Toxicología

<p>Applications An isotopically labelled analog of a serum lipid regulating agent used as an antihyperlipoproteinemic.<br>References Kissebach, A.H., et al.: Atherosclerosis, 24, 199 (1976), Lewis, J.E., et al.: Pract. Cardiol., 9, 99 (1983), Rubins, H.B., et al.: N. Engl. J. Med., 341, 410 (1999)<br></p>

<p>Applications Felodipine-13C4, d3 is the labeled analogue of Felodipine (F232375), a dihydropyridine calcium channel blocker.<br>References Berntsson, P.B., et al.: Acta Pharm. Suec., 18, 221 (1981); Kratochwil, N., et al.: Biochem. Pharmacol., 64, 1355 (2002); O'Brien, S., et al.: J. Med. Chem., 48, 1287 (2005); Castilho, M., et al.: Bioorg. Med. Chem., 14, 516 (2006)<br></p>

<p>Applications Bifenazate-d5 is the labelled analogue of Bifenazate (B383021), which is a selective miticide for the control of a variety of mite pests on crops. Used in Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Sipes, N.S., et al.: Chem. Res. Toxicol., 26, 878 (2013); Sbartai, I., et al.: Adv. Environ. Biol., 6, 2249 (2012);<br></p>

<p>Stability Moisture Sensitive<br>Applications Chlorpyriphos-methyl is an derivative of Chlorpyrifos (C425300), an insecticide that acts on the nervous system of insects by inhibiting acetylcholinesterase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sipes, N.S., et al.: Chem. Res. Toxicol., 26, 878 (2013); Zhao, Q.,et al.: Anal. Bioanal. Chem., 405, 4765 (2013);<br></p>

<p>Applications Pyrogallol Acid, has antiseptic and antipsoriatic properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tanenbaum, B., et al.: Biochim. Biophys. Acta, 28, 21 (1958), Dollahite, J.W., et al.: Am. J. Vet. Res., 23, 1264 (1962),<br></p>

<p>Stability Unstable in Solution<br>Applications p-Hydroxypenicillin V is a byproduct in the synthesis of Penicillin V (P223500), an antibacterial agent.<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Dunham, J.M., et al.: Anal. Profiles Drug Subs., 1, 249 (1972),<br></p>

<p>Applications Nicotine Salicylate is used for treatment of smoking withdrawal syndrome.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Eneroth, P., et al.: Med. Biol., 55, 158 (1977),<br></p>

<p>Applications Cyhalofop-butyl is an aryloxyphenoxypropionate compound that is used as a herbicide to eliminate grass weeds in rice fields. Cyhalofop-butyl works by selectively inhibiting acetyl CoA carboxylase, an enzyme that is important for the metabolism of fatty acids.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Iwakami, S., et al.: Pest Manag. Sci., 68, 1098 (2012); Ottis, B., et al.: J. Agr. Food Chem., 53, 4064 (2005); Ruiz-Santaella, J., et al.: Planta, 223, 191 (2006)<br></p>

<p>Applications Oryzalin is an herbicide of the dinitroaniline class of compounds which works through the disruption of microtubules.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liang, Q. et al.: Plant. Biotechnol., 33, 59 (2016);<br></p>

<p>Impurity Clindamycin Phosphate EP Impurity A<br>Stability Hygroscopic<br>Applications Lincomycin (Clindamycin Phosphate EP Impurity A) is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.This compound is a contaminant of emerging concern (CECs).<br>References Mason, D.J., et al.: Antimicrob. Agents Chemother., 555 (1962), Gray, et al.: Toxicol. Appl. Pharmacol., 6, 476 (1964), Muti, H.Y., et al.: Anal. Profiles Drug Subs. Excip., 23, 269 (1994),<br></p>

<p>Applications Fungicide. Iprodione is also used in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lacroix, L., et al.: Phytiatr.-Phytopharm., 23, 165 (1974), Brenneman, T.B., et al.: Plant Dis., 71, 546 (1987),<br></p>

