Compuestos deuterados

<p>Applications A labelled derivative of Dibarbituric acid.<br>References Hitchings, G.H., et al.: J. Biol. Chem., 177, 357 (1949),<br></p>

<p>Applications Bis(4-hydroxyphenyl) Sulfone-d4 is the isotope labelled compound commonly used as a reactant in epoxy reactions and is also used as a latent thermal catalyst for epoxy resin.<br>References Fu, J.W., et al.: Adv. Mat. Rsch., 266, 1022 (2011); Li, J.X., et al.: Polymers. Adv. Tech., 23, 803 (2012);<br></p>

<p>Applications 6-Nitrodopamine-d4 is the labeled analogue of 6-Nitrodopamine(N493722), a reagent used in the detection of cancer biomarker prostate specific antigen (PSA).<br>References Li, H., et. al.: Biosensors Bioelectronics, 26, 3044 (2011)<br></p>

<p>Applications 1-Hexanol-d11 is the labelled analogue of 1-Hexanol (H281220), a perturbing agent on actomyosin ATPase and and was found to modulate the function of actomyosin motor via intermediate-specific structural perturbation.<br>References Komatsu, H., et al.: J. Muscle. Res. Cell. Motil., 25, 77 (2004); Hua, J.F., et al.: J. Insect. Physiol., 59, 690 (2013);<br></p>

<p>Applications Ethyl-d5 Butyrate is the labeled analogue of Ethyl Butyrate (E900690), which is used in the preparation of novel 2-cyanopyrimidines as cathespin K inhibitors. Also used in the synthesis of pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of β-1,6-glucan.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References By Rankovic, Z. et al.: Bioorg. Med. Chem. Lett.,, 20, 1524 (2010); Takeshita, H. et al.: Bioorg. Med. Chem. Lett., 20, 3893 (2010)<br></p>

<p>Applications It is listed as a known human carcinogen. Used in manufacturing of dyes, as antioxidant in rubber.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References IARC Monographs, 4, 97 (1974),<br></p>

<p>Applications N,N-Dimethylformamide-d7 is the isotope labelled analog of N,N-Dimethylformamide. N,N-Dimethylformamide-d7 is used as a cofactor for enzymic oxidation of brassinin, which allows the transformation of dithiocarbamate group into an aldehyde equivalent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pedras, M., et al.: Bioorg. Med. Chem., 19, 1390 (2011);<br></p>

<p>Applications Ethyl Acetate-13C2 can be used in the synthesis of carbon-13-labeled 5-(diethylphosphono)-2-pentanone ethylene ketal, a reagent for the synthesis of multi carbon-13-labeled steroids.Environmental contaminants; Food contaminants<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Degraw, J., et al.: J. Lable Compd Radiopharma, 19, 945 (1982);<br></p>

<p>Applications A labelled metabolite of a mixed disulfide S-(N,N-diethyldithiocarbamoyl)-N-acetyl-L-cysteine (AC-DDTC), an antimutagenic mixed disulfide from disulfiram.<br>References Madan, A., et al.: Drug Metab. Dispos., 23, 1153 (1995), Lambert, D., et al.: J. Med. Chem., 48, 5059 (2005), Tsuboi, K., et al.: J. Biol. Chem., 280, 11082 (2005),<br></p>

<p>Applications O,O-Di(Ethyl-d5)phosphate Sodium Salt is labelled Diethyl Phosphate Sodium Salt (D444720) which is used in a cosmetic composition for treating keratin materials, for example, keratin fibers such as the hair.<br></p>

<p>Stability Hygroscopic<br>Applications Labelled rac 3-Hydroxybutyric Acid (H833020). Optically active 3-hydroxybutyric acids are key intermediates of the biosynthesis and metabolism of fatty acids and exist widely in biological systems.<br>References Freeman, J., et al.: Pediatrics, 102, 1358 (1998), Thio, L., et al.: Neurology, 54, 325 (2000), Rho, J., et al.: Epilepsia, 43, 358 (2002),<br></p>

