Anticuerpos para la investigación del cáncer

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse IL-12 p40. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Mouse IL-12 p40. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse IL-12 p40, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Mouse IL-12 p40. You can calculate the concentration of Mouse IL-12 p40 in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human IFN-γ. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Human IFN-γ. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human IFN-γ, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Human IFN-γ. You can calculate the concentration of Human IFN-γ in the samples by comparing the OD of the samples to the standard curve.

<p>Carbidopa (Lodosyn) is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM).</p>

<p>Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine.</p>

<p>Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (</p>

<p>LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.</p>

<p>BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.</p>

<p>OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor.</p>

<p>Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.</p>

<p>GW779439X is an inhibitor of CDK.</p>

<p>Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.</p>

<p>Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM).</p>

<p>Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor.</p>

<p>Bindarit (AF2838) is an aryl hydrocarbon receptor (AHR) antagonist.Cost-effective and quality-assured.</p>

<p>Paederosidic acid shows anti-tumor, anticonvulsant, and sedative properties, may treat epilepsy by modulating brain GABA and glutamate levels.</p>

<p>MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.</p>

<p>HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.</p>

<p>Neogambogic acid, an active ingredient in garcinia, can inhibit the growth of some solid tumors and result in an anticancer effect.</p>

<p>α-Linolenic Acid (ALA) is an essential fatty acid. α-Linolenic acid improves memory, inhibits thrombosis, and lowers blood lipids. Cost-effective and quality-assured.</p>

<p>Alflutinib mesylate (AST2818 mesylate) ,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M.</p>

<p>MMP-9-IN-1 is an inhibitor of specific matrix metalloproteinase-9 (MMP-9).</p>

<p>Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).</p>

<p>MSX-130 is CXCR4 Antagonist.</p>

<p>Azido-PEG11-alcohol is a PEG-based PROTAC linker that can be used in PROTAC synthesis.</p>

<p>Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also</p>

<p>JNJ-63576253 free base (TRC253) is a potent and orally active full antagonist of androgen receptor (AR). JNJ-63576253 can be used for the research of CRPC.</p>

<p>Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation.</p>

<p>M2N12 selectively inhibits Cdc25C (IC50=0.09μM) and has anti-tumor properties, affecting Cdc25A and B as well.</p>

<p>(E)-Akt inhibitor-IV ((E)-AKTIV)  ((E)-AKTIV) is an inhibitor of PI3K-Akt.</p>

<p>BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.</p>

<p>Raf inhibitor 2 (CID 25014542) is novel inhibitor of Raf kinases.</p>

<p>XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.</p>

<p>RBN012759 inhibits PARP14 protein and is more than 300-fold selective over all PARP family members.Cost-effective and quality-assured.</p>

<p>Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.</p>

<p>AMTB HCl: Novel TRPM8 blocker, relieves pain, treats urinary issues, moderates bladder reflexes in rats.</p>

<p>Maleimide surface group on nanoparticles allows simple conjugation with peptides via click chemistry, preserving biofunctions.</p>

<p>LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.</p>

<p>Boc-11-aminoundecanoic acid is an Alkyl/ether-based PROTAC linker that can be used in the synthesis of MS432.</p>

<p>Fursultiamine (Alinamin F) is a disulfide derivative of thiamine, or an allithiamine. It has potential uses in the treatment of vitamin B1 deficiency.</p>

<p>TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM).</p>

<p>YUM70 inhibits GRP78 (IC50: 1.5μM), inducing ER stress and apoptosis in pancreatic cancer.</p>

<p>Physcion 8-O-β-D-glucopyranoside (Physcion 8-O-beta-D-monoglucoside) has anti-inflammatory and anti-cancer activities.</p>

<p>Glumetinib (SCC244) (SCC 244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM).</p>

<p>MSX-127 elicites positive response in peptide CXCR4.</p>

<p>Pellitorine (Pellitorin) is an extract of Tetradium daniellii, and acts as a TRPV1 antagonist.</p>

<p>Schisandrin C (Wuweizisu-C) is a phytochemical lignan isolated from Schizandra chinensis Baill; shows anticancer-effects in human leukemia U937 cells.</p>

<p>ZCL278 is a selective Cdc42 GTPase inhibitor.</p>

<p>Niraparib (MK-4827) inhibits PARP1/PARP2 (IC50: 3.8/2.1 nM), effective on BRCA mutant cancers, 330x less effective on PARP3, V-PARP, Tank1.</p>

ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).

