Ácidos y reactivos sintéticos

<p>Applications L-838417 is an anxiolytic agent and a selective GABAA receptor partial agonist that selectively binds to α1, α2, α3 and α5 subunits (1,2). It also exhibits antinociceptive and anti-inflammatory properties.<br>References (1) Knabl, J., et al.: Nature. 451, 330 (2008) (2) Johnston, G.A.R., et al.: Curr. Pharm. Design, 11, 1867 (2005)<br></p>

<p>Applications Sodium Orthovanadate is an inhibitor of several phosphatases and kinases. General inhibitor of tyrosine phosphatases, a large family of enzymes that catalyze the removal of phosphate groups from tyrosine residues.<br>References Khalil, A. A., et al.: Biochem., 82, 149-155 (2017)<br></p>

<p>Applications (S)-2-Amino-4-methylpentanol is a starting material for the synthesis of aminopeptidase N and phospholipase A2 inhibitors.<br>References Fournié-Zaluski, M., et al.: J. Med. Chem., 35, 1259 (1992); Bennion, C., et al.: J. Med. Chem., 35, 2939 (1992)<br></p>

<p>Applications Mepindolol is a non-selective β-adrenoceptor blocking agent. Mepindolol is used in the treatment of glaucoma.<br>References Luque Otero, M. et al.: Br. J. Clin. Pharmacol., 17, 361 (1984); Beckmann, R. et al.: Arzneim.-Forsch., 36, 811 (1986);<br></p>

<p>Applications 5-Benzylthio-1H-tetrazole is used in the preparation of organosilicon compounds that have antibacterial activity.<br>References Baghershiroudi, Mahrokh. et al., J. IRAN. CHEM. SOC. 15,1279-1286(2018);<br></p>

<p>Applications (±)-trans-9,10-Epoxystearic Acid Methyl Ester is a useful synthetic intermediate. It is an intermediate used to prepare (±)-erythro- and (±)-threo-9,10-difluorostearic acids. It is also used to synthesize monofluorinated fatty acids.<br>References Tavasli, M., et al.: Chem. Commun., 11, 1226 (2002); Buist, P., et al.: J. Chem. Soc., 17, 2617 (1997);<br></p>

<p>Applications Cyclohexanepropanoic Acid is a small lead compound that possess potential antifungal properties and effective against candida albicans and sacchromyces cerevisiae.<br>References Pilehvar-Soltanahmadi, Y., et al.: Novelty in Biomedicine, 2, 47 (2014)<br></p>

<p>Applications Nicergoline is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline protects against neuronal cell death induced by activated microglia and astrocytes through the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells. Nicergoline is a drug used for age-dependent cognitive impairment and it protects cultured neurons against β-amyloid toxicity.<br>References Caraci, F., et. al.: Brain Res., 1047, 30 (2005); Mizuno, T., et. al.: Brain Res., 1066, 78 (2005)<br></p>

<p>Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>

<p>Applications Calcium Carbonate is a common chemical reagent used in various organic reactions. It is used in the synthesis of small molecules which disrupt Wnp-dependent signalling in tissue regeneration and cancer. Also used in the preparation of non-cytotoxic, silver nanoparticle-polysaccharide nanocomposites shown to provide antimicrobial activity.<br>References Chen, B. et al.: Nat. Chem. Biol., 5, 100 (2009); Travan, A. et al.: Biomacromol., 10, 1429 (2009);<br></p>

<p>Applications Hepes<br></p>

<p>Applications Chromium(III) chloride is used as the precursor to many organochromium compounds. Phosphine complexes derived from CrCl3 catalyse the trimerization of ethylene to 1-hexene.<br>References Dixon, J., et al.: Advances in selective ethylene trimerisation – a critical overview” Journal of Organometallic Chemistry, 689, 3641 (2004); Zheng, F. et al: Coordination Chemistry Reviews, 251, 2056 (2007)<br></p>

<p>Applications It is an α2 receptor agonist. It is a drug used to treat glaucoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Katz, L.J., et al.: Am. J. Ophthalmol., 127, 20 (1999), Cantor, L. B., Expert Opin. Pharmacother., 1, 815 (2000),<br></p>

