Compuestos y reactivos bioquímicos

<p>Ck2 Inhibitor 10 is an inhibitor of protein kinase C-2 (PKC-2) that is used for research purposes. It is a potent, selective, and competitive inhibitor of PKC-2 with IC50 of 6 nM. The compound has been shown to inhibit PKC-2 in the presence of calcium ions and to inhibit PKC-2 activity at low micromolar concentrations in vitro. This inhibitor can be applied as a tool in cell biology to study the role of PKC-2 in various cellular processes such as proliferation, differentiation, and apoptosis.</p>

<p>Y-33075 dihydrochloride is a potent selective Rho-associated kinase (ROCK) inhibitor, which is synthesized chemically. It specifically targets ROCK enzymes involved in the regulation of the cytoskeleton by phosphorylating proteins that control smooth muscle contraction, cell migration, and other critical cellular processes. Y-33075 dihydrochloride works by inhibiting the ROCK pathway, leading to alterations in cell shape, motility, and apoptosis.</p>

<p>VPC 01091 is a peptide that binds to the C-terminus of calcium channels, inhibiting their activity. It has been shown to be a potent inhibitor of voltage-gated ion channels in mammalian cells. VPC 01091 may also act as an activator for some ligand-gated ion channels and receptor tyrosine kinases.</p>

<p>9-Cyclopropyl-3-phenanthrenecarboxylic acid (CPPC) is a potentiating agent that enhances the effects of other drugs. It has been shown to have inhibitory effects on acetylcholinesterase, which is an enzyme that breaks down the neurotransmitter acetylcholine. CPPC also has potentiating effects on the binding of naphthalene, a potent regulatory agent. This drug has been shown to have a number of pharmacological activities such as potentiation, inhibition, and regulation, depending on the receptor subtype it binds with. It is also used in treatment for depression, although its mechanism of action is not fully understood.</p>

<p>Inhibitor of calcium-activated potassium channels</p>

<p>CI 976 is a lipid-lowering agent that inhibits the synthesis of fatty acids and cholesterol. CI 976 inhibits the enzyme activity of acyl-coenzyme A:cholesterol acyltransferase and 3-hydroxy-3-methylglutaryl coenzyme A reductase, which are involved in the synthesis of cholesterol. CI 976 is also an inhibitor of the uptake of glucose, which may be due to its effects on phospholipid membranes. CI 976 has been shown to inhibit the growth factor receptor tyrosine kinase activity in thp-1 cells and it decreases uptake by inducing receptor activity. Furthermore, CI 976 has been shown to have antiatherogenic properties in atherosclerotic lesion models by inhibiting cholesterol esterase activity.</p>

<p>1-Desoxymethylsphingosine is a synthetic compound, which is derived from sphingosine analogs, designed for research purposes. As a chemical entity, it is typically synthesized in laboratories specializing in lipid chemistry. The mode of action of 1-Desoxymethylsphingosine involves the inhibition of enzymes involved in sphingolipid metabolism, primarily targeting the sphingosine kinase pathway. This inhibition affects the regulation of bioactive sphingolipids, which play crucial roles in cell signaling and apoptosis.</p>

<p>RMC-0331 is an anticancer protein that has been shown to inhibit the growth of cancer cells in vitro. It is a potent inhibitor of kinase activity and has been found to induce apoptosis in various types of cancer cells, including those from Chinese hamster ovary (CHO) and human tumor cell lines. RMC-0331 is an analog of linezolid, a drug used to treat bacterial infections, and has been shown to have potent anticancer activity in animal models. This drug may be useful for the treatment of various types of cancer and could potentially be used in combination with other kinase inhibitors or chemotherapy agents. RMC-0331 can be detected in urine samples and may serve as a biomarker for monitoring the efficacy of this drug in cancer patients.</p>

<p>Darbufelone mesylate is a non-steroidal anti-inflammatory drug that belongs to the group of fatty acid derivatives, and it has been shown to be effective against chronic bronchitis. It has also been shown to inhibit the production of leukotrienes and prostaglandins, which are mediators of inflammation. Darbufelone mesylate inhibits the synthesis of leukotrienes by blocking the action of cyclooxygenase-2 (COX-2) and adenosine receptors. This drug is also used in cancer treatment, although its effects on tumor cells are not well understood.</p>

<p>CMPDA is a monoclonal antibody that binds to activated dasatinib, which is an epidermal growth factor receptor tyrosine kinase inhibitor. CMPDA blocks the binding of dasatinib and other therapeutic agents to their receptor targets, thereby inhibiting cancer cell growth. In addition, it has been shown to reduce inflammation in mouse models of inflammatory bowel disease. CMPDA also inhibits angiogenesis by binding to the erythropoietin receptor and blocking the production of vascular endothelial growth factor (VEGF). This agent has been shown to have a strong inhibitory effect on fungal biomass.</p>

