Toxicología

<p>Applications 1-(2-Chlorophenyl)hydrazine Hyrochloride is the salt form of 1-(2-Chlorophenyl)hydrazine (C375525); a useful research reagent used in the preparation of halogen-substituted phenylhydrazine derivatives with antifungal properties.<br>References Usui, Y., et al.: Yakugaku Zasshi, 87, 43 (1967)<br></p>

<p>Applications 1-(4-(Aminomethyl)naphthalen-1-yl)-N,N-dimethylmethanamine is a potential impurity of Naftifine (N213100), an antimycotic allylamine. An antifungal (topical) agent.<br>References Georgopoulos, A., et al.: Antimicrob. Ag. Chemother., 19, 386 (1981), Meingassner, J.C., et al.: J. Invest. Dermatol., 77, 444 (1981), Paltauf, F., et al.: Biochim Biophys. Acta, 712, 268 (1982), Aggarwal, D., et al.: J. Pharm. Pharmacol., 56, 1509 (2004),<br></p>

<p>Applications Sodium Methanesulfonate-d3,13C is an intermediate used in the synthesis of Methanesulfonyl Chloride-d3,13C (M258847), which is a labeled analogue of Methanesulfonyl Chloride (M258845). Methanesulfonyl Chloride used in the synthesis of phosphodiesterase 9A Inhibitors, used in treatments for Alzheimer’s disease. It is also used in the preparation of sulfonamide derivatives showing antibacterial activity.<br>References Reddy, N. et al.: J. Chem. Sci., 124, 723 (2012); Claffey, M. et al.: J. Med. Chem., 55, 9055 (2012);<br></p>

<p>Applications A metabolite of Alpidem.<br>References Padovani, P., et al.: Eur. J. Drug Metab. Pharmacokinetics, 12, 295 (1987).<br></p>

<p>Applications Emtricitabine Glycosamine is an impurity of Emtricitabine(E525000) which is a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).<br>References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)<br></p>

<p>Applications 2,3,4,6-Tetra-O-acetyl-a-D-galactopyranosyl azide (CAS# 94427-00-6) is a useful research chemical compound.<br></p>

<p>Applications U 75875, is a peptidomimetic inhibitor, that inhibits HIV-1 gag-pol protein. In human peripheral blood mononuclear cells and in a continuous cell line, U-75875 completely blocked HIV replication, so it can be used as therapeutic potential of protease inhibitors for treatment of HIV infection.<br>References Ashorn, P., et al.: Proceedings of the National Academy of Sciences of the United States of America, 87, 7472 (1990);<br></p>

<p>Applications 4-(2-Propyn-1-yloxy) Trimethoprim is an analog of T795615, which is an antibacterial compound and a contaminant of emerging concern (CECs).<br>References Manius, G.J., et al.: Anal. Profiles Drug Subs., 7, 445 (1978), Roth, B., et al.: J. Med. Chem., 23, 379 (1980), Brogden, R.N., et al.: Drugs, 23, 405 (1982),<br></p>

<p>Applications Ganciclovir derivative.<br>References Albers, E., et al.: J. Pharm. Sci., 81, 756 (1992), Dias, C., et al.: J. Pharm. Sci., 91, 6607 (2002), Macha, S., et al.: Drug Metab. Dispos., 30, 670 (2002),<br></p>

<p>Applications (R)-Diclofop-methyl is a stereo-isomer of Diclofop-methyl(D431555) which isused as the active ingredient in many herbicides that are used to control weed growth in plants such as wheat and wild oats.<br>References Marzouk, E., et al.: J. Appl. Sci. Res., 9, 4907 (2013)<br></p>

<p>Applications Fenitrooxon is an organophosphorus insecticide.<br>References Ellman, G., et al.: Biochem. Pharmacol., 7, 88 (1961), Matthews, W., et al.: Pesticide Sci., 30, 21 (1990), Escartin, E., et al.: Environ. Toxicol. Chem., 15, 915 (1996), Barata, C., et al.: Toxicology, 66, 125 (2004),<br></p>

<p>Applications It is an antiepileptic.<br>References Burchall, J., et al.: Mol. Pharmacol., 1, 126 (1965), Cody, V., et al.: J. Med. Chem., 25, 427 (1982)<br></p>

<p>Applications A labelled isotpe of Isopropyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate (I485580). A short-acting intravenous anaesthetic agent used for dislocated joints, tracheal intubation, cardioversion and electroconvulsive therapy.<br>References Goetz, E., et al.: Anaesthesist, 23, 331 (1974), Chang, Z. L., et al.: Anal. Profiles Drug Subs., 12, 191 (1983),<br></p>

<p>Applications 4,4'-Dichlorodiphenyldichloroethane - d8 is a synthetic organochlorine insecticide. 4,4'-Dichlorodiphenyldichloroethane- d8 is a metabolite of 4,4'-Dichlorodiphenyltrichloroethane - d8 (D434197). 4,4'-Dichlorodiphenyldichloroethane - d8 is a probable carcinogen (Group B2).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tao, S. et al.: Environ. Sci. Technol., 39, 2494 (2005); Zhou, Q. et al.: J. Chrom. A, 1216, 6680 (2009); Weiderpass, E. et al.: Cancer Epidemiol. Biomark. Prev,., 9, 487 (2000)<br></p>

