Compuestos y reactivos bioquímicos

<p>Impurity Levothyroxine beta-Hydroxy Impurity / Levothyroxine beta-Hydroxy T4 Impurity<br>Applications It has been prepared for testing as possible antithyroid. It showed some thyromimetic activity.<br>References Wawzone, S., et al.: J. Med. Chem., 6, 442 (1963),<br></p>

<p>Applications (2S,4R)-4-Hydroxy-L-glutamic Acid is a metabolite of Glutamic acid (G596960).<br>References Hampson, D., et al.: J. Biol. Chem., 274, 33488 (1999), Jensen, A., et al.: Eur. J. Pharmacol., 397, 247 (2000),<br></p>

<p>Applications A sulfhydryl cross-linking reagent.<br>References Loo, T., et al.: J. Biol. Chem., 276, 40, 36877 (2001)<br></p>

<p>Applications Useful in the study of tyrosine-phosphorylation, which has been linked with the malignant transformation of cells by some RNA tumour viruses.<br>References Sefton, B.M., et al.: Cell, 20, 807 (1980), Erikson, R., et al.: Perspect. Virol., 11, 93 (1981), Lee, E-S, et al.: J. Org. Chem., 59, 2086 (1994)<br></p>

<p>Applications Poly(ethylene Glycol) molecules of an average molecular mass of 600. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.<br>References Borgens, R. et al.: J. Neurosci. Res., 66, 1179 (2001); Stavisky, R. et al.: Neurosci. Lett., 376, 98 (2005); Nalam, P. et al.: Tribiol. Lett., 37, 541 (2010); Steinmetz, N. et al.: J. Am. Chem. Soc., 131, 17093 (2009); Li, X. et al.: J. Am. Chem. Soc., 133, 11147 (2011); Li, L. et al.: Int. J. Pharm., 447, 192 (2013);<br></p>

<p>Applications Poly(ethylene Glycol) molecules of an average molecular mass of 2000. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.<br>References Borgens, R. et al.: J. Neurosci. Res., 66, 1179 (2001); Stavisky, R. et al.: Neurosci. Lett., 376, 98 (2005); Nalam, P. et al.: Tribiol. Lett., 37, 541 (2010); Steinmetz, N. et al.: J. Am. Chem. Soc., 131, 17093 (2009); Li, X. et al.: J. Am. Chem. Soc., 133, 11147 (2011); Li, L. et al.: Int. J. Pharm., 447, 192 (2013);<br></p>

<p>Applications 2,5-Diaminotoluene is an aromatic compound that is commonly used in permanent hair-dye formulations. 2,5-Diaminotoluene is weakly mutagenic and is also partially responsible for causing allergic contact dermatitis in humans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chung, K., et al.: Mutat. Res./Rev. Mutat. Res., 387, 1 (1997); Inouye, M. &amp; Murakami, U.: Food Cosm. Toxicol., 15, 447 (1977); Yazer, K., et al.: Cont. Derm., 66, 27 (2012)<br></p>

<p>Stability Hygroscopic, Temperature Sensitive<br>Applications Vitamin D4 is the active analogue of Vitamin D.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Holick, M., et al.: J. Biochemistry, 10, 2799 (1971), Haddad, J., et al.: J. Bone Miner. Res., 4, 243 (1989), Palmieri, G., et al.: J. Clin. Endocrin. Metab., 82, 3516 (1997),<br></p>

<p>Applications Labelled analogue of L-Phenylalanine, an essential amino acid.<br>References Hollunger, G. et al.: Acta Pharmacol. Toxicol., 34, 391 (1974); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977);<br></p>

<p>Applications A triterpenoid known for its anti-inflammatory properties, is commonly present in several medicinal plants. Inhibits secretory phospholipase A2.<br>References Andrikopoulos, N., et al.: J. Med. Food, 5, 1 (2002), Lanteri, S., et al.: Food Chem., 76, 501 (2002), Rodriguez-Rodriguez, R., et al.: Br. J. Pharmacol., 155, 535 (2008), Sotiroudis, T., et al.: Eur. J. Nutr, 47, 69 (2008),<br></p>

<p>Applications A metabolite of Cholesterol. Cholesterol oxidation product having cytotoxicity effects.<br>References Higley, N., et al.: Food Chem. Toxicol., 22, 983 (1984), Emanuel, H., et al.: J. Food Sci., 56, 843 (1991), Kilsdonk, E., et al.: J. Lipid Res., 36, 505 (1995), Cantwell, H., et al.: Cell Biol. Toxicol., 14, 401 (1998),<br></p>

<p>Applications 5β-Cholanic Acid-3α, 6β-Diol is a cholesterol derivative; Plasma lipophilic biomarkers in rats. Also, it is one of two major metabolites from the hydroxylation of hepatic lithocholic acid catalyzed by Cyp3a/Cyp3a11 enzymes in mice.<br>References Mayengbam, S., et al.: Eur. J. Nutr., 55, 1213-1223 (2016); Hrycay, E., et al.: Mol. Cell. Biochem., 389, 119-132 (2014)<br></p>

<p>Applications Vitamin K1 2,3-Epoxide is a metabolite of Vitamin K1 (V676080), which is occurs widely in green plants, algae, and photosynthetic bacteria.<br>References Smee, D.F., et al.: Antimicrob. Agents Chemother., 23, 676 (1983), Miyamoto, T., et al.: Biochem. Pharmacol., 35, 839 (1986); Hassan, M.M.A., et al.: Anal. Profiles Drug Subs., 17, 449 (1988), Breton, J., et al.: Biochemistry, 33, 12405 (1994), Dowd, P., et al.: Science, 269, 1684 (1995);<br></p>

<p>Applications 7ß-Hydroxycholesterol-d7 is a standard used in the simultaneous measurement of F2-isoprostane, hydroxyoctadecadienoic acid, hydroxyeicosatetraenoic acid, and hydroxycholesterols in plasma and liver of hepatitis patients.<br>References Yoshida, Yasukazu., Analytical Biochemistry, 379, 105-115, (2008)<br></p>

<p>Applications A deuterated acyclic phosphonate nucleotide analogue, reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>

<p>Applications MTT (cas# 298-93-1) is a useful research chemical. Dyes and metabolites.<br></p>