Compuestos deuterados

Applications 1-Hexanol-d11 is the labelled analogue of 1-Hexanol (H281220), a perturbing agent on actomyosin ATPase and and was found to modulate the function of actomyosin motor via intermediate-specific structural perturbation.
References Komatsu, H., et al.: J. Muscle. Res. Cell. Motil., 25, 77 (2004); Hua, J.F., et al.: J. Insect. Physiol., 59, 690 (2013);

Applications Sodium Octanoate-8,8,8-d3 (CAS# 1219795-01-3) is a useful isotopically labeled research compound.

Applications N-Nitrosodiethylamine-d10 is a labelled form of N-Nitrosodiethylamine (N525465) which is a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver.NDMA and NDEA were found as an impurity in generic versions of valsartan, losartan and irbesartan.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Oda, Y., et al.: Mutation Research, Genetic Toxicology and Environmental Mutagenesis, 584, 1 (2005); Yamazaki, H., et al.: Carcinogenesis, 13, 1789 (1992);Chem. and Eng. News, p.5, Feb. 25, 2019

Applications Naphthalene-d8, is the labeled analogue of Naphthalene, a polycyclic aromatic hydrocarbons as micropollutants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Di Toro, D., et al.: Environ. Toxicol. Chem., 19, 1971 (2000), Vines, C., et al.: Aquat. Toxicol., 51, 225 (2000), Incardona, J., et al.: Toxicol. Appl. Pharmacol., 196, 191 (2004), Junghans, M., et al.: Aquat. Toxicol., 76, 93 (2006),

Applications Thiodiglycolic Acid-d4 acts as a reagent for the synthesis of metabolites of S-carboxymethyl-L-cysteine and S-methyl-L-Cysteine and of some isotoically labelled (2H, 13C) analogs.
References Meese, C. O., et al.: Archiv der Pharmazie, 323, 957 (1990)

Applications A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.
References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),

Applications 3-Nitrobiphenyl is a nitrated benzene metabolite found in the bone marrow of B6C3F1 mice treated with benzene. 3-Nitrobiphenyl displays toxic effect on Tetrahymena pyriformis, Porphyromonas gingivalis, Selenomonas artemidis, and Streptococcus sobrinus.
References Laszlo, T. & Beteringhe, A.: QSAR Combinatorial Sci., 25, 944 (2006); Mintz, C. et al.: QSAR. Combinatorial Sci., 25, 912 (2006); Chen, K. et al.: Chem. Res. Toxicol., 17, 370 (2004)

Applications Labelled Creatinine. The end product of creatine catabolism. Normal constituent of urine. Also found together with creatine in muscle tissues and blood. Occurs in all soils and in grain seeds and other vegetable matter. Has been found in certain fish and in crab meat extract.
References Folin, et al.: J. Biol. Chem., 17, 463 (1914),

Applications Labelled Glycolic Acid (G645600). Constituent of sugar cane juice.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Smyth, H.F., et al.: J. Ind. Hyg. Toxicol., 23, 259 (1941),

Applications A labelled metabolite of polycyclic aromatic hydrocarbons in humans.
References Jacob, J., et al.: Xenobiotica, 12, 45 (1982), Becher, G., et al.: Cancer Lett., 17, 301 (1983), Hoffmann, D., et al.: Cancer Treat. Res., 72, 1 (1995), Einolf, H., et al.: Chem. Res. Toxicol., 10, 609 (1997),

Stability Volatile
Applications Ethyl Acetate-d8 is the labeled version of Ethyl Acetate and it can be used in technical or engineered material use in highly concentrated electrolyte as a low-​cost solvent for in situ neutron diffraction measurements of Li-​ion battery electrodes. It can also be used in biological study for volatile compounds from grape skin, juice and wine from five interspecific hybrid grape cultivars grown in Quebec (Canada) for wine production.Environmental contaminants; Food contaminants
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Petibon, R., et al.: Electrochim Acta, 174, 417-423 (2015); Slegers, A., et al.: Molecules, 20, 10980-11016 (2015)

Applications Used as an insecticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications The compund has cytotoxic effects. Labelled Norharmane.
References Elfarra, A., et al.: Drug Metab. Dispos., 26, 779 (1998), Da Costa, A., et al.: Biocell, 23, 65 (1999), Janetzky, B., et al.: Drug Dev. Res., 46, 51 (1999), Kutty, R., et al.: Toxicol. Appl. Pharmacol., 107, 377 (1991), Riederer, F., et al.: J. Neurochem., 81, 814 (2002), Schott, Y., et al.: Bioorg. Med. Chem. Lett., 16, 5840 (2006),

Applications Glutaric Acid (2,2,4,4-D4, 98%) (cas# 19136-99-3) is a useful research chemical.

Applications Labelled Triglyme. It is used as a solvent.

Applications Isotope labelled Ethyl Butyrate is used in the preparation of novel 2-cyanopyrimidines as cathespin K inhibitors. Also used in the synthesis of pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of β-1,6-glucan.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References By Rankovic, Z. et al.: Bioorg. Med. Chem. Lett.,, 20, 1524 (2010); Takeshita, H. et al.: Bioorg. Med. Chem. Lett., 20, 3893 (2010);

Applications Dibutyltin Dichloride-d18 is a labeled analogue of Dibutyltin Dichloride (D429550) (CAS# 683-18-1), which is an organotin compound that is widely used as a stabilizer for polyvinylchloride plastics. Studies show that exposure to Dibutyltin Dichloride induced acute interstitial pancreatitis in rats. Dibutyltin Dichloride showed in vitro trypanocidal activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Merkord, J. et al.: Hum. Exp. Toxicol., 17, 144 (1998); Shuaibu, M.N. et al.: Parasitol. Res., 91, 5 (2003); Whalen, M.M. et al.: Toxicol. Sci., 104, 312 (2008);

Applications Isotope labelled N-Nitrosodiphenylamine (N525775), which is the N-nitroso analogue of diphenylamine that was once used as a rubber additive but is no longer due to undesirable carcinogenic effects (1). N-Nitrosodiphenylamine may have potential carcinogenic activity and is currently classified as a probable carcinogen by EPA with genetic toxicity (2,3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
References 1. Boyland, D. et al.: Eur. J. Cancer. 1968. May;4(2):233-2342. Iversen, O. et al.: Eur. J. Cancer. 1980 May;16(5):695-8.3. McGregor, D. et al.: Mutat. Res. Rev. Gen. Toxicol. 1994 Jun:317(3):195-211

Applications Gallic Acid-d2 is the labelled analogue of Gallic acid (G188978) which is a phenolic acid with antioxidant activity. Gallic acid was found to protect human cells against oxidative damage and showed cytotoxicity against cancer cells. Gallic Acid and its esters also show antiviral and antifungal activities.
References Yen, G. et al.: Food Chem., 79, 307 (2002); Chen, C. et al.: Mol. Nutrit. Food Res., 51, 962 (2007); Kratz, J. et al.: Mem. Inst. Oswaldo Cruz, 103, 437 (2008); Osborne, L. et al.: Infect. Immun., 33, 769 (1981);