<p>Stability Hygroscopic<br>Applications Auristatin F is an antimitotic auristatin derivative that has been shown as a potent antitumor agent.<br>References Doronina S.O., et al.: Bioconjugate Chem., 17, 114-124 (2006);<br></p>

<p>Applications Aminoethoxyvinyl Glycine Hydrochloride is an ethylene synthesis inhibitor that is used as a plant growth regulator.<br>References Tsantili, E., et. al.: Sci. Hortic-Amsterdam, 140, 26 (2012); Cetinbas, M., Butar, S.: Eur. J. Hortic. Sci., 78, 126 (2013); Centibas, M., et. al.: Sci. Hortic-Amsterdam, 147, 1 (2012)<br></p>

<p>Applications N-Arachidonoyltaurine is a polyunsaturated lipid that inhibits the Cav3.3 current in T-type calcium channels.<br>References Cazade, M., et. al.: Mol. Phearmacol., 85, 218 (2014)<br></p>

<p>Applications 1,1'-Sulfonylbis[2-(methylthio)ethane]-d6 is the labelled analgoue of 1,1'-Sulfonylbis[2-(methylthio)ethane] which is an intermediate in synthesizing Bis(methylsulfinylethyl)sulfone (B494850), a sulfur mustard metabolite found in urine.<br>References Black, R., et al.: Xenobiotica, 22, 405 (1992); Li, C., et al.: J. Chromatogr. B, 917-918, 100 (2013);<br></p>

<p>Applications Estradiol 4-Carboxymethyl, is a metabolite of 17β-Estradiol (E888000). Estradiol is the major estrogen secreted by the premenopausal ovary.<br>References Bucala, R., et al.: J. Clin. Endocrinol. Metab., 60, 841 (1985), Telang, N., et al.: Anticancer Res., et al.: 11, 1021 (1991), Seeger, H., et al.: Med. Sci. Res., 26, 481 (1998), Bolton, J., et al.: Chem. Res. Toxicol., 13, 135 (2000),<br></p>

<p>Applications 7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-[(carboxymethoxy)imino]acetyl]amino]-cefixime is a cefixime impurity. Cefixime (C242800) is an orally active, third generation cephalosporin antibiotic.<br>References Kamimura, T., et al.: Antimicrob. Agents Chemother., 25, 98 (1984),Yamanaka, H., et al.: J. Antibiot., 38, 1738 (1985), Guay, D.R.P., et al.: Antimicrob. Agents Chemother., 30, 485 (1986),<br></p>

<p>Applications Propachlor is an acylanilide herbicide that is used to maintain crop protection from weeds. Propachlor is also known to induce Glutathione (G597951)-dependent cytotoxicity and sister chromatid exchanges in human cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bartha, R. &amp; Pramer, D.: Adv. Appl. Microb., 13, 317 (1970); Dierickx, P.: Cell Biol. Toxicol., 15, 325 (1999); Hill, A., et al.: Mut . Res.-Gen. Tox. En., 295, 159 (1997); Novick, N., et al.: J. Agr. Food Chem., 34, 721 (1986); Robert, H. &amp; Bond, W.: Weed Res., 15, 195 (1975); Villarreal, D. &amp; Turco, R.: Appl. Env. Microb., 57, 2135 (1991)<br></p>

<p>Applications Iprovalicarb is a systematic fungicide. Iprovalicarb is used for the control of pathogenic fungi from the oomycetes class in grapes, potatoes, tomatoes and other crops.<br>References Stubler, D. et al.: Pflanzensch.-Nach. Bay., 52, 33 (1999); Stenzel, K. et al.: Bright. Crop Prot. Conf. Pests Dis., 2, 367 (1998);<br></p>

<p>Applications Febuxostat 67M-1 is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and also used to reduce the risk of gout or kidney stone formation.<br>References Du, J., et al.: Handbook of Metabolic Pathways of Xenobiotics, 4, 1395 (2014)<br></p>

<p>Applications Nifluridide also known as L-27 reduces the growth and metastasis of MCF-7 tumor cells in xenografts models and thus may provide a new therapeutic approach for the treatment of breast and other types of cancer. A potential KGFR tyrosine kinase inhibitor. Nifluridide is also used in several pesticidal and insecticide compositions.<br>References Kesinger, J. W., et al.: Anticancer Res., 35, 47 (2015); Borth, P. W., et al.: J. Econ. Entomol., 79, 1632 (1986)<br></p>

<p>Applications (S)-6-Hydroxywarfarin is the S-enantiomer of the 6-hydroxyl metabolite of Warfarin (W498500).<br>References Wong, Y.W.J. et al.: Pharm. Res., 6, 982 (1989); O'Reilly, R.A. et al.: Clin. Pharmacol. Ther., 51, 656 (1992);<br></p>

