Toxicología

<p>Applications Atazanavir-d6 is the isotope labelled analog of Atazanavir (A790051); an azapeptide HIV protease inhibitor. Atazanavir has also been investigated as potential treatment of human immunodeficiency virus (HIV) and for anticancer purposes.<br>References Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004); Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004)<br></p>

<p>Stability Hygroscopic<br>Applications A major biodegradation product of Malathion (M111000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kim, Y. et al.: Chemosphere, 60, 1349 (2005); Yoshii, K. et al.: J. Health Sci., 54, 535 (2008); Hayasaka, M. et al.: Jap. J. Forensic Toxicol., 12, 15 (1994);<br></p>

<p>Applications (-)-Quinic Acid γ-Lactone is an intermediate in the synthesis of 4-O-(E)-Feruloylquinic Acid (F308985). 4-O-(E)-Feruloylquinic Acid is a phenolic acid with potential antioxidant and antifungal activities. Secondary metabolite in the coffee brewing process.<br>References Matei, M. et al.: J. Agri. Food Chem., 60, 12105 (2012); Dokli, I. et al.: Tetrahedron Asymm., 24, 785 (2013)<br></p>

<p>Applications 2-Amino-4-(methylsulfonyl)benzoic Acid is a reagent used in the synthesis of anthranilic diamides containing fluorinated groups as potential ryanodine receptors activators.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wu, C. et al.: Chem. Lett., 28, 1248 (2017);<br></p>

<p>Applications Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications Mepiquat Chloride is a plant growth regulator used to improve crop quality and maximize yield.<br>References Xiaoming, R., et al.: Field Crops Res, 149, 1-10 (2013)<br></p>

<p>Applications A prototypical BCRP inhibitor. Inhibits the Bcrp1-mediated transport.<br>References Neville, K., et al.: Clin. Cancer Res., 10, 2525 (2004), Reardon, D., et al.: J. Clin. Oncol. 23, 9359 (2005), Pan, G., et al.: Drug Metab. Dispos., 35, 1165 (2007).<br></p>

<p>Applications Cyantraniliprole is used as an insecticide and/or acaricide. Also useful in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Abbott, W., et al.: J. Econ. Entomol., 18, 265 (1925), Ali, A., et al.: Environ. Entomol., 19, 1066 (1990),<br></p>

<p>Applications A coumarin (C755380) derivative classified as an anticoagulant.<br>References Neau, J. et al.: Cereb. Dis., 11, 195 (2001); Boschetti, E. et al.: Chim. Ther., 7, 20 (1972);<br></p>

<p>Applications 3,5-Dihydroxybenzoic Acid 3-O-Sulfate is a possible metabolite of alkylresorcinol in humans.<br></p>

<p>Applications A labelled semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antineoplastic.<br>References Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)<br></p>

<p>Stability Moisture Sensitive<br>Applications Fenthion is an organothiophosphate used as an insecticide. Fenthion is also a potent acaricide. Useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pati, B.R. et al.: Plant Soil, 80, 215 (1984); Barros, A.T. et al.: Vet. Parasitol., 96, 243 (2001); Kyriakidis, N.V. et al.: Food Chem., 91, 241 (2005);<br></p>

<p>Applications 2,6-Dichloro-4-(trifluoromethyl)aniline is used in the synthesis of GABA receptor antagonists and insecticides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sammelson, R. et al.: Bioorg. Med. Chem., 12, 3345 (2004); Huang, W. et al.: Bioorg. Med. Chem., 14, 8280 (2006);<br></p>

<p>Applications 2,4-Dichlorophenol-13C6 is the labelled analog of 2,4-Dichlorophenol (D435685). 2,4-Dichlorophenol is a chlorinated derivative of phenol and is used as an intermediate for the preparation of herbicide 2,4-dichlorophenoxyacetic acid (D435680).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhong, W., et al.: J. Hazard. Mat., 217, 286 (2012); Rowe, V.K., et al.: Am. J. Vet. Res., 15, 622 (1954), Way, J.M., et al.: Residue Rev., 26, 37 (1969)<br></p>