<p>Applications A PDE7 inhibitor that has acceptable selectivity for in vivo studies. Potent PDE-7 inhibitor.<br>References Smith, S.J., et al.: Mol. Pharmacol., 66, 1679 (2004)<br></p>

<p>Applications Ethyl 3-Furoate is the ethyl ester derivative of 3-Furoic Acid (F863770) and is used as a reagent in the synthesis of disubstituted furan derivatives which exhibit antidiabetic activity. Also used as a reagent in the synthesis of sulfonylfuran ureas as selective endothelial lipase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Babu, S.P., et al.: Pharma Chem., 4, 2178 (2012); Goodman, K.B., et al.: Bioorg. Med. Chem. Lett., 19, 27 (2009)<br></p>

<p>Applications Dofetilide is a potassium channel blocker. Antidysrhythmic drug.<br>References Carmeliet, D., et al.: J. Pharmacol. Exp. Ther., 262, 809 (1992); Norgaard, B.L., et al.: Am. Heart J., 137, 1062 (1999); Torp-Pedersen, C., et al.: N. Engl. J. Med. 341, 857 (1999);<br></p>

<p>Applications Bromoacetic Acid is a relatively strong alkylating agent as well as a versatile building block used very commonly in organic synthesis. Bromoacetic acid has been shown to reversibly inhibit human erythrocyte carbonic anhydrase B.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Song, C. et al.: J. Org. Synth., 74, 8980 (2009); Kramer, S.P. et al.: J. Nat. Cancer Inst., 31, 297 (1963); Whitney, P.L. et al.: Eur. J. Biochem., 16, 126 (1970);<br></p>

<p>Stability Hygroscopic, Light Sensitive<br>Applications Orally active anthracycline; analog of Daunorubicin. Antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Arcamone, F., et al.: Caner Treat. Rep., 60, 829 (1976), Zini, G., et al.: Cancer Chemother. Pharmacol., 16, 107 (1986), Gillies, H.C., et al.: Br.J. Clin. Pharmacol., 23, 303 (1987), Villani, F., et al.: Eur. J. Cancer Clin. Oncol., 25, 13 (1989),<br></p>

<p>Stability Light Sensitive<br>Applications (Z)-Mycophenolic acid is the Z-isomer of Mycophenolic acid (M831500), an antibiotic drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Light Sensitive<br>Applications (1,1'-Bis(diphenylphosphino)ferrocene)dichloropalladium-dichloromethane is used in the preparation of imidazoles, benzimidazoles, and tetrahydropyrimidines.<br>References Geden, J. et al.: J. Org. Chem., 78, 4158 (2013);<br></p>

<p>Applications Methyl (S)-N-Tritylaziridine-2-carboxylate (cas# 75154-68-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Fundamental starting material for organic synthesis.Metabolite of dibromobenzene in urine of rabbit.<br>References Ruzo, L., et al.: J. Agric. Food Chem., 24, 291 (1976),<br></p>

<p>Applications Antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kent, J., et al.: Lancet, 355, 911 (2000), Pacher, P., et al.: Curr. Med. Chem., 8, 89 (2001), Titier, K., et al.: Ther. Drug Monit., 25, 581 (2003), Eap, C., et al.: Ther. Drug Monit., 26, 152 (2004),<br></p>

<p>Stability Hygroscopic<br>Applications Clothiapine, is a atypical antipsychotic of the dibenzothiazepine chemical class. It has shown efficacy in treatment-resistant schizophrenic patients.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schmutz, J., et al.: Helvetica Chimica Acta 50, 245 (1967); Geller, V., et al.: Schizophrenia Research 80 (2-3), 343 (2005);<br></p>

<p>Applications AZD-9291 Mesylate is a potent and selective epidermal growth factor receptor (EGFR) inhibitor.<br>References Finlay, M.; et al.: J. Med. Chem., 57, 8249 (2014)<br></p>

<p>Applications 9-Fluorenemethanol is used in the design and in the synthesis of novel type somatostatin analogs with antiproliferative activities on A431 tumor cells.<br>References Miyazaki, A., et al.: Tetrahedron Lett., 45, 6323 (2004)<br></p>

