Compuestos y reactivos bioquímicos

<p>Inhibitor of MEK kinase; anti-neoplastic</p>

<p>Neurokinin-1 (NK-1) receptor antagonist</p>

<p>C.I.Sulphur Blue 15 is a nanocomposite of sulfur and titanium dioxide, which is used in dyeing textiles and other materials. The colorant is soluble in water and can be used as a solution or paste. C.I.Sulphur Blue 15 has been shown to have antimicrobial properties against Gram-positive bacteria, such as Staphylococcus aureus and Clostridium perfringens, but not against Gram-negative bacteria, such as Pseudomonas aeruginosa and Escherichia coli.</p>

<p>Inhibitor of caspases; broad spectrum</p>

<p>Leu-Enkephalin is an endogenous opioid peptide that has been shown to produce analgesia, anti-inflammatory effects, and changes in locomotor activity. Leu-enkephalin binds to the kappa opioid receptor, which is found in high concentrations in the caudate putamen and hippocampal formation. The enkephalins are a family of basic proteins with two amino acids linked by a single amide bond. They are peptide hormones that act as neurotransmitters in the central nervous system and peripheral nervous system. Leu-enkephalin is a drug candidate for treatment of infectious diseases such as HIV and malaria. In addition, leu-enkephalin has been shown to have side effect profiles that are less severe than morphine or methadone.</p>

<p>H-HYYASSHWYFDVWGQGTL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-HYYASSHWYFDVWGQGTL-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-HYYASSHWYFDVWGQGTL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-HYYASSHWYFDVWGQGTL-OH at the technical inquiry form on this page</p>

<p>Platinum-based chemotherapeutic agent</p>

<p>AZD 7140 is a distal radius fracture treatment device that is designed to deliver a controlled force to the distal radius and to provide fluid therapy. It is made of an elastomeric material that has been shown to both access and distribute fluids in the proximal region of the forearm. The device has been shown to provide a force of up to 375 N, which can be delivered in three modes: constant, intermittent, or pulsatile. This device has also been shown to have no adverse effects on bone healing or blood flow.</p>

<p>H-SGLPHNSSANSTETLQHVPS-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-SGLPHNSSANSTETLQHVPS-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-SGLPHNSSANSTETLQHVPS-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-SGLPHNSSANSTETLQHVPS-OH at the technical inquiry form on this page</p>

<p>BX471 hydrochloride is a selective antagonist of the C-C chemokine receptor type 1 (CCR1), which is synthesized through rigorous chemical processes. It operates by inhibiting the binding of chemokines to the CCR1 receptor, thus interfering with the signaling pathways that lead to inflammation and immune responses. This mechanism is specifically effective in modulating immune system functions and controlling pathophysiological responses in various tissue types.</p>

<p>Il-1β is a pro-inflammatory cytokine, which is a type of signaling molecule involved in immune system regulation and inflammation. It is primarily produced by activated macrophages, which are a type of white blood cell that engulfs and digests cellular debris and pathogens. The mode of action of Il-1β involves binding to the interleukin-1 receptor (IL-1R) on target cells, which triggers a cascade of intracellular signaling pathways that lead to the expression of various inflammatory genes.</p>

<p>Tolterodine-D14 is a postoperative drug that belongs to the class of non-selective muscarinic receptor antagonists. It has been evaluated for pharmacokinetic properties in plasma samples from patients undergoing surgery. Tolterodine-D14 undergoes extensive hepatic metabolism, with only about 50% of the drug being excreted unchanged in urine. The elimination half-life of this drug ranges from 2 to 3 hours. Tolterodine-D14 has been shown to be bioequivalent to the reference drug (tolterodine) and can be used as a control level for chromatographic analyses.</p>

<p>Des-n-Octanoyl-[Ser3]-Ghrelin (Human, 1-14) is a non-Acylated Analog of Ghrelin (Human, 1-14), amino acids 1-14 of the peptide hormone Ghrelin. This peptide does not contain the unique N-octanoyl group which is linked to Ghrelin's third serine residue covalently and which allows Ghrelin to associate with the growth hormone secretagogue receptor (GHS-R). Through interaction with the GHS-R, Ghrelin can exert its various effects on the body such as stimulating appetite, nutrient sensing, meal initiation and the regulation of insulin resistance, diabetes and obesity. Its wider functions are also associated with glucose homeostasis, energy homeostasis, cardio-protective effects, bone metabolism and its potential to be a target for cancer means that it can be used to develop therapies for a whole spectrum of diseases. This molecule is used as a research tool for studying cell biology and pharmacology.</p>

<p>Formyl peptide receptor-1 (FPR-1) antagonist</p>

<p>H-IGPGGDGPGG-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-IGPGGDGPGG-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-IGPGGDGPGG-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-IGPGGDGPGG-OH at the technical inquiry form on this page</p>

<p>Sparteine hydroiodide is the salt form of sparteine. This compound acts as an inhibitor of voltage-gated sodium channels. In organic chemisty, it is used for chiral synthesis.</p>

