Toxicología

<p>Applications Ethalfluralin is a herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gama, A. F., et al.: J. Soils Sediments, 17, 1160-1169 (2017); Karasali, H., et al.: Sci. Total Environ., 541, 130-142 (2016)<br></p>

<p>Applications Acifluorfen-2-amino is a reduction product of Acifluorfen (A795248), a herbicide. Acifluorfen-2-amino is usually the first product in the degradation of Acifluorfen.<br>References Gennari, Mara, et al.: J. of Agri. and Food Chem., 42(5), 1232-6 (1994);Gooch, A. et al.: Env. Toxicol. Chem., 36, 2227 (2017)<br></p>

<p>Applications (+)-Nebivolol (N387896) metabolite.<br></p>

<p>Applications Protected Morphine metabolite.<br></p>

<p>Applications 2-Methylphenyl Diethylcarbamate-13C6 is an intermediate in the synthesis of o-Cresol-13C6 (C781912). Isotope labelled o-Cresol is a compound used as a disinfectant and have also been used as antiseptic in surgery.<br>References Razavi, S.M., et al.: Nat. Prod. Res., 26, 2148 (2012); Asadollahi-B. M., et al.: Environ. Toxicol. Pharmacol., 34, 826 (2012);<br></p>

<p>Applications N-Boc-3-hydroxy-L-valine is used as a reagent in the synthesis of metabolites of PPI-2458, which is a selective, irreversible inhibitor of methionine aminopeptidase-2 (MetAP2). N-Boc-3-hydroxy-L-valine is also used in the preparation of Boceprevir (B674500); an NS3 serine protease inhibitor of hepatitis C virus for the treatment of HCV infection.<br>References Arico-Muendel, C.C., et al.: Drug Metab. Dispos., 41, 814 (2013); Venkatraman, S., et al.: J. Med. Chem., 49, 6074 (2006)<br></p>

<p>Applications Morphine Methylsulfonate is a derivative of Morphine (M652285), which is the principle alkaloid of opium and an analgesic used to treat both acute and chronic pain.<br>References Stefano, G., et. al.: Folia Biol, 58, 49 (2012);Buchwald, M.E., et al.: J. Pharmacol. Exp. Ther., 71, 197 (1941); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 17, 259 (1988)<br></p>

<p>Applications (1S)-trans-Bifenthrin is an stereo isomer of B383000, which is a third generation synthetic pyrethroid. Insecticide, acaricide. Used in Pesticide detection<br>References Plummer, E.L., et al.: Pestic. Sci., 14, 560 (1983), Trumble, J.T., et al.: J. Econ. Entomol., 81, 608 (1988), Ross, M., et al.: Biochem. Pharmacol., 71, 657 (2006), Hillegass, J., et al.: Toxicol. Sci., 102, 413 (2008),<br></p>

<p>Applications Protected Fluvoxamine.<br></p>

<p>Applications Birinapant is a bivalent SMAC mimetic compound antagonist of TRAF2 associated cIAP1 and cIAP2.<br>References Benetatos, C.A., et. al.: Mol. Cancer Ther., 13, 867 (2014)<br></p>

<p>Applications 3-Fluoro-2-methoxy-benzenesulfonyl-d3 Chloride is the isotope labelled analog of 3-Fluoro-2-methoxy-benzenesulfonyl Chloride (F593265), which is a derivative of 2-Fluoroanisole (F587670); a useful synthetic intermediate with antifungal activity.<br>References Pinto, M. F. S., et al.: J. Mol. Struc.: Theochem., 539, 303-310 (2001)<br></p>

<p>Applications A labelled metabolite of the antipsychotic drug Trifluoperazine (TFP). Also a labelled metabolite of Fluphenazine.<br>References Mahju, M., et al.: Biochem. Pharmacol., 18, 2701 (1969), Breyer, U., et al.: J. Pharm. Sci., 63, 1842 (1974), Schmalzing, G., et al.: Drug Metab. Disp., 5, 104 (1977), Schmalzing, G., et al.: Xenobiotica, 8, 45 (1978),<br></p>

