Ácidos y reactivos sintéticos

<p>Applications MK 1775 is used in biological studies for the abrogation of G2/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma.<br>References Indovina, P., et al.: Cancer Bilo. Ther., 15, 380 (2014);<br></p>

<p>Applications A volatile alkyl compound present in tobacco smoke. It is used as a potential biomarker in breath for prediction of lung cancer.<br>References Phillips, M. et al.: Cancer Biomarkers, 3, 95 (2007); Li, Y. et al.: Yan. Keji, 10, 15 (2005);<br></p>

<p>Applications Bucindolol is a high-affinity, competitive beta blocker used in the treatment of congestive heart failure and hypertension.<br>References Hershberger, R., et al.: J. Cardiovasc. Pharm., 15, 959 (1990); Pollock, S., et al.: Am. J. Cardiol., 66, 603 (1990); Rotmensch, H., et al.: Am. J. Cardiol., 54, 353 (1984)<br></p>

<p>Applications It is a tight-binding, uncompetitive inhibitor of mitogen-activated protein kinase kinases (MEK) 1 and 2 currently in clinical development. It is useful as biomarker in human lung cancer cell. Potent MEK inhibitor.<br>References Ciardiello, F., et al.: Clin. Cancer Res., 7, 1459 (2001), Hidalgo, M., et al.: J. Clin. Oncol., 19, 3267 (2001),<br></p>

<p>Stability Hygroscopic<br>Applications The R-enantiomer of Lansoprazole; a gastric proton pump inhibitor. An antiulcerative.<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000), Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001), Barradell, L.B., et al.: Drugs, 44, 225 (1992), Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002), Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006),<br></p>

<p>Applications Tivozanib is known as an oral VEGF receptor tyrosine kinase inhibitor, exhibiting antitumor effects towards renal cell carcinoma.. Tivozanib suppresses angiogenesis by selectively inhibiting against vascular endothelial growth factor. Potent VEGFR inhibitor.<br>References Nosov, D.A., et al.: J. Clinical. Oncol., 30, 1678 (2012); Pal, S.K., et al., Molec. Cancer. Thr, 11, 526 (2012);<br></p>

<p>Applications Sodium Phosphate Dibasic Dihydrate is a treatment of Ischemic stroke with aptamers targeting toll-like receptor 4 (TLR-4).<br>References Perez Rodriguez, D., et al.: PCT Int. Appl., (2020);<br></p>

<p>Applications Phosphoric Acid Monosodium Salt Dihydrate, is a reagent widely used in the preparation of biological buffers. It is highly hygroscopic and can be used in many applications including in gel electrophoresis.<br>References Salaun, F.: "Influence of mineral environment on the buffering capacity of casein micelles", "Milchwissenschaft", 62(1):3<br></p>

<p>Applications Hydrochloride salt of benzyltriethylammonium which acts as a phase-transfer catalyst in chemical reactions.<br>References Shi, Z. et al.: Chem. Sci., 4, 829 (2013); Landeros, J. et al.: J. Mol. Struct., 1037, 412 (2013);<br></p>

<p>Applications LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice.<br>References Lin, C., et. al.: J. Biol. Chem., 286, 10483 (2011); Cao, H., et. al.: J. Biol. Chem., 288, 30399 (2013);<br></p>

<p>Applications 2,2'-Bis(diphenylphosphino)-1,1'-dinaphthalene is a powerful chiral auxiliary that is used as a homogeneous catalyst in some asymmetric chemical syntheses. 2,2'-Bis(diphenylphosphino)-1,1'-dinaphthalene is utilized for its high enantioselectivity and is used as a ligand to create coordination complexes.<br>References DiBari, L., et al.: J. Am. Chem. Soc., 121, 7998 (1999); Hatano, M., et al.: J. Am. Chem. Soc., 130, 16858 (2008); Kitamura, M., et al.: Tetrahedron Lett., 32, 4163 (1991); Shimada, T., et al.: J. Org. Chem., 66, 8854 (2001)<br></p>