<p>BMP7 is a protein that belongs to the TGF-β superfamily. It is a potent inhibitor of bone resorption in vitro and in vivo. BMP7 also has been shown to inhibit the synthesis of collagenase and other proteases by osteoclasts, leading to decreased bone resorption. This protein activates receptors for insulin-like growth factor and activin, which are proteins produced by bone cells (osteoblasts) that regulate bone formation. BMP7 can also be used as a research tool for studying receptor activation, ligand binding, or ion channel function.</p>

<p>Diflunisal is a nonsteroidal anti-inflammatory drug (NSAID), which is a synthetic derivative of salicylic acid. It is primarily sourced through chemical synthesis rather than extraction from natural elements. Diflunisal functions by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which play a crucial role in the biosynthesis of prostaglandins. This inhibition results in reduced production of prostaglandins, compounds involved in inflammation and pain signaling pathways.</p>

<p>H-LLWTLVVLL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LLWTLVVLL-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LLWTLVVLL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LLWTLVVLL-OH at the technical inquiry form on this page</p>

<p>H-LLLPHWAK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LLLPHWAK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LLLPHWAK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LLLPHWAK-OH at the technical inquiry form on this page</p>

<p>C.I. Direct Blue 72 is a versatile compound with various applications. It is used in the field of molybdenum crystallization and photocatalytic reactions. Additionally, it has cholinergic properties, which means it can interact with choline receptors in the body. This compound also contains secoisolariciresinol and sphingosine, which are both phytoestrogens known for their potential health benefits.</p>

<p>H-QQQQQAVPSPASAATPPASK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-QQQQQAVPSPASAATPPASK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-QQQQQAVPSPASAATPPASK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-QQQQQAVPSPASAATPPASK-OH at the technical inquiry form on this page</p>

<p>H-KLTVDKSRWQQGNVFSCS-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-KLTVDKSRWQQGNVFSCS-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-KLTVDKSRWQQGNVFSCS-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-KLTVDKSRWQQGNVFSCS-OH at the technical inquiry form on this page</p>

<p>Inhibits MET, VEGFR1-3, Tie and Ron tyrosine kinases; antineoplastic</p>

<p>Pigment YellOw 75 is a polymerization initiator that has a hydroxyl group and contains functional groups such as an amide, carboxylic acid, or alcohol. The monomers are vinyl acetate, ethylene glycol, and butanediol. Pigment YellOw 75 is used in the production of polyvinyl chloride (PVC). It acts as a radical polymerization initiator by abstracting hydrogen atoms from the vinyl acetate monomer to form radicals that initiate polymerization. This pigment also serves as a particle in radiation-curable coatings. Pigment YellOw 75 is highly reactive and can be used in reactive electrophotography.</p>

<p>Cyclo[Arg-Gly-Asp-D-Phe-Lys(Biotin)] is a peptide macrocycle that is known to bind to integrin and be active against cancer cells. It has been shown to inhibit the growth of cancer cells by inhibiting cell adhesion, which leads to a reduction in the production of biochemicals such as fibronectin. Cyclo[Arg-Gly-Asp-D-Phe-Lys(Biotin)] binds strongly to the integrin receptor on the surface of many types of cancer cells, including those that are resistant to conventional chemotherapy drugs. This peptide macrocycle also inhibits proteolytic cleavage by metalloproteinases and enhances tumor vascularization, making it an attractive candidate for use in cancer treatment.</p>

<p>Acid Orange 154 is a hydroxyalkyl, divalent cyclic compound that is used as a colorant for textiles and paper. This chemical is detected by absorbance at 400 nm and has an anionic charge. Acid Orange 154 has been shown to form benzyl, acidic chlorophenyl, and alkylene derivatives in the presence of metal ions or polymeric stabilizers. Acid Orange 154 can be analyzed using various techniques including gas chromatography and mass spectrometry.</p>

<p>Toxin; induces pulmonary hypertension</p>

<p>H-EIVCDSLDDYNRRVT-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-EIVCDSLDDYNRRVT-OH is provided at greater that &gt;80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-EIVCDSLDDYNRRVT-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-EIVCDSLDDYNRRVT-OH at the technical inquiry form on this page</p>

<p>Ac-SGQQQGLPRAAGGSVPC-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-SGQQQGLPRAAGGSVPC-NH2 is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-SGQQQGLPRAAGGSVPC-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-SGQQQGLPRAAGGSVPC-NH2 at the technical inquiry form on this page</p>

<p>Opiorphin is a naturally occurring peptide, which is derived from human bodily secretions, particularly from saliva. It acts as an endogenous inhibitor of enkephalin-degrading enzymes, thus enhancing the activity of endogenous opioid peptides by preventing their breakdown. This stabilization of enkephalins contributes to the body's natural pain regulation processes.</p>

<p>Inhibitor of glutaminase; glutamine analogue</p>

<p>Fmoc-Ser(tBu)-Wang resin is a versatile building block that is used in the synthesis of complex compounds. It has a CAS number and is available as a fine chemical or reagent. Fmoc-Ser(tBu)-Wang resin is an intermediate for research chemicals, reaction components, and speciality chemicals. This material can be used as an important building block in the synthesis of many useful compounds and has high quality.</p>

