Compuestos y reactivos bioquímicos

<p>Antagonist of neuropeptide receptor Y1</p>

<p>CIN16645 is a peptide inhibitor of protein interactions. It has been shown to bind to the receptor and inhibit the activation of ion channels, which are proteins that form pores in cell membranes to allow ions to pass through. CIN16645 is a ligand for the receptor and can be used as a research tool for studying ion channels. The purity of this product is high, with no detectable impurities. This product is intended for use in life sciences research applications, such as antibody production and cell biology research.</p>

<p>Sparstolonin B is a natural anti-inflammatory compound, which is derived from the Chinese herb *Sparganium stoloniferum*. It primarily functions as a selective antagonist of Toll-like receptors 2 and 4 (TLR2 and TLR4), thereby inhibiting the activation of these pathways which are crucial in mediating inflammatory responses.</p>

<p>This activated peptide-cleavable linker has an extended functionality linked to the Gly in the peptide sequence. This is quite useful in conjugation in enzymatically cleavable environments inside target cells for controlled release of the drug or payload.</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Please enquire for more information about PSY1 Precursor Peptide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>IRAK4-IN-1 is a small molecule inhibitor, which is a synthetic compound designed to interfere with specific biological pathways. This product originates from extensive chemical synthesis and medicinal chemistry efforts, aimed at targeting key components of the immune signaling cascade. Its primary mode of action involves selective inhibition of interleukin-1 receptor-associated kinase 4 (IRAK4), a crucial kinase in the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) pathway. By inhibiting IRAK4, IRAK4-IN-1 effectively downregulates downstream inflammatory signaling processes.</p>

<p>Mots-C acetate salt form</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Monoclonal antibody against RANKL; anti-resorptive agent for osteoperosis treatment</p>

<p>Policosanol is a natural substance that is obtained from sugar cane. It is a mixture of various alcohols, including octacosanol, hexacosanol, heptacosanol, and octacosanol. Policosanol has been studied for its potential to treat high cholesterol levels in the blood by reducing low-density lipoprotein-cholesterol (LDL-C) and triglycerides. Animal studies have shown that policosanol can lower LDL-C and reduce the risk of heart disease by preventing the formation of plaque in the arteries. Policosanol also reduces the risk of heart attack and stroke by lowering blood pressure and decreasing platelet aggregation. It may also be used as an antioxidant or anti-inflammatory agent.</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

D-Val-Leu-Lys-p-nitroanilide is a selective colorimetric substrate for plasmin used to determine plasmin formation from plasminogen in amidolytic activity assays and plasminogen activating assays. Plasmin is a plasma serine protease whose main role is to dissolve fibrin blood clots. After cleavage by plasmin, the protease activity is quantified by the release of p-nitroaniline (pNA) from the substrate.

<p>CJC-1295-no DAC acetate is a synthetic peptide, which is a modified form of the growth hormone-releasing hormone (GHRH) analog, derived from recombinant sources. Its mode of action involves binding to the growth hormone secretagogue receptor, thereby promoting the release of growth hormone from the anterior pituitary. This mechanism of action facilitates the increase of circulating insulin-like growth factor 1 (IGF-1), enhancing various physiological processes.In scientific research, CJC-1295-no DAC acetate is primarily utilized to study its potential effects on muscle growth, body composition, and overall metabolic function. It is also used to explore its ability to modulate the aging process through growth hormone pathways. Unlike its counterpart with DAC, this variant has a shorter half-life, thus allowing researchers to examine the temporal effects of pulsatile GH release. Furthermore, its applications extend to understanding disorders related to growth hormone deficiencies, contributing valuable insights into therapeutic strategies for such conditions. The peptide serves as an important tool in endocrinology research, providing a platform for studying the complex interactions between hormonal regulation and physiological outcomes.DAC is 'drug affinity complex' and in this peptide works by not having a lysine at the end of the sequence.</p>

<p>Key subunit of extracellular plaques found in the brains of patients with Alzheimer's disease; Hydrochloride salt</p>