<p>Stability Light Sensitive, Volatile<br>Applications An antibacterial agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kind, T., et al.: Anal. Biochem., 363, 185 (2007), Spratlin, J., et al.: Clin. Cancer Res., 15, 431 (2009),<br></p>

<p>Applications Anesthetic, analgesic, antimicrobial and cooling agent for prevention or treatment of skin irritation.<br>References Gaster, L.M., et al.: J. Med. Chem., 36, 4121 (1993),<br></p>

<p>Applications Bepotastine is a histamine H1 receptor antagonist. Bepotastine suppresses some allergic inflammatory processes such as allergic rhinitis, chronic urticaria or pruritus associated with skin conditions (eczema/dermatitis, prurigo or pruritus cutaneus).<br>References Kaminuma, O. et al.: Biol. Pharm. Bull., 21, 411 (1998); Kitaba, S. et al.: J. Allergy, No pp. given (2008); Lyseng-Williamson, K.A., Drugs, 70, 1579 (2010);<br></p>

<p>Applications Sodium Tetrachloroaurate(III) Dihydrate, is an essential chemical compound used in chemical synthesis as gold catalyst.<br></p>

<p>Applications 3,3-Diphenylpropylamine is a metabolite of Prenylamine (P712800). 3,3-Diphenylpropylamine showed antiextensor effects as well as neuroexcitatory effects and antagonized barbital-induced loss of the righting reflex.<br>References Hornke, I. et al.: Arzneim.-Forsch., 20, 791 (1970); Remberg, G. et al.: Biomed. Mass Spec., 4, 197 (1977); Helke, C. et al.: Eur. J. Pharmacol., 48, 231 (1978);<br></p>

<p>Applications Gepirone is an antidepressant and anxiolytic of the azapirone class. It acts as a selective partial agonist of the 5-HT1A receptor.<br>References Sharp, T., et al.: Brit. J. Pharm., 96, 283 (1989); Dunn, R., et al.: Eur. J. Pharm., 169, 1 (1989)<br></p>

<p>Applications Bromocyclopentane, is an organic reagent that can be used as both the starting material and an intermediates in the chemical synthesis. It can be used as an starting material in the synthesis of Glycopyrrolate Bromide (G656980), which is a is a medication of the muscarinic anticholinergic group.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kaltiala, E., et al.: J. Pharm. Pharmacol., 26, 352 (1974), Kongsrud, F., et al.: Acta Anaesthesiol. Scand., 26, 620 (1982),<br></p>

<p>Applications Tetrabutylammonium Acetate acts as a catalyst in organic syntheses of anion sensors.<br>References Gu, X. et al.: J. Mol. Liq., 222, 425 (2016); Bayindir, S. et al.: RSC Adv., 6, 72959 (2016);<br></p>

<p>Applications Sofalcone is a substituted chalcone with anti-ulcer activity.<br>References Matsuo, Y., et al.: Arzneim. Forsch., 33, 242 (1983), Suwa, T., et al.: Jpn. J. Pharmacol., 35, 47 (1984),<br></p>

<p>Stability Hygroscopic<br>Applications Brobactam is a potent semi-synthetic β-lactamase inhibitor as well as an impurity of Sulbactam (S699185).<br>References Melchior, N.H. et al.: Proc. Int. Congr. Chemother., 3, 55 (1983);<br></p>

<p>Applications Orally active inhibitor of central and peripheral catechol-O-methyltransferase (COMT). Antiparkinsonian.<br>References Dingemanse, J., et al.: Clin. Pharmacol. Ther., 57, 508 (1995), Keating, K.A., Drugs, 19, 165 (2005),<br></p>

<p>Applications Dofetilide is a potassium channel blocker. Antidysrhythmic drug.<br>References Carmeliet, D., et al.: J. Pharmacol. Exp. Ther., 262, 809 (1992); Norgaard, B.L., et al.: Am. Heart J., 137, 1062 (1999); Torp-Pedersen, C., et al.: N. Engl. J. Med. 341, 857 (1999);<br></p>

