Heterociclos con nitrógeno (N)

<p>Applications 4-BROMO-2-PYRIDINECARBOXAMIDE (cas# 62150-46-3) is a useful research chemical.<br></p>

<p>Applications 5-Amino-2-cyclopropyl-4-oxazolecarboxylic Acid Ethyl Ester, is a heterocyclic building block used in the chemical synthesis.<br></p>

<p>Applications 2,3,5,6-Tetramethylpyrazolo[1,2-a]pyrazole-1,7-dione (cas# 68654-22-8) is a compound useful in organic synthesis.<br></p>

<p>Applications dimethyl 4-hydroxy-1H-pyrazole-3,5-dicarboxylate (cas# 23705-85-3) is a useful research chemical.<br></p>

<p>Applications (R)-Benzyl 2-((5-bromo-1H-indol-3-yl)methyl)pyrrolidine-1-carboxylate is used in the preparation of indole-derivative serotoninergic receptor agonists.<br></p>

<p>Stability Light Sensitive<br>Applications 4-(1-Naphthylvinyl)pyridine (cas# 16375-56-7) is a useful research chemical.<br></p>

<p>Applications 2,4-Diamino-6-hydroxypyrimidine-15N3 (cas# 1638736-04-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Amino-5-formylpyridine-3-carbonitrile is a useful research reagent<br>References Babaev, E.V., et al.: J. Am. Chem. Soc., 115, 2416 (1993)<br></p>

<p>Applications α-(2,3-Dimethylphenyl)-α-methyl-1H-imidazole-5-methanol-d3 is the isotope labelled analog of α-(2,3-Dimethylphenyl)-α-methyl-1H-imidazole-5-methanol (D473780); a reagent in the synthesis of Medetomidine (M203250) which is an α2-adrenergic agonist. Also a sedative and analgesic.<br>References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987); Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987); Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988); Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996); Chen, W., et al.: Faming Zhuanli Shenqing. CN 101921234 A 20101222. Dec 22, 2010<br></p>

<p>Applications A useful synthetic intermediate<br></p>

<p>Applications 4-(2-Oxopyrrolidin-1-yl)butanoic acid (cas# 6739-80-6) is a useful research chemical.<br></p>

<p>Applications A stable and versatile reagent for the efficient and chemically specific guanylation of sterically unhindered primary and secondary aliphatic amines under mild conditions. Useful reagent in peptide synthesis.<br>References Baslow, M., et al.: J. Inherit. Metab. Dis., 23, 684 (2000), Lee, Y., et al.: Bioorg. Med. Chem. Lett., 10, 2771 (2000), Baslow, M., et al.: Neurochem. Res., 27, 403 (2002),<br></p>

<p>Applications 5-Methoxyoxazole-2-carboxylic Acid Methyl Ester,is a oxazole-containing compound, that can be extensively used in medicinal chemistry. The oxazole group is a key element of a number of biologically active natural products.<br>References Thalhammer, A., et al.: Tetrahedron Lett., 50, 1045 (2009);<br></p>

<p>Applications (4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone is used in the synthesis of Ezetimibe (E975000), an antihyperlipoproteinemic; a cholesterol absorption inhibitor.<br>References Bankowski, K., et. al.: Przemysl Chemiczny, 91, 289 (2012); van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>

<p>Applications 2,3-Diamino-4-chloropyridine<br></p>

<p>Applications 5-Hydroxy-3H-imidazole-4-carboxamide (cas# 56973-26-3) is a compound useful in organic synthesis.<br></p>

<p>Applications N-1H-Imidazol-2-yl-formamide is used as a reagent in the synthesis of N-pyridinyl-2-[(thienylcarbonyl)amino]benzamides and its analogs as anticoagulants.<br>References Arnaiz, D.O., et al.: U.S. US 6140351 A 20001031. Oct 31, 2000<br></p>

<p>Applications 3-(difluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid (cas# 1394042-15-9) is a useful research chemical.<br></p>

<p>Applications Pyrrole-d5 (CAS# 18430-85-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-benzenamine is one of the key reactants with N-[1-(4-Aminophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide used in the synthesis of a pyrrolo[3,2-c]pyridine derivative [N-[1-[4-[[[[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide (I)], an anticancer diarylurea derivative with multiple-kinase inhibitory effect; Also, it is an intermediate used in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.<br>References El-Gamal, M. I., et al.: Bull. Korean Chem. Soc., 33, 1571-1576 (2012); Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);<br></p>

