Ácidos y reactivos sintéticos

<p>Applications o-Chloramine T (cas# 110076-44-3) is a useful research chemical.<br></p>

<p>Applications 4-Aminoresorcinol Hydrochloride is a reactant in the preparation of diethers with antiviral activity against group A and B human Rhinoviruses.<br>References Bernard, A.M., et. al.: Bioorg. Med. Chem., 22, 4061 (2014)<br></p>

<p>Applications 5-Methylindole is used in the synthesis of novel protein kinase inhibitors.<br>References Guengerich, F. et al.: J. Med. Chem., 47, 3236 (2004);<br></p>

<p>Applications 1,4-Dichloro-2-butyne used in the synthesis of 1,4-disubstituted 1,2,3-triazoles. Also, it is used in the approach of the 20S-camptothecin family of antitumor agents.<br>References Feldman, A. et al.: Org. Lett., 6, 3897 (2004); Josien, H. et al.: Chem. Eur. J., 4, 67 (1998);<br></p>

<p>Applications (S)-(+)-3,3-Dimethyl-2-butylamine is a reagent used in organic synthesis. Used in the synthesis of allosteric modulators in the treatment of schizophrenia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, P. et al.: Org. Lett., 17, 3698 (2015); Turlington, M. et al.: J. Med. Chem., 56, 7976 (2013);<br></p>

<p>Applications Bis(1,5-cyclooctadiene)nickel(0) is a reagent in the synthesis of self-assembled organometallic nickel complexes as catalysts for selective dimerization of ethylene into butene.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boulens, P., et al.: Organometallics, 34, 1139 (2015)<br></p>

<p>Applications Di-tert-Butyl Disulfide is a general reagent used in the synthesis of a novel neuropeptide Y (NPY) Y5 receptor antagonist Velneperit) used in the treatment of obesity.<br>References Oda, S. et al.: Org. Proc. Res. Dev., 19, 531 (2015);<br></p>

<p>Applications 4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid (cas# 60875-16-3) is a useful research chemical.<br></p>

<p>Applications Chiral ligand for metal mediated asymmetric catalysis.<br>References Ito, H., et al.: Nat. Chem., 2, 972 (2010), Lam, K., et al.: Eur. J. Med. Chem., 45, 5527 (2010),<br></p>

<p>Applications Budralazine a new antihypertensive agent. Budralazine is a direct-acting vasodilator.<br>References Moroi, R. et al.: Chem. Pharmac. Bull., 24, 2850 (1976); Ono, K. et al.: Xenobiotica, 9, 227 (1979); Yoshioka, M. et al.: Prog. Hypertens., 1992, 309 (1992);<br></p>

<p>Stability Light Sensitive<br>Applications Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kajikawa, N., et al.: Arzneim.-Forsch., 39, 495 (1989), Demolis, J.-L., et al.: J. Cardiovasc. Pharmacol., 22, 711 (1993), Okuda, Y., et al.: Prostaglandins, 52, 375 (1996),<br></p>

<p>Applications (Chloromethyl)cyclopropane is a used as a reagent to synthesize 6-alkylamino-9-alkylpurines, compounds that have potential to be antipsychotic agents. (Chloromethyl)cyclopropane is also used as a reagent to prepare acylmorphinans, a class of compounds that have analgesic effects in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kelley, J., et al.: J. Med. Chem., 40, 3207 (1997); Mohacsi, E., et al.: J. Med. Chem., 28, 1177 (1985)<br></p>

<p>Applications 1-Iodo-3-nitrobenzene is a reactant used int he synthesis of Vismodegib (V674700), an, antineoplastic drug that targets the Hedgehog (Hh) pathway. Inhibition of the Hh signaling may be effective in the treatment and prevention of many types of human cancers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cao, M., et. al.: Chem. Papers, 68, 1408 (2014); Gupta, S. et al.: Ther. Advances in Med. Oncology 2,237(2010)<br></p>