<p>Applications Bis(1,5-cyclooctadiene)diiridium(I) Dichloride is a catalyst used in the iridium-catalyzed asymmetry hydrogenation of unfunctionalized exocyclic double carbon bonds. Also, it is used to test new NeoPHOX ligands derived from serine or threonine.<br>References Xia, J., et al.: Chem. Eur. J., 22, 18354-18357 (2016); Padevet, J., et al.: Beilstein J. Org. Chem., 12, 1185-1195 (2016)<br></p>

<p>Applications A dihydropyridine calcium channel blocker.<br>References Ikeda, K., et al.: Oyo Yakuri, 44, 433 (1992), Hosono, M., et al.: J. Pharmacobio-Dyn., 15, 547, (1992), Ishii, M.: Japan Pharmacol. Ther., 21, 59 (1993),<br></p>

<p>Stability Hygroscopic<br>Applications 6-Amino-2-hydroxymethyl Hexan-1-ol (cas# 125162-81-4) is a compound useful in organic synthesis.<br>References Rubina, A., et al.: Anal. Biochem., 325, 92 (2004),<br></p>

<p>Applications N-Methylcaprolactam is a reagent that is used in the synthesis of 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone-13C5, which is a chlorinated furanone that accounts for more of the mutagenic activity of drinking water than any other disinfection byproduct.<br></p>

<p>Applications Magnesium Monoperoxyphthalic Acid Hexahydrate is used as an oxidant in various synthetic reactions. For example: it is a mild and efficient oxidant for the synthesis of selenones which are useful synthetic intermediates in the synthesis of different heterocyclic compounds.<br>References Temperini, A., et al.: Beilstein J. Org. Chem., 10, 1267 (2014); Salvador, J.A.R., et al.: Beilstein J. Org. Chem., 8, 164 (2012); Carvalho, J.F.S., et al.: Tetrahedron, 65, 2773 (2009)<br></p>

<p>Applications Magnesium Chloride Hexahydrate is used in magnesium replacement therapy for those deficient in magnesium. Effective anaesthetic for cephalopods.<br>References Iezhitsa, I. et al.: Nutr. Neurosci., 14, 10 (2011); Culloty, S. et al.: Aquaculture., 107, 249 (1992);<br></p>

<p>Applications 4-Aminobutylcarbamic Acid tert-Butyl Ester is used in the synthesis of iron chelators expressing antitumor activity. Also used in the synthesis of iron oxide nanoparticles which are used in cellular and small animal imaging.<br>References Corce, V. et al.: Bioconj. Chem., 25, 320 (2014); Stanicki, D. et al., J. mat. Chem. B. Mat. Biol. Med.: 2, 387 (2014);<br></p>

<p>Applications Cobalt Carbonyl is a metal carbonyl used as a reagent and catalyst in organometallic chemistry and organic synthesis. Cobalt Carbonyl is commonly used as a hydroformylation catalyst for the conversion of alkenes to aldehydes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mirbach, M. et al.: J. Am. Chem. Soc., 103, 7594 (1981); Haukka, M. et al.: J. Mol. Cat. A Chem., 102, 79 (1995); Haumann, M. et al.: Catal. Tod., 79, 43 (2003);<br></p>

<p>Applications 3-Ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide is used in the novel synthesis of benzoin catalyzed by thiazolium salts.<br></p>

<p>Applications Carmofur is a derivative of fluorouracil (F596002) an is an antineoplastic agent showing antitumor activity against several cells including L1210 leukemia and L5178Y lymphoma cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hoshi, A., et al.: J. Pharmacobio-dynam., 3, 478 (1980);<br></p>

<p>Applications Alizapride is a dopamine antagonist with prokinetic and antiemetic effects. Alizapride is used in the treatment of post-operative nausea and vomitting.<br>References Bleiberg, H. et al.: Cancer Chemother. Pharmacol., 22, 316 (1988);<br></p>

<p>Applications Ammonium iron(III) citrate (cas# 1185-57-5) is a useful research chemical.<br>Chemical Name: Ammonium iron(III) citrate (cas# 1185-57-5) is a useful research chemical.<br></p>

<p>Applications Cupriethylenediamine Hydroxide is used as a solvent for cellulose.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yang, L., et al.: J. Applied Polym. Sci., 126, E244 (2012); Shi, W., et al.: Ind. Eng. Chem. Res., 52, 586 (2013); Cyrot, J., et al.: Bulletin de l'Institut Textile de France, 18, 211 (1964)<br></p>