<p>Applications Metazosulfuron is a herbicide used in paddy fields to control annual and perennial weeds.<br>References Lee, I., et. al.: The Korean Soc. Weed Sci., 31, 308 (2011)<br></p>

<p>Applications Labelled, primary metabolite of Tianeptine.<br>References Dresse, A., et al.: J. Clin. Pharmacol., 28, 1115 (1988), Grislain, L., et al.: Drug Metab. Dispos., 18, 804 (1990),<br></p>

<p>Applications L-Menthyl 2,2-Dihydroxyacetate is used as a reagent in the synthesis of Lamivudine (L172500); a potent nucleoside reverse transcriptase inhibitor used for the treatment of chronic hepatitis B. L-Menthyl 2,2-Dihydroxyacetate is also used as a reagent in the synthesis of 4-acetoxy-3-hydroxyethylazetidin-2-one, a key intermediate for the preparation of penem and carbapenem antibiotics.<br>References Morris, D.M., J. Pharm. Biomed. Anal., 12, 255 (1944); Nevens, B.F., et al.: Gastroenterology, 113, 1258 (1997); Perry, C.M., et al.: Drugs, 53, 657 (1977); Goodyear, M.D., et al.: Tetrahedron Lett., 46, 8535 (2005); Kametani, T., et al.: Heterocycles, 25, 241 (1987)<br></p>

<p>Applications SN-38 4-Deoxy-glucuronide is a byproduct formed during the preparation of SN-38 Glucuronide.<br></p>

<p>Applications Labelled 2,4'-Dichlorodiphenyltrichloroethane (D434205). 2,4'-Dichlorodiphenyltrichloroethane is a chlorinated organic pesticide having estrogenic activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Iwata, H., et al.: Environ. Sci. Technol., 27, 1080 (1993), Beyer, A., et al.: Environ. Toxicol. Chem., 21, 941 (2002), Cunningham, S., et al.: Science, 317, 935 (2007),<br></p>

<p>Applications An intermediate in the preparation of HIV-integrase inhibitors<br>References Itoh, F., et al.: Chem. Pharm. Bull., 43, 230 (1995), Summa, V., et al.: J. Med. Chem., 51, 5843 (2008),<br></p>

<p>Applications N-Acetyl Cefixime is the N-acetylated analogue and impurity of the third generation cephalosporin antibiotic, Cefixime (C242800).<br></p>

<p>Applications A labelled Tamoxifen; a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen (H954725) are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.<br>References Sutherland, R., et al.: Nature, 267, 434 (1977); Lerner, L., et al.: Cancer Res., 50, 4177 (1990); Love, R., et al.: J. Clin. Oncol., 20 2559 (2002);<br></p>

<p>Applications 2,3,4,5,6-Pentachlorobenzeneamine is a chemical in pesticides used to protect crops from various fungus and bacterium.<br>References Gartrell, M. et al.: J. Assoc. Off. Anal. Chem., 68, 1163 (1985); Renner, G. et al.: App. Env. Microbio. 46, 765 (1983);<br></p>

<p>Applications Aminoethoxyvinyl Glycine Hydrochloride is an ethylene synthesis inhibitor that is used as a plant growth regulator.<br>References Tsantili, E., et. al.: Sci. Hortic-Amsterdam, 140, 26 (2012); Cetinbas, M., Butar, S.: Eur. J. Hortic. Sci., 78, 126 (2013); Centibas, M., et. al.: Sci. Hortic-Amsterdam, 147, 1 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications Auristatin F is an antimitotic auristatin derivative that has been shown as a potent antitumor agent.<br>References Doronina S.O., et al.: Bioconjugate Chem., 17, 114-124 (2006);<br></p>

<p>Applications 3-Cyano-6,7-dihydro-4-trifluoromethyl-1,5H-cyclopenta-[b]-pyrid-2-one (cas# 371967-27-0) is a useful research chemical.<br></p>