<p>Applications β-Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic; antiglaucoma.<br>References Nakagawa, K., et al.: J. Med. Chem., 17, 529 (1974), Morita, S., et al.: Biochem. Pharmacol., 25, 1836 (1976), Chu, S.Y., et al.: J. Pharm. Sci., 67, 1623 (1978), Chiba, S., et al.: Arzneim.-Forsch., 29, 895 (1979), Chrisp, P., et al.: Drugs Aging, 2, 58 (1992),<br></p>

<p>Applications Direct Blue 218 is an azo dye used in diagnostic imaging. Used in the prediction of rat carcinogenisis. Also used in textile dyes contributing to textile effluents and wastewaters.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.<br>References Baughman, G. et al.: Textile. Chemist. Color. Am. Dye. Rep., 32, 51 (2000);<br></p>

<p>Impurity Clarithromycin EP Impurity C<br>Applications Clarithromycin 9-Oxime (Clarithromycin EP Impurity C) is an impurity of Clarithromycin (C559750), a macrolide antibiotic.<br>References Stephanic, V. et al.: J. Med. Chem., 54, 719 (2011); Chen, X. et al.: Zhong. Yao., 17, 32 (2008);<br></p>

<p>Applications Potent, non-competitive CCR5 receptor antagonist; inhibits binding of HIV viral coat protein gp120. Antiviral.<br>References Fumero, E., et al.: Clin. Microbiol. Infect., 9, 1077 (2003), Walker, D.K., et al.: Drug Metab. Dispos., 33, 587 (2005), Wood, A., et al.: Prog. Med. Chem., 43, 239 (2005),<br></p>

<p>Applications Larotaxel (RPR 109881A) is a taxane analog with a broad spectrum of activity and different toxicity profile and with the possible advantages of surpassing some mechanisms of resistance and penetrating into the CNS.<br>References Kurata, T., et al.: J. Clin. Oncol., 18, 3164 (2000), Kemper, E., et al.: Eur. J. Cancer, 40, 1269 (2004), Nyman, D., et al.: J. Clin. Oncol., 23, 7785 (2005),<br></p>

<p>Applications A fat-metabolism stimulator.<br>References Plotzker, R., et al.: Am. J. Med. Sci., 283, 79 (1982),<br></p>

<p>Applications Carbonic anhydrase inhibitor. Antiglaucoma agent.<br>References Lippa, E.A., et al.: Ophthalmology, 98, 308 (1991); Wang, R.-F., et al.: Arch. Ophthalmol., 109, 1297 (1991); Whikehart, D., et al.: J. Ocul. Pharmacol., 7, 195 (1991); Sjoquist, B., et al.: Drug Metab. Dispos., 26, 745 (1998);<br></p>

<p>Applications Labelled Pyrimethanil, broad spectrum anilino-pyrimidine foliar fungicide. Pyrimethanil functions by inhibiting the biosynthesis of methionine in Botrytis cinerea.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Neumann, G.L. et al.: Brigh. Crop Prot. Conf. Pests Dis., 1, 385 (1992); Fritz, R. et al.: Pest. Sci., 49, 40 (1997);<br></p>

<p>Applications Labelled Nitisinone. Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I.<br>References Lindstedt, S., et al.: Lancet, 340, 813 (1992), Ellis, M.K., et al.: Toxicol. Appl. Pharmacol., 133, 12 (1995), Lock, E.A., et al.: J. Inherited Metab. Dis., 21, 498 (1998),<br></p>

<p>Applications 22,23-Dihydrospinasterol is extracted from Citrullus colocynthis leaves and used as a pesticide against cabbage aphid Brevicoryne brassicae.<br>References Ahmed, M. et al.: Mol.., 25(9), 2184, (2020)<br></p>

<p>Stability Hygroscopic<br>Applications N-Lauroyl-N-methyltaurine Sodium Salt is used in skin cleansing products containing combinations of anionic and nonionic surfactants and detergents.<br>References Sakurai, N.; Eur. Pat. Appl. 20 pp. Patent 1996 CODEN:EPXXDW<br></p>

<p>Applications 6-Hydroxy Bromantane is a metabolite of Bromantane (B678450).<br>References Bi, H., et al.: J. Steroid Biochem. Mol. Biol., 42, 229 (1992), Pozo, O., et al.: Anal. Bioanal. Chem., 389, 1209 (2007), Kiousi, P., et al.: Bioanalysis, 1, 1209 (2009),<br></p>