<p>Applications Labelled Isavuconazole (I777832). It is a new triazole currently undergoing phase III clinical trials. This compound has shown in vitro activity against a large number of clinical important yeasts and molds including Aspergillus spp., Fusarium spp., Scedosporium spp., Candida spp., the Zygomycetes and Cryptococcus spp.<br>References Ohwada, J., et al.: Bioorg. Med. Chem. Lett., 13, 191 (2003), Guinea, J., et al.: Antimicrob. Agents Chemother., 52, 1396 (2008)<br></p>

<p>Applications 2-Chlorophenylboronic Acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.<br>References Kang, S., et al.: J. Med. Chem., 57, 5293 (2014);<br></p>

<p>Applications Cyclosporin is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>

<p>Applications Anticholinergic. Antispasmodic.<br>References Lundstam, S., et al.: Lancet, 1, 1096 (1982), Thompson, J., et al.: Br. Med. J., 299, 1140 (1989), Marthak, K., et al.: Curr. Med. Res. Opi., 12, 366 (1991), Panderi, I., et al.: J. Pharm. Biomed. Anal., 12, 151 (1994),<br></p>

<p>Applications 2-Methylisoborneol solution - (CAS# 2371-42-8) is a useful research chemical compound.<br></p>

<p>Applications D,L-2-Amino-3-phosphonopropionic acid is a phosphonate substituted derivative of Aspartic acid (A788955) and is a known antagonist of a receptor that is coupled to phosphoinositide metabolism in brain slices. D,L-2-Amino-3-phosphonopropionic acid is also an inhibitor of metabotropic glutamate receptors in rat brain.<br>References Hedberg, T. &amp; Stanton, P.: Eur. J. Pharma., 310, 19 (1996); Saugstad, J., et al.: Eur. J. Pharm.: Mol. Pharm., 289, 395 (1995); Schoepp, D., et al.: Mol. Pharm., 38, 222 (1990)<br></p>

<p>Applications Betrixaban is a novel anticoagulant. An oral direct inhibitor of factor Xa (FXa) for use in the prevention of venous thromboembolism (VTE).<br>References Turpie, A.G.G. et al.: Thromb. Haemost., 101, 68 (2009); Gomez-Outes, A. et al.: Curr. Vasc. Pharmacol., 7, 309 (2009);<br></p>

<p>Applications An aldose reductase inhibitor. It is used in treatment of diabetic neuropathy.<br>References Terashima, H., et al.: J. Pharmacol. Exp. Ther., 229, 226 (1983), Kikkawa, R., et al.: Diabetologia, 24, 290 (1983), Kojima, K., et al.: Jpn. J. Ophthalmol., 29, 99 (1985),<br></p>

<p>Applications 2-Fluoro-3-methoxyphenylboronic acid<br></p>

<p>Applications dTAG-13 is a degradation tag which was tested for its efficiency at depleting FKBP12F36V -MELK(sg3R) and was found to have significantly degraded FKBP12F36V -MELK(sg3R) within 4 hours.Used in the study of cancer research.<br>References Hai-Tsang Huang., eLife, 1-29, (2017)<br></p>

<p>Applications Tetraethylammonium Bromide, can be used as a source of tetraethylammonium ions for various pharmaceutical studies. It has also the ability to block K+ channels in various tissues.<br>References Kevill, D.N., et al.: J. Am. Chem. Soc., 83, 3812 (1961); Armstrong, C.M. et al.: J. Gen. Physiol. 59, 388 (1972);<br></p>

<p>Applications A non-peptide proteaseinhibitor.<br>References Ayoyama, T., et al.: Chem. Pharm. Bull., 33, 1458 (1985)<br></p>

<p>Stability Sensitive to moisture<br>Applications Isonicotinyl Chloride Hydrochloride, is a heterocyclic building block used for the synthesis of various pharmaceutical and biologically active compounds. It can be used for the preparation of Tetrahydropyrroloquinolinone type dual inhibitors of Aromatase/Aldosterone Synthase, as a novel stagey for breast cancer patients with the risk of cardiovascular diseases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yin, L., et al.: J. Med. Chem., 56 (2), 460 (2013);<br></p>

