Ácidos y reactivos sintéticos

<p>Stability Light Sensitive<br>Applications Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kajikawa, N., et al.: Arzneim.-Forsch., 39, 495 (1989), Demolis, J.-L., et al.: J. Cardiovasc. Pharmacol., 22, 711 (1993), Okuda, Y., et al.: Prostaglandins, 52, 375 (1996),<br></p>

<p>Applications A specific serotonin-S2 antagonist. A selective drug for the control of behavioral disorders in epileptic and alcoholic patients.<br>References Gelders, Y.G., et al.: Acta Psychiatrica Belgica, 84, 151 (1984), Kennis, L.E.J., et al.: Drug Develop. Res., 8, 133 (1986),<br></p>

<p>Applications (Chloromethyl)cyclopropane is a used as a reagent to synthesize 6-alkylamino-9-alkylpurines, compounds that have potential to be antipsychotic agents. (Chloromethyl)cyclopropane is also used as a reagent to prepare acylmorphinans, a class of compounds that have analgesic effects in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kelley, J., et al.: J. Med. Chem., 40, 3207 (1997); Mohacsi, E., et al.: J. Med. Chem., 28, 1177 (1985)<br></p>

<p>Applications 2,4,5-Trifluorobenzaldehyde is a reactant in the enantioselective synthesis of (R)-selegiline, an anti-Parkinson's drug, (S)-benzphetamine, an anti-obesity agent, and (S)-sitagliptin, an anti-diabetic drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dey, S., Sudalai, A.: Tetrahedron-Asymmetr., 26, 67 (2015)<br></p>

<p>Applications Used in the preparation of 5,7-disubstituted-4-aminopyrido[2,3-d]pyrimidines as adenosine kinase inhibitors.<br>References Dave, C., et al.: Indian J. Pharma. Sci., 48, 75 (1986),<br></p>

<p>Stability Moisture Sensitive<br>Applications An inhibitor with antitumor activity.<br>References Plumb, J., et al.: Mol. Cancer Ther., 2, 721 (2003), de Ruijter, A., et al.: Biochem. J., 370, 737 (2003), Dey, P., et al.: Curr. Med. Chem., 13, 2909 (2006), Maiso, P., et al.: Cancer Res., 66, 5781 (2006), Paris, M., et al.: J. Med. Chem., 51, 1505 (2008),<br></p>

<p>Applications Used for the preparation of N-sulfonylamino acid derivatives as metalloproteinase inhibitors.<br>References Reed, R., et al.: Biochem. J., 191, 867 (1980), Fehske, K., et al.: Biochem. Pharm., 30, 687 (1981),<br></p>

<p>Applications α-L-Idopyranose pentaacetate is used in the synthesis of mucopolysaccharides as antagonists agents.<br>References Hopwood., et al.: Clinica Chem. Acta, 123, 241 (1982), Ogamo., et al.: Carbohydr. Res., 105 (1982),<br></p>

<p>Applications 4-(Methylthio)benzaldehyde, is a building block for the synthesis of various pharmaceutical and biologically active compounds. It can be used for the synthesis of sulfur-containing terpyridine ligands. It is the intermediate for the synthesis of a class of pyrrole derivatives showing analgesic/anti-inflammatory activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Romashkina, R. B., et al.: Russian Chemical Bulletin, 61, 2265 (2012); Battilocchio, C., et al.: Bioorg. Med. Chem., 21, 3695 (2013);<br></p>

<p>Applications Reducing reagent.<br></p>

<p>Applications 4-(2,3-Dimethoxyphenyl)butanoic acid is a butyrate analogue with effects on apoptosis, proliferation and histone deacetylase (HDAC) activity in HT-29 colorectal cancer cells.<br>References Scheppach, W., et al.: Eur. J. Cancer, 31A, 1077 (1995), Wu, J., et al.: J. Lipid Res., 46, 1944 (2005), Kiefer, J., et al.: Br. J. Nutr., 96, 803 (2006),<br></p>

<p>Applications 2',4',6'-Trihydroxyacetophenone monohydrate (cas# 249278-28-2) is a useful research chemical.<br></p>

<p>Applications 1,5-Dichloroanthraquinone is a reagent in the preparation of anthraquinones, which has antitumor activities.<br>References Barasch, D., et al.: Eur. J. Med. Chem., 34, 597 (1999)<br></p>

<p>Applications Troxipide is a drug used in the treatment of gastroesophageal reflux disease. It is capable of inhibiting the chemotactic migration and superoxide generation in the gastric mucosa.<br>References Yu, S., et al.: Eur. J. Clin. Pharmacol., 76, 547-555 (2020)<br></p>