<p>Acid Black 26 is a polyphenol with antioxidant properties. It has been shown to have an inhibitory effect on the oxidation of basic dyes and control agents. Acid Black 26 has also been used in biological treatment to remove organic matter from wastewater. The thermodynamic data for Acid Black 26 are complex, but it displays a high reactivity toward particle surfaces and functional groups. Immobilized Acid Black 26 can be used as a surface methodology for the production of activated carbon filters, which removes reactive substances from air streams.</p>

<p>Proteinase K is used for the general digestion of proteins and removal of protein contamination in nucleic acids. Addition of Protease K also stabilizes nucleic acids by degrading any nucleases present. Proteinase K is active in wide range of pH range, in the presence of SDS, urea and Guanidinium chloride at low to moderate concentrations. Proteinase K is also known under names of protease K and endopeptidase K.</p>

<p>H-LHLILDYINGGELFTHLSQR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LHLILDYINGGELFTHLSQR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LHLILDYINGGELFTHLSQR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LHLILDYINGGELFTHLSQR-OH at the technical inquiry form on this page</p>

<p>Naloxone hydrochloride is a competitive antagonist at mu-, delta- and kappa-opioid receptors. Naloxone binding to receptors blocks the effects of opioids such as morphine, heroin, or oxycodone. Naloxone has been shown to be effective in treating acute overdoses of these drugs and reversing the depression of respiratory function that accompanies opioid overdose. It is also used to alleviate withdrawal symptoms and in the treatment of neonatal abstinence syndrome (NAS). NAS is a condition that occurs when infants are exposed to addictive levels of opioids in utero and go through withdrawal after birth.</p>

<p>Inhibitor of VEGFR; antineoplastic</p>

<p>Ac-TTKDHGHQPFSLRC-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-TTKDHGHQPFSLRC-NH2 is provided at greater that &gt;85% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-TTKDHGHQPFSLRC-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-TTKDHGHQPFSLRC-NH2 at the technical inquiry form on this page</p>

<p>H-TGQSYNQYSQRPYLGVYVFK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-TGQSYNQYSQRPYLGVYVFK-OH is provided at greater that &gt;98% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-TGQSYNQYSQRPYLGVYVFK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-TGQSYNQYSQRPYLGVYVFK-OH at the technical inquiry form on this page</p>

<p>Opioid receptor agonist</p>

<p>Z-Gln-Gly-OH is a synthetic dipeptide, which is a modified amino acid sequence commonly used in biochemical applications. It consists of a carbobenzoxy-protected glutamine and a glycine residue. This compound originates from custom organic synthesis, derived through specific chemical protocols to introduce protective groups that block reactive sites on the amino acids. This controlled modification alters the peptide's stability and solubility.The mode of action involves the protection of active sites during complex syntheses, enabling the sequential construction of peptide chains without unintended reactions. This protection is critical in solid-phase peptide synthesis methodologies where precision and specificity of reactions are paramount. The Z-group (benzyloxycarbonyl) ensures the stability of glutamine under various chemical conditions, preventing side reactions that may compromise the integrity of peptide constructs.In research, Z-Gln-Gly-OH finds applications in the design of peptide-based inhibitors, structural studies, and the synthesis of longer chain peptides that mimic biologically relevant structures. The protection strategy allows scientists to develop and manipulate peptides with high fidelity, facilitating advancements in understanding protein functions and interactions in physiological contexts.</p>

<p>H-EAPWEYQK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-EAPWEYQK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-EAPWEYQK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-EAPWEYQK-OH at the technical inquiry form on this page</p>

<p>H-Phe-Met-Arg-Phe-NH2 acetate is a high quality reagent that is useful in the synthesis of complex compounds. It can be used as an intermediate for the production of fine chemicals and speciality chemicals, as well as being a versatile building block in the synthesis of organic compounds. H-Phe-Met-Arg-Phe-NH2 acetate can also be used to make research chemicals or reaction components.</p>

<p>Please enquire for more information about C.I.Solvent Violet 56 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Estrogen receptor antagonist; tamoxifen metabolite</p>

<p>Competitive, reversible inhibitor of α-glucosidases used for the control of postprandial hyperglycaemia in patients with type 2 diabetes mellitus. It inhibits digestive enzymes with α-glucosidase activity, which breakdown complex sugars to absorbable monosaccharides. It also reduces the levels of glycated haemoglobin (HbA1c).</p>

<p>Partial agonist of α4β2 nicotinic receptors; acetylcholine receptor α7 agonist</p>

<p>Opioid analgesic</p>

<p>(2R)-Arimoclomol maleate is an investigational pharmaceutical compound, which is an orally bioavailable small molecule with pharmacological activity primarily targeting cellular protein homeostasis mechanisms. This therapeutic agent is derived from molecular chaperones and operates by selectively enhancing the expression of heat shock proteins (HSPs). The mechanism of action involves the modulation of the heat shock response, wherein (2R)-Arimoclomol maleate amplifies the natural cellular defense pathways against protein misfolding and aggregation.</p>