<p>Applications N-Desmethyl-6-O-methylerythromycin (9E)-Oxime is a derivative of Clarithromycin (C559750); a semi-synthetic macrolide antibiotic and derivative of Erythromycin (E650000).<br>References Benson, C., et al.: Eur. J. Clin. Microbiol., 6, 173 (1987); Boyanova, L., et al.: J. Med. Microb., 61, 85 (2012); Lin, Z., et al.: Toxicol. Sci., 126, 114 (2012)<br></p>

<p>Stability Moisture Sensitive<br>Applications Isotope labelled Potassium Thiocyanate has been used as a catalyst in a one-pot reaction of dialkyl acetylenedicarboxylates with indane-1,3-dione. Potassium Thiocyanate has been used as a selective bacterial inhibitor to create ESS-3 broth to allow co-​enrichment of the target pathogens and suppress growth of some non-​target pathogens<br>References Hassanabadi, A., Zhiani, R., et. al.: J. Chem. Res., 37, 458 (2013); Zhang, Q., et. al.: Plant. Biotech., 29, 103 (2012)<br></p>

<p>Applications Isotope labelled Linoleoyl Carnitine (L486200), a carnitine ester of unsaturated fatty acid. Used in the studies of fibroblasts in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and fatty acid oxidation disorders.<br>References Gross R.W., et al.: J. Biol. Chem., 258, 5221 (1983),<br></p>

<p>Applications Thiosultap Sodium Salt is used as an insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yan, X., et. al.: J. Plant Diseases Protection, 119, 152 (2012)<br></p>

<p>Applications Cefcapene Pivoxil (C242550) derivative. Δ2-Cephalosporins are potentially related compounds in cephalosporin antibacterial compounds.<br>References Chavette, R.R., J. Med. Chem., 9, 741 (1966), Miyouchi, M., et al.: J. Chem. Pharm. Bull., 38, 1906 (1990), Sugioka, T., et al.: Chem. Pharm. Bull., 38, 1998 (1990),<br></p>

<p>Applications Labelled Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rooks, W.H., et al.: Agents Actions, 12, 684 (1982), Guzman, A., et al.: J. Med. Chem., 29, 589 (1986), McQuary, H.J., et al.: Clin. Pharmacol. Ther., 39, 89 (1986),<br></p>

<p>Applications Fipronil Sulfone is a sulfone metabolite of the insecticide Fipronil (F342200). Fipronil Sulfone blocks γ-aminobutyric acid- and glutamate-activated chloride channels in mammalian and insect neurons.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhao, X. et al.: J. Pharmacol. Exp. Therap., 314, 363 (2005); Mulrooney, J.E. et al.: J. Econ. Entomol., 92, 1364 (1999); Hainzl, D. et al.: Chem. Res. Toxicol., 11, 1529 (1998);<br></p>

<p>Impurity Ceftazidime EP Impurity E<br>Applications Ceftazidime t-Butyl Ester (Ceftazidime EP Impurity E) Ceftazidime t-Butyl ester is an impurity of Ceftazidime (C244100). Ceftazidime impurity C.<br>References Miyake, A., et al.: Antimicrob. Agents Chemother., 486, 182 (1989), Seibert, G., et al.: Arzneim.-Forsch., 33, 1084 (1983),<br></p>

<p>Applications L-Kynurenine is a tryptophan metabolite which is a precursor of kynurenic acid (K660500) and an antagonist of N-methyl-aspartate receptor.<br>References Swartz, K., et al.: J. Neurosci., 10, 2965 (1990);, Hasegawa, H., et al.: Anal. Bioanal. Chem., 377, 886 (2003); Tsai, Y., et al.: Anal. Biochem., 319, 34 (2003); Mitsuhashi, S., et al.: Anal. Chim. Acta, 584, 315 (2007)<br></p>

<p>Applications Lactofen is a complex ester derivative of Acifluoren, a diphenyl ether herbicide. Lactofen can be used in postemergence applications and is commonly used as foliar spray. Lactofen is used in agriculture to control broadleaved weeds in soybean, cereals, potatoes and peanuts.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kurtz, M.E.: Indust. Crop. Prod., 5, 119 (1996); Novo, M.C.S.S. et al.: Sci. Agric., 55, 276 (1998); Dann, E.K. et al.: Phytopathology, 89, 598 (1999);<br></p>