<p>Applications 4-Fluoro-α-methylstyrene is used in the synthesis of Paroxetine (P205750), which is a selective serotonin reuptake inhibitor. Used as an antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lassen, J.B.: Eur. J. Pharmacol., 47, 351 (1978), Lund, J., et al.: Acta Pharmacol. Toxicol., 51, 351, (1982),<br></p>

<p>Applications SP 2509 reduces the effect of the LSD1 binding to CoREST, resulting in increased methylation of H3K4 and driving increased expression of p21, p27 and CCAAT/enhancer binding protein α in acute myeloid leukemia cells. Anti-leukemia agent.<br>References Sorna, V. et al.: J. Med. Chem., 56, 9496 (2013); Fiskus, W. et al.: Leukemia, 11, 2155 (2014);<br></p>

<p>Applications Diphenyl Phosphite is a reactant used in the synthesis of α-hydroxyphosphonates and α-hydroxyphosphinates for their antioxidant and antimicrobial activity.<br>References Sampath, C. et al.: Phosphor. Sulfur Silicon. Rel. Elem., 191, 95 (2016);<br></p>

<p>Applications TETRAMETHYLAMMONIUM BOROHYDRIDE (cas# 16883-45-7) is a useful research chemical.<br></p>

<p>Applications 1-(2-Chloroethyl)pyrrolidine is a haloalkyl substituted pyrrolidine used in the preparation of various pharmaceutical compound such as the estrogen receptor antagonist Nafoxidine (N212800) and its analogues.<br>References Neyyarapally, A.T. et al.: Ind. J. Chem., 11, 325 (1973); Jones, C.D. et al.: J. Med. Chem., 27, 1057 (1984); Nakata, K. et al.: Molecules, 15, 6773 (2010);<br></p>

<p>Applications N-Acetyl-DL-Valine is an amino acid.<br>References Hirschmann R., et al.: Science, 265, 234 (1994); Gu Z. T., et al.: J. Magn. Reson., 140, 340 (1999); Bodalo, A., et al.: Enzyme Microb. Technol., 24, 381 (1999)<br></p>

<p>Applications 2-(2-Aminophenyl)-1H-benzimidazole is a chemical reagent used in the synthesis of small molecule inhibitors targeting ubiquitin-like domains for treatments of diseases caused by the cellular accumulation of damaged proteins. Also used in the synthesis of pharmaceutical agents targeting leishmania related parasites.<br>References Keurulainen, L. et al.: Bioorg. Med. Chem. Lett., 25, 1933 (2015); He, Y. et al.: Bioorg. Med. Chem., 23, 2798 (2015);<br></p>

<p>Applications Tetramethoxymethane has application within an electrolyte solution for the use of rechargeable lithium batteries. It has also been used as a reactant in the synthesis of novel anti-HIV-1 compounds.<br>References Cadger, T.G. et al.: Proc. Electrochem. Soc., 88, 699 (1988); Kazmierski, W.M. et al.: J. Med. Chem., 54, 3756 (2011);<br></p>

<p>Applications Diethyl Bromomalonate is a chemical constituent of the asymmetric cyclopropanation of chalcones. Also used in the preparation of nanaplatforms for NIR imaging-guided photodynamic therapy of cancer cells.<br>References Herchl, R. et al.: Tetra. Lett., 54, 2472 (2013); Liu, X. et al.: Chem. Comm., 49, 3224 (2013);<br></p>

<p>Applications 4-Nitro-benzeneethanol is a useful synthetic intermediate. It can be used to synthesize N-phenylethylindole carboxamides as SAR study of allosteric modulators of CB1 receptor. It can also be used to prepare 2-aza-2'-deoxyinosine-containing oligodeoxyribonucleotide duplexes.<br>References Piscitelli, F., et al.: J. Med. Chem., 55, 5627 (2012); Acedo, M., et al.: J. Org. Chem., 60, 6262 (1995)<br></p>

<p>Applications A useful synthetic intermediate. Used for asymmetric hydroxylation.<br>References Davis, F.A., et al.: J. Am. Chem. Soc., 112, 6679 (1990)<br></p>

<p>Applications Magnesium Bromide Hexahydrate is an inorganic salt used in the synthesis of superconductors and nanowires. Also present in polymer nanocomposites to improve conductivity.<br>References Alam, M. et al.: Polym. Int., 63, 1465 (2014); McDonald, T. et al.: J. Am. Chem. Soc., 135, 7056 (2012);<br></p>