<p>Applications Used in the preparation of labelled indolizine compounds for use in antifungal combination therapy.<br></p>

<p>Applications 4-Amino-1,5-dimethylpyrazole is used in the preparation of pyridine compounds as focal adhesion kinase inhibitors.<br></p>

<p>Applications Intermediate in the preparation of various enzymatic inhibitors<br>References Poeckel, D., et al.: Mol. Pharmacol., 70, 1071 (2006), Wigle, T., et al.: Bioorg. Med. Chem. Lett., 17, 3249 (2007),<br></p>

<p>Applications tert-Butyl 2-cyanopiperazine-1-carboxylate (cas# 1053656-76-0) is a useful research chemical.<br></p>

<p>Applications An intermediate in the production of labelled Enrofloxacin.<br>References Chao, Q., et al.: J. Med. Chem., 52, 7808 (2009), Bebbington, D., et al.: Bioorg. Med. Chem. Lett., 19, 3586 (2009),<br></p>

<p>Applications (±)-N-(2,6-Dimethylphenyl)-1-iso-propyl-d7-2-piperidinecarboxamide (CAS# 1276197-11-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Piperidinemethanol, is a building block that can be used for the synthesis of selective inhibitors of sphingosine kinase 1 (SK1), that may serve as therapeutic agents for proliferative diseases, including hypertension.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baek, D., et al.: Chem.l Commun., 49, 2136 (2013);<br></p>

<p>Applications 5-Pyrimidinemethanamine (cas# 25198-95-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Hydroxy-N-methyl-2-pyrrolidinone-d3 is an isotopically labelled analogue of the metabolite of N-methylpyrrolidone (NMP, M326120).<br>References Payan, J., et al.: Drug Metab. Dispos., 30, 1418 (2002), Carnerup, M., et al.: Food Chem. Toxicol., 43, 1441 (2005), Angerer, J., et al.: Toxicol. Sci., 93, 3 (2006),<br></p>

<p>Applications methyl 1-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyrazole-5-carboxylate (cas# 929899-20-7) is a useful research chemical.<br></p>

<p>Applications N-(4-Methoxybenzyl)-N-2-pyridinyl-1,2-ethanediamine (cas# 109912-28-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Pyrrole-2-carboxylic Acid is a reagent used in the synthesis of potent small molecule inhibitors of severe acute respiratory syndrome (SARS) coronavirus. Also used in the synthesis of [2,3-c]pyridine-7-one scaffolds.<br>References Jacobs, J. et al.: 56, 534 (2013); Nechayev, M. et al.: Mol. Div., 16, 749 (2012);<br></p>

<p>Applications 2,6-Dichloro-4-nitraminopyridine (cas# 2587-03-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Chloromethyl-3H-benzoimidazole-5-carbonitrile (cas# 150613-50-6) is a useful research chemical.<br></p>

<p>Applications 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-B]PYRIDINE (cas# 1189853-67-5) is a useful research chemical.<br></p>

<p>Applications 4-(Dimethylamino)pyridin-1-ium ((2-Nitrophenyl)sulfonyl)(phenoxycarbonyl)amide is an intermediate used in the synthesis of Monosulfuron (M567185), which is a sulfonylurea herbicide that inhibits Acetohydroxyacid synthase enzyme.<br>References Wang, J., et al.: J. Comput. Aided Mol. Des., 19, 801 (2005);<br></p>

<p>Applications 7-Methyl-1-phenylpyrazolo[1,5-a]pyrimidine-2,5(1H,4H)-dione, is a building block used in the synthesis of various 5-pyrazolone derivatives.<br>References El-Zanfally, S. et al.: Indian Journal of Chemistry, Vol. 16B, Iss. 6, P: 496-8 (1978);<br></p>

<p>Applications Methyl 4-hydroxy-1H-pyrrole-2-carboxylate is a useful reagent for organic synthesis.<br></p>

<p>Applications 5-(Difluoromethyl)-1h-pyrazol-3-amine<br></p>

<p>Applications Pyrazinoic Acid Ethyl Ester (cas# 6924-68-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-phenyl-1H-pyrrole-2-carboxylic acid (cas# 802052-63-7) is a useful research chemical.<br></p>

<p>Applications N-(Benzoyl)piperazine-2,2,3,3,5,5,6,6-d8 (CAS# 1219805-49-8) is a useful isotopically labeled research compound.<br></p>