<p>Applications A selective HIV protease inhibitor. Antiviral.<br>References Roberts, N.A., et al.: Science, 248, 358 (1990), Craig, J.C., et al.: Antiviral Res., 16, 295 (1991),<br></p>

<p>Applications Reserpine (R144600) derivative as a neuroleptic compound. Reserpine and SU 9064 prolonged the duration for the larva development and only SU 9064 had a mortal effect on larvae.<br>References Schafer, E.W., Jr., et al.: Arch. Environ. Contam. Toxicol., 12, 355 (1983),<br></p>

<p>Applications Norethylmorphine 6-Glucuronide is a derivative of Norethylmorphine (N721600) is used in formation of ethylmorphine. Ethylmorphine is a metabolite in liver hepatocytes.<br>References Xu, B., et al.: Pharmacology &amp; Toxicology, 73, 35 (1993),<br></p>

<p>Stability Hygroscopic<br>Applications Antibiotic complex produced by Streptomyces kanamyceticus Okami &amp; Umezawa from Japanese soil. Comprised of three components, kanamycin A, the major component, and kanamycins B and C, two minor congeners. Antibacterial.A representative lot contains d4, d5, d6, d7, d8, and d9.<br>References Ito, et al.: J. Antibiot., 17, 189 (1964), Toda, S., et al.: J. Antibiot., 30, 1002 (1977), Claes, P.J., et al.: Anal. Profiles Drug. Subs., 6, 259 (1977),<br></p>

<p>Applications Semi-synthetic cephalosporin antibiotic. Antibacterial.A representative lot contains some d5.<br>References Buck, R.E., et al.: Antimicrob. Agents Chemother., 11, 324 (1977),<br></p>

<p>Applications Palmitoyl-16,16,16-d3-L-carnitine Hydrochloride is the isotope labelled analog of Palmitoyl-L-carnitine Hydrochloride (P155050); a long-chain fatty ester of carnitine which is accumulated and released into the circulation in fatty-acid oxidation defects.<br>References Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Applications Labelled analogue of Tefluthrin, a pyrethroid based insecticide. Tefluthrin is used in the control of a broad range of soil pests, including members of the Coleoptera, Lepidoptera, and Diptera.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McDonald, E. et al.: Bright. Crop Prot. Conf. Pest Dis., 3, 1143 (1986); Jutsum, A.R. et al.: Bright. Crop Prot. Conf. Pest. Dis. Proc., 1, 199 (1986);<br></p>

<p>Applications 2-Imidazolidinethione is a pesticide used in production of fruits and vegetables. It is also used as a new contrast agent for MRI studies based on proton chemical exchange dependent saturation transfer (1) . 2-Imidazolidinethione is also a corrosion inhibitor (2) due to the adsorption of the mol. species. Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Ward, K. et al.: J. Magn. Reson. 2000 Mar:143(1) 79-872. Pillai, K. et al.: J. Electrochem. Soc. 1978 Aug:125(9) 1393-1397<br></p>

<p>Applications Flumorph can be used in analytical study of simultaneous determination of 106 pesticides in nuts by LC-​MS​/MS using freeze-​out combined with dispersive solid-​phase extraction purification.<br>References Wang, J., et al.: J Sep Sci, 40, 2398 (2017)<br></p>

<p>Applications Adrenalone is a ketone derivative of Epinephrine (E588585) and a potential dopamine β oxidase inhibitor.<br>References Goldstein, M., et al.: Nature, 192, 1081 (1961)<br></p>

<p>Stability Moisture Sensitive<br>Applications Naled is a cholinesterase inhibitor. Insecticide; acaricide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969),<br></p>

<p>Applications Dichloroprop is a herbicide used for the post-emergence control of annual and perennial broad-leaved weeds and some brush species.<br>References Freitas, M.R., et al.: RSC Adv., 5, 7547 (2015); Aizawa, H.: Handbook of Metabolic Pathways of Xenobiotics, 3, 1212 (2014)<br></p>