<p>Trehalose 6-decanoate is a specialized sugar ester, which is a derivative of the disaccharide trehalose. It is synthesized typically through esterification processes involving enzymatic or chemical methods, where a decanoic acid chain is introduced to the trehalose molecule. This modification results in altered physicochemical properties compared to the native sugar.</p>

<p>Please enquire for more information about Gly-Amyloid b-Protein (15-25)-Gly-epsilon-aminocaproyl(-Lys)6 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>YKL-5-124 is an inhibitor that binds to the receptor site on the membrane of cells. It blocks the activation of ion channels, which is needed for cell communication and movement. YKL-5-124 is an antibody that can be used as a research tool to study protein interactions in cell biology. This drug has a molecular weight of 5,124 daltons and CAS Number 1957203-01-8.</p>

<p>(1-Adamantaneacetyl1,D-Tyr(Et)2,Val4, Abu 6, Arg8·9)-vasopressin is a vasopressor analog that has been shown to be an effective treatment for congestive heart failure by acting as an agonist at the V1 receptor. It has been shown to stimulate cyclase activity and increase levels of adenosine 3',5'-cyclic monophosphate (cAMP). This drug also stimulates the production of immunoglobulin A antibodies in mice and increases the expression of leucine aminopeptidase and immunofluorescence in rat kidney cells. Vasopressin analogs are used primarily for their vasoconstrictive properties.</p>

<p>Please enquire for more information about Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-aldehyde trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Amyloid beta-Protein (1-43) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Mca-(Asn670,Leu671)-Amyloid beta/A4 Protein Precursor770 (669-674)-Lys(Dnp) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Amyloid b-Protein (6-20) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Amyloid beta-Protein (1-46) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Amyloid Dan Protein (1-34) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about FITC-epsilonAhx-Amyloid b-Protein (1-42) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Ac-Ala-Ala-Ala-pNA is a synthetic peptide that is derived from the natural amino acid sequence of cholecystokinin. It has been shown to have high affinity for phospholipid bilayers, which are lipid membranes that form the boundaries of cells and organelles. Ac-Ala-Ala-Ala-pNA can be used as a substrate molecule to study membrane permeability and selectivity in bioreactors. Ac-Ala-Ala-Ala-pNA also acts as a modulator of liposomal membranes, increasing the permeability of these membranes in order to allow more substrate molecules to pass through them.</p>

<p>Please enquire for more information about Mca-Pro-Leu-Gly-Leu-Dap (Dnp)-Ala-Arg-NH2 trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Dengue Virus Type 1 Envelope Antigen, Recombinant including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about H-Gly-2-chlorotrityl resin (200-400 mesh) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Nle-Leu-Phe-OH is a potent colony-stimulating factor that binds to the receptor on the surface of cells and stimulates the production of white blood cells. Nle-Leu-Phe-OH has been shown to induce actin filament formation, which is necessary for cell movement. It also induces cytosolic calcium release and enhances protein synthesis. Nle-Leu-Phe-OH also binds to phosphatase and inhibits its activity, which may be due to a conformational change in the enzyme. This process is necessary for the synthesis of DNA and other proteins from amino acids. Nle-Leu-Phe-OH also causes an increase in the uptake of Ca2+ ions by cells.</p>

<p>Rec FGF basic (human) is a human recombinant growth factor that has been shown to be effective in the treatment of life-threatening conditions. Rec FGF basic (human) stimulates the proliferation of various tissue cells, including butyric acid, which are found in abdominal and intestinal tissues. Rec FGF basic (human) also promotes the synthesis of collagen, a protein that is important for healthy skin and vascular walls. Rec FGF basic (human) has been shown to inhibit platelet-derived growth factor and estradiol production, which may be beneficial in the treatment of breast cancer. Rec FGF basic (human) has also been shown to stimulate tissue plasminogen activator production, which prevents blood clot formation and helps dissolve blood clots that have already formed.</p>

<p>Please enquire for more information about (Arg13)-Amyloid b-Protein (1-40) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Amyloid Dan Protein (1-34) (reduced) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