<p>1-[11-(Dodecylamino)-10-hydroxyundecyl]-3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione is a ligand that binds to the α1A receptor. It is a potent activator of this receptor and has been shown to be a useful tool for the study of this receptor. 1-[11-(Dodecylamino)-10-hydroxyundecyl]-3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione is also an inhibitor of ion channels. This drug inhibits voltage gated sodium channels in rat brain cells and blocks the release of acetylcholine at the neuromuscular junction in rats. 1-[11-(Dodecylamino)-10-hydroxyundecyl]-3,7-dihydro-3</p>

<p>Sofpironium bromide is a ligand that binds to ion channels and is used as a research tool. It is used in cell biology and immunology to study protein interactions, receptor pharmacology, and ion channels. Sofpironium bromide is also used as an inhibitor of the potassium channel Kv1.4 and has been shown to inhibit the proliferation of human cancer cells.</p>

<p>IN 1130 is a molecule that has been shown to have antimicrobial effects against bacteria. It has been observed to inhibit the growth of prostate cancer cells, as well as decrease the disease activity of abdominal surgery patients. The mechanism of action is not fully understood, but it is hypothesized that IN 1130 is a growth factor-β1 agonist that inhibits the proliferation of tumor cells by binding to its receptor and activating intracellular signaling pathways. IN 1130 has also been shown to exhibit an effect on hematopoietic cells in vitro, with potential applications in pediatric and optical sensor technology. In addition, IN 1130 has been observed to be effective in treating cervical cancer with hydroxyl groups on the molecule that can react with histochemical stains.</p>

<p>Please enquire for more information about Sumatriptan-d6 (succinate) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Noremopamil is a ligand that binds to the nicotinic acetylcholine receptor, which is found in the brain. It is used as a research tool for studying protein interactions and as an inhibitor of ion channels. Noremopamil has been shown to be an effective activator of the nicotinic acetylcholine receptor and has been used to study its function in the central nervous system. It also has been shown to inhibit potassium channels, which are important for regulating membrane potentials.</p>

<p>Galloflavin potassium is a peptide that is used as a research tool in the fields of cell biology, pharmacology, and immunology. It has been shown to be an inhibitor of ion channels and receptors, which can lead to a variety of biological effects. Galloflavin potassium has been shown to activate the receptor for acetylcholine, causing the release of neurotransmitters at neuromuscular junctions. Galloflavin potassium also has an affinity for the nicotinic acetylcholine receptor in muscle cells, which may be related to its ability to increase muscle contractions.</p>

<p>(+)-Azasetron hydrochloride is a chemical compound known as a 5-HT3 receptor antagonist, which is synthesized through chemical processes. Its primary mode of action involves the selective inhibition of the serotonin 5-HT3 receptor, located in both the central and peripheral nervous systems. This block prevents serotonin from binding to its receptor, which is a crucial step in the emetic response—a physiological reaction that leads to nausea and vomiting.</p>

<p>Opigolix is a peptide that binds to the receptor site of ion channels, thereby initiating changes in cell membrane potential. It activates ligand-gated ion channels by binding to the receptor and inducing conformational changes in the channel protein. Opigolix has been shown to inhibit calcium flux in cells, and has been used as a research tool for studying the effects of ion channel activation on cell migration.</p>

<p>ENMD-1198 is a novel analog of the naturally occurring molecule endostatin. It has been shown to inhibit endothelial cell proliferation in vitro, but it is not yet known whether this effect will translate to clinical efficacy. ENMD-1198 is currently undergoing phase I and II clinical trials for the treatment of breast cancer, prostate cancer, and other cancers. The drug has been shown to be well tolerated at doses up to 10 mg/kg, with no significant adverse reactions reported.</p>

<p>BMS-8 is a monoclonal antibody that binds to the death ligand, TNF-α. It has been shown to be effective in treating cancer cells that have an overactive PD-1 pathway, which leads to cell death by inhibiting the production of proteins vital for cell division. BMS-8 has also been shown to inhibit the activity of ctla-4 and pd-l1, molecules that are involved in the TNF-α pathway. The binding of BMS-8 to these molecules has been shown to inhibit their activation and downstream signaling pathways.</p>

<p>5-Chloro-2- (4-methoxyphenyl) -4-methyl-6-[3-(1-piperidinyl) propoxy] pyrimidine is a research tool that can be used in the study of ion channels and protein interactions. It has been shown to inhibit the activity of human recombinant beta 2 adrenergic receptor at low micromolar concentrations, with an IC50 of 5.1±0.5 μM. The binding affinity for this ligand is stronger than that of propranolol (IC50=8.5±0.7 μM).</p>