<p>Applications Isoquinoline-d7 (CAS# 17157-12-9) is a useful isotopically labeled research compound.<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Homarine (H458500). Quaternary ammonium base occurring in tissues of marine animals.<br>References Stein, W., et al.: J. Biol. Chem., 211, 915 (1954), Bystedt, J., et al.: J. Sci. Food Agric., 10, 301 (1959),<br></p>

<p>Applications n-Pentyl 4-Hydroxybenzoate-2,3,5,6-d4 (CAS# 1219798-66-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Boc-piperazine-d8 is a useful synthetic intermediate for the preparation of labelled compounds.<br></p>

<p>Applications A labelled chloropropanol which shows toxic effects.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Andersen, H., et al.: Toxicology, 136, 67 (1999), Fry, J., et al.: Food Chem. Toxicol., 37, 351 (1999), Garle, M., et al.: Xenobiotica, 29, 533 (1999),<br></p>

<p>Applications Isotope labelled (±)-Propylene Oxide (P835241), which is a carcinogenic substance to rats and potentially humans (1). (±)-Propylene oxide also has the ability to self-polymerize at room temperature in the presence of powdered potassium hydroxide (2). (±)-Propylene oxide is used in industry for fumigation in the food industry, inducing the formation of persistent toxic chlorohydrins. Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> E3<br>References 1. Narang, S. et al.: Ind. Eng. Chem. Res. 2013 Feb:52(11);3967-39732. Timofeeva, M. et al.: Microporous Mesoporous Mater. 2013 Jan:165(1);84-91<br></p>

<p>Applications Strobilurin fungicide; inhibits mitochondrial respiration by blocking electron transfer between cytochromes b and c1. Agricultural fungicide. Used in Pesticide detection.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Smalling, K., et al.: Environ. Toxicol. Chem., 29, 2593 (2010), Lu, X., et al.: Phytopathol., 100, 1162 (2010), Schafer, R., et al.: Environ. Sci. Technol., 45, 1665 (2011),<br></p>

<p>Applications Trimethyl-d9-sulfonium Iodide (CAS# 106776-17-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Hydroxychlorpropham-d7 is an intermediate in the synthesis of 4-Hydroxychlorpropham-d7 Sulfate Sodium Salt (H825077). 4-Hydroxychlorpropham-d7 Sulfate Sodium Salt is derived from Isopropanol-d7 (I822752), which is a deuterated alcohol used in the study of lignite liquefaction. 4-Hydroxychlorpropham-d7 is also the labelled analogue of 4-Hydroxychlorpropham (H825078). 4-Hydroxychlorpropham is an intermediate in synthesizing 4-Hydroxychlorpropham Sulfate Sodium Salt (H825075), which is a chemical herbicide used in the protection of crops. It also maintains the ability to induce mitochondrial dysfunction in rat hepatocytes.<br>References Kuznetov, P.N. et al.: Fuel, 70, 559 (1991); EPA.: Fed. Reg., 72, 37646 (2007); Nakagawa, Y. et al.: Toxicol., 200, 123 (2004)<br></p>

<p>Applications (±)-Fluazifop-d4 is a labeled analogue of (±)-Fluazifop (F407430), a grass-selective herbicide which inhibits acetyl-CoA carboxylase in sensitive plant species.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Walker, K.A., et. al.: Biochem. J., 254, 307 (1988); Hajslova, J., et. al.: J. Chrom., 438, 55 (1988)<br></p>

<p>Applications Isosilybin A+B mixture - d3 is the isotope labelled mixture of Isosilybin A and Isosilybin B. Isosilybin (I901000) is useful in the treatment of liver disease.<br>References Parthasarathy, M.R., et al.: Phytochemistry, 18, 506 (1979),<br></p>

<p>Applications Labelled Fenvalerate (F279450). An insecticide, used to control insects from food crops, animal feed and cotton products.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sharma, R., et al.: Environ. Ecol., 27, 1481 (2009), Choudhary, S., et al.: J. Industrial Poll. Cont., 25, 145 (2009), Tang, J., et al.: Pest Man. Sci., 66, 121 (2010), Ai, G., et al.: J. Agric. Food Chem., 58, 694 (2010),<br></p>