<p>Stability Very unstable<br>Applications Cefixime Impurity is an impurity of Cefixime (C242800); an orally active third generation cephalosporin antibiotic.<br>References Kamimura, T., et al.: Antimicrob. Agents Chemother., 25, 98 (1984); Yamanaka, H., et al.: J. Antibiot., 38, 1738 (1985); Guay, D.R.P., et al.: Antimicrob. Agents Chemother., 30, 485 (1986)<br></p>

<p>Applications 2’,3’,4’-Tri-O-benzoyl Propofol-d17 β-D-Glucuronide Methyl Ester is an protected metabolite of Propofol (P829750), an anesthetic used in veternary medicine.<br>References Fujiwara, R., et al.: Drug Metab. Dispos., 35, 747 (2007), Soars, M., et al.: J. Pharmacol. Toxicol. Methods, 47, 161 (2002),<br></p>

<p>Applications Thiophanate Ethyl-d10 is the isotope labelled analog of Thiophanate Ethyl; a systemic fungicide used in plant protection. Thiophanate Ethyl was shown to be effective against Botryotinia [ Sclerotinia] fuckeliana and Uncinula necator on grapevines, Mycosphaerella fragariae on strawberries, and powdery mildew of cucumber.<br>References Baicu, T., et al.: Analele Institutului de Cercetari pentru Protectia Plantelor, 8, 227 (1970)<br></p>

<p>Applications 2,6-Dibromo-4-cyanophenyl Octanoate-d15 is a useful isotopically labeled compound of Bromoxynil Octanoate (B694345)<br></p>

<p>Applications Nabam-d4 Hexahydrate is a labeled fungicide used to synthesize zinc ethylenebis(dithiocarbamate):amine complexes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Clifford, D.P., Carson, C.: Pesticide Sci., 23, 93 (1988)<br></p>

<p>Applications 5-Bromo-2-nitrophenol is a halonitrophenol with antifungal activity.<br>References Gershon, H., et al.: Monatshefte fuer Chemie, 126, 1161 (1995)<br></p>

<p>Applications 9-(2-Hydroxypropyl)adenine-13C5 is an intermediate used in the synthesis of rac Tenofovir-13C5 (&gt;90%) (T018501), which is he isotope labelled analog of Tenofovir (T018500); an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. Also used as an anti-HIV agent and antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005); Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006); Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)<br></p>

<p>Applications Lomitapide is a drug used in the treatment of obesity and aids in lowering LDL cholesterol and overall cholesterol levels in subjects.<br>References Cuchel, M. et al.: Lancet., 381, 40 (2013); Stefanutti, C. et al.: Atherosclero. Suppl., 14, 19 (2013);<br></p>

<p>Applications Dydrogesterone (D826000) intermediate. Used in the preparation of 10α-steroids.<br></p>

<p>Applications A labelled isotpe of Isopropyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate (I485580). A short-acting intravenous anaesthetic agent used for dislocated joints, tracheal intubation, cardioversion and electroconvulsive therapy.<br>References Goetz, E., et al.: Anaesthesist, 23, 331 (1974), Chang, Z. L., et al.: Anal. Profiles Drug Subs., 12, 191 (1983),<br></p>

<p>Applications Parathion-methyl is an derivative of Parathion (P192220), an organophosphate insecticide used on cotton, rice and fruit trees. Useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sykes, M., et al.: J. Agri. Food. Chem., 61, 4205 (2013); Sipes, N.S., et al.: Chem. Res. Toxicol., 26, 878 (2013);<br></p>

<p>Applications The dopamine receptors play important role in cognition, memory, learning, and motor control (1). These receptors have been implicated as a therapeutic target for many psychiatric and neurological disorders. R(-)-2,10,11-Trihydroxy-N-propyl-noraporphine Hydrobromide is a potent and selective D2 dopamine receptor agonist (2).<br>References (1) Ptácek, R., et al.: Med Sci Monit. 17, RA215 (2011) (2) Gao, Y. G., et al.: J Med Chem. 33, 1800 (1990)<br></p>