<p>MF-766: potent, selective oral EP4 antagonist, Ki=0.23 nM, IC50=1.4 nM; shifts to 1.8 nM with 10% HS. Useful in cancer, inflammation studies.</p>

<p>15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM.</p>

<p>LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.</p>

<p>O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.</p>

<p>RHPS4 (RHPS 4 methosulfate) is a potent inhibitor of Telomerase at submicromolar.</p>

<p>Umbralisib (TGR 1202) is a PI3Kδ inhibitor.</p>

<p>Otenaproxesul (ATB 346) is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.</p>

<p>(S)-Indoximod (L-Abrine) is an indoleamine-2,3-dioxygenase (IDO) inhibitor for cancer research.</p>

<p>Palbociclib monohydrochloride (PD 0332991 hydrochloride) is a selective inhibitor of CDK4/6, with no inhibition against a panel of 36 additional protein kinases</p>

<p>Osimertinib (AZD-9291) is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of NSCLC.</p>

<p>ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase</p>

<p>CDIM8 (DIM-C-pPhOH) opposes NR4A1, halts TGF-β breast cancer migration, induces ROS/ER stress, and mimics Nur77 RNAi in pancreatic cancer.</p>

<p>Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.</p>

<p>Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity.</p>

<p>MAT2A Inhibitor 4 acts as an inhibitor targeting the catalytic subunit of methionine S-adenosyltransferase-2 (MAT2A), offering potential utility in cancer</p>

<p>Ketorolac (Acuvail) is an NSAID that blocks prostaglandin synthesis, related to heterocyclic acetic acids.</p>

<p>Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.</p>

<p>Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with strong antitumor activity.</p>

<p>Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)</p>

<p>Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.</p>

<p>Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.</p>

<p>Galloflavin is a lactate dehydrogenase inhibitor. Galloflavin inhibits both human LDH isoforms (type A and type B).Cost-effective and quality-assured.</p>

<p>Thalidomide derivative compound 114 inhibits protomyosin receptor kinase, targets E3 ligase, potential for disease research.</p>

<p>Clobenpropit dihydrobromide is a potent antagonist and inverse agonist of histamine H3R (histamine H3LR,pEC50 of 8.07)</p>

<p>Nirogacestat (PF 03084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay).</p>

<p>D-Tagatose, a rare hexoketose and isomer of d-galactose, is naturally found in Sterculia setigera gum and various dairy products.</p>

<p>β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.</p>

<p>(-)-Epipodophyllotoxin: anticancer, GI50=0.36μM (HeLa), 0.24μM (MCF-7), inhibits spindle assembly.</p>

<p>KRAS inhibitor-9 (DUN09716) hinders GTP-KRAS formation, with a Kd of 92 μM, causes G2/M arrest, and induces apoptosis in mutated NSC-LC cells.</p>

<p>Tazemetostat (EPZ6438): Oral EZH2 inhibitor, blocks histone H3K27 methylation, potential cancer therapy.</p>

<p>Rhamnose monohydrate (L-(+)-Rhamnose Monohydrate) is a naturally-occurring deoxy sugar that is found primarily in plants and some bacteria.</p>

<p>Steviolbioside (CCRIS-6025) is a natural sweetener, which could be a potential remedy for human breast cancer.</p>

<p>Amsilarotene (TAC101) blocks RB phosphorylation, boosts 2 CDK inhibitors, halts cell cycle, and reduces thymidylate synthase and cyclin A levels.</p>

<p>SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.</p>

<p>AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.</p>

<p>MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.</p>

<p>Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.</p>

<p>Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1).</p>

<p>BC-DXI-843 is inhibitor of AIMP2-DX2, and is potential for development of novel therapeutics targeting AIMP2-DX2 in lung cancer.</p>

<p>MRT-10 is a Smoothened (Smo) receptor antagonist.</p>

<p>AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.</p>

<p>Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.</p>

<p>PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).</p>

<p>YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo.</p>

<p>Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.</p>

<p>Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.</p>

<p>PF-9363 (CTX-3648) is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.</p>

<p>(6R)-FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect.</p>

<p>Cephalomannine (Baccatin III) is a taxol derivative obtained from Taxus yunnanensis with antitumor activity.</p>

<p>Methyl caffeate (Methyl caffeate acid) acid</p>

<p>Bioymifi (DR5 Activator), a novel TRAIL activator, binds to DR5's ECD, inducing DR5 aggregation and stimulating cell apoptosis. Cost-effective and quality-assured.</p>

<p>HUHS015 is a potent PCA-1/ALKBH3 inhibitor.</p>