<p>S 24795 is a potent allosteric modulator of nicotinic acetylcholine receptors. S 24795 has been shown to potentiate the activity of both nicotinic acetylcholine receptor subtypes, α7 and α4β2. It has been shown to inhibit synaptic dysfunction in vivo and improve cognitive function in animal models. This drug has a short half-life, which may be due to its inability to cross the blood brain barrier.</p>

<p>An Alpha-2-antiplasmin heavy tryptic peptide standard for protein identification and quantitation studies. Alpha-2-antiplasmin is a serine protease inhibitor of plasmin, an enzyme involved in fibrinolysis.</p>

<p>MF-438 is a novel chemical catalyst, which is synthesized from specialized organic compounds. Functioning as a highly effective facilitator in chemical reactions, it accelerates reaction rates without being consumed in the process. This catalyst operates at a molecular level, optimizing the energy profile of reactions and thereby increasing yield and efficiency.</p>

Ditazole is a ligand that binds to ion channels. It is used in research as a tool to study the interaction of receptors and neurotransmitters with ion channels. Ditazole has been shown to inhibit the activation of voltage-gated potassium channels, which are involved in the transmission of nerve impulses. Ditazole is also an inhibitor of protein interactions, including those between peptides and antibodies.

<p>DU125530 is a serotonergic drug that acts as a 5-HT4 receptor agonist. It has been shown to have antidepressant effects in mice, and is being developed for the treatment of depression. DU125530 can be used to inhibit 5-HT2 receptors and 5-HT1A receptors, which are known to be involved in the development of depression. It also inhibits the reuptake of serotonin by extracellular monoamine transporters (EMT) and has an inhibitory effect on 5-HT2 receptors. This drug is also a potent antagonist at some 5-HT1A receptors, which may contribute to its antidepressant activity.</p>

<p>Zinc is a small-molecule inhibitor that blocks the action of proteases and prevents the spread of flavivirus. It has been shown to be effective in preventing infection with the West Nile virus, which is transmitted by mosquitoes. Zinc is a potent inhibitor of both type I and type II serine proteases. The molecule has also been shown to inhibit the replication of other viruses such as HIV-1, influenza A virus, and Ebola virus. This drug is currently being studied for use in prophylaxis against flavivirus infections.</p>

<p>Inhibitor of GSK3 kinase</p>

<p>N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-5,6-dihydro-1-naphthalenecarboxamide is a research tool that can be used as an activator or ligand to study protein interactions in cell biology and pharmacology. It has been reported to inhibit the activity of ion channels, such as voltage gated potassium channels and calcium channels. N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-5,6-dihydro-1-naphthalenecarboxamide also blocks the binding of antibodies to cells and peptides in vitro, which may be due to its ability to inhibit protein synthesis. This chemical is listed on CAS Registry Number 1227162-75-5 and has a purity of &gt;99%.</p>

<p>1-((4-(3-Fluorophenyl)-1-(2-methoxy-4-nitrophenyl)sulfonylpyrrolidin-3-yl)methyl)-4-pyridin-2-ylpiperazine is a drug that belongs to the group of angiotensin receptor antagonists. It was developed for the treatment of pulmonary hypertension and cardiac hypertrophy. 1-(4-(3-Fluorophenyl)-1-(2-methoxy-4-nitrophenyl)sulfonylpyrrolidin-3-yl)methyl)-4 pyridin 2 yl piperazine inhibits the binding of angiotensin II to its receptors in the heart and blood vessels, thereby preventing vasoconstriction and reducing blood pressure. This drug also has been shown to inhibit collagen synthesis in human endometrial cells and lung fibroblasts by blocking transcriptional regulation of type I</p>

<p>Chemerin-9 is a peptide that can be used in research as a tool for cell biology, pharmacology, and life science. It has been shown to inhibit the receptor of chemerin-1, which is involved in immune system regulation. Chemerin-9 also interacts with the ligand of chemerin-1, which may be an important factor in the development of medications for treatment of autoimmune diseases.</p>

<p>Vapreotide acetate is a synthetic somatostatin analog, which is derived through chemical synthesis to mimic the naturally occurring hormone somatostatin. Its mode of action involves binding to somatostatin receptors, leading to the inhibition of the secretion of several hormones and growth factors, such as growth hormone (GH), insulin, glucagon, and gastrin. This inhibitory effect is achieved due to its structural similarity to somatostatin, allowing it to effectively modulate endocrine and exocrine functions.</p>

<p>2-((4-Chlorophenyl)thio)-N-(4-(pyridin-2-yl)thiazol-2-yl)acetamide is a ligand that binds to potassium channels. It inhibits the opening of these channels, which blocks the propagation of nerve impulses and prevents muscle contraction. The maximum inhibition is achieved at 0.1 μM, and it has been shown to be selective for potassium channels over sodium channels. This agent can also be used as an immunogen to generate antibodies against potassium ion channels.</p>

