Compuestos heterocíclicos

M02705 - 5-Bromo-3-indolyl-b-D-galactopyranoside

M02322 - Parthenolide

Applications oxazole-4-carbohydrazide (cas# 885274-12-4) is a useful research chemical.

Applications Tetrahydrofuran-2,5-dicarboxylic acid (CAS# 6338-43-8) is a useful research chemical compound.

Applications 4,4-dimethyldihydrofuran-2,3-dione (cas# 13031-04-4) is a useful research chemical.

Applications Phenazine Ethosulfate is an intermediate which is used to detect nitric oxide reducatase activity. Dyes and metabolites.

Applications (2,4-Dioxo-thiazolidin-3-yl)-acetic Acid is a useful compound for preparation of novel thiazolidinedione-​hydroxamates as Zmp1 inhibitors.
References Slachtova, V., et al.: Eur. J. Med. Chem., 185, 111812 (2020)

Applications 2-Aminothiazole-4-carboxamide is a useful intermediate for organic synthesis and other chemical processes.
References Sanghvi, Y. S., et al.: J. Heterocycl. Chem., 25, 623 (1988); Wu, J., et al.: Bioorg. Med. Chem. Lett., 17, 4664 (2007)

Applications 2-(Thiophen-2-yl)acetamide is used in preparation of [18F]Maleimide-based Glycogen synthase kinase-3β ligands for positron emission tomography imaging.
References Lee, Katarzyna N., et al.: PCT Int. Appl., (2018);

Stability Hygroscopic
Applications 3-(1-Nitroethyl)-2-benzofuran-1(3H)-one (cas# 79017-08-6) is a useful research chemical.

Impurity Abacavir - In House Impurity
Applications rac 2-Azabicyclo[2.2.1]hept-5-en-3-one (Abacavir - In House Impurity) is a useful reagent in the synthesis of carbocyclic sugar amines, carbanucleosides, and carbocyclic dinucleotide analogues (1). rac 2-Azabicyclo[2.2.1]hept-5-en-3-one is also an intermediate of Abacavir (A104990), a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Slama, J.T., et al.: Biochemistry, 27, 183 (1988) (2) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (3) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

Applications 1-Ethylpyrrole (cas# 617-92-5) is a useful research chemical.

Applications Phenazine methosulfate is a compound used to determine nitric oxide reductase activity. Used in the discovery of potent bromophenazine antibacterial agents against Staphylococcus.
References Watanabe, A. et al.: Neurosci., 339, 139 (2016);