<p>Applications N-Ethyl-2-hydroxysuccinimide-d5 is the isotope labelled analog of N-Ethyl-2-hydroxysuccinimide (E919180); a metabolite of N-ethyl-2-pyrollidone (NEP) which is a frequently used industrial solvent shown to be embryotoxic in animal experiments.<br>References Schindler, B.K., et al.: Anal. Chem., 84, 3787 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications Ethanolamine-13C2 Hydrochloride is the labeled analogue of Ethanolamine (E676500), which is used in the preparation of various pharmaceutical compounds and inhibitors. Ethanolamine-13C2, is also a 13C-labeled lipid precursor, used for the detection of phospholipid metabolism and the synthesis of phosphatidylethanolamine in T47D human breast cancer cells.<br>References Ronen, S. M., et al.: Magnetic Resonance Med., 25, 384 (1992); Lombardo, L. et al.: J. Med. Chem., 47, 6658 (2004); Egan, T.: J. Med. Chem., 43, 283 (2000);<br></p>

<p>Applications A deuterated acyclic nucleotide.<br></p>

<p>Applications 4-Nitrobenzoic Acid-d4 is labelled 4-Nitrobenzoic Acid (N493550) which is used in the synthesis of anti-Trypanosoma cruzi agents in the treatment of chagas disease.<br>References Palace-Berl, F. et al.: Bioorg, Med. Chem. Lett., 21, 5395 (2013); Zhou, L. et al.: J. Med. Chem., 56, 796 (2013);<br></p>

<p>Applications β-Cyclodextrin Deuterated is an isotope analog of β-Cyclodextrin (C987830), which is a cyclic oligosaccharide produced from starch via enzymatic conversion. β-Cyclodextrin is commonly used to produce HPLC columns allowing chiral enantiomers separation.<br>References Motoyama, A. et al.: J. Pharmac. Biomed. Anal., 28, 97 (2002); Nakamura, N. et al. Biotechnol. Bioeng., 19, 87 (1977); Riddle, L. A. et al.: J. Chrom. Sci., 45, 330 (2007);<br></p>

<p>Applications N-Nitrosodiethylamine-d10 is a labelled form of N-Nitrosodiethylamine (N525465) which is a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver.NDMA and NDEA were found as an impurity in generic versions of valsartan, losartan and irbesartan.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Oda, Y., et al.: Mutation Research, Genetic Toxicology and Environmental Mutagenesis, 584, 1 (2005); Yamazaki, H., et al.: Carcinogenesis, 13, 1789 (1992);Chem. and Eng. News, p.5, Feb. 25, 2019<br></p>

<p>Applications 3-Hydroxybutyrylcarnitine-d3 is labelled 3-Hydroxybutyrylcarnitine (H830900) which is a reagent used to study acylcarnitine profile in thyroid disease.<br>References Wong, S., et al.: Clinical Biochem., 46, 180 (2013); Alu, F., et al.: Heredity, 110, 253 (2013); Adam, B., et al.: Clinical Biochem., 44, 1445 (2011)<br></p>

<p>Applications 3-Nitrobiphenyl is a nitrated benzene metabolite found in the bone marrow of B6C3F1 mice treated with benzene. 3-Nitrobiphenyl displays toxic effect on Tetrahymena pyriformis, Porphyromonas gingivalis, Selenomonas artemidis, and Streptococcus sobrinus.<br>References Laszlo, T. &amp; Beteringhe, A.: QSAR Combinatorial Sci., 25, 944 (2006); Mintz, C. et al.: QSAR. Combinatorial Sci., 25, 912 (2006); Chen, K. et al.: Chem. Res. Toxicol., 17, 370 (2004)<br></p>

<p>Applications Tetraphenylstannane-d20 is an isotope labelled organometallic compound and an intermediate in the synthesis of isotope labelled Chlorotriphenylstannane (C4222525), a compound used in the synthesis of nano particles that bears triamide ligands.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Volatile<br>Applications Isotope labelled Acetonitrile is used as a polar aprotic solvent in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hu, H.H., et al.: Phy. Chem. Phys., 15, 7666 (2013); Kim, J.Y., et al.: J. Mater. Chem. A., et al.: 1, 5982 (2013);<br></p>