<p>Applications Deshydroxyethoxy Ticagrelor analog of Ticagrelor (T437700) an antiplatelet agent, and preventative in the treatment of heart attacks, myocardial infarction, and other pulmonary diseases.<br>References Zhang, H. et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012);<br></p>

<p>Applications Sodium Phosphate Buffer Solution is used in the development of liquid chromatographic assay for determination of opicapone and BIA 9-1079 in rat matrixes. in the design of novel pyrimidin-4(3H)-one hydroxamate derivatives that showes inhibitory activity against histone deacetylase and exhibited antiproliferative activities against human cervical cancer HeLa and lung carcinoma A549 cells.<br>References Lu, H., et al.: Chem. Res. Chin. Univ., 32, 576 (2016); Goncalves, D., et al.: Biomed. Chromatogr., 30, 312 (2016)<br></p>

<p>Applications Synthetic keto-derivative of Petromyzonol (P293500), a bile salt derivative isolated from the sea lamprey (Petromyzon marinus ) ammocoete (larval form). May be used to study the biochemical characteristics of these and other compounds containing the allocholic acid ring nucleus.<br>References Haslewood, G., et al.: Biochem. J., 114, 179 (1969); Sorensen, P.W., et al.: J. Gen. Physiol., 105, 569 (1995), Krasowski, M., et al.: Mol. Endocrinol., 19, 1720 (2005),<br></p>

<p>Applications A catalyst used in wide range of polymerization reaction. It has been used as a mild Lewis acid catalyst for the stereoselective Diels-Alder reaction as wel as in a Ziegler-Natta type catalyst system for the polymerization of 1,3-butadiene.<br>References Gong, D. et al.: Polymer, 50, 2826 (2009); Gorman, D. B. et al.: Chem. Comm., 1, 25 (2004);<br></p>

<p>Applications Larixol, is an intermediate in the synthesis of larixyl acetate. This compound is also found to have antibacterial activity and high potential antioxidant activity.<br>References Prideevech, P., et al.: Chiang Mai J. Sci, 40, 214 (2013)<br></p>

<p>Applications 1,1-Bis(hydroxymethyl)cyclopropane is used in the synthesis of morphine alkaloids. It also serves as an inhibitor of 5-lipoxygenase.<br>References Evans, D.A. et al.: Tetrahedron Lett., 23, 285 (1982); Arai, Y. et al.: J. Med. Chem., 26, 72 (1983);<br></p>

<p>Stability Air Sensitive, Hygroscopic<br>Applications N-1-Naphthylethylenediamine Dihydrochloride, is an organic building block used for the chemical synthesis. It can also be used as highly selective organic fluorescent probe for azide ion.<br>References Sahana, A., et al.: Analyst , 137, 1544 (2012);<br></p>

<p>Applications 5-Methyl-4-nitroimidazole can cause mutations with Klebsiella pneumonia and Salmonella typhimurium.<br>References Voogd, C.E., et. al.: Mutat. Res. Genet. Tox. Testing, 66, 207 (1979); Kramers, P.G.N.: Mutat. Res. Genet. Tox. Testing, 101, 209(1982)<br></p>

<p>Applications A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stock, J., et al.: J. Biol. Chem., 267, 19753 (1992), Levitzki, A., et al.: Science, 267, 1782 (1995), Meydan., N., et al.: Nature, 379, 645 (1996), Lu, H., et al.: Drug Metab. Dispos., 31, 572 (2003),<br></p>

<p>Applications Iodine monochloride is a powerful elecrtrophilic iodinating agent used for aromatic substitution. Iodine monochloride is also used to synthesize radioiodinated fatty acids for heart imaging.<br> E0<br>References Robinson Jr., G. &amp; Lee, A.: J. Nuc. Med., 16, 17 (1975); Woollett, G. &amp; Johnson, W.: Org. Synth. Coll., 2, 196, 343 (1943)<br></p>

<p>Applications An antitussive.<br>References Yamatsu, et al.: Jpn. J. Pharmacol., 17, 538 (1967), Tellini, N., et al.: Boll. Chim. Farm., 109, 476 (1970),<br></p>

<p>Applications It is an Olefin Metathesis Catalyst for cis-selective ring-opening metathesis polymerization and Z-Selective Olefin Metathesis.<br></p>