<p>Applications An Aurora kinase inhibitor, used to treat patients with chromic myeloid leukemia. It is a COVID19-related research product.<br>References Fancelli, D., et al.: J. Med. Chem., 49, 7247 (2006), Carpinelli, P., et al.: Mol. Canc. Ther., 6, 3158 (2007), Coumar, M., et al.: J. Med. Chem., 52, 1050 (2009),<br></p>

<p>Stability Moisture Sensitive<br>Applications Zinc Di[bis(trifluoromethylsulfonyl)imide] is a reactant used in the assembly of pyrene-based Schiff base MII4L6 architectures.<br>References Ronson, T. et al.: J. Am. Chem. Soc., 137, 14502 (2015); Riddell, I. et al.: Chem. Sci., 6, 3533 (2015);<br></p>

<p>Applications Foretinib (GSK1363089) is an ATP-competitive inhibitor of hepatocyte growth factor (HGF) and Vascular endothelial growth factor (VEGF) Receptor Tyrosine Kinases.<br>References Qian, F., et al.: Cancer Res., 69, 8009 (2009); Eder, J., et al.: Clin. Cancer Res., 16, 3507 (2010)<br></p>

<p>Applications Methyl (R)-3-Hydroxybutyrate, a derivative of 3-hydroxybutyric acid, has inhibitory effects on cell apoptosis which is mediated by signaling pathways related to the elevation of cytosolic Ca2+ concentration. Also a potential effective neutral protective agent.<br>References Xiao, X.Q., et al.: Biomaterials, 28, 3608 (2007)<br></p>

<p>Applications Scandium Triflate is an important catalyst used in Friedel-Crafts acylation, Baylis-Hillman reaction and other carbon-carbon bond forming reactions.<br>References Kawada, A., et al.: Synlett, 7, 545 (1994); Aggarwal, V., et al.: J. Org. Chem., 63, 7183 (1998);<br></p>

<p>Applications Dirhodium tetracaprolactamate is an organometallic complex used as a catalyst in the regioselective azidation of arenes.<br>References Wang, Y.; et al.: Org. Lett., 20, 5732 (2018).<br></p>

<p>Applications tert-Butyl 4-Hydroxybutanoate is used as a reagent in the synthesis of theranostic vitamin-linker-taxoid conjugates. tert-Butyl 4-Hydroxybutanoate is also used as a reagent in the synthesis of teroxazoles as α-helix mimetics.<br>References Vineberg, J.G., et al.: J. Med. Chem., 58, 2406 (2015); Pinto Gomes, C., et al.: Eur. J. Org. Chem., 2012, 3270 (2012)<br></p>

<p>Stability Toxic<br>Applications Sodium Tetraphenylboroate is a salt that is commonly used in inorganic and organometallic chemistry as a precipitating agent. Sodium Tetraphenylboroate is also utilized for the preparation of N-acylammonium salts and in coordination chemistry due to their favourable solubility in nonpolar sovlents and their crystallinity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jesson, J.P., et al.: Inorg. Syn., 20, 76 (2007); Kharitononv., S.V., et al.: J. Anal. Chem., 61, 9 (2006);<br></p>

<p>Applications (E)-2-Thiopheneacrylic Acid is used in the synthesis of anti-HIV HEPT analogs. Also used in the synthesis of benzimidazole and caffeine (C080100) analogs as inhibitors of monoamine oxidase B.<br>References Pontikis, R. et al.: J. Med. Chem., 40, 1845 (1997); van den Berg, D. et al.: Bioorg. Med. Chem., 15, 1692 (2007);<br></p>

<p>Applications 2-Phenylpropionaldehyde is a precursor in the synthesis of N,N,β-Trimethyl-phenethylamine Hydrochloride (T796625).<br></p>

<p>Applications Intermediate used in the synthesis of a series of anaplastic lymphoma kinase (ALK) inhibitors, a new target for therapy of non-small-cell lung cancer (NSCLC).<br>References Okamoto, M., et al.: Bioorg. Med. Chem. Lett., 19, 3086 (2011),<br></p>

<p>Applications Manganese(II) chloride monohydrate (cas# 64333-01-3) is a useful research chemical.<br></p>

<p>Applications Indium(III) Chloride is a potent genotoxic chemical that has genotoxic effect on mammalian cells both in vivo and in vitro and which may be mediated partly by inducing oxidative stress.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lin, R., et al.: Environ. Toxicol., 28, 595 (2013); Takagi, R., et al.: J. Occup. Health, 53, 102 (2011)<br></p>