Please enquire for more information about (Cyclo(Glu22-Lys26),Leu27)-pTH (1-31) amide (human) including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>C11 Bodipy 581/591 is an inhibitor used in cancer research to study the effects of protein kinase inhibitors on tumor cells. This fluorescent analog is used to track the activity of cyclin-dependent kinases, which are involved in cell cycle regulation and apoptosis. C11 Bodipy 581/591 has been shown to be effective at inhibiting the growth of human cancer cells and inducing apoptosis. It is also used as an anticancer agent in Chinese medicine. This inhibitor can be detected in urine samples, making it a valuable tool for non-invasive cancer diagnosis and monitoring. Overall, C11 Bodipy 581/591 is a promising compound for cancer research due to its potent inhibitory effects on cancer cell growth and proliferation.</p>

<p>O-(3-Hexyl) dabigatran ethyl ester is an analog of dabigatran, a potent inhibitor of human thrombin. It has been shown to have anticancer properties by inducing apoptosis and inhibiting the cell cycle in Chinese hamster ovary cells. This compound has also demonstrated promising results in inhibiting tumor growth in mice with cancer. O-(3-Hexyl) dabigatran ethyl ester is a protein kinase inhibitor that may be useful as a medicinal agent for the treatment of cancer. Its bioavailability can be measured by analyzing urine samples to determine its pharmacokinetic profile. Overall, this compound shows great potential as an effective anticancer agent with further research needed for clinical applications.</p>

<p>Please enquire for more information about 5-TAMRA-Amyloid beta-Protein (1-42) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Amyloid beta-Protein (1-11) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Saridegib is a novel, potent and selective inhibitor of the protein kinase C-epsilon (PKC-epsilon). Saridegib has been shown to inhibit the activity of PKC-epsilon in vitro. PKC-epsilon is expressed in high levels in metastatic pancreatic cancer cells, which are resistant to conventional chemotherapy. Saridegib inhibits cancer cell growth and survival by blocking the production of inflammatory cytokines such as interleukin-1beta (IL-1β) and tumor necrosis factor alpha (TNFα). Saridegib also inhibits human skin cancer cells by inhibiting the production of IL-8 and TNFα. This drug has also been shown to be effective against inflammatory diseases such as rheumatoid arthritis and psoriasis.</p>

<p>Please enquire for more information about (Nle 35)-Amyloid b-Protein (25-35) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (Lys22)-Amyloid b-Protein (1-40) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Amyloid beta/A4 Protein Precursor770 (586-595) (human, mouse, rat) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (Val34)-Amyloid b-Protein (1-40) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (667-676) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

Please enquire for more information about Insulin B (22-25) including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>Acetyl-(Pro18,Asp21)-Amyloid b-Protein (17-21) amide is a peptide that was generated by incubating β-amyloid with the protease papain. This peptide has been shown to induce population and biochemical changes in cells, including focusing of β-amyloid aggregates. It also induces reactive oxygen species and promotes extracellular protofibril formation. Acetyl-(Pro18,Asp21)-Amyloid b-Protein (17-21) amide is a conjugate of acetylated lysine residues and amyloid β-protein that can be used as an anti-amyloid therapeutic. The peptide is characterized by dichroism spectroscopy, which has revealed its specific binding to the fibrils' surface.</p>

<p>Please enquire for more information about Cys-Gly-His-Gly-Asn-Lys-Ser-Amyloid b-Protein (33-40) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Amyloid Bri Protein Precursor277 (89-106) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about ([13C6]Leu6)-Endothelin-1 (human, bovine, dog, mouse, porcine, rat) acetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about N-Me-Abz-Amyloid beta/A4 Protein Precursor770 (708-715)-Lys(Dnp)-D-Arg-D-Arg-D-Arg amide trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (Asn670, Sta671,Val672)-Amyloid b/A4 Protein Precursor770 (662-675) ammonium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Amyloid beta-Protein (1-40) (scrambled) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>PFK-158 is a novel compound with potent antimicrobial activity that inhibits the growth of bacteria by inhibiting mitochondrial membrane potential and reducing the synthesis of ATP. PFK-158 has been shown to be effective against antibiotic resistant strains of bacteria in vitro, including colistin resistant Gram-negative bacteria such as Acinetobacter baumannii. This drug also has been shown to suppress tumor growth in vivo and inhibit cancer cell proliferation. PFK-158 has pharmacokinetic properties that are favorable for oral administration and it does not appear to have any toxicity in animals.</p>