<p>Applications α-L-Idopyranose pentaacetate is used in the synthesis of mucopolysaccharides as antagonists agents.<br>References Hopwood., et al.: Clinica Chem. Acta, 123, 241 (1982), Ogamo., et al.: Carbohydr. Res., 105 (1982),<br></p>

<p>Applications N-Carbethoxyphthalimide is used in the synthetic preparation of a novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors.<br>References Hua, Z., et al.: J. Med. Chem., 56, 10003 (2013);<br></p>

<p>Applications 4-(2,3-Dimethoxyphenyl)butanoic acid is a butyrate analogue with effects on apoptosis, proliferation and histone deacetylase (HDAC) activity in HT-29 colorectal cancer cells.<br>References Scheppach, W., et al.: Eur. J. Cancer, 31A, 1077 (1995), Wu, J., et al.: J. Lipid Res., 46, 1944 (2005), Kiefer, J., et al.: Br. J. Nutr., 96, 803 (2006),<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-Acetamido-5-nitrophenylboronic acid, pinacol ester<br></p>

<p>Applications Ethyl 2,4-Dioxovalerate is an analog of Ethyl Pyruvate (P998915) and exhibits anti-inflammatory properties in vivo and/or in vitro. It is a potential antifungal agent that inhibits the growth of Candida albicans and Microsporum canis.<br>References Sappington, P.L., et al.: Biochem. Pharmacol., 70, 1579 (2005); Burch, H.A., et al.: J. Med. Chem., 15, 429 (1972)<br></p>

<p>Applications 2-Bromophenylethylamine is an intermediate used to prepare potent antagonists of antiapoptotic protein XIAP for treatment of cancer. It is also used in the synthesis of aryl aminosulfonamide derivatives as potent 5-HT6 receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Oost, T., et al.: J. Med. Chem., 47, 4417 (2004); Nirogi, R., et al.: Bioorg. Med. Chem. Lett., 20, 4440 (2010)<br></p>

<p>Applications 5-Nitrothiophene-2-carboxaldehyde is a reagent that is used in the activity of mefloquine-oxazolidine derivatives against multidrug-resistant Mycobacterium tuberculosis.<br>References Goncalves, R. S. B., et al.: Bioorg. Med. Chem., 20, 243 (2012);<br></p>

<p>Applications Hydrazine Sulfate Salt is a reagent used in the heterocyclization of primary amines and may be cyclized itself. It is also used in the synthesis of novel triazole corrosion inhibitors for mild steel.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bentiss, F. et al.: J. App. Electrochem., 29, 1073 (1999); Ju, Y. et al.: J. Org. Chem., 71, 135 (2006);<br></p>

<p>Applications 1,2,4,5-BENZENETETRACARBOXYLIC ACID (cas# 89-05-4) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Omeprazole Sodium Salt is the salt analogue of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>

<p>Applications 5-Chloro-2-methylaminopyridine is used in the preparation of aminosulfuranes with N-heterocyclic groups.<br>References Pashinnik, V.E. et al.: Ukr. Khim. Zhur., 73, 45 (2007);<br></p>

<p>Applications 15-Crown-5 is a catalyst used in the synthesis of organic molecules and lanthanide complexes. It can induce cytotoxicity and oxidative stress markers in WI38 cells. Studies show that 15-Crown-5 is also an effective chelating agent used for removing cesium in cesium-exposed mice.<br>References Li, L. et al.: J. Organometal. Chem., 794, 231 (2015); Gonzalez-Bello, C. et al.: J. Am Chem. Soc., 137, 9333 (2015); Llobet, J.M., et al.: Metal Ions Biol. Med., 4, 487 (1996)<br></p>

<p>Applications N-Methylcyclohexanamine is a chemical reagent used in the synthesis of Mps1 kinase inhibitors used in cancer research. Also used in the synthesis of antituberculosis agents as indole-2-carboxamides.<br>References Bursavich, M. et al.: Bioorg. Med. Chem. Lett., 23, 6829 (2013); Kondreddi, R. et al.: J. Med. CHem., 56, 8849 (2013);<br></p>