<p>Applications The dopamine receptors play important role in cognition, memory, learning, and motor control (1). These receptors have been implicated as a therapeutic target for many psychiatric and neurological disorders. 2-Bromo-α-Ergocryptine is a dopamine receptor agonist and a derivative of the ergotoxin group of ergot alkaloids (2). It is also a prolactin inhibitor (3).<br>References (1) Ptácek, R., et al.: Med Sci Monit. 17, RA215 (2011) (2) Lieberman, A. N. and Goldstein, M.: Pharmacol Rev. 37, 217 (1985) (3) Nazli, K., et al.: Br J Clin Pract. 43, 322 (1989)<br></p>

<p>Applications Isaxonine is a neurotropic agent. Isaxonine prevents synaptic remodeling by suppression of the redundant nerve endings from additional axons. Isaxonine is transformed by cytochrome P 450 into reactive metabolites that lead to immunoallergic hepatitis in man.<br>References Becker, C.M., et. al.: Eur. Surg. Res., 18, 383 (1986); De Reuck, J., et. al.: Acta Neuropath., 72, 406 (1987); Loeper, J., et. al.: Hepatology, 9, 675 (1989)<br></p>

<p>Applications Ammonium Hydroxide is in numerous household cleaning agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lokshin, E.P., et al.: Russ. J. App. Chem., 86, 450 (2013); Alghamdi, A.A., et al.: J. Material. Chem. A. Mater. Energy. Sustain., 1, 5165 (2013);<br></p>

<p>Applications Tin(II) Oxalate is used in stannous oral care compositions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Surerus, K., et al.: Biochemistry, 1994, 33, 4980 (1994),<br></p>

<p>Applications 4-Fluoro-1,2-phenylenediamine has shown anticancer activity in human prostate adenocarcinoma cell.<br>References Ahmed, H.A.: Bull. Faculty Pharmacy, 49, 25 (2011)<br></p>

<p>Applications Used in the synthesis of D-erythroascorbic acid from D-glucose.<br>References Gan, L.X., et al.: Carbohydrate Res., 220, 117 (1991),<br></p>

<p>Applications An Aurora kinase inhibitor, used to treat patients with advanced solid tumors.<br></p>

<p>Applications (1S,2S)-1,2-Diphenyl-1,2-ethanediamine (cas# 29841-69-8) is a compound useful in organic synthesis.<br></p>

<p>Applications is an (2S)-2-(Methoxydiphenylmethyl)pyrrolidine intermediate in the synthesis of α-Zingiberene which is a sesquiterpine found in leaf glandular trichomes that is currently being evaluated for its cytotoxicity towards human tumour cell lines.<br>References Bou, D., et al.: Molecules, 18, 9477 (2013); Freitas, J., et al.: Euphytica, 127, 275 (2002)<br></p>

<p>Stability Volatile<br>Applications N-Ethylbutylamine is used as a reagent in the synthesis of substituted pyrimidines as corticotropin releasing factor (CRF) receptor ligands.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kuppast, B., et al.: Eur. J. Med. Chem., 78, 1 (2014)<br></p>

<p>Stability Hygroscopic<br>Applications 5-Amino-6-nitroquinoline is a reagent used in the synthesis of benzodiazepine sulfonamide-based bombesin receptor 3 agonists. It is also used in the synthesis of quinoxalinediones.<br>References Liu, P. et al.: ACS. Med. Chem. Lett., 2, 933 (2011); Bigge, C. et al.: J. Med. Chem., 38, 5720 (1995);<br></p>

<p>Applications PF 670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor. PF 670462 has been shown to inhibit PER protein nuclear translocation causing phase shifts in circadian rhythms. PF 670462 attenuates methamphetamine-stimulated locomotion in vivo.<br>References Bryant, D.D. et al.: Psychopharmacology, 203, 703 (2009); Badura, L. et al.: J. Pharmacol. Exp. Therap., 322, 730 (2007); Sprouse, J. et al.: Psychopharmacology, 210, 569 (2010):<br></p>

<p>Applications 3-Phenylpropionyl Chloride is a derivative of phenylpropionic acid used in the preparation of a wide range of pharmaceutical compounds such as antivirals and antitumor agents.<br>References Ermolova, G.I. et al.: Khim.-Farm. Zh., 24, 35 (1990); Bernier, J.L. et al.: J. Med. Chem., 28, 497 (1985); Jung, J.-C. et al.: Bioorg. Med. Chem. Lett., 14, 5527 (2004);<br></p>

<p>Applications 1-Chloro-3-methyl-2-butene is a reactive allylic chloride that is used as an alkylating agent in synthetic chemistry. 1-Chloro-3-methyl-2-butene is also used as a reagent to synthesize Hyperforin, an antibiotic originating from St. John’s wort that has the ability to inhibit growth of tumour cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hatch, L. &amp; Gerhardt, L.: J. Am. Chem. Soc., 71, 1679 (1949); Lee, M., et al.: Org. Lett., 6, 1241 (2004); Reitsema, R. &amp; Hunter, J.: J. Am. Chem. Soc., 71, 1680 (1949); Schempp, C., et al.: Oncogene, 21, 1242 (2002); Sparling, B., et al.: J. Am. Chem. Soc., 135, 644 (2013)<br></p>