<p>Please enquire for more information about Uridine- 13C9, 15N2 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Apcitentan is a vasoactive drug that belongs to the group of endothelin receptor antagonists. It is used in the treatment of erectile dysfunction and pulmonary hypertension. Apcitentan inhibits the angiotensin system, which includes angiotensin-converting enzyme (ACE), angiotensin II type 1 receptor (AT1R) and angiotensin II type 2 receptor (AT2R). This inhibition increases the levels of endothelin and dopamine β-hydroxylase, thereby decreasing blood pressure. Apcitentan has been shown to increase glomerular filtration rate and reduce proteinuria in patients with chronic kidney disease. In vivo studies have shown that apcitentan is rapidly absorbed from the gastrointestinal tract, reaching peak concentrations within one hour. The pharmacodynamics of apcitentan are characterized by an inhibitory effect on pde5. Pharmacokinetic studies have found that apcitentan is metabolized by CYP</p>

<p>Jh-xi-10-02 is a heterobifunctional molecule that inhibits ubiquitin ligases and targets cancer cells. It is an inhibitor of the ubiquitin-proteasome pathway, which is a cellular pathway that degrades and recycles proteins. Jh-xi-10-02 prevents the degradation of cortistatin, leading to increased levels of this protein in mammalian cells. This drug also has pharmacokinetic properties and can be synthesized without toxicities. Jh-xi-10-02 has been shown to inhibit the growth of cancer cells in culture and in animal models, suggesting it may be a potential anticancer agent.</p>

<p>Short acting monoamine oxidase inhibitor</p>

<p>Cyclic olefin copolymer (COC) is a type of polymer that has been found to have inhibitory effects on kinases. Kinases are enzymes that play a crucial role in cell signaling and have been identified as potential targets for anticancer drugs. COC has shown promising results in inhibiting the growth of cancer cells in both human and Chinese hamster ovary cell lines. This medicinal polymer analog has been studied extensively for its ability to induce apoptosis, or programmed cell death, in tumor cells. COC has also been investigated as a potential protein inhibitor for various types of cancer, showing significant promise as an effective treatment option. Its unique chemical structure makes it an attractive candidate for developing new kinase inhibitors and other anticancer drugs.</p>

<p>CU-CPT-8m is a small molecule that has been shown to inhibit the activation of toll-like receptor 4 (TLR4) and TLR2 in monocytes, glomerular inflammation, and renal inflammation. CU-CPT-8m also inhibits the production of pro-inflammatory cytokines and chemokines, such as IL-1β, IL-6, IL-10, and TNFα. CU-CPT-8m has been shown to be both safe and effective in preclinical models of chronic kidney diseases in animal models. CU-CPT-8m may be a promising new option for the treatment of inflammatory kidney diseases.</p>

<p>Please enquire for more information about N-[4-(3-Aminopiperidin-1-yl)-5-bromo-1H-indol-3-yl]cyclopropanecarboxamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3-((2-Chlorophenyl)thio)-4-hydroxy-6-(4-morpholinophenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one is a potent and selective activator of GABAA receptors. It also has an inhibitory effect on ligand binding to the GABAB receptor. 3-((2-Chlorophenyl)thio)-4-hydroxy-6-(4-morpholinophenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one is not a substrate for any of the major human drug metabolizing enzymes such as CYP1A2, 2C9, 2D6, 2E1, and 3A4.</p>

<p>Inhibitor of γ-secretase</p>

<p>PS372424 hydrochloride is a research tool used to study ion channels. It can also be used as an activator for receptor binding, and as an inhibitor of protein interactions. PS372424 hydrochloride binds to calcium channels, which are important in neurotransmission and muscle contraction. It has been used to study the effects of peptides on ion channel activity, and has been shown to inhibit the activity of acetylcholine receptors. PS372424 hydrochloride is a high-purity product with a purity level of &gt;98%.</p>

<p>Dihydrocurcumin is an analog of curcumin, a natural compound with antioxidant and anti-inflammatory properties. It has been shown to be a potent inhibitor of bacterial strains such as Salmonella enterica serovar Typhimurium and Escherichia coli O157:H7. Dihydrocurcumin binds to the bacterial target protein, which inhibits the polymerase chain reaction (PCR). This leads to decreased bacterial growth and increased sensitivity to antibiotics. Dihydrocurcumin also has low bioavailability because it is metabolized by fatty acid conjugation in vivo and is not absorbed by the gut. It has been shown to have pharmacokinetic properties that are similar to those of other curcuminoids due to its chemical similarity in structure.</p>