<p>Applications Pentachlorothioanisole-13C6, is the labeled analogue of Pentachlorothioanisole (P238170), which can be used in the preparation of arenethiols and arenethiolates as seen in agrochemicals or fungicides.<br>References Dulik, D. et al.: Xenobiotica, 22, 325 (1992); Rakitin, O. et al.: Sci. Synth., 31a, 949 (2007);<br></p>

<p>Applications 2-Ethyl 13C6-toluene is a labelled aromatic standard.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability No Data Avaialble<br>Applications 2-Chlorophenol (Ring-D4, 99%) was an analyte in a study looking to optimize ultrasonic extraction for efficient detection of polycyclic aromatic hydrocarbons (PAHs) in soil.<br>References Stankov Jovanovic, V., et al.: Anal. Lett., 50, 2491 (2017)<br></p>

<p>Stability Hygroscopic<br>Applications Dioxybenzone-d3 is an isotopic analog of Dioxybenzone (D486365), a compound used in sunscreen formulations to block out UVB and UVA harmful rays.<br>References Baumgartner, V. et al.: J. Planar. Chrom. Modern. TLC., 22, 19 (2009); Kunisue, T. et al.: Anal. Meth., 2, 707 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Glyoxylic Acid (G755000). Occurs in unripe fruit and in young green leaves; has also been found in very young sugar beets.<br>References Lelieveld, J., et al.: Nature, 452, 737 (2008), da Silva, G., et al.: Environ. Sci. Technol., 44, 250 (2010),<br></p>

<p>Stability Hygroscopic<br>Applications Decanoyl-L-carnitine-d3 Chloride is the isotope labelled analog of Decanoyl-L-carnitine Chloride (D212580); a metabolite of L-Carnitine (C184110) which is an essential cofactor of fatty acid metabolism. Also required for the transport of fatty acids through the inner mitochondrial membrane.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)<br></p>

<p>Applications Labelled Physcion. A natural anthraquinone derivative, on the infection process of Blumeria graminis on wheat. Physcion is one of the important active ingredients of ethanol extract from the roots of Chinese rhubarb (Rheum officinale) for controlling powdery mildew.<br>References Thiericke, R., et al.: Nat. Prod. Rep.,10, 265 (1993), Lin, C., et al.: J. Nat. Prod., 58, 1934 (1995), Julia, S., et al.: J. Biotechnol., 124, 690 (2006), Wang, W., et al.: J. Antibiot., 60, 603 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications 3,4-Dihydroxybenzaldehyde-d3 is an intermediate in synthesizing DL-threo-Droxidopa-d3 (D689953). It is an isotope labelled compound of DL-threo-Droxidopa (D689950), a synthetic amino acid precursor of Norepinephrine. An antiparkinson.<br>References Bartholini, J., et al.: J. Pharmacol. Exp. Ther ., 193, 523 (1975), Kato, T., et al.: Biochem. Pharmacol., 36, 3051 (1987), Kawabata, A., et al.: Br J. Pharmacol., 111, 503 (1994),<br></p>

<p>Stability Hygroscopic<br>Applications (±)-Albuterol-d3 (3-hydroxymethyl-d2; alpha-d1) (CAS# 1219798-60-3) is a useful isotopically labeled research compound.<br></p>

<p>Stability Volatile<br>Applications 2,​2,​3,​3,​3-​Pentafluoropropanoic Acid-13C is the labeled analogue of 2,​2,​3,​3,​3-​Pentafluoropropanoic Acid (P227235), which is used in the analysis of gentamicin with Gemini column by liquid chromatographic (LC) methods. It was also used to prepare [(R)-(amino)(oxo)(fluorophenyl)butyl]tetrahydro(fluoroethyl)-1,2,4-triazolo[4,3-a]pyrazine using (fluoro)propanoic acid.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Manyanga, V., et al.: J. Pharm. Biomed. Analysis, 45, 257 (2007); Kim, D., et al.: J. Med. Chem., 48, 141 (2005)<br></p>