<p>Applications 4-(Chlorocarbonyl)benzoic Acid Methyl Ester, is a building block, that can be used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of benzophenone residues. and also for the synthesis of novel novel bulky hydrophobic retinoids, having therapeutic potential.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Amano, Y., et al.: Bioorg. Med. Chem., 21 (14), 4342 (2013);<br></p>

<p>Applications Non-selective MAO-A/B inhibitor.<br>References Stout, S.C., et al.: J. Pharmacol. Exp. Ther., 300, 1085 (2002),<br></p>

<p>Applications Ifenprodil is a NMDA receptor antagonist.<br>References Berger, et al.: J. Pharmacol. Exp. Ther., 289, 1584 (1999);<br></p>

<p>Applications GSK126 is a potent and highly selective S-adenosyl-methionine-competitive small molecule inhibitor of EZH2 methyltransferase enzyme activity. The inhibition activity of GSK126 on EZH2 activity may provide a promising treatment for EZH2 mutant lymphoma.<br>References McCabe, M.T., et al.: Nature., 492, 108 (2012);<br></p>

<p>Applications Tetramethylammonium Tetrafluoroborate (cas# 661-36-9) is a useful research chemical.<br></p>

<p>Applications 4-(Aminomethyl)-Cyclohexanecarboxylic Acid (cas# 701-54-2) is a useful research chemical.<br></p>

<p>Applications 1-Phenyl-1-cyclohexene is metabolite of Phencyclidine (P295500), an anesthetic.<br>References Wong, L.K., et al.L Biomed. Sci. Spec., 2, 204 (1975); Chen, G., et al.: J. Pharmacol. Exp. Ther., 127, 241 (1959); Bailey, K., et al.: J. Pharm. Pharmacol., 28, 713 (1976); Balster, R.L., J. Psychedelic Drugs., 10115 (1978); Johnson, K.M., et al.: Annu. Rev. Pharmacol. Toxicol., 30, 707 (1990)<br></p>

<p>Applications 2-Cl-IB-MECA acts as an A3 adenosine receptor-selective nucleoside.<br>References Tosh, D. et al.: J. Med. Chem., 55, 4847 (2012);<br></p>

<p>Applications Manganese Sulfate Monohydrate is used in the preparation of lithium-ion batteries and cathode catalysts.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kavakli, C. et al.: ChemCatChem., 5, 3358 (2013); McCalla, E. et al.: J. Electrochem. Soc., 161, A606 (2014);<br></p>

<p>Applications AZD4547 is a bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor (FGFR) tyrosine kinases. AZD4547 is particularly effective in inhibiting FGFR1, 2, and 3 tyrosine kinases and is under clinical investigation for the treatment of FGFR-dependent tumors.<br>References Gavine, P.R. et al.: Cancer Res., 72, 2045 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications Tubastatin A Hydrochloride is a neuroprotective HDAC6 inhibitor and is also known to induce hyperacetylation in primary cortical neuron cultures.<br>References Cenik, B., et al.: J. Biol. Chem., 286, 16101 (2011);<br></p>

<p>Applications Rhodium Carbonyl Chloride is a reagent for rhodium-catalyzed [4+2+1] cycloaddition of in situ generated ene/yne-ene-allenes and carbon monoxide to produce [4+2+1] cycloadducts<br>References Tian, Z.Y., et al.: Angewandte Chemie Int. Ed.’ 57, 15544 (2018)<br></p>

<p>Applications It is used in the synthesis of nickel-chelating fluorinated lipids for protein monolayer crystallizations.<br>References Vince, R., et al.: J. Med. Chem., 14, 402 (1971), Melander, W., et al.: Arch. Biochem. Biophys., 183, 200 (1977),<br></p>

<p>Applications 2-Chloroquinoline is an intermediate used in the synthesis of various compounds that exhibits antifungal properties.<br>References Gershon, H., et al.: Contrib. Boyce. Thompson. Inst., 24, 149 (1969);<br></p>

<p>Applications (S)-4-(prop-1-En-2-yl)cyclohex-1-enecarbaldehyde (cas# 18031-40-8) is a useful research chemical. A possible biomarker of Parkinson’s disease.<br>References Drupad, K. T., et al.: ACS Central Science, (2019)<br></p>