis of novel phosphorothioates and phosphorodithioates as cholinesterase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Millard, C., et al.: J. Neurochem., 64, 1909 (1995), Nicolet, Y., et al.: J. Biol. Chem., 278, 41141 (2003), Casida, J., et al.: Chem. Res. Toxicol., 17, 983 (2004),<br></p>

<p>Applications Morpholine-d8 Hydrochloride is used as a reactant in the synthesis of Moclobemide-d8 (M481002), the labeled analogue of Moclobemide (M481000), a reversible monoamine oxidase inhibitor.<br>References Wiesel, F.A., et al.: Eur. J. Clin. Pharmacol., 28, 89 (1985), Burkard, W.P., et al.: J. Pharmacol. Exp. Ther., 248, 391 (1989)<br></p>

<p>Applications Phenethyl Alcohol-d5 (cas# 35845-63-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Formetanate-d6, Hydrochloride (cas# 1185240-24-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Labelled Glycerol (G598400). Glycerol is used both in sample preparation and gel formation for polyacrylamide gel electrophoresis. Glycerol (5-10%) increases the density of a sample so that the sample will layer at the bottom of a gel’s sample well. Glycerol is also used to aid in casting gradient gels and as a protein stabilizer and storage buffer component.<br>References Bartsch, W., et al.: Arzeim.-Forsch., 26, 1581 (1976),<br></p>

<p>Applications L-Valine (1-13c, 99%) (cas# 81201-85-6) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Bufuralol, a β-Adrenergic blocker with peripheral vasodilating activity.<br>References Boobis, A.R., et al.: Biochem. Pharmacol., 34, 65 (1985), Yamazaki, H., et al.: Mol. Pharmacol., 46, 568 (1994), Mast, N., et al.: Biochem., 42, 14284 (2003),<br></p>

<p>Applications Chlorpromazine-d6 Oxalate (N,N-dimethyl-d6) (CAS# 1276197-23-9) is a useful isotopically labeled research compound.<br></p>