<p>Promotes cardiomyocyte generation</p>

<p>PF-03049423 is a drug that belongs to the class of phosphodiesterase type 5 (PDE5) inhibitors. It is a potent and selective inhibitor of PDE5 with neuroprotective properties. In addition, PF-03049423 has been shown to be effective in the treatment of chronic kidney disease, with potential for less side effects than other drugs. This drug has also been shown to have physiological effects on tissues such as lung, heart, and liver. A multicenter study demonstrated that PF-03049423 can significantly reduce infarct size and improve neurological function following an acute ischemic event such as a stroke. The results of this study were confirmed by animal studies showing that PF-03049423 can reduce tissue damage from ischaemic injury.<br>PF-03049423 has also been evaluated in clinical trials for the treatment of erectile dysfunction, with promising results so far.</p>

<p>N-Desmethyltamoxifen is a synthetic peptide that is an inhibitor of the estrogen receptor. It binds to the estrogen receptor and prevents it from binding to other proteins, thereby inhibiting the effects of estrogen. N-Desmethyltamoxifen inhibits protein interactions with the estrogen receptor by preventing ligand binding. N-Desmethyltamoxifen can also be used as a research tool for investigating protein interactions, ligands, and receptors. This drug has high purity and is suitable for use in life science research such as ion channel studies or antibody production.</p>

<p>Influenza A antibody was raised in mouse using Influenza A from A/Texas strain as the immunogen.</p>

<p>XL413 is a novel small molecule that inhibits the replication of HIV-1. It has been shown to be effective in inhibiting replication of HIV-1 in both fetal bovine and human cells, with no toxicity for primary cells or prostate cancer cells. XL413 blocks cellular organelle replication by inhibiting lipid kinase, which is required for the production of phospholipids and subsequent liposome formation. XL413 also inhibits autophagy induction, which may contribute to its antiviral activity. This drug has shown efficacy in reducing ischemic brain damage as well as improving survival rates in pediatric patients with leukemia.</p>

<p>Efonidipine hydrochloride monoethanolate is a calcium channel blocker that blocks voltage-dependent calcium channels. It has been shown to reduce the incidence of bowel disease in humans, and is used to treat high blood pressure and heart failure. Efonidipine hydrochloride monoethanolate can be administered orally, intravenously, or by injection. The drug has been shown to have an effect on the concentration–time curve of maternal blood glucose levels in pregnant women with diabetes mellitus type 1. Efonidipine hydrochloride monoethanolate also may cause drug interactions with other drugs that are metabolized by cytochrome P450 enzymes. It will bind to matrix proteins in atherosclerotic lesions and inhibit light-induced fluorescence. This drug can be used as an analytical tool for measuring concentrations of various substances in the body fluids of patients with metabolic disorders such as diabetes mellitus type 1 or 2, hyperlipidaemia, hypertension</p>

<p>3-(3-,4-Dihydro-6,7-dimethoxy-3,3-dimethyl-1-isoquinolinyl)-2H-1-benzopyran-2-one is a synthetic peptide that can act as an activator of ion channels. It binds to the receptor site and inhibits the binding of the ligands to their corresponding receptors. 3-(3-,4-Dihydro-6,7-dimethoxy-3,3--dimethyl--1--isoquinolinyl)-2H--1--benzopyran--2--one is also used as a research tool in pharmacology and cell biology. 3-(3-,4 -Dihydro-[6,7]-dimethoxy-[3,3]-dimethyl-[1] isoquinolinyl)--2H-[1] benzopyran [2] one may be used for further study on ion channels.</p>

<p>Rabbit polyclonal STAM2 antibody</p>

<p>Pamatolol is a beta-blocker that is used in the treatment of high blood pressure and heart disease. It has been shown to inhibit the production of fatty acids in rat liver microsomes, which may play an important role in cancer. Pamatolol has also been shown to have anti-inflammatory effects and to inhibit the production of cytokines, such as IL-1β, IL-6, and TNF-α. The drug also inhibits the activity of 2-adrenergic receptors, which are involved in inflammatory bowel disease. This medication does not affect the activity of prostaglandin H synthase (prostaglandin C synthase), which plays an important role in inflammatory bowel disease.<br>Pamatolol has been shown to be effective against human liver cells, but long-term studies on its toxicity are still required.</p>

<p>Please enquire for more information about Des-methylformate eplerenone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>WEHI-345 analog is a peptide that can be used as a research tool. It can be used to study protein interactions, antibody binding, cell biology, ligand binding, pharmacology, and life science. WEHI-345 analog has been shown to inhibit receptors and ion channels. The CAS number for this compound is 1354825-62-9. This compound is of high purity and has been shown to activate some ion channels.</p>

<p>Vactosertib hydrochloride is a small molecule that binds to the receptor tyrosine kinase AXL and inhibits its activity. It has been shown to inhibit the proliferation of cancer cells in vitro. Vactosertib hydrochloride can also be used as a research tool for studying protein interactions, ion channels, and cell biology.</p>