<p>Applications tert-Butyl (R)-3-Aminopiperidine-1-carboxylate, is an heterocyclic building block used for the synthesis of more complex pharmaceutical compounds. It is also found to act as a γ-secretase modulators, and a potent structure for lowering Aβ42 production in both in vitro and in vivo.<br>References Kobayashi, T., et al.: Bioorg. Med. Chem. Lett., 24, 378 (2014);<br></p>

<p>Applications 4-Chlorobenzenethiol is a reagent used in the synthesis of small-molecule inhibitors of the protein geranylgeranyltransferase Type I (GGTase-I), acting as anti-tumor agents. Also is used in the synthesis of β-sulfanyl carbonyl compounds via Michael addition.<br>References Ranu, B. et al.: Tetrahedron, 60, 4183 (2004); J. Med. Chem., 43, 2310 (2000);<br></p>

<p>Stability Hygroscopic<br>Applications (S)-(+)-2-Methylbutyric Acid is a chiral starting reagent used in various synthetic preparations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Neves, F., et al.: Beilstein. J. Org. Chem., 7, 1504 (2011); King, A.M., et al.: J. Medn. Chem., 54, 6432 (2011); Ferrarni, A., et al.: Chirality., 26, 9 (2011);<br></p>

<p>Applications (3-Glycidoxypropyl)triethoxysilane is used in the fabric industry to treat and modify fabrics.<br>References Schramm, Christian, et al.: Coloration Tech., 133(3), 234-242 (2017);Grancaric, Ana Marija, et al.: Pro. in Org. Coatings, 103, 174-181 (2017); Yeo, Jun-Seok, et al.: J. of Ind. and Eng. Chem., 45, 301-306 (2017)<br></p>

<p>Applications (R)-2-Hydroxybutanoic acid (cas# 20016-85-7) is a useful research chemical.<br></p>

<p>Applications Barium hydroxide octahydrate is a reagent that is used in solid state metathesis of rocksalt oxides for synthesis of perovskite oxides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mandal, T. K., et al.: J. Mat. Chem., 14, 1273 (2004);<br></p>

<p>Applications A multikinase inhibitor once used for cancer treatment.<br>References Ulisse, S., et al.: J. Endocrinol., 204, 135 (2010), McDermott, U., et al.: Cancer Res., 70, 1625 (2010), Donato, N., et al.: Biochem., Pharmacol., 79, 688 (2010),<br></p>

<p>Applications Ammonium thiocyanate is used in synthetic chemistry as a thiocyanation reagent. Ammonium thiocyanate is also a knwn plant poison and is used as a weed eradicant in the agricultural industry.<br>References Harvey, R.: Agronomy J.: 23, 944 (1931); Sandhoff, A. &amp; Skinner, C.: Soil Sci., 48, 287 (1939); Wu, G., et al.: Tetrahedron Lett., 46, 5831 (2005)<br></p>

<p>Applications (R)-(+)-Citronellic Acid is an oxidized derivative of Citronellal (C525025), a monoterpene compound that is formed by the metabolism of plants.<br>References Brito, R.G., et al.: J. Nat. Med., 66, 637 (2012);<br></p>

<p>Applications Phosphoric acid, ammonium salt (1:1) is a useful reagent for organic synthesis.<br></p>

<p>Stability Light Sensitive<br>Applications β-Caryophyllene is notable for having a cyclobutane ring, a rarity in nature. β-Caryophyllene is one of the chemical compounds that contributes to the spiciness of black pepper. β-Caryophyllene was shown to selectively bind to the cannabinoid receptor type-2 (CB2) and to exert significant cannabimimetic antiinflammatory effects in mice.<br>References Kaul, P.N., et al.: J. Sci. Food Agric., 83, 53 (2003); Singh, G., et al.: J. Agric. Food Chem., 54, 174 (2006);<br></p>

<p>Applications Triacetyl-β-cyclodextrin is a derivative of β-Cyclodextrin (C987830) and can be used as an extractant agent or drug carrier for controlled drug delivery.<br>References Nunes, A.V.M., et al.: J. Supercrit. Fluids., 54, 357 (2010); Kim, L., et al.: Supramol. Chem., 21, 131 (2009); Ivanova, G.I., et al.: Magn. Reson. Chem., 47, 133 (2009)<br></p>

