Estándares farmacéuticos

Applications Isotope labelled N-(1-Naphthyl)phthalamic Acid is an auxin-transport inhibitor in plants resulting in the attenuation of root growth through decreasing the cell production rate.
References Rahman, A. et al.: Plant, J., 50, 514 (2007); Ott, K. et al.: Phytochem., 62, 971 (2003);

Applications 2’,3’,5’-Tri-O-benzoyl Xanthine-13C5 is an intermediate used in the synthesis of Xanthosine-13C5 (X742102), which is the labeled analogue of Xanthosine (X742100), the deamination product of Guanosine. It is also a potential biomarker for detecting radiation exposure.
References Magasanik, B, et al.: J. Bio. Chem., 206, 83 (1954);

Applications N,N'-Diisopropylthiourea is a reagent for the improved synthesis of cefathiamidine. Studies on the chemical nature of the thyroid inhibiting actions of compounds. Design and testing of antithyroid agents with decreased antioxidant activity.
References Wang, H., et al.: Zhongguo Xiandai Yingyong Yaoxue, 27, 126 (2010); Astwood, E. B., et al.: Endocrinology, 37, 456 (1945); Abou-Shaaban, R. R. A., et al.: Pharm. Res., 13, 129 (1996)

Applications 2’,3’-Isopropylidene Adenosine (cas# 362-75-4) is a compound useful in organic synthesis.

Applications 4-tert-Butyl-2-nitrophenol (cas# 3279-07-0) is a useful research chemical.

Applications N-Methyl-N-1-naphthalenylacetamide is a useful compound for organic synthesis.

Applications 5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylic Acid is an intermediate used to prepare benzothienoazepine compounds as respiratory syncytial virus (RSV) RNA polymerase inhibitors.
References Xiong, H., et al.: Bioorg. Med. Chem. Lett., 23, 6789 (2013)

Applications Intermediate for the synthesis of 2-Hydroxymethyl Loratadine.
References Cerrada, V., et al.: ARKIVOC, 9, 200 (2005).

Applications 5-Acetylsalicylic Acid Methyl Ester (cas# 16475-90-4) is a compound useful in organic synthesis.

Applications Isoguanosine Triacetate (cas# 173098-06-1) is a compound useful in organic synthesis.

Applications o-Cresol-3,4,5,6-d4,OD (CAS# 3647-00-5) is a useful isotopically labeled research compound.

Applications 5-Bromo-2-nitrophenol is a halonitrophenol with antifungal activity.
References Gershon, H., et al.: Monatshefte fuer Chemie, 126, 1161 (1995)

Applications cis-8,11,14-Eicosatrienoic Acid Methyl Ester-d3 is the isotope labelled analog of cis-8,11,14-Eicosatrienoic Acid Methyl Ester (E477925); the methyl ester derivative of cis-8,11,14-Eicosatrienoic Acid (E477930) which is a fatty acid with selective tumoricidal activity.
References Das, U., et al.: Cancer Lett., 56, 235 (1991); Rudra, P., et al.: Anticancer Res., 21, 29 (2001); Menendez, J., et al.: Breast Cancer Res. Treat., 72, 203 (2002)

Applications 2,2'-Dibromobiphenyl
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Diethyl 2,2'-(1,3-Dithietane-2,4-diylidene)bis(cyanoacetate) is used in the synthesis of Olanzapine Thiohydroxymethylidene Impurity (O253795), which is a serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity.
References Moore, N.A., et al.: Curr. Opin Invest. Drugs, 2, 281 (1993), Baldwin, D.S. and Montgomery, S.A.: Int. Clin. Psychopharmacol., 10, 239 (1995), Tohen, M., et al.: Am. J. Psychiatry, 156, 702 (1999)

Applications 2-Chloro-5-nitrophenol (cas# 619-10-3) is a compound useful in organic synthesis.

Applications Intermediate in the preparation of Caffeic Acid metabolties.

Applications tert-Butyl 5-Iodovalerate is used as a reactant in the labeling of site-specific cell surface proteins with biophysical probes using biotin ligase.
References Chen, I., et al.: Nat. Methods, 2, 99 (2005);

Applications 2,2'-Dihydroxy-3,3',5,5'-tetrabromodiphenyl ether is a useful reactant and building block, and has been shown to display antimicrobial activity.
References Xin, Y.; et al.: Huaxue Yanjiu Yu Yingyong, 18, 1346 (2006).

Applications 1-(adamantan-1-yl)-3-(prop-2-enoyl)urea (cas# 852399-58-7) is a useful research chemical.

