Toxicología

<p>Applications 5-(Trifluoromethyl)-1H-pyrazole-4-carboxylic acid (cas# 543739-84-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications CK 1827452 is a promising new drug in systolic heart failure. It accelerates the transition of myosin into the force-generating state without affecting cardiac myocyte calcium homeostasis. CK 1827452 increases cardiac function by increasing the duration of ejection without changing the rates of contraction.<br>References Meijs, M. et al.: Eur. J. Heart. Fail., 14, 232 (2012); Malik, F. et al.: J. Mol. Cell. Card., 51, 454 (2011)<br></p>

<p>Applications (S)-6-Hydroxywarfarin is the S-enantiomer of the 6-hydroxyl metabolite of Warfarin (W498500).<br>References Wong, Y.W.J. et al.: Pharm. Res., 6, 982 (1989); O'Reilly, R.A. et al.: Clin. Pharmacol. Ther., 51, 656 (1992);<br></p>

<p>Applications Testosterone (T155000) derivative. Intermediate in the preparation of Epostane (E588850).<br></p>

<p>Applications Anesthetic.<br>References DesJarlais, R., et al.: J. Med. Chem ., 31, 722 (1988), Woo, Y., et al.: Toxicol. Lett., 79, 219 (1995), Blundell, T., et al.: Nature, 384, 23 (1996),<br></p>

<p>Applications 2-PHENOXYBENZOIC ACID (cas# 2243-42-7) is a useful research chemical.<br></p>

<p>Applications 2-Phenoxypropionic Acid is used in organic chemistry reduction reactions. Used in the synthesis of PPAR (peroxisome proliferator-activated receptor (PPAR) ligands.<br>References Brown, P. et al.: Synthesis., 7, 778 (1997);<br></p>

<p>Applications 3,4-Dimethyl-N-(1-methylpropyl)-2,6-dinitrobenzenamine is a herbicide.<br>References Victoria F. R., et al.: Planta Daninha, 4, 11 (1981); Stoller, E. W., et al.: J. Environ. Qual., 6, 124 (1977); Van Yahres, R. D., et al.: Proceedings of the Annual Meeting of the Northeastern Weed Science Society, 36, 292 (1982)<br></p>

<p>Applications Mepronil is an benzanilide based fungicide found in the raw materials of herbal medicine.<br>References Inoue, T., et al.: J. Agr. Food. Chem., 59, 3857 (2011);<br></p>

<p>Applications Chlorflurenol-methyl is an auxin polar transport inhibitor that effects elongation growth of the excised fourth internode of tulips. Chlorflurenol-methyl is a pesticide.<br>References Wegrzynowicz-Lesiak, E., et al.: J. Hort. Res., 21, 31-39 (2013);<br></p>

<p>Impurity Atazanavir Impurity 1<br>Applications An epimeric impurity of Atazanavir, novel azapeptide HIV protease inhibitor. Atazanavir Impurity 1<br>References Chitturi, S.R. et al.: J. Pharmac. Biomed. Anal., 55, 31 (2011);<br></p>

<p>Applications Phorate is a non-biocumulative organophosphate used as an insecticide and acaricide. Phorate is an inhibitor of acetylcholinesterase and pseudocholinesterase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pandey, G.C. et al.: Ind. J. Comp. Anim. Physiol., 6, 1 (1988); Henderson, M.C. et al.: Biochem. Pharmacol., 68, 959 (2004); Peter, J.V. et al.: NeuroToxicology, 29, 335 (2008);<br></p>

<p>Applications Testosterone Methanesulfonate is an intermediate in the synthesis of Androstadienone (A637340), a prominent androstene present on male human axillary hair and on the male axillary skin surface.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Diniconazole is a pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lehotay, S., et al.: J. AOAC Int., 88, 595 (2005); Hiemstra, M., et al.: J. Chromat. A, 1154, 3 (2007)<br></p>