<p>Applications A trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes.<br>References Kim, D., et al.: J. Med. Chem., 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005), Bergman, A., et al: Clin. Ther., 28, 55 (2006).<br></p>

<p>Applications Eszopiclone is the active stereoizomer of Zopiclone and belongs to the class of drug known as cyclopyrrones. It is a nonbenzodiazepine hypnotic agent used as a treatment for insomnia.This is a controlled substance (depressant) in the US but not in Canada.<br>References Gottesmann, C., et al.: Eur. J. Neurosci., 10, 409 (1998), Yoshimoto, M., et al.: Eur. Neuropsychopharmacol., 9, 29 (1999),<br></p>

<p>Applications Used in the synthesis of labelled 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents.<br>References Gordon, C., et al.: J. Med. Chem., 48, 1 (2005), Ikejiri, M., et al.: Bioorg. Med. Chem., 15, 6882 (2007),<br></p>

<p>Applications Triflusulfuron-methyl, is a widely used sulfonylurea herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Song, N., et al.: Huanjing Kexue, 33, 4400 (2012);<br></p>

<p>Applications Dimethenamide-P<br></p>

<p>Applications The main cis-monohydroxylated metabolite of Praziquantel (P702095).<br>References Buehring, K., et al.: Eur. J. Drug Metab. Pharm., 3, 179 (1978), Moldeus, P., et al.: Methods Enzymol., 52, 60 (1978), Cioli, D., et al.: Pharmacol. Ther., 68, 35 (1995),<br></p>

<p>Applications The major metabolite of Mosapride (M731000).<br>References Somogyi, A., et al.: Clin. Pharmacokinet., 8, 463 (1983), Cashman, J., et al.: Drug Metab. Dispos., 21, 587 (1993), Berkman, C., et al.: Biochem. Pharmacol., 50, 565(1995), Blake, B., et al.: Xenobiotica, 25, 377 (1995),<br></p>

<p>Stability Hygroscopic<br>Applications Tenofovir (T018500) impurity.<br></p>

<p>Applications A M1 muscarinic agonist designed as an innovative therapy for Alzheimer’s disease.<br>References Wanibuchi, F., et al.: Eur. J. Pharmacol., 187, 476 (1990), Court, J.A., et al.: Pharmacol. Ther., 52, 423 (1991), Ladner, C.J., et al.: J. Neuropathol. Exp. Neurol., 57, 719 (1998),<br></p>

<p>Applications Emamectin B1 Benzoate is a neurotoxic pesticidal compound. A potential anti-leukemia agent. Also applied in pesticidal screening and control techniques.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, H., et al.: Agr. Sci. Tech., 15, 1707 (2014); Tang, T., et al.: Zhiwu Baohu, 42, 222 (2016); Yun, X., et al.: Environ. Toxicol. Pharmacol., 52, 280 (2017)<br></p>

<p>Stability Hygroscopic<br>Applications Found in many plants, especially the buckwheat plant. Identity with Ilixanthin. Capillary protectant. Rutin is colored brown by tobacco enzyme under experimental conditions.<br>References Harrison, et al.: J. Am. Pharm. Assoc., 39, 557 (1950), Humphreys, et al.: Econ. Bot., 18, 195 (1964), Khalifa, T.I., et al.: Anal. Profiles Drug Subs., 12, 623 (1983).<br></p>

<p>Applications Fenoxaprop-P is an agro-product, used in pesticide formulations.<br>References Han, Y. et al. et al.: J. Sep. Sci., 40, 878 (2017);<br></p>

<p>Applications A metabolite of Atrazine (ATR) (A794600).<br>References Compton, D., et al.: Eur. J. Pharmacol., 110, 157 (1985), Das, P., et al.: Toxicol. Sci., 59, 127 (2001), Das, P., et al.: Life Sci., 73, 3123 (2003), Coban, A., et al.: J. Neurochem., 100, 1177 (2007),<br></p>

<p>Applications Sodium 2-((2-Ethyl-6-methylphenyl)amino)-2-oxoethanesulfonate is a pesticide metabolite found in surface water and groundwater. It is a degradation product of herbicide Acetochlor (A162500).<br>References Thurman, E., et al.: J. Chromatogr. A, 957, 3 (2002); Thurman, E., et al.: ACS Symp. Ser., 850, 128 (2003); Hamer, K., Freudenberger, U.: Wasser und Abfall, 13, 42 (2011); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013);<br></p>