<p>Applications A labelled antihypertensive. Angiotensin converting enzyme (ACE) inhibitor.<br>References Brown, N.L., et al.: Eur. J. Pharmacol., 148, 79 (1988), Kober, L., et al.: N. Engl. J. Med., 333, 1670 (1995), Malik, R.A., et al.: Lancet, 352, 1978 (1998)<br></p>

<p>Applications O-Methyl Atovaquone-13C,d3 is the labeled analogue of O-Methyl Atovaquone (M288300). O-Methyl Atovaquone is a Atovaquone derivative that shows protozoacidal activity against Plasmodium falciparum.<br>References Danoun, S., et. al.: Heterocycl. Commun., 5, 343 (1999)<br></p>

<p>Applications Propineb-d3 is the labeled analog of Propineb (P771450), which is used as a fungicide.<br>References Sharma, I.M., et. al.: J. Mycology Plant Pathology, 44, 92 (2014); Gupta, R.C., et. al.: Pestology, 37, 43 (2013)<br></p>

<p>Applications N-Docosanoyl Taurine is found to activate multiple members of the transient receptor potential (TRP) family of calcium channels, including TRPV1 and TRPV4 which are expressed in kidney.<br>References Saghatelian, A., et al.: Biochem., 45, 9007-9015 (2006)<br></p>

<p>Applications It is an antiepileptic.<br>References Burchall, J., et al.: Mol. Pharmacol., 1, 126 (1965), Cody, V., et al.: J. Med. Chem., 25, 427 (1982)<br></p>

<p>Impurity Abacavir EP Impurity E<br>Applications (1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol (Abacavir EP Impurity E) is an impurity of Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>

<p>Applications LY 364947, is a potent ATP-competitive inhibitor of Tgf-β signaling.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ichida, J.K., et al.: Cell Stem Cell, 5, 491 (2009);<br></p>

<p>Applications Fenitrooxon is an organophosphorus insecticide.<br>References Ellman, G., et al.: Biochem. Pharmacol., 7, 88 (1961), Matthews, W., et al.: Pesticide Sci., 30, 21 (1990), Escartin, E., et al.: Environ. Toxicol. Chem., 15, 915 (1996), Barata, C., et al.: Toxicology, 66, 125 (2004),<br></p>

<p>Applications Prometon-d14 (di-iso-propyl-d14) (CAS# 1219803-45-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications (R)-Diclofop-methyl is a stereo-isomer of Diclofop-methyl(D431555) which isused as the active ingredient in many herbicides that are used to control weed growth in plants such as wheat and wild oats.<br>References Marzouk, E., et al.: J. Appl. Sci. Res., 9, 4907 (2013)<br></p>

<p>Applications Monosulfuron Ester is herbicidal compound containing Monosulfuron-Ester and Nicosulfuron.<br>References Ge, J., et al.: Faming Zhuanli Shenqing, (2018);<br></p>

<p>Applications Penconazole is an conazole based fungicide that works by inhibiting cell membrane ergosterol biosynthesis, thus stopping the development of fungi.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sharma, H., et al.: J. Mycol. Plant. Pathol., 42, 494 (2012); Sen, K., et al.: Food. Chem. Toxicol., 50, 3990 (2012); Pitt, W.M., et al.: Plant Disease., 96, 1303 (2012);<br></p>

<p>Applications 6-Methyl-1,3,5-triazine-2,4(1H,3H)-dione is a metabolite of metsulfuron methyl that has been found in soil.<br>References Ye, Q., Sun, J., Wu, J.: Environ. Pollut., 126, 417 (2003)<br></p>

<p>Applications An achiral intermediate of Voriconazole (V760000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ferretti, R., et al.: Chromatographia, 47, 649 (1998),<br></p>