Applications β-Guaiene is an essential oil extracted from natural sources and exhibits antimicrobial and antiparasitic activities
References Gutierrez, Y.I., et al.: Molecules, 24, 1615 (2019);Doungchawee, J., et al.: Chemistry & Biodiversity, 16 (2019);Yaldiz, G., et al.: J. Sci. Food and Agri., 99, 2005 (2019);

Applications (+)-β-Eudesmol-7,7,8a,8’8’-D5 is an isotope labeled analog of (+)-β-Eudesmol (E938600), which is a sesquiterpenoid molecule that affects the central nervous system (CNS). It is known to induce neurite outgrowth. Antiangiogenic activity.
References Obara, Y. et al.: J. Pharmacol. Exp . Ther., 30, 803 (2011); Tsuneki, H. et al.: Eur. J. Pharmacol., 512, 105 (2005);

Stability Hygroscopic
Applications 3-Iodothyronacetic Acid is a 3-Iodothyronamine metabolite that has functional effects in FRTL-5 thyroid cells.
References Agretti, P. et al.: J. Mol. Endocrinol., 47, 23 (2011);

Applications Hesperetin Benzyl Ether is an intermediate in the synthesis of (S)-Hesperetin (H289480), a flavanone found in citrus fruits.
References Tsujimoto, M., et al.: Biol. Pharm. Bull., 32, 671 (2009), Wang, H., et al.: J. Pharm. Biomed. Anal., 49, 1157 (2009)

Applications A useful building block for oligoribonucleotide synthesis.
References Zlatev, I., et al.: J. Med. Chem., 51, 5745 (2008),

Applications Naphthalene-1-d1 (CAS# 875-62-7) is a useful isotopically labeled research compound.

Applications Azelaic Acid 2-Ethylhexyl Ester-d17 is labelled Azelaic Acid 2-Ethylhexyl Ester (A808180) which is an ester of Azelaic acid (A808140), an antiacne agent.
References Bladon, P.T., et al.: Br. J. Dermatol., 114, 493 (1986)

Applications Labelled Vanillin. Occurs naturally in a wide variety of foods and plants such as orchids; major commercial source of natural vanillin is from vanilla bean extract. Synthetically produced in-bulk from lignin-based byproduct of paper processes or from guaicol.
References Jenner, P.M., et al.: Food Cosmet. Toxicol., 2, 327 (1964), Clark, G.S., et al.: Perfum. Flavor., 15, 45 (1990),

Applications 2,2'-Dimethoxy-1,1'-biphenyl is used in the synthesis of biphenyl scaffolds in the preparation of biphenyl-tetrathiafulvalene derivatives.
References Delogu, G. et al.: J. Org. Chem., 71, 9096 (2006);

Applications Cresyl Diphenyl Phosphate-d7 Isomer 2 is the deuterated form of Cresyl Diphenyl Phosphate (C783015), which is a phosphorus flame retardant additive.
References van der Veen., et al.: Chemosphere, 88, 1119 (2012);

Applications Urea-urethane Compound is a reaction product of 4,4'-sulfonylbis[benzenamine] and 2,4-TDI.

Applications L-Methionine-d3-N-FMOC (S-methyl-d3) (CAS# 502692-58-2) is a useful isotopically labeled research compound.

Stability Freezer
Applications An intermediate used for the synthesis of 6-substituted purine ribosides.

Applications 1-Isocyanato-4-nitrobenzene is a useful synthetic intermediate. It can be used as a reactant in the synthesis of potent human NK1 tachykinin receptor antagonist. It can also be used to prepare N-{2-[(7-chloroquinolin-4-yl)amino]ethyl}ureas with antiprotozoal and antimycobacterial activities.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Walpole, C., et al.: J. Med. Chem., 41, 3159 (1998); Nava-Zuazo, C., et al.: Bioorg. Med. Chem., 18, 6398 (2010)

Applications Paroxetine intermediate.
References Oefner, C., et al.: Chem. Biol., 6, 127 (1999), Bower, J., et al.: Org. Biomol. Chem., 4, 1868 (2006)

Applications 4,4'-Bi(1,2-naphthoquinone) is a reagent used in the preparation of antimalarial agents.
References Archer, S., et al.: Journal of Medicinal Chemistry, 23, 516 (1980);