<p>Applications Manganese(II) chloride monohydrate (cas# 64333-01-3) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications GFT-505 is a dual PPARα/δ agonist. Studies have shown that GFT-505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. It may also be a potential new drug candidate for treating lipid and glucose disorders.<br>References Carious, B., et al.: Diabetes Care 36, 2923 (2013); Carious, B., et al.: Diabetes Care 34, 2008 (2011)<br></p>

<p>Applications 3-Aminobutyric Acid is one of the three positional isomer of the chemical compound butryric acid. 3-Aminobutyric Acid is a nonprotein amino acid. 3-Aminobutyric Acid has been shown to be a plant defense primer that suppresses growth of some insect herbivores when applied as a root drench.<br>References Hodge, S. et al.: Biocontrol, 56, 699 (2011); He, Y.-Y. et al.: 38, 641 (2010); Cohen, Y. et al.: Plant Dis., 86, 448 (2002);<br></p>

<p>Applications (2R,5R)-(+)-5-Benzyl-3-methyl-2-(5-methyl-2-furyl)-4-imidazolidinone is a reactant used in the preparation of allyl heterocycles using palladium-catalyzed allylic amination of allylic alcohols with heterocycles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Banerjee, D., et al.: Angew. Chem. Int. Ed., 51, 11556 (2012);<br></p>

<p>Stability Moisture Sensitive<br>Applications SIPr is used as a reagent in the synthesis of mononuclear [(η6-arene)Ni(N-heterocyclic carbene)] complexes which are useful precursors of the Ni0-NHC unit.<br>References Hoshimoto, Y., et al.: Organometallics, 33, 1276 (2014)<br></p>

<p>Stability Moisture Sensitive<br>Applications N,N′-Disuccinimidyl Carbonateis a commonly used reagent for the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate, synthesis of urea, carbamates and coupling of ligands to proteins. The coupling reagent property of N,N’-Disuucinimidyl Carbonate speeds up coupling process, while reduces the loss of chiral integrity.<br>References Rebane, R., et al.: J. Chromatography., 904, 99 (2012);<br></p>

<p>Applications (3-Aminopropyl)trimethoxysilane is used in the synthesis of aspirin imprinted polymer on silica gel surface and appreciation on drug sustained release. Fluorine-doped; lectin functionalized ZnO nanoarrays as 3D nano-biointerface for bacterial detection.<br>References Lu, P., et al.: Gaofenzi Cailiao Kexue Yu Gongcheng, 33, 130 (2017); Zheng, L., Talanta, 167, 600 (2017)<br></p>

<p>Stability Hygroscopic<br>Applications 2,4-Dinitrophenylsulfonyl Chloride, can be used to protect primary amines. It is also used as starting material in the synthesis of tert-butyl 2-[(2,4-dinitrophenyl) sulfonyl]aminoacetate.<br>References Rachel J Ball et. al.: Artificial DNA, PNA &amp; XNA, 1(1), undefined (2011-6-21);<br></p>

<p>Applications 3-Phenylpropionyl Chloride is a derivative of phenylpropionic acid used in the preparation of a wide range of pharmaceutical compounds such as antivirals and antitumor agents.<br>References Ermolova, G.I. et al.: Khim.-Farm. Zh., 24, 35 (1990); Bernier, J.L. et al.: J. Med. Chem., 28, 497 (1985); Jung, J.-C. et al.: Bioorg. Med. Chem. Lett., 14, 5527 (2004);<br></p>

<p>Applications Silver benzoate is an aromatic salt that is used as a catalyst to prepare β-amino acids (such as N-Acetyl-β-alanine [A168070]) from α-amino acids (such as D-Alanine [A480995]). Silver benzoate is also used as a catalyst in Wolff rearrangement reactions.<br>References Barnes, R. &amp; Prochaska, R.: J. Am. Chem. Soc., 72, 3188 (1950); Ogilvie, W., et al.: Bioorg. Med. Chem., 7, 1521 (1999); Podlech, J. &amp; Seebach, D.: Lieb. Ann., 1995, 1217 (1995)<br></p>