<p>Applications 2-Naphthylacetic acid can be used to synthesize hydrolase inhibitors. It can also be utilized for developing γ-dipeptide derivatives that can bind human somatostatin receptors.<br>References Tarzia, G., et al.: J. Med. Chem. 46, 2352 (2003); Seebach, D., et al.: Angew. Chem. Int. Ed. 42, 776 (2003)<br></p>

<p>Applications Romidepsin is a histone deacetylase inhibitor that can alter chromatin structure and gene transcription leading to multiple changes in cellular protein production. This may result in cell cycle arrest and tumor growth inhibition. Romidepsin has shown anti-proliferative activity in vitro against multiple mouse and human tumor cell lines and in vivo in human tumor xenograft models. Romidepsin can be administered with a second agent, such as a cytotoxic agent, a steroidal agent, a proteasome inhibitor, or a kinase inhibitor.<br>References Ueda, H., et al.: J. Antibiot., 47, 301 (1994), Weidle, U., et al.: Anticancer Res., 20, 1471 (2000), Kitazono, M., et al.: Cancer Res., 61, 6328 (2001), Sandor, V., et al.: Clin. Cancer Res., 8, 718 (2002),<br></p>

<p>Stability Hygroscopic<br>Applications Spiroxamine is a spiroketalamine fungicide for use on cereal crops. Spiroxamine inhibits ergosterol synthesis. Spiroxamine is used as agricultural fungicide. Useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, J., et al.: J. Agric. Food Chem., 53, 1857 (2005), Abrahim, A., et al.: J. Pharm. Biomed. Anal., 51, 131 (2010), Wang, J., et al.: Anal. Bioanal. Chem., 396, 1513 (2010),<br></p>

<p>Applications Clindamycin (C580000) impurity in bulk drug.<br>References Birkenmeyer, R., et al.: J. Med. Chem., 13, 616 (1970), Platzer, D., et al.: J. Pharm. Biomed. Anal., 41, 84 (2006), Platzer, D., et al.: J. Pharm. Biomed. Anal., 41, 84 (2006),<br></p>

<p>Applications Tembotrione is one of the pesticides found in surface waters. It can also be found as pesticide residues in fruits and vegetables.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Moschet, C., et al.: Environ. Sci. Technol., 48, 5423 (2014); Wang, J., et al.: J. Agric. Food Chem., 62, 10375 (2014);<br></p>

<p>Stability Hygroscopic<br>Applications Disodium salt of Mosapride (M731000) derivative.<br>References Yoshida, N., et al.: Arch. Int. Pharmacodyn. Ther., 300, 51 (1989), Yatera, S., et al.: Japan. Pharmacol. Ther., 21, 21 (1993), Ruth, M., et al.: Aliment Pharmacol. Ther., 12, 35 (1998),<br></p>

<p>Applications Dimethoate is an organophosphate insecticide (1). It is an anti-cholinesterase which disables cholinesterase, an enzyme essential for central nervous system function (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Used as a standard for Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Tripathy, N. et al.: Mutat. Res.1988 Nov;206(3):351-60.2. Papp, A. et al.: Pest. Biochem. Physiol. 1998 August:61(1) 21-26<br></p>

<p>Applications Atorvastatin Calcium Salt Trihydrate is a compound used as standard in the method development and validation for simultaneous determination of Atorvastatin calcium (A791750) and Ezetimibe (E975000) in tablets using UV spectrophotometric, HPLC and HPTLC methods.<br>References Rajamanickam, V., et al.: World Appl. Sci. J., 9, 1424-1429 (2010);<br></p>

<p>Applications Heterocyclic inhibitor of the RNA-dependent RNA polymerase enzyme transcribed by the Hepatitis C virus.<br>References Mashino, T., et al.: Bioorg. Med. Chem. Lett., 15, 1107 (2005), Liu, Y., et al.: Biochem., 45, 11312 (2006), Tedesco, R., et al.: J. Med. Chem., 49, 971 (2006),<br></p>