<p>Applications Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Blebbistatin also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. Blebbistatin blocks both blebbing and cytokinesis at 50-100µM.[Blebbistatin:a]D= -103 (c= 1.21 CHCl3)(-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-oneBlebbistatin is a selective inhibitor of nonmuscle myosin II; Blebbistatin inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Blebbistatin rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.<br>References Straight, A.F., et al.: Science, 299, 1743 (2003), Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004), Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)<br></p>

<p>Applications Adenosine receptors are related to many diseases such as cardiovascular, autoimmune, and cancer. CGS 21680 is a potent and selective agonist of the adenosine A2A receptor, a member of G protein coupled receptor (1,2,3).<br>References (1) Jones, K. R., et al.: Sci Rep. 7, 44816 (2017) (2) Hutchison, A. J., et al.: J. Pharm. Exp. Ther. 251, 47 (1989) (3) Hasko, G., et al.: Nat. Rev. Drug Discov. 7, 759 (2008)<br></p>

<p>Applications Metol is the hemisulfate salt of 4-Hydroxy-N-methylaniline (H918925), used to synthesize arylidene amino azolones with anticancer activity. It is also used to prepare N-(4-hydroxyphenyl)retinamide analogs with antitumor and apoptosis-inducing activities.<br>References Subtel’na, I., et al.: Bioorg. Med. Chem., 18, 5090 (2010); Mershon, S., et al.: Bioorg. Med. Chem. Lett., 17, 836 (2007)<br></p>

<p>Applications Monomethyl Adipate is a useful synthetic intermediate. It can be used to prepare 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors which show potential antitumor activities. It can be also used to synthesize mannose-linked biphenylylacetic acid derivatives as novel inhibitors of selectin-mediated cell adhesion.<br>References Guan, P., et al.:Bioorg. Med. CHem., 20, 3865 (2012); Kogan, T., et al.: J. Med. Chem., 41, 1099 (1998)<br></p>

<p>Applications A minor antimicrobial used in veterinary medicine.<br>References Dowling, P.M., et al.: Antimicrob. Ther. Vet. Med., 285 (2006), 4th Edition,<br></p>

<p>Impurity Latanoprost USP Related Compound B<br>Applications An impurity of commercially prepared Latanoprost (L177280). Latanoprost USP Related Compound B.<br>References Resul, B., et al.: J. Med. Chem., 36, 2242 (1993),<br></p>

<p>Applications MK-0822 is a newly developed bone-targeting dual action pro-drug for osteoporosis and bone metastasis. It is also an inhibitor of cathepsin K, an enzyme involved in bone resorption.<br>References Arns, S., et al.: Bioorg. Medn. Chem., 20, 2131 (2012); Cusick, T., et al., J. Bone. Mineral. Rsch., 27, 524 (2013);<br></p>

<p>Applications Used for preparation of antidiabetic agents comprising antiinflammatory or analgesic drugs.<br>References Nemoto, H., et al.: J. Med. Chem., 38, 1673 (1995),<br></p>

<p>Applications A neuroprotective effect of lithium carbonate in amyotrophic lateral sclerosis (ALS). Dyes and metabolites.<br>References Gordon, P., et al.: Lancet Neurol., 6, 1045 ( 2007), Shin, J., et al.: Mol. Pharmacol., 71, 965 (2007), Chio, A., et al.: Amyotroph. Lateral Scler., 10, 310 (2009),<br></p>

<p>Applications Pixantrone is an antineoplastic drug belonging to group of antitumor antibiotics. Pixantrone is an anlogue of Mitoxantrone (M373425) and is just as potent in the treatment of multiple sclerosis with fewer toxic effects on cardiac tissue. Studies suggest that Pixantrone significantly reduces amyloid beta (A beta(1-42)) neurotoxicity, a mechanism implicated in Alzheimer's disease.<br>References Cavalletti, E. et al.: Invest. New Drugs, 25, 187 (2007); Gonsette, R.E. et al.: J. Neurol. Sci., 223, 81 (2004); Colombo, R. et al.: Electrophoresis, 30, 1418 (2009)<br></p>

<p>Applications Trametinib (DMSO Solvate) is a highly potent and selective MEK inhibitor with significant antitumor activity.<br>References Abe, H., et al.: ACS Med. Chem. Lett., 2, 320 (2011)<br></p>