<p>Applications Cyclohexanol-d12 (CAS# 66522-78-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Glyburide-d3 (methoxy-d3) (CAS# 1219803-02-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromonaphthalene-d7 (cas# 37621-57-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Phenethyl Alcohol-d5 (cas# 35845-63-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Isobutyric-d6 Acid is the isotope labelled analogue of Isobutyric Acid, a carboxylic acid found in vanilla. Isobutryic Acid was used as an intermediate in the synthesis of novel inhibitors of signal transducer and activators of transcription 3 signaling pathway.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhang, M.M., et al.: Euro. J. Med. Chem., 62, 301 (2013);<br></p>

<p>Applications Irbesartan-d6 is deuterium labelled Irbesartan (I751000) which is an angiotensin II type 1 (AII1)-receptor antagonist.<br>References Gillis, J.C. and Markham, A.: Drugs, 54, 885 (1997); Chando, T.J., et al.: Drug. Metabol. Dispos., 26, 408 (1998),<br></p>

<p>Applications Vardenafil oxopiperazine-D6 is a labelled analogue of Vardenafil oxopiperazine (V098030)<br></p>

<p>Applications Griseofulvin-d3 is the labeled analogue of Griseofulvin (G787500), an antifungal drug. It is used both in animal and in humans, to treat rigworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum.Environmental contaminants; Food contaminants<br>References Oxford, et al.: Biochem. J., 33, 240 (1939); Townley, E.R., et al.: Anal. Profiles Drug Subs., 8, 219 (1979)<br></p>

<p>Applications Medetomidine-d5 (d5-Major) is an intermediate in the synthesis of Dexmedetomidine-d4 L-Tartrate (d4-Major) (D299006). Dexmedetomidine-d4 L-Tartrate is the labeled salt analogue of Dexmedetomidine (D299000), an α2-Adrenergic agonist; (+)-isomer of Medetomidine; sedative; analgesic.<br>References Rajala, R., et al.: Eur. J. Pharm. Sci., 1, 219 (1994); Jalonen, J., et al.: Anesthesiology, 86, 331 (1997); Talke, P., et al.: Anesth. Analg., 85, 1136 (1997); Bhana, N., et al.: Drugs, 59, 263 (2000)<br></p>

<p>Applications Propoxyphenyl-​thiohydroxyhomosilde​nafil-d4 is labelled Propoxyphenyl-thiohydroxyhomosildenafil (P831630), an analogue of Hydroxythiohomo Sildenafil (H963150).<br>References Balayssac, S., et. al.: J. Pharmaceut. Biomed., 63, 135 (2012)<br></p>

<p>Applications Gefitinib-d6 is the labeled version of Gefitinib (G304000), which is an antineoplastic.<br>References Anderson, N.G., et al.: Int. J. Cancer, 94, 774 (2001), Hirata, A., et al.: Cancer Res., 62, 2554 (2002), Kris, M.G., et al.: J. Am. Med. Assoc., 290, 2149 (2003), Tamura, K., et al.: Expert Opin. Pharmacother., 6, 985 (2005)<br></p>

<p>Applications 4-Nitroaniline-2,3,5,6-D4 is a labelled analogue of 4-Nitroaniline (N490770). 4-Nitroaniline is used in the synthesis of photorefractive polymers, as novel chromophores in analytical study. As well, due to the absorption spectrum associated with 4-Nitroaniline, it is used to determine catechol derivatives in syntheses.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nagaraja, P. et al.: J. Pharm. Biomed. Anal., 25, 417 (2001)<br></p>

<p>Applications 2,2′,4,4′-Tetrahydroxybenzophenone-d4 is an isotopic analog of 2,2′,4,4′-Tetrahydroxybenzophenone (T295900), a benzophenone-type UV filter with known or suspected endocrine disrupting properties detected in surface waters, sunscreens, personal care products, clothing and food packaging. It is used to protect the skin and materials from the adverse effects of UV-radiation.<br>References Wu, M., et al.: Ecotoxicol. Environ. Saf., 141, 235-241 (2017); Krause, M., et al.: Environ. Int., 99, 177-184 (2017); Jimenez-Diaz, I., et al.: J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 1035, 57-66 (2016)<br></p>