<p>Applications N,N-Dimethylnicotinamide-2-sulfonamide (cas# 112006-75-4) is a compound useful in organic synthesis.<br></p>

<p>Applications A labelled semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antineoplastic.<br>References Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)<br></p>

<p>Applications A metabolite of Amonafide.<br>References Felder, T.B., et al.: Drug Metab. Dispos., 15, 773 (1987), Frei, E., et al.: Cancer Res., 48, 6417 (1988), Liu, Y., et al.: Bioorg. Med. Chem., 14, 2935 (2006),<br></p>

<p>Stability Hygroscopic<br>Applications 4-Hydroxyestradiol 4-O-β-D-Glucuronide Sodium Salt, is a glucuronide derivative of 4-Hydroxy-17β-estradiol (H941895); a metabolite of Estradiol (E888000) which is the major estrogen secreted by the premenopausal ovary.<br>References Bucala, R., et al.: J. Clin. Endocrinol. Metab., 60, 841 (1985); Telang, N., et al.: Anticancer Res., et al.: 11, 1021 (1991); Seeger, H., et al.: Med. Sci. Res., 26, 481 (1998); Bolton, J., et al.: Chem. Res. Toxicol., 13, 135 (2000); Salole, E.G., et al.: Anal. Profiles Drug Subs., 15, 283 (1986); Lievertz, R.W., et al.: Am. J. Obstet. Gynecol., 156, 1289 (1987)<br></p>

<p>Applications The labelled trans-isomer of the third generation synthetic pyrethroid insecticide, Bifenthrin (B383000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Plummer, E.L., et al.: Pestic. Sci., 14, 560 (1983), Trumble, J.T., et al.: J. Econ. Entomol., 81, 608 (1988), Ross, M., et al.: Biochem. Pharmacol., 71, 657 (2006), Hillegass, J., et al.: Toxicol. Sci., 102, 413 (2008),<br></p>

<p>Applications Carboxine is an fungicide used for the control of fruit rot of custard apple.<br>References Kosiada, T., et al.: J. Plant. Protect. Res,, 51, 342 (2011); Goswami, S., et al.: J, App. Natural. Sci., 4, 264 (2012);<br></p>

<p>Stability Unstable at room temperature!<br>Applications Group 1 carbapenem antibiotic. An antibacterial.<br>References Sundelof, J.G., et al.: Antimicrob. Agents Chemother., 41, 1743 (1997),<br></p>

<p>Stability: Hygroscopic<br>Applications: Labelled Oseltamivir (O701000). Orally active inhibitor of influenza virus neuraminidase; converted in vivo to the active acid metabolite. An antiviral drug. It is a COVID19-related research product.<br>References Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998), Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998), Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999), Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000)<br></p>

<p>Applications τ-Fluvalinate is a synthetic pyrethroid aracacide. τ-Fluvalinate is commonly used to control Varroa jacobsoni (a parasitic mite) in honey bee colonies.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Delaplane, K.S. et al.: J. Econ. Entomol., 88, 1206 (1995); Ferrer-Dufol, M. et al.: J. Apicul. Res., 34, 147 (1995); Lindberg, C.M. et al.: J. Econ. Entomol., 93, 189 (2000);<br></p>

<p>Stability Hygroscopic<br>Applications rac Indapamide-N-sulfonamido-β-D-glucuronide_x000D__x000D_(Mixture of Diastereomers) is a compound useful in organic synthesis.<br></p>

<p>Applications Labelled Clomiphene. Synthetic estrogen agonist-antagonist. Gonad-stimulating principle.<br>References Palopoli, F.P., J. Med. Chem., 10, 84 (1967), Ernst., et al.: J. Pharm. Sci., 65, 148 (1976), Baustian, C.L., et al.: Pharm. Biomed. Anal., 4, 237 (1986),<br></p>

<p>Applications Carbamate fungicide used in the agriculture industry<br>References Judelson, H., et al.: Mol. Plant Pathol., 7, 17 (2005), Grunwald, N., et al.: Phytopathol., 96, 1397 (2006), Celik, L., et al.: Chem. Res. Toxicol., 21, 2195 (2008),<br></p>