<p>Applications Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.<br>References Walker, D., et al.: Pediatr. Blood Cancer 60,616 (2013); Kang, M., et al.: J. Chemother., 24, 292 (2012); Lipshultz, S., et al.: New England J. Med., 35, 145 (2004)<br></p>

<p>Applications (S)-α,α-Bis[3,5-di(trifluoromethyl)phenyl]-O-(trimethylsilyl)pyrrolidine-2-methanol, is a diarylprolinol silyl ether organocatalyst. It is able to catalyze a variety of bond-forming reactions such as C-C, C-N, C-O, C-S, and C-Hal in high yields and excellent levels of enantiocontrol.<br>References Jensen KL, et al. Accounts of Chemical Research 45(2), 248-264, (2011);<br></p>

<p>Applications A receptor adenine derivative binding membrane brain animal cell line.<br>References Camaioni, E., et al.: Bioorg. Med. Chem., 6, 523 (1998), Kelly, M., et al.: Br. J. Pharmacol., 125, 979 (1998), Redzic, Z., et al.: Brain Res., 888, 66 (2001), Levy, D., et al.: J. Med. Chem., 46, 2177 (2003),<br></p>

<p>Applications Toceranib Phosphate is a useful compound in the treatment of chemotherapy-induced diarrhea.<br>References Conte, L. A.: U.S. Pat. Appl. Publ. (2020), US 20200345687 A1<br></p>

<p>Stability Light Sensitive<br>Applications Gallic Acid is a phenolic acid with antioxidant activity. Gallic acid was found to protect human cells against oxidative damage and showed cytotoxicity against cancer cells. Gallic Acid and its esters also show antiviral and antifungal activities.<br>References Yen, G. et al.: Food Chem., 79, 307 (2002); Chen, C. et al.: Mol. Nutrit. Food Res., 51, 962 (2007); Kratz, J. et al.: Mem. Inst. Oswaldo Cruz, 103, 437 (2008); Osborne, L. et al.: Infect. Immun., 33, 769 (1981);<br></p>

<p>Applications ORM-15341 is a metabolite of Darolutamide. Darolutamide is a potent androgen receptor antagonist with strong efficacy in prostate cancer models.<br>References Sugawara, T., et al.: Int. J. Cancer, 145, 1382 (2019); Yu, J., et al.: Eur. J. Med. Chem., 182, 111608 (2019)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Ampicillin. Orally active, semi-synthetic antibiotic; structurally related to penicillin. Antibacterial.<br>References Ivashkiv, E., et al.: Anal. Profiles Drug Subs., 2, 1 (1973), Campoli-Richards, D.M., et al.: Drugs, 33, 577 (1987), Sill, M. L., et al.: Antimicrob. Agents Chemother., 52, 1551 (2008),<br></p>

<p>Impurity Voriconazole EP Impurity E (1R)-Isomer<br>Stability Hygroscopic<br>Applications (1R)-(-)-10-Camphorsulfonic Acid (Voriconazole EP Impurity E (1R)-Isomer) is a chiral derivative of Camphor. Used in the preparation of a chiral recognition polymer that is used in the chiral separation of amino acids. A catalyst in direct animation of α-branched aldehydes (including important biological molecules such as α-Me phenylglycine) with near perfect enantioselectivity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Guo, H. et al.: Polym. Preprints Am. Chem. Soc., 40, 506 (1999); Liu, C. et al.: Org. Lett., 13, 2638 (2011);<br></p>

<p>Applications PYR-41 is the cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.<br>References Yang, Y., et al.; Cancer Res., 67, 9472 (2007); Ungermannova, D., et al.: J. Biomol. Screening, 17, 421 (2012)<br></p>

<p>Applications Croscarmellose Sodiumis a super disintegrant used in pharmaceuticals in the synthesis of tablets for oral administration.<br>References Reddy, V. et al.: Asian J. Pharm. Anal. Med. Chem., 2, 1 (2014);<br></p>