<p>Applications 2,4-D 1-butyl ester<br></p>

<p>Applications Fensulfothion Sulfide is a metabolite of the insecticide fensulfonthion (F265490), an inhibitor of cholinesterase activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Solly, S.R.B., et al.: New. Zea. J. Agri. Res., 14, 88 (1971); Hansch, C., et al.: Biochem. Toxicol. Insectic. Proc., 33 (1970);<br></p>

<p>Applications Tetrahydrophthalic Acid is a plasticizer; used in preparation method of concrete coating. Also, used in preparation method of polyester resin for two-piece can ink.<br>References Mao, X., et al.: Faming Zhuanli Shenqing, (2020); Zhang, L., et al.: Faming Zhuanli Shenqing, (2020);<br></p>

<p>Applications is the labeled analogue of Cyprodinil (C989060), which is a a broad-spectrum fungicide of the class of pyrimidinamines. It is commonly used for protection of cereal crops and fruits against fungal infections.<br>References Heye, U.J. et al.: Bright. Crop Prot. Conf., Pests Dis., 2, 501 (1994); Boric, B. et al.: Pesticidi, 12, 277 (1997); Knauf-Beiter, G. et al.: Plant Dis., 79, 1098 (1995);<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Venlafaxine.<br></p>

<p>Stability Unstable in Solution<br>Applications (S)-(-)-Carbidopa is a peripheral decarboxylase inhibitor that is commonly used in combination with L-DOPA (D533751) for treatment of Parkinsonism. S(-)-Carbidopa ( has also been shown to prolong the elimination half-life of L-DOPA from blood plasma and skeletal muscle.<br>References Henry, G.M. et al.: Psychosom. Med., 38, 95 (1976); Leguire, L.E. et al.: Invest. Ophthalmol. Vis. Sci. 34, 3090 (1993); Deleu, D. et al.: Naun. Schmied. Arch. Pharmacol. 348: 576 (1993);<br></p>

<p>Applications Labelled Sarafloxacin (S139500). Sarafloxacin is a fluorinated quinolone antibacterial.<br>References Fernandes, P.B., et al.: Antimicrob. Ag. Chemother., 29, 201 (1986), Digranes, A., et al.: Chemotherapy, 34, 298 (1988),<br></p>

<p>Applications 17β-Hydroxy Exemestane 17-O-β-D-Glucuronide is the glucuronidated conjugate of the hydroxy metabolite of Exemestane (E957000).<br>References Sun, D. et al.: Pharmacogen. Genom., 20, 575 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications (αS)​-​rel-α-​(4-​Chlorophenyl)​-​α-​[(1R)​-​1-​cyclopropylethyl]​-​1H-​1,​2,​4-​triazole-​1-​ethanol is a diastereomer of Cyproconazole (C989070), a fungicide treatment for wood preservative that prevents decay from fungi in above-ground applications.<br>References Aiello, D., et al.: Plant. Disease., 97, 37 (2013); Bakirci, G.T., et al.: Food. Chem., 135, 1901 (2012); Sugitate, K., et al.: J. Pesticides. Sci., 37, 148 (2012);<br></p>

<p>Applications Erlotinib is a EGFR-targeted drug in the treatment of non-small cell lung cancer. EGFR small tyrosine kinase inhibitor that shows most substantial effect on tumor growth inhibition and animal survival.<br>References Zhu, B., et al.: Xiandai Zhenduan Yu Zhiliao, 25, 4679 (2014); Yao, T., et al.: Ther. Targets Neurol. Dis., 2, 585 (2015)<br></p>

<p>Applications A tryptamine derivative; shows α-adrenolytic activities.<br>References Ishida, Yukio., et al.: Chem. Pharma. Bull., 25, 1851 (1977),<br></p>

<p>Applications 11-Hydroxytestosterone-[9,11,12,12-2H4] is a metabolite of Testosterone (T155000), a principal hormone of the testes, produced by the interstitial cells.<br>References McFarland, K., et al.: Science, 245, 494 (1989), Heckert, L., et al.: Mol. Endocrinol., 12, 1499<br></p>