<p>Stability N/A<br>Applications (R)-(-)-4-Phenyl-2-oxazolidinone (cas# 90319-52-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl 2,5-Dibromo-1,3-oxazole-4-carboxylate is useful for the synthesis of substituted oxazoles.<br>References Hodgetts, K. J., et al.: Org. Lett., 4, 2905-2907 (2002)<br></p>

<p>Applications {6-[(Oxolan-3-yloxy)methyl]pyridin-2-yl}methanamine Dihydrochloride is the acid form of {6-[(Oxolan-3-yloxy)methyl]pyridin-2-yl}methanamine (CAS: 1701690-73-4) which is a useful reagent for making triazolo pyrimidine intermediates.<br>References By, K., et at.: PCT Int. Appl. (2018), WO 2018183965 A1 20181004<br></p>

<p>Applications 1-(4-Chlorophenyl)-3-[(2-nitrophenyl)methoxy]pyrazole is an intermediate for the synthesis of Pyraclostrobin-d6 (P840402). Isotope labelled Pyraclostrobin is a fungicide for use in seed grass and food crops.<br>References Gyldenkaerne, S., et al.: Pestic Sci., 55, 1210 (1999), Pennington, D., et al.: Environ. Sci. Technol., 39, 1119 (2005), Wang, S., et al.: Food Control., 18, 731 (2007),<br></p>

<p>Applications 5-(2-Pyridyl)-1,2-dihydropyridin-2-one is used in the synthesis of AMPA receptor antagonists in the treatment of neurological diseases causing dysfunction of glutamatergic neurotransmission.<br>References Hibi, S. et al.: J. Med. Chem., 55, 10584 (2012); McElhinny, C. et al.: Synthesis, 44, 57 (2012);<br></p>

<p>Applications rac-α-N-Boc-Amino-4-pyridineaceic Acid is a reagent used in the preparation of lactam-containing diaminoalkanes, β/α-amino acids and derivatives of Xa inhibitors.<br></p>

<p>Applications A product from the pyrolysis of phenylalanine.<br>References Kim, D., et al.: Bioorg. Med. Chem. Lett., 15, 2129 (2005), Che, W., et al.: Env. Toxicol. Pharmacol., 24, 11 (2007), Heitman, L., et al.: J. Med. Chem., 51, 4724 (2008),<br></p>

<p>Applications Ethyl 5-(thiophen-2-yl)isoxazole-3-carboxylate is a useful reagent for organic synthesis.<br></p>

<p>Applications Used for preparation of substituted phenyl-containing imidazolium ionic liquid.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Peris, E., et al.: Coord. Chem. Rev., 248, 2239 (2004),<br></p>

<p>Applications 1-PHENYL-3-(PIPERIDIN-1-YL)PROPAN-1-ONE HCL (cas# 886-06-6) is a useful research chemical.<br></p>

<p>Applications 2-Oxo-2-(1-phenyl-1H-pyrazol-4-yl)acetic Acid is a derivative of N-Phenylpyrazole, a reactant in the synthesis of candesartan cilexetil(C175580), an ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive.<br>References Seki, M. et. al: ACS Catalysis, 4, 4047 (2014); Shibouta, Y., et al.: J. Pharmacol. Exp. Ther., 266, 114 (1993; Ogihara, T., et al.: Clin. Ther., 16, 74 (1994)<br></p>

<p>Applications 6-methylimidazo[1,2-a]pyridin-2-amine (cas# 39588-33-5) is a useful research chemical.<br></p>

<p>Applications 6-Amino-2-chloro-5-nitropyridine (cas# 27048-04-0) is a compound useful in organic synthesis.<br></p>

<p>Applications tert-Butyl 4-(3-hydroxypropyl)piperidine-1-carboxylate is a reagent in the preparation of 1-alkyloxy-2-methoxy-4-nitrobenzene fragments: potent human glutaminyl cyclase inhibitors<br>References Hoang, Van-Hai, et al.: J. of Med. Chem., 60(6), 2573-2590 (2017)<br></p>

<p>Applications 5-Bromo-4-chloro-2,6-dimethoxypyrimidine (cas# 42362-16-3) is a compound useful in organic synthesis.<br></p>

<p>Applications DI-TERT-BUTYL 2-(HYDROXYMETHYL) PIPERAZINE-1,4-DICARBOXYLATE (cas# 143540-05-0) is a useful research chemical.<br></p>