<p>Applications Diphenyl-2,2',4,4',6,6'-d6-amine (CAS# 99234-91-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Bis(butoxyethyl) Phosphate-d4 is an isotope labelled analog of Bis(butoxyethyl) Phosphate. Bis(butoxyethyl) Phosphate is used in biological studies as to study metabolism of phosphate flame retardants and plasticizers found in human liver fractions.<br>References Van den Eede, N., et al.: Toxicol. Lett., 223, 9 (2013)<br></p>

<p>Applications 2-Butoxyethanol-d4 is the isotope labelled analog of 2-Butoxyethanol; a reagent in the synthesis of 4-butoxyethoxy-N-octadecyl-1,8-naphthalimide as a new fluorescent probe for the determination of proteins. Also used as a reagent in the synthesis of 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors.<br>References Sun, Y., et al.: Bioorg. Med. Chem. Lett., 21, 3798 (2011); Yi, W., et al.: Eur. J. Med. Chem., 45, 639 (2010)<br></p>

<p>Applications 2,3,4-Trihydroxybenzophenone-2’,3’,4’,5’,6’-d5 is the isotope labelled analog of 2,3,4-Trihydroxybenzophenone; a trihydroxy derivative of Benzophenone (B204980) which is a compound used in the manufacturing of antihistamines, hypnotics, and insecticides.<br>References Wallace, W., et al.: Environ. Toxicol. Chem., 19, 962 (2000); Hayashi, T., et al.: Toxicol. Lett., 167, 1 (2006); Bechard, K., et al.: Aquat. Toxicol., 90, 310 (2008)<br></p>

<p>Applications 2,4-Dichlorophenol-13C6 is the labelled analog of 2,4-Dichlorophenol (D435685). 2,4-Dichlorophenol is a chlorinated derivative of phenol and is used as an intermediate for the preparation of herbicide 2,4-dichlorophenoxyacetic acid (D435680).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhong, W., et al.: J. Hazard. Mat., 217, 286 (2012); Rowe, V.K., et al.: Am. J. Vet. Res., 15, 622 (1954), Way, J.M., et al.: Residue Rev., 26, 37 (1969)<br></p>

<p>Applications A labelled metabolite of Temozolomide, an antineoplastic.<br></p>

<p>Applications Pentadecafluorooctanoic Acid-13C is an isotopomeric compound of Pentadecafluorooctanoic Acid (P268100). Pentadecafluorooctanoic Acid is used to produce fluoropolymers. It also exhibits a long half-life in human blood and interferes with the binding between liver-fatty acid binding protein and fatty acids.<br>References Biegel, L. B., et al.: Toxicol. Sci 60, 44 (2001); Luebker, D. J., et al.: Toxicology 176, 175 (2002); Butenhoff, J., et al.: Toxicol. Sci 60, 44 (2002)<br></p>

<p>Applications Methionine-methyl-d3 is the labeled Methionine-methyl, a useful building block.<br></p>

<p>Applications 5-(4-Chlorobutyl)-1-cyclohexyltetrazole-d11 (cas# 1073608-19-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Benzothiazolethiol-d4 (cas# 1346598-64-8) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Light Sensitive, Volatile<br>Applications A labelled antibacterial agent.<br>References Kind, T., et al.: Anal. Biochem., 363, 185 (2007), Spratlin, J., et al.: Clin. Cancer Res., 15, 431 (2009),<br></p>

<p>Applications Sodium Butyrate (13c4, 99%) (cas# 312623-84-0) is a useful research chemical.<br></p>

<p>Applications Bis(4-hydroxyphenyl) Sulfone-d8 is the isotope labelled compound commonly used as a reactant in epoxy reactions and is also used as a latent thermal catalyst for epoxy resin.<br>References Fu, J.W., et al.: Adv. Mat. Rsch., 266, 1022 (2011); Li, J.X., et al.: Polymers. Adv. Tech., 23, 803 (2012);<br></p>