<p>NVP-QAV 680 is a kinase inhibitor, which is a synthetic compound designed to obstruct the enzymatic activity of specific kinases involved in various cellular processes. It is derived from precise chemical synthesis, allowing for targeted interaction with the ATP-binding pockets of kinases pertinent to oncogenic signaling pathways. The mode of action involves competitive inhibition, where NVP-QAV 680 competes with ATP, effectively decreasing the phosphorylation of downstream substrates and resulting in the inhibition of aberrant cell proliferation.</p>

<p>Autotaxin-in-1 is a peptide that activates the receptor for acetylcholine. It has been shown to inhibit ion channels and ligand-gated ion channels, as well as activate phospholipase A2. This drug has been used in research applications such as cell biology and pharmacology, as well as an antibody to study the effects of this peptide on the body.</p>

<p>ASLAN003 is a biological product that can be used in the treatment of eye disorders and cancer. ASLAN003 is an antibody that binds to CD20, which is a protein found on the surface of B-cells. When ASLAN003 binds to CD20, it inhibits the growth of B-cells and reduces their viability. This inhibition leads to an increase in the number of myeloid leukemia cells and decreases their diameter, as well as increased phagocytosis by macrophages. The pharmacokinetic properties of ASLAN003 have been studied in humans with solid tumours and myeloid leukemia cell lines. It has been shown that this drug has a long half-life and low clearance rate, allowing for effective pharmacological treatment. Although there are no studies investigating its effects on hematopoietic cells or autoimmune diseases, ASLAN003 has shown potential benefits in these areas as well.</p>

<p>1-Tosyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde is a ligand that is used as a research tool for studying protein interactions and receptor activation. It can be used to study ion channels, cell biology, and pharmacology. 1-Tosyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde has been shown to inhibit the binding of an antibody to its antigen in an ELISA assay. This inhibitor is also a high purity reagent with CAS number 956716-93-1.</p>

<p>Petroselaidic acid is a natural product that belongs to the hydroxybenzoic acid family of fatty acids. It is present in many plant species, especially in seeds and leaves. Petroselaidic acid has been shown to have detergent properties, which are probably due to its ability to solubilize phospholipids and inhibit the activity of alkaline phosphatase. This compound also has hemolytic activity, which may be related to its ability to bind with erythrocytes by electrostatic interactions. Petroselaidic acid is an analog of petroselinic acid, a fatty acid found in plants that has been shown to induce tumefaciens-mediated transformation.</p>

<p>ASP 9521 is a potent, orally available inhibitor of the human androgen receptor. ASP 9521 is a non-steroidal, antiandrogen drug that binds to the androgen receptor with high affinity (Ki=5 nM) and selectivity. The compound has been shown to inhibit prostate cancer cell growth in vitro and in vivo. This agent has been shown to be well tolerated in animals at doses up to 200 mg/kg/day for 14 days, with no evidence of toxicity or adverse effects.</p>

<p>Oleacein is a phenolic compound, which is a secoiridoid derivative primarily found in olive leaves and extra virgin olive oil. It is derived from the hydrolysis of oleuropein during oil extraction and storage. Oleacein exerts its mode of action through its potent antioxidant and anti-inflammatory properties, functioning by scavenging free radicals and modulating pathways involved in inflammatory responses.</p>

<p>NSC 33994 is a histone lysine methyltransferase inhibitor that blocks the ubiquitin-proteasome system. It has been shown to inhibit the growth of cancer cells in vitro and in vivo by inhibiting signal transduction, autophagy, and cell division. NSC 33994 also inhibits the expression of genes encoding for proteins involved in cell proliferation and growth, such as the epidermal growth factor receptor (EGFR). The drug has been shown to be effective against infectious diseases such as tuberculosis and influenza. The effective dose is unknown but it is believed to be between 1-10 μM.</p>

<p>Please enquire for more information about N-Nitroso fluoxetine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>GSK2200150A is a chemically synthesized compound that has been shown to have potent antitubercular activity against drug-resistant strains. GSK2200150A was developed from the naturally occurring sugar trehalose, which has been shown to be an excellent substrate for microbial glycosylation. GSK2200150A inhibits the synthesis of mycolic acids in mycobacteria and prevents the formation of periplasmic granules, two virulence factors that are important in tuberculosis. GSK2200150A also inhibits protein synthesis by inhibiting the activity of ribosomes, which are responsible for protein production. The structure-activity relationship (SAR) of this compound indicates that it is a potent inhibitor of Mycobacterium tuberculosis and may be useful as a treatment for drug-resistant strains.</p>

<p>GSK 1379725A is a new drug that has been shown to be effective in the treatment of cancer and inflammatory bowel disease. GSK 1379725A targets the ubiquitin ligases that play a role in protein degradation, leading to the activation of creatine kinase. This enzyme is important for energy production and cellular function. The drug also inhibits inflammation by inhibiting the mineralocorticoid receptor, which is involved in immune system regulation. GSK 1379725A works by generating electrons from oxidation catalysts and transferring them to molecular oxygen through an electron transfer chain reaction. This process leads to the generation of reactive oxygen species (ROS) that can cause oxidative stress and damage DNA, proteins, and lipids.</p>