<p>Applications 2,3,5-Trichloropyridin-4-amine (cas# 28443-69-8) is a useful research chemical.<br></p>

<p>Applications A metabolite of Chlorpyrifos (C425300).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Barron, M.G., et al.: Environ. Toxicol. Chem., 12, 1469 (1993), Tang, J., et al.: Drug Metab. Dispos., 29, 1201 (2001),<br></p>

<p>Applications Labelled Clopidogrel derivative.<br>References Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992), Pereillo, J., et al.: Drug Metab. Dispos., 30, 1288 (2002), Ksycinska, H., et al.: J. Pharm. Biomed. Anal., 41, 533 (2006), Farid, N., et al.: Clin. Pharmacol. Ther., 81, 735 (2007),<br></p>

<p>Stability Very Hygroscopic<br>Applications A benzoquidine diimine derivative useful as animal growth substance.<br>References Clark, R., et al.: J. Agric. Food Chem., 44, 3643 (1996), Sadowski, J., et al.: J. Med. Chem., 41, 332 (1998), Estrada, E., et al.: J. Med. Chem., 43, 1975 (2000),<br></p>

<p>Applications Esfenvalerate is the most potent insecticidal isomer of Fenvalerate (F279450), a pyrethroid insecticide used to control insects from food crops, animal feed and cotton products.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nakayama, I. et al.: Adv. Pestic. Sci., Plenary Lect. Symp. Pap. Int. Congr. Pestic. Chem., 2, 174 (1979); Mikami, N. et al.: Pest. Sci., 16, 46 (1985); Palmquist, K.R. et al.: Environ. Toxicol. Chem., 27, 1721 (2008);<br></p>

<p>Applications Lynestrenol is an orally available progestogen hormone used in contraception to avoid hereditary angiodema as well as in treatment of ischemic stroke.<br>References Saule, C. et al.: Clin. Exp. Allergy, 43, 475 (2013); Beraki, S. et al.: PLoS One., 8, e69233 (2013);<br></p>

<p>Applications Phthalimide is a reagent used to transform allyl- and alkyl halides into protected primary amines. Phthalimide analogues have been extensively used in medicinal chemistry owing to their wide spectrum of applications as anti-convulsant, anti-inflammatory, analgesic, hypolipidimic and immunomodulatory activities. Dyes and metabolites, Environmental Testing.<br>References Sharma, U., et al.: Med. Chem., 10, 678 (2010); Reddy, P.Y., et al.: J. Org. Chem., 62, 2652 (1997); Le, Z.G., et al. Synthesis., 208 (2004);<br></p>

<p>Applications Its application as nitrification inhibitor of nitrogen fertilizers.<br>References Williams, B., et al.: J. Soil Sci., 34, 113 (1983), Leinweber, P., et al.: Biol. Fertil. Soils, 20, 17 (1995),<br></p>

<p>Applications Labelled antilipemic.<br>References Fuccella, L.M., et al.: Clin. Pharmacol. Ther., 28, 790 (1980), Lovisolo, P.P., et al.: Pharmacol. Res. Commun., 13, 151 (1981), Aktories, K., et al.: Arzneim.-Forsch., 33, 1525 (1983), Boatman, P., et al.: J. Med. Chem., 51, 7653 (2008), Rigazio, S., et al.: Am. J. Physiol., 295, E413 (2008),<br></p>

<p>Applications A labeled metabolite of Diosmetin (D485000) isolated and identified from Chrysanthemum morifolium L. v. Ramat leaves.<br>References Porra, R., et al.: Biochem. Biophys Acta, 975, 384 (1989), Watanabe, M., et al.: J. Agric. Food Chem., 47, 4500 (1999),<br></p>

<p>Applications Labelled Flupirtine (F598510). Analgesic. Substituted pyridine with central analgesic properties. A potassium channel opener<br>References Vaupel, D., et al.: Eur. J. Pharmacol., 162, 447 (1989), Nickel, B., et al.: Arzneim.-Forsch., 40, 909 (1990), Lunemann, J., et al.: J. Immunol., 168, 4881 (2002),<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Carnitine.<br>References Huang, Z., et al.: Anal. Biochem., 199, 98 (1991), Friolet, R., et al.: J. Clin. Invest., 94, 1490 (1994), Rashed, M., et al.: Pediatr. Res., 38, 324 (1995), Costa, C., et al.: J. Lipid Res., 38, 173 (1997),<br></p>