<p>Applications Iron(III) meso-Tetraphenylporphine Chloride along with Cameroonian smectite clay has been employed to modify glassy carbon electrodes used in the simultaneous quantification of ascorbic acid, uric acid and nitrite.<br>References Kemmegne-Mbouguen, J.C., et al.: Sens Actuators B Chem, 212, 464-471 (2015);<br></p>

<p>Applications Ziprasidone free base (cas# 146939-27-7) is a useful research chemical.<br></p>

<p>Applications 2-Acetylphenothiazine is a potent and selective NADPH oxidase 1 (NOX1) inhibitor that blocks NOX1-dependent ROS generation. 2-Acetylphenothiazine has been shown to inhibit SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.<br>References Gianni, D. et al.: ACS Chem. Biol., 5, 981 (2010); Azuine, M.A. et al.: Pharmacol. Res., 49, 161 (2004);<br></p>

<p>Applications Deshydroxyethoxy Ticagrelor analog of Ticagrelor (T437700) an antiplatelet agent, and preventative in the treatment of heart attacks, myocardial infarction, and other pulmonary diseases.<br>References Zhang, H. et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012);<br></p>

<p>Applications Sclareol is used in biological studies as it has anti-inflammatory activity in both lipopolysaccharide-stimulated macophages and λ-carrageenan-induced paw edema model.<br>References Huang, G., et al.: J. Nat. Prod., 75, 54 (2012); Weninger, S., et al.: Nat. Med 7, 527 (2001)<br></p>

<p>Applications AR-AO 14418 is a glycogen synthase kinase 3β (GSK-3β) inhibitor (1,2,3). GSK-3β is a serine/threonine protein kinase that is involved numerous diseases such as type II diabetes and Alzheimer's.<br>References (1) Koh, S., et al.:Toxicol., 247, 112 (2008) (2) Vadivelan, S., et al.: Eur. J. Med. Chem., 44, 2361 (2009) (3) Min, W., et al.: Neuropharmacol., 56, 463 (2009)<br></p>

<p>Applications Serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.<br>References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),<br></p>

<p>Applications Sodium Borohydride is used as a reagent in the reduction of amino acids and their derivatives. Also used in the catalysis of ammonia borane dehydrogenation.<br> E0<br>References McKennon, M. et al.: J. Org. Chem., 58, 3568 (1993); Denney, M. et al.: J. Am. Chem. Soc., 128, 12048 (2006);<br></p>

<p>Stability Hygroscopic<br>Applications Tris(3-sulfophenyl)phosphine Trisodium Salt is a reagent used in organic synthesis such as benzothiazole-based cycloplatinated chromophores.<br>References Lalinde, E. et al.: Chem. A Eur. J., 24. 2440 (2018);<br></p>

<p>Applications Silodosin is an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertrophy.<br>References (1) Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995) (2) Murata, S., et al.: J. Urol., 164, 578 (2000)<br></p>

<p>Applications 1-Cyclohexenylcarboxylic Acid is a reagent used in the synthesis and optimization of small-molecule HIV-1 entry inhibitors. Also used in the stereoselective synthesis of diazabicyclic β-lactams for antimicrobial activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tuyishime, M. et al.: Bioorg. Med. Chem. Lett., 24, 5439 (2014); Zhang, S. et al.: J. Org. Chem., 81, 956 (2016);<br></p>

<p>Applications Myxochelin A is a potent inhibitor of human 5-lipoxygenase (5-LO). Studies show that Myxochelin A is a natural product that may possess potent antitumor activity at non-cytotoxic concentrations.<br>References Schieferdecker, S., et al.: Tetrahedron Lett., 57, 1359 (2016); Korp, J., et al.: ChemBioChem., 16, 2445 (2015); Schieferdecker, S., et al.: J. Nat. Prod., 78, 335 (2015)<br></p>

<p>Applications An oral angiogenesis inhibitor targeting VEGFR and PDGFR.<br>References Olaussen, K., et al.: Oncogen., 28, 4249 (2009), Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009),<br></p>