<p>Please enquire for more information about Amyloid Bri Protein (1-23) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Amyloid beta/A4 Protein Precursor770 (667-676) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Cys-Gly-Lys-Lys-Gly-Amyloid b-Protein (36-42) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Mca-(Asn670,Leu671)-Amyloid beta/A4 Protein Precursor770 (667-675)-Lys(Dnp) amide ammonium salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Heat shock protein 90 (HSP90) inhibitor</p>

<p>Please enquire for more information about (Gly21)-Amyloid b-Protein (1-40) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>HMG-CoA reductase antagonist</p>

<p>Perakine is an indole alkaloid, which is a naturally occurring compound obtained primarily from the plant Rauvolfia species. As an indole alkaloid, it is synthesized through complex biosynthetic pathways within the plant, involving the secondary metabolism that characterizes many biochemical systems in flora.</p>

<p>Inhibitor of calpain, a calcium-dependent cysteine protease which is implicated in the calcium-mediated processes such as apoptosis and neuronal membrane excitability. Calpain inhibitor XII has antiviral properties as it can inhibit the main protease Mpro (3CLpro) from SARS-CoV-2 with IC50 of 0.45 μM.</p>

<p>Please enquire for more information about DABCYL-(Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (661-675)-EDANS ammonium salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (Arg17)-Amyloid b-Protein (1-42) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Inhibitor of protein tyrosine phosphatase PTP1B</p>

<p>Bremelanotide is a synthetic cyclic peptide, classified as a melanocortin receptor agonist. It is derived from the analogs of the alpha-melanocyte-stimulating hormone (α-MSH), with its origins in melanocortin system research. This product acts primarily through the activation of melanocortin 4 receptor (MC4R) pathways in the central nervous system.Bremelanotide exerts its physiological effects by stimulating these receptors, leading to increased neural signals related to sexual arousal and desire. The melanocortin receptors, especially MC4R, play a significant role in modulating various neural networks involved in sexual function.This compound is utilized primarily for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. By enhancing sexual desire and arousal, Bremelanotide provides a therapeutic option for individuals experiencing clinically significant distress related to low sexual desire. Its application in clinical settings highlights the potential of melanocortin pathways as therapeutic targets beyond their established roles in pigmentary and energy balance modulation.</p>

<p>Sovateltide is a peptide that is composed of 21 amino acids. It is an agonist of the endothelin receptors ET A and ET B. Succinyl-(Glu9,Ala11·15)-Endothelin (8,21) Sovateltide has been shown to be neuroprotective in preclinical studies and may have potential as a therapeutic agent for the treatment of radiation damage to the brain.</p>

<p>Please enquire for more information about Amyloid b-Protein (1-40) amide trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>A carboxyl-terminal cleavage product of collagen 6 alpha-3 chain which is produced and released by adipocytes and massively upregulated in malignant tumors of breast, liver colon and pancreas. Endotrophin provides a link between obesity and aggressive tumor growth and may serve as sensitive diagnostic marker and valid therapeutic target for designing better strategies to treat cancer and ameliorate obesity-induced insulin resistance.</p>

<p>Methyl-d3-magnesium iodide solution, 1.0 M in diethyl ether, is a specialized organometallic reagent used extensively in synthetic chemistry. This compound is a labeled Grignard reagent, where the methyl group is fully deuterated. It is sourced through the synthesis involving the reaction of deuterated methyl iodide with magnesium in an anhydrous diethyl ether solvent.</p>

PRGL493 is a synthetic peptide that binds to the ion channel TRPC1 and inhibits its activity. It is used as a research tool in pharmacology, cell biology, and protein interactions. PRGL493 has been shown to inhibit the activation of TRPC1 by calcium ions, thereby inhibiting calcium-dependent signaling pathways. This drug also binds to and inhibits the function of other ion channels such as TRPC4, TRPV2, TRPV3, TRPM8, and TRPA1. PRGL493 is supplied as a lyophilized powder at 5mg per vial. The purity of this product is >98% by HPLC analysis.br> PRGL493 can be reconstituted with sterile water or buffer to produce a concentration of 10 µg/mL or 20 µg/mL in appropriate buffers.br> The reconstituted material should be stored at -20°C for no more than one month