<p>Applications Labelled Pyruvic acid (P998900). Intermediate in sugar metabolism and in enzymatic carbohydrate degradation (alcoholic fermentation) where it is converted to acetaldehyde and CO2 by carboxylase. In muscle, Pyruvic acid (derived from glycogen) is reduced to lactic acid during exertion, which is reoxidized and partially retransformed to glycogen during rest. The liver can convert Pyruvic acid to alanine by amination. A diagnostic agent for Parkinson disease.<br>References Wenzel, A., et al.: J. Neurosci., 21, 53 (2001), Martinez., et al.: Development, 6, 851 (2002), Nakayama, K., et al.: J. Biochem., 146, 757 (2009), Tanaka, T., et al.: J. Pharmacol. Sci., 109, 24 (2009),<br></p>

<p>Applications Azafenidin is a weed controlling herbicide used in various crops.<br>References Chandran, R.S., et al.: Weed. Technol., 14, 556 (2000); Sharma, S.D., et al.: Bull. Environ. Contamin. Toxiciol., 67, 594 (2001);<br></p>

<p>Applications 1-(1-Ethylpropyl)-5,6-dimethyl-7-nitro-1H-benzimidazole is a metabolite of Pendimethalin(P221900). Pendimethalin herbicide used to control the spread of weedgrass.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Haith, D., et al.: Environ. Sci. Technol., 44, 6496 (2010), Jabran, K., et al.: Int. J. Agric. Biol., 12, 335 (2010)<br></p>

<p>Applications An aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.<br>References Nakao, K., et al.: Sci. Rep., 9, 18202 92019); Ebert, K, PLoS One, 14, 0223225 (2019)<br></p>

<p>Stability Moisture Sensitive, Unstable in Solution<br>Applications Bensulfuron-methyl inhibits the growth of Anabaena azotica. ALS inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liao, J. Z., et al.: Fresenius Environ. Bull., 25, 5000 (2016)<br></p>

<p>Applications Pyruvic Acid-13C3 is labelled Pyruvic acid (P998900).Pyruvic acid is an Intermediate in sugar metabolism and in enzymatic carbohydrate degradation (alcoholic fermentation) where it is converted to acetaldehyde and CO2 by carboxylase. In muscle, Pyruvic acid (derived from glycogen) is reduced to lactic acid during exertion, which is reoxidized and partially retransformed to glycogen during rest. The liver can convert Pyruvic acid to alanine by amination.<br>References Wenzel, A., et al.: J. Neurosci., 21, 53 (2001); Martinez., et al.: Development, 6, 851 (2002); Nakayama, K., et al.: J. Biochem., 146, 757 (2009); Tanaka, T., et al.: J. Pharmacol. Sci., 109, 24 (2009)<br></p>

<p>Applications Tridihexethyl Chloride, is an anticholinergic, antimuscarinic and antispasmodic drug.<br>References Gohil, V., et al.: Nature Biotech., 28, 249 (2010); Rider, J. A., et al.: Curr. therap. Res., 20, 142 (1976);<br></p>

<p>Stability Moisture Sensitive<br>Applications Labelled Rapamycin. A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic.This compound contains aproximately 2% d0.<br>References Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004),<br></p>

<p>Applications Taurine (1,2-13c2, 98%) (cas# 70155-54-3) is a useful research chemical.<br></p>

<p>Applications (S)-(+)-Methoprene is used as an insect growth regulator. May be used to inhibit metamorphosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Koureas, Mi. et al.:Sci. Total Env., 496, 358 (2014); Knaus, M. et al.: Veterin. Parasitol., 202, 40 (2014);<br></p>

<p>Applications A metabolite of Bromethalin rodenticide found in the blood and liver of treated animals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Van Lier, R.B.L., et at.: Fundamental Appl. Toxicol., 11, 664 (1988),<br></p>

<p>Applications Benoxacor is a herbicide used as a part of pesticidal compositions.<br>References Portoles, T. et al.: Chemosphere., 179, 242 (2017); Hong, J. et al.: Food Contr., 79, 134 (2017);<br></p>