<p>Applications Labelled Endosulfan Sulfate, a pesticide used in the control and protection of plant and vegetation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Weston, D. et al.: Env. Sci. Tech., 38, 2752 (2004); Antonious, G. et al.: Env. Tox. Chem., 16, 644 (1997);<br></p>

<p>Applications Carbon (Amorphous) (13c, 99%) 97% Pure (cas# 14762-74-4) is a useful research chemical.<br></p>

<p>Applications 1-Bromobutane-2,2-d2 (CAS# 55724-40-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Geraniol-D6 is the deuterium labeled analog of Geraniol, which is used in the synthesis of insect repellant. It is also used in the synthesis of Angelicoin A and Herecinone J, which inhibit collagen-induced platelet aggregation.<br>References Barnard, D. et al.: J. Med. Entomol., 41, 726 (2004); Mori K. et al.: Phytomedicine, 17, 1082 (2010);<br></p>

<p>Applications Carbon 13 Labelled analogue of Adenosine (A280400), a purine nucleoside that plays an important role in various biochemical processes.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010)<br></p>

<p>Applications Isotope labelled D-Fructose (F792500), a monosaccharide that naturally occurs in large number of fruits and plants.<br>References Shum, M., et al.: Am. J. Physiol., 304, 197 (2013); Zeng, S.S., et al.: J. Pharma. Biomed. Anal., 76, 87 (2013);<br></p>

<p>Applications Trinexapac-d5, is the labeled analogue of Trinexapac (T886315), a plant growth regulator that studies have shown to have the enzymic activity of histone lysine demethylases and histone modifications during the neural stem/progenitor cell differentiation<br>References Vavilala, D. et al.: Toxicology Reports, Vol.1, P: 1152-1161 (2014);<br></p>

<p>Applications Isotope labelled Methiocarb Sulfoxide acts as a pesticide which is used in the protection of crops from insects and fungus.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wong, J. et al.: J. Agri,. Food. Chem., 58, 5897 (2010); Ghini, S. et al.: Arch. Env. Cont. Toxicol., 47, 479 (2004);<br></p>

<p>Applications Labelled Lactose Monohydrate (L114000), which is used in the synthesis of casing for various methods of oral drug delivery, including dissolving pellets, and long-lasting pellets.<br>References Kamble, M. et al.: Int. J. Pharm. Chem. Biol. Sci., 3, 55 (2013); Hiorth, M. et al.: Int. J. Pharm., 441, 544 (2013);<br></p>

<p>Applications (±)-Atropine-D3 is a racemic isotope-labeled analog of Atropine, (A794630), which is a nerve agent that occurs naturally in plants oft he nightshade family.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kujak, R., et al.: J. Pharma. Biomed. Anal., 2015<br></p>

<p>Applications Pentadecanoic-d29 Acid (CAS# 130348-95-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled analog of a naturally occurring purine derivative.<br>References Wetmore, D., et al.: J. Biol. Chem., 285, 30516 (2010), Jung, Y., et al.: J. Agric. Food Chem., 58, 10458 (2010), Cao, H., et al.: J. Biol. Chem., 285, 28044 (2010),<br></p>

<p>Applications Isotope labelled Ethyl Caproate is used in the synthesis of novel EP2/EP4 dual agonist of γ-lactam prostaglandin E1 analogs. Also used as a chemical reagent in the synthesis of PPARα antagonists in the treatment of metabolic diseases.<br>References Kambe, T. et al. Bioorg. Med. Chem. Lett., 22, 396 (2012); Ammazzalorso, A. et al.: Bioorg. Med. Chem. Lett., 21, 4869 (2011);<br></p>

<p>Applications Labelled Propionic Acid, used in the synthesis of novel inhibitors of signal transducer and activator of transcription 3 signaling pathway in the potential treatment of human cancers. In addition it is used in the synthesis of morphans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhang, M. et al.: Eur. J. Med. Chem., 62, 301 (2013); Bradshaw, B. et al.: Org. Lett., 15, 2458 (2013);<br></p>