<p>Applications 3-Acetopropanol is a substrate for alcohol dehydrogenase and is an intermediate in the synthesis of Didesethyl Chloroquine (D440960), a metabolite of Chloroquine.<br>References Ohkuma, S., et al.: J. Cell. Biol., 90, 656 (1981); Araki, N., et al.: J. Biol. Chem., 267, 10211 (1992); Projean, D., et al.: Drug Metab. Dispos., 31, 748 (2003); Traebert, M., et al.: Eur. J. Pharmacol., 484, 41 (2004)<br></p>

<p>Applications Dimethyl Aminoterephthalate is used to prepare imidazotetrazinones as probes for action of temozolomide. It can be used to prepare aminoquinazolines with neurokinin-2 receptor antagonist activity.<br>References Clark, A., et al.: J. Med. Chem., 38, 1493 (1995); Jacobs, R., et al.: Bioorg. Med. Chem. Lett., 5, 2879 (1995)<br></p>

<p>Applications Sodium Thiosulfate is used primarily as a medicament against cyanide poisoning, able to convert cyanide into thiocyanate, a reaction which is catalyzed by the enzyme Rhodanese. Antioxidant.<br>References Emuebie, O. et al: Aus. J. Basic App. Sci., 5, 507 (2011); Cambal, L. et al.: Chem. Res. Toxicol., 24, 1104 (2011); Lam, X. et al.: J. Pharm. Sci., 86, 1250 (1997);<br></p>

<p>Applications Anti-bacterial agent.<br>References Banfi, E., et al.: J. Chemotherapy, 5(3), 164 (1993),<br></p>

<p>Stability Hygroscopic<br>Applications Hydrochloride salt of isotope labelled N,N-Di(methyl)methanamine is an intermediate in the preparation of Trimethylamine N-Oxide Dihydrate, an oxygen transfer agent.<br>References Li, Q. et al.: Fen. Cuihua, 12, 1 (1998); Patra, N. et al. Polym. Degrad. Stab., 96, 1377 (2011); Cozzoli, P.D. et al.: J. Am. Chem. Soc., 126, 3868 (2004);<br></p>

<p>Applications SRT1720 acts as a therapeutic in the treatment of type 2 diabetes. It modulates calories and contributes to glucose homeostasis and insulin sensitivity.<br>References Milne, J. et al.: Nature, 450, 712 (2007);<br></p>

<p>Applications 4-Acetylbenzenesulfonyl Chloride is used as one of the substances for mutagenic and carcinogenic risk assessment of carboxylic and sulfonic acid halides as drug impurities. Also, acts as a reagent for the synthesis of (+)-Dehydroabietylamine derivatives which are targeted for triple-negative breast cancer treatment.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Amberg, A., et al.: Org. Process Res. Dev., 19, 1495 (2015); Ling, T., et al.: Eur. J. Med. Chem., 102, 13, (2015)<br></p>

<p>Stability Hygroscopic<br>Applications Sodium Sulfate is a chemical reagent with a wide variety of uses, ranging from filler in laundry detergents, to manufacture of textiles. Also used in the process of paper pulping.<br>References Quina, F. et al.: J. Phys. Chem., 99, 17028 (1995); Wartena, R. et al.: J. App. Electrochem., 32, 415 (2002);<br></p>

<p>Applications A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It has shown its efficacy against neurodegenerative diseases including Alzheimer's and Parkinson's.<br>References Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004),<br></p>

<p>Applications N-(chloroacetoxy)succinimide is a N-hydroxysuccinimide ester of a simple carboxylic acid. N-(chloroacetoxy)succinimide is used in the preparation of organometallic complexes and other synthetic probes for the labeling of proteins.<br>References Salmain, M. et al.: Bioconj. Chem., 4, 425 (1993); Nonaka, H. et al.: J. AM. Chem. Soc., 129, 15777 (2007);<br></p>

<p>Applications Chiral derivative of 3-Hydroxyisobutyrate.<br>References Waldmann, H., et al.: Bioorg. Med. Chem., 2, 477 (1994), Vonstein, V., et al.: J. Bacteriol., 177, 4540 (1995),<br></p>