<p>Applications 2-Amino-N-isopropylbenzamide is a metabolite formed from Bentazon (B120580), a post-emergence, acidic herbicide used for selective control of broadleaf weeds and sedges in beans, rice, corn, peanuts and mint.<br>References Pinto, G. &amp; Jardim, I.: J. Chromatogr. A, 846, 369 (1999); Salman, J. &amp; Hameed, B.: J. Hazard Mater., 175, 133 (2010)<br></p>

<p>Applications Phenamacril is a fungicide.<br>References Tang, L., et al.: Synthesis, 46, 1621-1629 (2014);<br></p>

<p>Applications O6-Methyl-7,8-dihydro-6-isomorphine is an impurity of Hydromorphone(H714650), an analgesic(narcotic).<br>References Buchwald, M.E., et al.: J. Pharmacol. Exp. Ther., 71, 197 (1941), Zernig, G., et al.: Life Sci., 57, 2113 (1995), Keith, D., et al.: J. Biol. Chem., 271, 19021 (1996), Pawar, M., et al.: Eur. J. Pharmacol., 563, 92 (2007)<br></p>

<p>Applications 2'-O-Methyl-d3 Paclitaxel is a labeled analogue of 2'-O-Methyl Paclitaxel (M326135), a potential cytotoxic agent.<br>References Kant, J., et. al.: Bioorg. med. Chem. Lett., 3, 2471 (1993)<br></p>

<p>Applications Dihydro Normorphine is a metabolite of Normorphine (N740300).<br>References Hug, C.C, et al.: J. Pharmacol. Exp. Therap., 149, 446 (1965),<br></p>

<p>Stability Hygroscopic<br>Applications A labelled Ibuprofen (I140000) impurity.<br>References Kalafut, P. et al.: J. Pharm. Biomed. Anal., 49, 1150 (2009); Kucera, R. et al.: J. Pharm. Biomed. Anal., 38, 609 (2005);<br></p>

<p>Applications 2,3,5-Trimethylphenol is a reagent used in the synthesis of antibiotics. Also used in the preparation of vitamin E synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Velema, W. et al.: Nat. Chem., 5, 924 (2013); Carril, M. et al.: J. Catal., 283, 55 (2011);<br></p>

<p>Applications Pemetrexed Disodium Heptahydrate is an chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed Disodium Heptahydrate exhibit inhibitory activities towards thymidylate synthase as well as other folate dependent enzymes.<br>References Vogelzang, N.J., et al.: J. Clin. Oncol., 21,2636 (2003); Paz-Ares, L., et al.: Lancet. Oncol., 13, 247 (2012);<br></p>

<p>Applications Methoxychlor-d6 (dimethoxy-d6) (CAS# 106031-79-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 7-methoxy-4-phenyl-1,2-dihydroquinolin-2-one (cas# 30034-43-6) is a useful research chemical.<br></p>

<p>Applications 4-(1,1-Dimethylpropyl)-β-methylbenzenepropanol is a useful synthetic intermediate in the synthesis of Amorolfine Hydrochloride (A634170); a morpholine antifungal drug and topical solution for the treatment of toenail infections.<br>References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984); Zhang, S., et al.: Faming Zhuanli Shenqing. CN 103288768 A 20130911. Sep 11, 2013<br></p>

<p>Applications (S)-1-Amino-3-chloro-2-propanol Hydrochloride is used in biological studies as an orally active male antifertility agent which is mediated by an effect on epididymal and vas deferens sperm.<br>References Coppola, J. A., et al.: Contraception, 9, 459 (1974);<br></p>

<p>Stability Moisture Sensitive<br>Applications Quinalphos is an organothiophosphate pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lehotay, S., et al.: J. AOAC Int., 88, 595 (2005); Paya, P., et al.: Anal. Bioanal. Chem., 389, 197 (2007)<br></p>

<p>Applications N-Methyl Esomeprazole-d3 is the isotope labelled analog of N-Methyl Esomeprazole (M304640); an impurity of Omeprazole (O635000) which a compound that binds covalently to proton pumps and inhibits gastric secretion. Also used as an antiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>

<p>Applications Androstenedione (A637550) analog, an aromatase inhibitor.<br>References Marsh, D.A., et al.: J. Med. Chem., 28, 788 (1985),<br></p>