<p>Applications Uracil-15N2 can be used as a stable-isotopic standard to measure of post-replicative DNA metabolic and damage in brains of rodents. This compound can also be used for isotope tracing to determine the mechanism and stem-cell activity of 5-carboxycytosine decarboxylation.<br>References Patel, J.P., et.al., Chem. Res. Toxicol., 28, 2352-2363, (2015); Schiesser, S., et.al., Angew. Chem. Int. Ed., 51,6516-6520, (2012);<br></p>

<p>Applications 9-cis-Retinyl Stearate-d5, is the labeled analogue of 9-cis-Retinyl Stearate (R275600), a fatty acid ester of Retinol isomer, found mainly in the retina.<br>References Bridges, C.D.B., et al.: Methods Enzymol., 81, 463 (1982),<br></p>

<p>Vitamin D2 is a fat-soluble vitamin that is required for the absorption of calcium and phosphate. It can be obtained through dietary supplements or by exposure to sunlight. Vitamin D2 is a prohormone that needs to undergo two hydroxylation reactions in the liver and kidney before it becomes the active form, calcitriol. Vitamin D2 has been shown to have beneficial effects on bone mineralization and phosphatase activity, as well as an inhibitory effect on the production of parathyroid hormone. Hydroxyapatite, a component of bone tissue, has been shown to react with vitamin D2 in vitro, which may be due to its ability to act as an additive or stabilizer.END&gt;&gt;</p>

<p>5-(Hydroxymethyl)-2’-deoxycytidine is an activator that can be used in the synthesis of nucleosides and phosphoramidites. It is a novel compound that has antiviral, anticancer, and ribonucleoside activities. 5-(Hydroxymethyl)-2’-deoxycytidine is a monophosphate derivative that can be used to synthesize diphosphates, which are important for DNA replication. The drug has been shown to have anticancer properties against breast cancer cells. It also inhibits the growth of leukemia cells by preventing the synthesis of DNA and RNA.</p>

Chlorobenzene-d5 is a synthetic compound that can be used as an analytical reference material. It is reactive and has been shown to have chemical ionization, vibrational, and light emission properties. Chlorobenzene-d5 has been used in the analysis of solutes in the environment, detection of volatile organic compounds (VOCs), and identification of unknown substances. The usefulness of chlorobenzene-d5 as a reference material is due to its stability and high abundance in nature.

<p>Amodiaquine-d10 is a quinoline derivative that is used in the treatment of malaria. It has been shown to have a good bioavailability and is not metabolized by the body. Amodiaquine-d10 has a low risk of toxicity, which makes it appropriate for use in patients with an uncomplicated malaria infection. The plasma concentrations are determined through an analysis of the presence of amodiaquine-d10 in plasma samples. The pharmacokinetic study was performed using an ionization interface and a spectrometer. The evaporation technique was used to measure the concentration of amodiaquine-d10 in plasma samples, which were then analyzed using high performance liquid chromatography (HPLC). This technique allows for the measurement of amodiaquine-d10 at low concentrations and can differentiate between drugs that are chemically similar.</p>

6-Fluorovitamin D3 is a synthetic analog of vitamin D3, which is a modified form of the naturally occurring hormone known as cholecalciferol. This molecule is typically derived through chemical synthesis, incorporating a fluorine atom at a specific position on the vitamin D3 structure. The introduction of the fluorine atom is designed to enhance the stability of the compound and potentially alter its biological activity.

Albendazole-sulphone-D3 is an analyte that is extracted from a dispersive sulphoxide. It is extracted by an acetonitrile phase extraction and analyzed by liquid chromatography. Albendazole-sulphone-D3 has been shown to have anthelmintic properties, which are due to its ability to inhibit the synthesis of folic acid in nematodes. This drug binds to the acetylcholine receptor site on the worm's neuromuscular junction, preventing acetylcholine from accessing this site and causing paralysis. It has also been shown to be effective against roundworms (Ascaris lumbricoides), hookworms (Ancylostoma duodenale), and whipworms (Trichuris trichiura).