<p>Applications TEMPO is a stable radical prepared through the oxidation of 2,2,6,6-tetramethylpiperidine. TEMPO has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy. TEMPO can also be used as a mediator in free radical polymerization.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Seaton, T.A. et al.: Brain Res., 777, 110 (1997); Tanielyan, S.K. et al.: Top. Catal., 55, 556 (2012); Wolinska-Grabczyk, A. et al.: Polymer, 46, 2461 (2005); Keoshkerian, B. et al.: Polym. Prep., 35, 675 (1994);<br></p>

<p>Stability Moisture, Light Sensitive<br>Applications A fluoresent compound used for the rapid and selective modification of sulfhydryl groups of enzymes.Fluorescence: max. Abs. 535nm; max. Em. 605nm;<br>References Stauffer, D.A., and Karlin, A.: Biochemistry, 33, 6840 (1994), Yang, N. et al.: Neuron, 16, 113 (1996), Kuner, T. et al.: Neuron, 17, 343 (1996)<br></p>

<p>Applications Magnesium Sulfate is used in the production of epsom salts, as well as being a potential agent to protect against cerebral palsy and other neurological disorders in preterm infants.<br>References Doyle, L. et al.: Obst. Gyne., 6, 1327 (2009); Mukhopadhyay, C. et al.: J. Hetero. Chem., 47, 136 (2010);<br></p>

<p>Applications OCTADECYLTRIETHOXYSILANE (cas# 7399-00-0) is a useful research chemical.<br></p>

<p>Applications 5-Hydroxymethyl-2-furoylglycine can be used as analyte for analytical and biological studies of determination of metabolites of 5-​hydroxymethylfurfural in human urine after oral application.<br>References Hardt-Stremayr, M., et al.: J Sep Sci., 36, 670-676 (2013)<br></p>

<p>Applications An impurity of the anti-convulsant (S)-Pregabalin (P704790).<br>References Lin, S. et al.: J. Liq. Chrom. Rel. Technol., 19, 2699 (1996); Sripathi, S. et al.: ARKIVOC, 10, 266 (2010);<br></p>

<p>Applications α-Copaene is a tricyclic sesquiterpenes and can be extracted from the oil of S. aethiopis. It also exhibit anti-plasmodial activity against P. falciparum in culture.<br>References Boyom, F. F., et al.: Phytochemistry 64, 1269 (2003); Rustaiyan, A., et al.: Flavour Frag. J 14, 276 (1999)<br></p>

<p>Stability Hygroscopic<br>Applications Bis(tributylammonium) Pyrophosphate is an phosphorylating reagent used in the synthesis of phosphorylated deoxynucleosides.<br>References Santner, T. et al.: Bioorg. Med. Chem, 20, 2416 (2012); Sun, D. et al.: ChemMedChem, 4, 1649 (2009)<br></p>

<p>Applications Hydrazine Hydrate used as a reactant in the cyclizations of pyridinones. It is also used in the study of nanocrystal semiconductors, participating in the functionalization and passivation of surface states.<br> E0<br>References Smolyar, N. et al.: Rus. J. Org. Chem., 44, 1205 (2008); Traub, M. et al.: J. Am. Chem. Soc., 130, 955 (2008);<br></p>

<p>Applications Diclofenac and its combination with Pitofenone and Fenpiverinium shows antispasmodic activity.<br>References Lundstam, S., et al.: Lancet, 1, 1096 (1982), Thompson, J., et al.: Br. Med. J., 299, 1140 (1989), Marthak, K., et al.: Curr. Med. Res. Opi.,12, 366 (1991),<br></p>

<p>Applications Zinc Chloride is a common chemical reagent used in organic syntheses, often alkylation reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Huo, S. et al.: Org. Lett., 5, 423 (2003);<br></p>

<p>Applications 1,1-Bis(4-hydroxyphenyl)-2-phenyl-1-butene (cas# 91221-46-4) is a compound useful in organic synthesis.<br></p>