<p>Applications Levofloxacin-d3, is the labeled analogue of Levofloxacin (L360000), an antibiotic used against gram-negative organisms.<br>References Kato, M., et al.: Arzneim.-Forsch., 42, 365 (1992), North, D.S., et al.: Pharmacotherapy, 18, 915 (1998), Hwang, D.G., et al.: Br. J. Ophthalmol., 87, 1004 (2003),<br></p>

<p>Applications Labelled Cefuroxime (C248050). Antibacterial.<br>References O’Callaghan, C.H., et al.: Antimicrob. Agents Chemother., 9, 511 (1976), Norrby, R., et al.: J. Antimicrob. Chemother., 3, 355 (1977), Brogden, R.N., et al.: Drugs, 17, 233 (1979), Wozniak, J.R., et al.: Anal. Profiles Drug Subs., 20, 209 (1991),<br></p>

<p>Applications NN703 (Tabimorelin) is an orally active growth hormone (GH) secretagogue intended for use as an alternative to daily injections of GH. In vitro studies in human liver microsomes have indicated that NN703 is a mechanism-based inhibitor of CYP3A4.<br>References Fabre, G., et al.: Biochem. Pharmacol., 37, 4389 (1988), Thummel, K., et al.: Clin. Pharmacol. Ther., 59, 491 (1996), Yu, D., et al.: J. Clin. Pharmacol., 39, 1203 (1999),<br></p>

<p>Applications Labelled Folpet (F402000). Agricultural fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cohen, S., et al.: Crit. Rev. Toxicol., 40, 531 (2010), Wong, J., et al.: J. Agric. Food Chem., 58, 5884 (2010),<br></p>

<p>Applications Tralomethrin-d5, is the labeled analogue of Tralomethrin (T712400), which is a pyrethroid insecticide. It is effective against most members of class Arachnida as well as insects.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Laskowski, D.A., et al.: Review Env. Conatmin. Toxic., 174, 49 (2002); Tanaka, Y., et al.: Shokuhin Eiseigaku Zasshi, 41, 335 (200);<br></p>

<p>Stability Hygroscopic<br>Applications Asenapine N-β-D-Glucuronide is a metabolite of Asenapine (A788000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Bicyclomycin benzoate is a polar metabolite with activity against Gram negative bacteria.<br></p>

<p>Applications Anidulafungin, is a semisynthetic echinocandin that inhibits glucan synthase, an enzyme important in the formation of (1→3)-β-D-glucan, a major fungal cell wall component, and thus is used as antifungal drug.<br>References Denning, D. W., et al.: J. Antimicrob. Chemother, 40, 611 (1997); Vazquez, J. A., et al.: Clin. Ther., 27(6), 657 (2005);<br></p>

<p>Applications Bictegravir-15N, d2 is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.<br>References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;<br></p>

<p>Applications 2'-O-Methyl Uridine-d3 is an isotope labelled compound of 2'-O-Methyl Uridine (M338200), a uridine analog used for the preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.<br>References Gratzner, H., et al.: Science, 218, 474 (1982), Jarvis, T., et al.: J. Biol. Chem., 271, 29107 (1996), Pavco, P., et al.: Clin. Cancer Res., 6, 2094 (2000),<br></p>

<p>Applications Metyrapone acts as a glucocorticoid synthesis inhibitor, maintaining stress-hormone levels.<br>References Keller, C. et al.: Drug. Alc. Dep., 133, 405 (2013); Vilela, F. et al.: Neuroendocrinol., 97, 322 (2013);<br></p>

<p>Applications β-Cypermethrin is a pyrethroid compound that is used as an insecticide to eliminate unwanted pests from crop fields. β-Cypermethrin has been advertised to be safe for humans despite the fact that considered a possible human carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chen, S., et al.: Appl. Micro. 94, 505 (2012); Li, Z., et al.: Bull. Env. Cont. Toxicol., 80, 335 (2008)<br></p>

<p>Applications A metabolite of Imipramine (I465980).<br>References Magdalou, J., et al.: J. Biol. Chem., 257, 13624 (1982), Orzechowski, A., et al.: Carcinogenesis, 15, 1549 (1994), Hawes, E., et al.: Drug Metab. Dispos., 26, 830 (1998),<br></p>