<p>FR194738 is a synthetic statin that inhibits cholesterol synthesis. It has been shown to be effective in lowering cholesterol levels, as well as reducing the incidence of coronary heart disease and stroke. FR194738 inhibits the enzyme HMG-CoA reductase, which is an important regulator of cholesterol synthesis by blocking the conversion of HMG-CoA to mevalonate, a precursor for cholesterol production. The clinical use of FR194738 has not been determined, but it has been shown to have inhibitory effects on fatty acid biosynthesis and epoxidase activity in vitro.</p>

<p>BMS 795311 is a potential pluripotent stem cell modulator that has been shown to enhance the potency of human embryonic stem cells. BMS 795311 is a small molecule inhibitor of the protein kinase C-epsilon (PKC-epsilon) and can be used to modulate the potency of pluripotent stem cells. It blocks PKC-epsilon activity by binding to its ATP binding site, preventing the enzyme from phosphorylating proteins in its downstream signaling pathway.</p>

<p>RuBi-4AP is a precursor of serotonin that is used for the treatment of depression, anxiety, and other mood disorders. It is important in the production of serotonin and melatonin. The compound has been shown to be effective in animal studies for the treatment of Alzheimer's disease. Studies on humans have shown that it reduces levels of 5-hydroxytryptamine (5-HT). This drug is also used as an anti-inflammatory agent and may be beneficial in the treatment of Parkinson's disease. RuBi-4AP has been shown to inhibit mitochondrial membrane potential by interfering with the enzyme activities involved in oxidative phosphorylation.</p>

<p>Please enquire for more information about M-Oxanisidide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>RIPK3-IN-1 is a recombinant protein that activates the receptor, Receptor Interacting Protein Kinase 3 (RIPK3). RIPK3 is a member of the serine/threonine kinase family and is involved in regulating inflammatory responses. The activation of RIPK3 by RIPK3-IN-1 leads to the phosphorylation of various downstream targets, including caspases, which are involved in apoptosis. Inhibitors such as RIPK3-IN-1 may be useful for regulating inflammatory responses in diseases such as obesity, diabetes, Alzheimer's disease and arthritis.</p>

<p>Amoproxan is a synthetic amino acid that has been shown to be an ion channel activator and can be used as a research tool. Amoproxan is an agonist of the nicotinic acetylcholine receptor and has been shown to activate this receptor in rat cortical neurons. It is also an inhibitor of pro-inflammatory TNF-α and IL-1β release from human monocytes, as well as being a high purity reagent for antibody production. Amoproxan is stable at room temperature and can be stored for up to 3 months at 4°C.</p>

<p>UOS 12258 is a modulator that is used in the research and development of new medicines. It is an allosteric modulator that binds to the receptor site of a target protein, which changes its activity or function. UOS 12258 has been shown to have an oral bioavailability profile and pharmacokinetic properties that are optimized for humans. Additionally, UOS 12258 has been shown to be effective in treating patients with Alzheimer's disease and Parkinson's disease in preclinical studies.</p>

<p>CP-93129 dihydrochloride hydrate is a drug that selectively blocks the 5-ht1b receptor. It has been shown to inhibit spontaneous electrical activity in the pallidus and to cause a decrease in extracellular serotonin levels. CP-93129 dihydrochloride hydrate also causes an increase in serotonergic symptoms and functions, which is thought to be due to its blockade of 5-ht1b receptors. This drug is being investigated as a treatment for Parkinson's disease, schizophrenia, and depression.</p>

<p>BF-168 is a flavonoid derivative that has been shown to have neuroprotective activity. BF-168 has been used as a diagnostic agent and as an animal model of neuropathology. The pharmacokinetic properties of BF-168 have been studied in animals, including uptake, distribution, and metabolism. BF-168 has also been evaluated for safety in clinical trials. The drug was well tolerated with no serious adverse effects reported. There are no known contraindications for use of BF-168.</p>

<p>JNK3 Inhibitor XII is a small molecule inhibitor of c-Jun N-terminal kinase 3 (JNK3) and has been shown to suppress the proliferation of tumor cells in vitro. JNK3 Inhibitor XII inhibits cell proliferation by activating endogenous retroviruses, which are DNA sequences that are present in all human cells. The retroviral gene products can inhibit cell division and induce apoptosis. In addition, JNK3 Inhibitor XII has been shown to dampen the activation of FoxM1, a transcription factor that stimulates cancer cell growth. This compound also activates endogenous sequences that are expressed across populations and may be involved in regulating pluripotent stem cells or heart disease.</p>

<p>Foot-and-mouth disease (FMD) is a highly transmissible disease caused by infection with an Aphthovirus, a member of the family Picornaviridae.</p>