<p>Applications Labelled Asenapine. Asenapine is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist; structurally related to Mianserin. Antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Meltzer, H. et al.: J. Pharmacol. Exp. Ther., 251, 238 (1989); Schotte, A. et al.: Brain Res., 631, 191 (1993); Andree, B. et al.: Psychopharmacology, 131, 339 (1997); Richelson, E. et al.: Life Sci., 68, 29 (2000);<br></p>

<p>Applications An additive which contributes spiciness to foods. This compound is also often used as a regent in the preparation of its reduced alcohol, a compound commonly used in perfumery.<br>References Hardcastle, I., et al.: Biochem. Pharmacol., 57, 801 (1999), Mookdasanit, J., et al.: Food Sci. Technol. Res., 8, 367 (2002), Jang, Y., et al.: J. Agric. Food Chem., 53, 7892 (2005),<br></p>

<p>Stability Hygroscopic<br>Applications 3-[N-(2-Carboxyethyl)methylamino]-7-[N-ethyl(3-sulfonatopropyl)amino]phenoxazin-5-ium sodium is a fluorescent dye for covalent labeling.<br></p>

<p>Applications Perampanel-d5, is the labeled analogue of Perampanel (P285520), an antiepileptic drug.<br>References Shih, J., et al.: Therap. Clinical Risk Management, 9, 285 (2013); Rogawski, M. A., et al.: Epilepsy Curr., 11, 56 (2011);<br></p>

<p>Applications A metabolite of Clopidogrel.<br></p>

<p>Applications Intermediate in the preparation of labelled Calindol<br></p>

<p>Applications Labelled Hydroxy Atrazine (H828600). Hydroxy Atrazine is a major metabolite of Atrazine (A794600).<br>References Thurman, E., et al.: Environ. Sci. Technol., 26, 2440 (1992), Evgenidou, E., et al.: J. Agric. Food Chem., 50, 6423 (2002), Namiesnik, J., et al.: Anal. Bioanal. Chem., 381, 279 (2005), Hultgren, S., et al.: Anal. Bioanal. Chem., 393, 929 (2009),<br></p>

<p>Applications Labelled Clonazepam (C587080) metabolite.<br>References Huang, W., et al.: J. Anal. Toxicol., 19, 333 (1995), Rittner, M., et al.: J. Anal. Toxicol., 25, 115 (2001),<br></p>

<p>Applications Tetrahydrophthalic Acid is a plasticizer; used in preparation method of concrete coating. Also, used in preparation method of polyester resin for two-piece can ink.<br>References Mao, X., et al.: Faming Zhuanli Shenqing, (2020); Zhang, L., et al.: Faming Zhuanli Shenqing, (2020);<br></p>

<p>Applications is the labeled analogue of Cyprodinil (C989060), which is a a broad-spectrum fungicide of the class of pyrimidinamines. It is commonly used for protection of cereal crops and fruits against fungal infections.<br>References Heye, U.J. et al.: Bright. Crop Prot. Conf., Pests Dis., 2, 501 (1994); Boric, B. et al.: Pesticidi, 12, 277 (1997); Knauf-Beiter, G. et al.: Plant Dis., 79, 1098 (1995);<br></p>

<p>Applications 2,5-Bis(Trifluoromethyl)Nitrobenzene (cas# 320-88-7) is a useful research chemical.<br></p>

<p>Stability Unstable in Solution<br>Applications Cefathiamidine is an antibacterial agent that exhibits a broad spectrum of bactericidal activity against gram-positive bacteria.<br>References Chen, H.Y., et al.: J. Antimicrob. Chemother., 12, 19 (1983); Philpott-Howard, J., et al.: Scand. J. Infect. Dis. Suppl., 39, 109 (1983); Chen, H.Y., et al.: J. Med. Microbiol., 23, 141 (1987);<br></p>

<p>Applications Triadimenol-d4 (4-chlorophenoxy-d4) (mixture of stereoisomers) (CAS# 2121989-56-6) is a useful isotopically labeled research compound.<br></p>

<p>Stability Light Sensitive<br>Applications (1R,​3S)​-3-​(2,​2-​Dichloroethenyl)​-​2,​2-​dimethylcyclopropanecarboxam​ide is a useful research chemical.<br></p>

<p>Applications 2,5-Dichlorophenol-d3 is the labelled analogue of 2,5-Dichlorophenol (D436105), which is an intermediates in the manufacture of more complex chemical compounds such as fungicides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, F., et al.: Bull. Enviro. Contamin. Toxicol., 89, 316 (2012); Zhong, W., et al.: J. Hazard. Mat., 217, 286 (2012);<br></p>

<p>Applications 11-Hydroxytestosterone-[9,11,12,12-2H4] is a metabolite of Testosterone (T155000), a principal hormone of the testes, produced by the interstitial cells.<br>References McFarland, K., et al.: Science, 245, 494 (1989), Heckert, L., et al.: Mol. Endocrinol., 12, 1499<br></p>