<p>Applications Psychotropic agent with anxiolytic and anticonvulsant activity.<br>References Boissier, J.R., et al.: Therapie, 27, 325 (1972), Bente, D., et al.: Arzneim. Forsch., 25, 944 (1975),<br></p>

<p>Applications A labelled selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in the treatment of familial adenomatous polyposis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),<br></p>

<p>Applications 2,5-Dimethoxy-4-methylamphetamine (DOM, STP) is one of the potent hallucinogenic phenylalkylamines with neurotoxic properties. Hallucinogen.<br>References Monte, A., et al.: J. Med. Chem., 39, 2953 (1996), Pedersen, W., et al.: Addiction, 94, 1695 (1999), Kanamori, T., et al.: J. Anal. Toxicol., 26, 61 (2002),<br></p>

<p>Applications (Z)-Hexadec-11-en-1-ol is a pheromone antagonist that regulates optimal mating time in moth Helicoverpa armigera.<br>References Chang, H., et al.: Curr. Biol., 27, 1610 (2017); Du, M., et al.: Insect Biochem. Mol. Biol., 87, 154 (2017)<br></p>

<p>Applications Cyclanilide is a plant growth regulator that functions by interactting with auxin-regulated processes. Cyclanilide is commonly used on cotton plants to either suppress vegetative growth or accelerate senescence. Cyclanilide is also used as a bioregulator of deciduous fruit trees.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Burton, J. et al.: Proc. Plant Growth Reg. Soc. Am., 36, 56 (2009); Burton, J. et al.: J. Plant Growth Reg., 27, 342 (2008); Elfving, D.C. et al.: Act Horticul., 884, 159 (2010);<br></p>

<p>Applications Labelled Desloratadine (D290250). Nonsedating-type labelled histamine H1-receptor antagonist. An active labelled metabolite of Loratadine. Also inhibits generation and release of inflammatory mediators from basophils and mast cells.<br>References Kreutner, W., et al.: Arzneimittel-Forsch., 50, 345 (2000), Salmun, L.M., et al.: Clin. Ther., 22, 613 (2000), Agrawal, D.K., et al.: Expert Opin. Invest. Drugs, 10, 547 (2001),<br></p>

<p>Applications A nonsteroidal estrogen antagonist.<br>References Gladek, A., et al.: J. Biol. Chem., 264, 16847 (1989), Han, X., et al.: Cancer Res., 52, 1360 (1992), Williams, G., et al.: Carcinogenesis, 14, 315 (1993),Coradini, D., et al.: Anticancer Res., 14, 1059 (1994),<br></p>

<p>Applications 1,4-Butane-1,1,2,2,3,3,4,4-d8-diamine (D416027) is a labelled isotope of 1,4-Diaminobutane (D416025). It is an amino acid degradation product. Used in the preparation of hexahydropyrimidines as novel hepatitis C virus inhibitors. Also a reagent in the synthesis of antibacterial castor oil-based polyurethane membranes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hwang, J. et al.: Eur. J. Med. Chem., 70, 315 (2013); Yari, A. et al.: J. Biomed. Mat. Res., 102A, 84 (2014);<br></p>

<p>Applications Propisochlor is an herbicide that is absorbed through the shoots of germinating plants.<br></p>

<p>Applications rac cis-Paroxetine N-Methyl is an impurity formed in the synthesis Paroxetine (P205750) related compounds.<br>References Gangula, S., et al.: Syn. Commun., 42, 3344 (2012);<br></p>

<p>Applications Labelled Cephapirin (C261500). An antimicrobial agent.<br>References Tan, J.S., et al.: Antimicrob. Agents Chemother., 15, 510 (1979),<br></p>