<p>R788 (Fostamatinib) Disodium is a drug that is used for the diagnosis of autoimmune diseases. It inhibits the activity of tyrosine kinases, which are enzymes that transmit signals in cells. Fostamatinib disodium has been shown to inhibit T-cell lymphomas in vivo and has been shown to have significant cytotoxicity against various leukemia cell lines. In vitro studies have shown that this drug is an inhibitor of effector proteins such as leukemia inhibitory factor and protein kinase C. The oral prodrug of R788 (fostamatinib) disodium has been found to be absorbed rapidly and to be glucuronide conjugated in humans. This drug also has pharmacokinetic properties that can be used to monitor its exposure in patients with autoimmune diseases and t-cell lymphomas.</p>

<p>2-Epi-darunavir is a peptide that acts as an activator of the HIV-1 protease. It has been shown to be a potent inhibitor of HIV-1 protease, with IC50 values in the low nanomolar range. The 2-Epi-darunavir peptide binds to the active site of HIV-1 protease, blocking access by other molecules and preventing cleavage at the P1' position on the substrate. This results in a conformational change that prevents its interaction with the binding site on HIV-1 gp41. The 2-Epi darunavir peptide also inhibits protein interactions with ion channels and receptor proteins, which may inhibit cellular processes such as cell proliferation and apoptosis.</p>

<p>ML 193 is a synthetic cannabinoid that binds to the CB2 receptor. It has been shown to reduce pain in animal models and may act by modifying nerve transmission in the spinal cord. ML 193 has also been shown to be a potent inhibitor of protein synthesis, which may contribute to its analgesic properties. The molecular modeling of ML 193 revealed that it is structurally similar to the endocannabinoid anandamide, which also inhibits protein synthesis. This similarity may account for its inhibition of protein synthesis and subsequent analgesic effects.</p>

<p>Budralazine is a synthetic vasodilator, which is derived from a series of hydrazine analogs, known for their ability to modulate vascular tone. Its mode of action involves the direct relaxation of vascular smooth muscle. This relaxation leads to a decrease in peripheral vascular resistance and, consequently, a reduction in blood pressure. Intriguingly, Budralazine is thought to selectively target arterioles over veins, making it of particular interest in the study of vascular dynamics and hypertension.</p>

<p>KUNB31 is a synthetic enzyme inhibitor, which is an engineered compound designed to interfere with the activity of specific enzymes in various biochemical pathways. This product is synthesized through a series of complex chemical reactions, ensuring high specificity and activity against target enzymes. Its mode of action involves binding to the active sites of enzymes, thereby preventing substrates from interacting and altering enzymatic activity.</p>

PSI 7411 is a molecule that inhibits the synthesis of RNA. This activity may be due to its ability to bind to the enzyme fatty acid synthase and inhibit the enzyme's activity. PSI 7411 has also been shown to reduce protein synthesis in herpes simplex virus, which has been shown to reduce replication of the virus. PSI 7411 also inhibits protein synthesis in rat liver microsomes, which may be due to its binding to an enzyme called uridine kinase and preventing it from catalyzing reactions. PSI 7411 binds with high affinity to replicon cells and can inhibit replicon growth by interfering with RNA polymerization.

<p>Please enquire for more information about IL-1 Receptor Peptide (human) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Rocilinostat (ACY-1215) is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity.</p>

<p>BC2059 is a cytosolic calcium ionophore that binds to the extracellular domain of the survivin protein, which regulates cellular proliferation and differentiation. BC2059 has been shown to inhibit the proliferation of bone cancer cells in vitro. It also inhibits the proliferation of metastatic colorectal cancer cells by binding to cyclin D2. The drug is not toxic to normal cells with low expression of survivin or cyclin D2, and it can be used for treatment in conjunction with surgery or chemotherapy for solid tumours.</p>