<p>Applications (S)-(-)-1-(2-Naphthyl)ethanol is a useful biochemical for proteomics research.<br></p>

<p>Applications Tetramethylammonium Tetrafluoroborate (cas# 661-36-9) is a useful research chemical.<br></p>

<p>Applications 4-(Aminomethyl)-Cyclohexanecarboxylic Acid (cas# 701-54-2) is a useful research chemical.<br></p>

<p>Applications (R,R)-(-)-N,N′-Bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamine is a versatile ligand used in the preparation of Jacobsen's catalyst.<br>References Jacobsen, E.N. et al.: J. Am. Chem. Soc., 113, 7063 (1991); Deng, L. et al.: J. Org. Chem., 57, 4320 (1992);<br></p>

<p>Applications 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenyl-phosphine is an organophosphorus compound derived from the heterocycle xanthene. It is used as a bidentate ligand and is noteworthy for having a particularly wide bite angle. Such ligands are useful in the hydroformylation of alkenes.<br>References Leeuwen, P., et al.: Chem. Rev., 100, 2741 (2000); Yuki, Y., et al.: J. Am. Chem. Soc., 135, 17393 (2013); Makado, G., et al.: Adv. Synth. Catal., 352, 299 (2010)<br></p>

<p>Applications (2-Bromoethyl)trimethylammonium Bromide (cas# 2758-06-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Paetzel, M., et al.: J. Biol. Chem., 272, 9994 (1997), Francavilla, C., et al.: Bioorg. Med. Chem. Lett., 19, 2731 (2009),<br></p>

<p>Applications SU 5416 is a vascular endothelial growth factor receptor blocker that may induce severe pulmonary hypertension if combined with chronic hypoxia. Angiogenesis inhibitor used for deep penetration into tumor tissues.<br>References Mizuno, S. et al.: Am. J. Respir. Cell. Mol. Biol., 47, 679 (2012)); Yoshizawa, Y. et al.: Mol. Pharm., 9, 3486 (2012);<br></p>

<p>Applications Hydrohchloride Salt of α-Aminoacetophenone, used in the preparation og pseudopeptidic inhibitors of human sirtuins1-3. This action effectually displays antiproliferative protperties in cancer cells. Also used in the preparation of dual δ/μopiod receptor agonists in th<br>References Mellini, P. et al.: J. Med. Chem., 56, 6681 (2013); Breslin, H. et al.: Bioorg. Med. Chem. Lett., 22, 4869 (2013);<br></p>

<p>Applications Cesium Acetate (cas# 3396-11-0) is a useful research chemical.<br></p>

<p>Applications Protected Propargyl. A possible genotoxic compound that can affect the bacterial and mammalian cell systems.<br>References Glowienke, S. et al., Mutat. Res. Genet. Tox., 581, 23 (2005)<br></p>

<p>Applications Tetrabutylammonium Hydroxide is used in biological studies for the detection of counter-anion effect on antimicrobial activity of tetrabutylammonium salts.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ingalsbe, M.L., et al.: Bioorg. Med. Chem., 19, 4984 (2009)<br></p>

<p>Applications Intermediate for the synthesis of enantiopure substituted 1,4-Dioxanes. Extremely valuable and versatile alcohol used as a chiral building block in organic synthesis.<br>References Bagnoli, L., et al.: Chem. Eur. J., 17, 993 (2011)<br></p>

<p>Applications VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by Scopolamine (S200000) in a preclinical rodent model.<br>References Bridges, et al.: Bioorg. Med. Chem. Lett., 20, 1972 (2010); Lebois, et al.: ACS Chem. Neurosci., 1, 104 (2010),<br></p>

<p>Applications Benzyl Isocyanate is a general reagent used in the synthesis of complex bisindolylmethanes. Also used in the preparation of urea derivatives of thiazol-2-ethylamines for their anti-trypanosomal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Patrick, D. et al.: Bioorg. Med. Chem., 24, 2451 (2016);<br></p>