Applications Indole-3-pyruvic Acid Methyl Ester-D5 is an intermediate used in the synthesis of Indole-3-pyruvic Acid-d5 (I627182), which is an isotope labelled compound of Indole-3-pyruvic Acid (I627189). Indole-3-pyruvic Acid is a compound involved in the biosynthesis of Indole-3-acetic acid, a plant hormone which plays important roles in regulating growth and responses to environmental changes.
References Kong, W., et al.: Plant Cell Physiol, 56, 715-726 (2015)

Stability Hygroscopic
Applications Guanosine 3',5'-cyclic monophosphate is an intracellular second messenger which are involved in the transduction of a diverse array of stimuli, mediating metabolic and growth regulation.
References Aladelokun, O., et al.: Curr. Drug Metab., 18, 1132-1135 (2017)

Applications 2-(3-Nitrophenyl)ethanamine (cas# 83304-13-6) is a useful research chemical.

Applications 1,2-Dimethyl 4-nitrophthalate

Applications Didemethyl Curcumin-d6 is an isotope labelled form of Didemethyl Curcumin(D439500); a metabolite of Curcumin (C838500) with potent activity against Trypanosoma and Leishmania species.
References Asai, A., et al.: Life Sci., 67, 2785 (2000), Sharma, R., et al.: Eur. J. Cancer, 41, 1955 (2005), King, R., et al.: Curr. Drug Metab., 7, 541 (2006),

Applications (2,6-difluorobenzoyl)urea (cas# 1342075-20-0) is a useful research chemical.

Applications (±)-Fluoxetine-d5 Oxalate (phenyl-d5) (CAS# 1219804-82-6) is a useful isotopically labeled research compound.

Applications Hydrazinecarboximidothioic Acid Methyl Ester Hydroiodide

Stability Moisture Sensitive
Applications Pentathiodiphosphorus(V) Acid P,P′-Bis(pyridinium betaine) is an thionating agent used in synthetic chemistry.
References Bergman, J., et al.: J. Org. Chem., 76, 1546 (2011);

Applications 4’-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-[1,1’-biphenyl]-4-carboxylic Acid is a building block for the preparation of vitronectin receptor antagonists.
References Neustadt, B.R., et. al.: Bioorg. Med. Chem. Lett., 8, 2395 (1998)

Applications 3-Amino-2-naphthol (90%) contains 90% 3-Amino-2 naphthol ( B404810), which is a research reagent used for designing potent antimicrobial and anticancer agent.
References Afifi, T.H., et al.: Current Org. Syn., 14, 1036 (2017)

Applications Bis(2-ethylhexyl) Azelate-d34 is the isotope labelled analog of Bis(2-ethylhexyl) Azelate (B433820); a compound used in the preparation of plasticizers.
References Nakajima, N., et al.: J. App. Polym. Sci., 95, 448 (2005); van Oosterhout, J., et al.: Polym., 44, 8081 (2003)

Applications Methyl(4-methylnaphthalen-1-ylmethyl)amine is a reagent in the preparation of heterocyclic compounds as enoyl-acyl carrier protein reductase FabI inhibitors and antibacterial agents.
References Stuetz, A., et al.: J. Med. Chem., 29, 112 (1986); Berman, J., et al.: PCT Int. Appl., 2004:515512 (2004)

Applications Filipin III is a cholesterol-binding, fluorescing antibiotic. Also, it is a pentaene macrolide produced by Streptomyces filipinensis, widely used for the detection and quantitation of cholesterol in biological membranes and as a tool for the diagnosis of Niemann-Pick type C disease;Polyene antibiotic, most extensively used tool for the specific detection of fluorescently labeled 3-β-hydroxysterols.
References Payero, T. D., et al.: Microb. Cell Fact., 14, 1-14 (2015); Stanislas, T., et al.: Methods Mol. Biol., 1209, 13-29 (2014)

Stability Hygroscopic
Applications 2,4-Dinitrophenylsulfonyl Chloride, can be used to protect primary amines. It is also used as starting material in the synthesis of tert-butyl 2-[(2,4-dinitrophenyl) sulfonyl]aminoacetate.
References Rachel J Ball et. al.: Artificial DNA, PNA & XNA, 1(1), undefined (2011-6-21);

Applications 3’,4’-Dichloropropiophenone is used as a reagent in the preparation of antidepressant aryl-alkyl-piperidine derivatives. Also used in the synthesis of mGlu5 receptor negative allosteric modulators. Also in the genetic screening of compounds countering the growth of methylthioadenosine phosphorylase involved in cancer spread.
References Zheng, Y. et al.: Eur. J. Med. Chem., 54, 123 (2012); Kadariya, Y. et al.: J. Biomol. Scroon., 16, 44 (2011);