<p>Applications Copper Acetoarsenite has been used as a rodenticide and insecticide, and also as a pigment, despite its toxicity. It is also used as a blue colorant for fireworks.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.: Toxicol. Appl. Pharm., 2, 88 (1960); Jameson, F.: Paint Manu., 13, 6 (1943)<br></p>

<p>Applications (aS,bR)-Bedaquiline is a diarylquinoline derivative that acts as a mycobacterial inhibitor. Bedaquiline shows promise as potential drug in the treatment of tuberculosis.<br>References Cheepsattayakorn, A., et al.: Anti-Infect. Drug. Discover.,7, 141 (2012); de Jonge M.R. et al.: Proteins, 67, 971 (2007); Diacon A.H. et al.: N. Eng. J. Med., 360, 2397 (2009);<br></p>

<p>Stability Hygroscopic<br>Applications Used as a herbicide.<br>References Abbas, H., et al.: J. Agric. Food Chem., 50, 5246<br></p>

<p>Applications Labelled synthetic peptide agonist analog of LH-RH. Triptoreline is a potent agonist of LH-releasing hormone, currently used in the treatment of prostatic cancer where therapy may be required over months or years. Antineoplastic (hormonal). Used in the treatment of endometriosis and infertility.<br>References Sanders, L., et al.: Eur. J. Drug Metab. Pharmacokinet., 15, 95 (1990), Chiba, M., et al.: Biomaterials, 18, 893 (1997), Blanco, D., et al.: Eur. J. Pharm. Biopharm., 45, 285 (1998), Sinha, V., et al.: J. Control. Rel., 90, 261 (2003),<br></p>

<p>Stability Hygroscopic<br>Applications An alpha agonist, causing constriction of conjunctival blood vessels. Used in over-the-counter eye drops, this compound relieves the redness left by ocular irritants.<br>References Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 13, 2881 (2005), Sandri, G., et al.: Eur. J. Pharm. Biopharm., 62, 59 (2006), Rosenthal, R., et al.: J. Ocular Pharmacol. Ther., 22, 440 (2007), Sabio, S., et al.: J. App. Oral Sci., 16, 280 (2008),<br></p>

<p>Applications Gestagenic Testosterone (T155000) derivative. A steroid ligand for the cytosol androgen receptor (AR) of rat prostate.<br>References Ojasoo, T. et al.; J. Steroid Biochem. 27, 255 (1987); Dore, J. et al.; J. Med. Chem. 29, 54 (1986)<br></p>

<p>Applications Antiarrhythmic (class IA). Sodium channel blocker.<br>References Adelstein, et al.: J. Med. Chem., 16, 309 (1973), Czeisler, J.L., et al.: J. Pharm. Sci., 74, 750 (1985), Taylor, E.H., et al.: Ann. Clin. Lab. Sci., 16, 289 (1986),<br></p>

<p>Applications Thiobencarb-d10 (diethyl-d10) (CAS# 1219804-12-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications A potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Has antimitogeni, antithrombotic, vasodilatory and cardiotonic properties in vivo. Also affects lipid levels in vivo.<br>References Suri, A., et al.: J. Clin. Pharmacol., 38, 144 (1998), Park, S.-W., et al.: Am. J. Cardiol., 84, 511 (1999), Tsuchikane, E., et al.: Circulation, 100, 21 (1999),<br></p>

<p>Applications Isotope labelled analogue of Bifendate (B382890), a synthetic intermediate of Schisandrin C and also a anti-HBV drug used in the treatment of chronic hepatitis B.<br>References Pan, S.Y., et al.: Euro. J. Pharmacol. 522, 170 (2006); Zeng, Y., et al.: Acta. Pharmacol. Sinica., 30, 478 (2009);<br></p>

<p>Applications Ibogaine Hydrochloride is a naturally occurring psychoactive substance. It is a β-carboline derivative that cause both hallucinations and tremor.<br>References O’Hearn, E., et al.: Neurosci., 55, 303 (1993)<br></p>

<p>Applications Principle alkaloid of opium.This is a controlled substance (opiate). Analgesic (narcotic).<br>References Buchwald, M.E., et al.: J. Pharmacol. Exp. Ther., 71, 197 (1941), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 17, 259 (1988),<br></p>