<p>Applications 2,2,6,6-Tetramethylpiperidine is used in the syntheses of HMP-Y1, Hibarimicinone and HMP-P1, tyrosine kinase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liau, B. et al.: J. Am. Chem. Soc., 134, 16765 (2012); Tatsuta, K. et al.: Tetrahedron Lett., 53, 422 (2012);<br></p>

<p>Applications Niobium Pentachloride is a reagent used in the synthesis of mixed chloro-aryloxide compounds and dyes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ilin, A. et al.: J. Alloy. Comp., 748, 543 (2018); Yuan, L. et al.: Inorg. Chem., 57, 4226 (2018);<br></p>

<p>Applications 5-Methoxy-2-formylphenylboronic acid is a reagent used in the total synthesis of laetevirenol A via intramolecular Friedel-Crafts alkylation.<br>References Choi, Y. L., et al.: J. Org. Chem., 77, 8762 (2012)<br></p>

<p>Applications Trifluoromethanesulfonic Acid Magnesium Salt is a strong acid that is used as a catalyst for esterification.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Howells, R. D., et al.: Chemical Rev., 77, 69 (1977);<br></p>

<p>Applications Bromomethyl Methyl Ether acts as a reagent in the synthesis and evaluation of hydroxymethyl-aminocyclitols as glycosidase inhibitors, preparation of pyridine derivatives for minimizing CYP2C9 inhibition for cancer therapy. Also a reagent in the discovery of GBT 440, an orally bioavailable R state stabilizer of sickle cell Hb.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Trapero, A., et al.: J. Org. Chem., 80, 3512 (2015); Zak, M., et al.: J. Med. Chem., 59, 8345 (2016); Metcalf, B.; et al.: ACS Med. Chem. Lett., 8, 321 (2017)<br></p>

<p>Applications Diethylenetriamine-pentaacetic acid calcium trisodium salt<br></p>

<p>Applications Manganese is a transition metal which is used as a component in alloys such as stainless steels. Manganese is also a component of many pigments and is used to make catalysts for reduction reactions.<br>References Tambat, S., et al.: World J. Pharm. Res., 6, 1570-1585 (2017); Leonard, D., et al.: ACS Catal., 9, 11125-112129 (2019)<br></p>

<p>Applications 1-Methyl-D-tryptophan is used in biological studies to determine the effect of IDO2 enzyme (indoleamine-(2,3)-dioxygenase) activity and IDO2-mediated arrest of human T cell proliferation. It reverses IDO-mediated immune suppression<br>References Qian, F., et al.: Cancer Immunology Immunothrapy, 61, 2013 (2012)<br></p>

<p>Applications (+/-)-Nutlin-3 is a small molecule MDM2 antagonist.<br>References Vassilev, L.T., et. al.: Sci., 303, 844 (2004)<br></p>

<p>Stability Hygroscopic<br>Applications Plerixafor Hydrochloride (1:8), is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients. It is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>

<p>Applications Methyl 3-Mercaptopropionate is used in the synthesis of thioisoindolinones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sakulsombat, M. et al.: Isr. J. Chem., 53, 127 (2013);<br></p>

<p>Applications Thiorphan Disulfide is an impurity of Racecadotril (R070600); an antidiarrheal and enkephalinase inhibitor that reduces the amount of water and electrolytes into the intestine.<br>References Cezard, J., et al.: Gastroenterol., 120, 799 (2001); Sato, T., et al.: J. Med. Chem., 51, 7705 (2008); Lakshmana, P., et al.: J. Pharm. Res., 8, 39 (2009); Fournie-Zaluski<br></p>

<p>Applications Aluminum isopropoxide is a compound used as an initiator for the polymerization of various compounds, such as lactides. Aluminum isopropoxide is also used as a reducing agent for the reduction of Cinnamaldehyde (C442020).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dubois, P., et al.: Macromolecules. 24, 2266 (1991); Hájek, J., et al.: Appl. Catal. A: Gen., 251, 385 (2003); Lou, X., et al.: Macromol. Rapid Comm., 23, 126 (2002)<br></p>