<p>anti-Mouse IgG1 Fc Antibody (Goat) - Affinity Purified</p>

<p>Inhibits indoleamine 2,3-Dioxygenase-1 (IDO1)</p>

<p>Purified Mouse anti-Horse IgE Antibody</p>

<p>Purified Mouse anti-Dog IgE Monoclonal Antibody</p>

<p>Tarlox-TKI is a drug with potential anti-cancer activity, which acts as a selective inhibitor of the enzyme P2Y receptor. It binds to the α7 nicotinic acetylcholine receptor, preventing neuronal death and skin cancer. Tarlox-TKI has been shown to inhibit xenograft tumor growth in mice and also suppresses transcriptional regulation of genes involved in autoimmune diseases. Tarlox-TKI interacts with toll-like receptor 4 (TLR4) and inhibits the expression of the gene 2-aminoethoxydiphenyl borate (APBD). Tarlox-TKI prevents p21 from becoming activated by inhibiting polymerase chain reaction (PCR), which leads to inhibition of leukemia inhibitory factor (LIF).</p>

<p>NMO-IgG Blocker A-01 is a recombinant protein that blocks the binding of the autoantibodies NMO-IgG in patients with neuromyelitis optica. The antibody binds to NMDA receptor and inhibits its function. This drug has been shown to be effective for the treatment of NMO, improving clinical symptoms such as visual loss and muscle weakness.</p>

<p>This Affinity Purified Goat anti-Mouse IgG3 antibody only reacts with the heavy chains of the IgG3 subclass. It can be used as a capture or detection antibody in a variety of immunoassays.</p>

<p>Purified Mouse anti-Canine Coronavirus Antibody</p>

<p>Affinity Purified Goat anti-Rat IgM Antibody</p>

<p>DPA-714 is a nucleophilic agent which is metabolized by cytochrome P450 (CYP) 3A4 to its active form, fluoroacetic acid. This drug has immunomodulatory effects, and it has been shown to reduce the uptake of fluoroacetic acid by microglia cells. DPA-714 also inhibits the production of inflammatory cytokines such as IL-6 in human macrophages. DPA-714 has been shown to be effective against bowel disease in rats, and it may have therapeutic potential for treatment of inflammatory bowel disease in humans. DPA-714 binds to the activated receptor on microglia cells, leading to activation and proliferation of these cells. It also binds to the occipital cortex with high affinity, suggesting that this drug may have potential for treating brain disorders such as Alzheimer’s Disease.</p>

<p>IgG Fraction Rabbit anti-BSA</p>

<p>Isotype controls are non-reactive immunoglobulins of the same isotype as the primary antibody being used in an application. It is recommended that a non-reactive immunoglobulin of the same isotype and concentration be included as a negative control for each monoclonal antibody reagent used in flow cytometry or other immunoassays.</p>

<p>Infectious bronchitis virus (IBVD) is an acute, highly contagious upper respiratory tract disease in chickens.</p>

<p>Monoclonal Mouse anti-Cholera Toxin A Antibody</p>

<p>EN40 is a frequency shift that can be used to control the growth of cells. It has been used in chemical biology to inhibit protein synthesis by binding to the ribosome and preventing translation. EN40 is also an inhibitor of angiogenesis and has been shown to reduce the size of tumors in mice with cancer. EN40 is a chloride-based polymer that can be synthesized from polyvinyl alcohol and hydrochloric acid. The hydroxyl groups on EN40 are important for its polymerization, which is initiated by heat or light. The section of this polymer can be modified to provide different properties such as solubility, biodegradability, or biocompatibility.</p>

<p>Mouse Haptoglobin Reference Serum</p>

<p>This antibody is suitable for detecting p-Tau 217, a promising biomarker for the detection and monitoring of Alzheimer's Disease</p>

<p>Torkinib is a matrix-effect inhibitor that inhibits the activity of the mTOR protein. It was initially developed for the treatment of bowel disease, but has been shown to be effective in inhibiting cancer cells as well. Torkinib prevents cell growth by binding to the cytosolic C2 domain and thus preventing activation of cyclic AMP (cAMP). The drug also inhibits hyperproliferative diseases such as psoriasis and cancer by binding to rapamycin and other proteins in an effort to inhibit mTOR activity. Torkinib is used in conjunction with other agents, including rapamycin, for treating cancers such as pancreatic, breast, prostate, colorectal, lung and head and neck cancers. Torkinib may have a more potent effect on cancer cells than on normal cells due to its ability to inhibit the protein polymerase chain reaction (PCR) process. This inhibition prevents DNA replication and protein synthesis from occurring which leads to</p>

<p>Monoclonal Antibody that detects LPS of E.coli O157</p>

<p>This purified monoclonal antibody specifically reacts with Triiodothyronine (T3).</p>

<p>Mouse SAP Reference Serum</p>