Estándares farmacéuticos

Applications 1-Aminonaphthalene-d9 (CAS# 78832-56-1) is a useful isotopically labeled research compound.

Applications ESCULIN SESQUIHYDRATE (cas# 66778-17-4) is a useful research chemical.

Applications (1R,4S)-4-Amino-2-cyclopentene-1-carboxylic Acid Methyl Ester Hydrochloride is an intermediate used in the synthesis of ent-Abacavir (A105015), which is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Applications (E)-Cinnamoyl Chloride is used in the preparation of aminodihydroquinoline analogs displaying anticancer activity. It is also used in the preparation of lysergol and related derivatives for use as antibacterials.
References Lee, E. et al.: Bioorg. Med. Chem. Lett., 23, 3976 (2013); Maurya, A. et al.: Chem. Biol. Drug Des., 81, 484 (2013);

Applications N,N-Dipropyl-2-(2-methyl-3-nitrophenyl)ethylamine is an intermediate used to prepare 4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone and related compounds as a prejunctional dopamine receptor agonist.
References Gallagher, G., et al.: J. Med. Chem., 28, 1533 (1985); DeMarinis, R., et al.: J. Med. Chem., 29, 939 (1986)

Applications Isovaleryl L-Carnitine Chloride is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.
References Gong, X., et al.: J. Chem. Res., 6, 327 (2008)

Applications 2-Nitropropane-1,1,1,3,3,3-d6 (CAS# 52809-86-6) is a useful isotopically labeled research compound.

Applications 3-Chloro-4-nitrophenol was used as a reactant in the synthetic preparation of highly potent BTK and JAK3 dual inhibitors and it may also have antifungal activity.
References Ge, Yang, et al.: Euro. J. of Med. Chem., 143, 1847-1857 (2018); Gershon, H., et al.: Monatshefte fuer Chemie, 126(10), 1161-6  (1995)

Applications 4-Chlorobiphenyl-2',3',4',5',6'-d5 (CAS# 51624-37-4) is a useful isotopically labeled research compound.

Applications 2-Quinoxalinecarboxylic Acid Methyl Ester has been used as a reactant in the synthesis of quinoxaline derivatives that show antimycobacterial activity, while displaying minor activity itself. In addition to having the substructure that exhibits antitumor activity, it is also used in the design of guanine-guanine selective DNA cleaving agents.
References Seitz, L.E. et al.: J. Med. Chem., 45, 5604 (2002); Toshima, K. et al.: Chem. Comm., 3, 212 (2002);

Applications S-Benzoyl Tiopronin-d5 is labelled S-Benzoyl Tiopronin (B209585) which is used to prepare radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders.
References DeGrado, W., et al.: PCT Int. Appl., WO 9422494 A1 19941013 (1994)

Applications 2-Methylnaphthalene-D10 is a labelled analogue of 2-Methylnaphthalene (M323130). 2-​Methylnaphthalene is a polycyclic aromatic hydrocarbon (PAH) that has been used as an indicator of smoke exposure in food and packaging materials.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Johnston, J.J., et. al.: J. Agr. Food Chem., 42, 1954 (1994)

Applications N-[(2-Methoxyphenyl)methyl]-N,α,4-trimethylbenzeneethanamine is a new psychoactive substance that is a highly potent hallucinogen.
References Caspar, A. T., et al.: Talanta, 188, 111 (2018); Westphal, F., et al.: Drug Test. Anal., 8, 910 (2016);

Applications A potent and selective agonist of the putative, excitatory neurotransmitter L-glutamic acid. AMPA does not interfere with binding sites for kainic acid in vitro, and AMPA- induced neuronal excitation is not significantly affected by NMDA antagonists.
References Krogsgaard-Larsen, et al.: Nature, 284, 64 (1980), Honore, T., et al.: J. Neurochem., 38, 173 (1982), MacDonald, J.F., et al.: Science, 253, 1132 (1991)

Applications Isotope labelled N-(1-Naphthyl)phthalamic Acid is an auxin-transport inhibitor in plants resulting in the attenuation of root growth through decreasing the cell production rate.
References Rahman, A. et al.: Plant, J., 50, 514 (2007); Ott, K. et al.: Phytochem., 62, 971 (2003);

Applications 2’,3’,5’-Tri-O-benzoyl Xanthine-13C5 is an intermediate used in the synthesis of Xanthosine-13C5 (X742102), which is the labeled analogue of Xanthosine (X742100), the deamination product of Guanosine. It is also a potential biomarker for detecting radiation exposure.
References Magasanik, B, et al.: J. Bio. Chem., 206, 83 (1954);

Applications 5-Amino-1H-indazole-7-carboxylic Acid Methyl Ester can be used in preparation of azabenzimidazoles as AMPA receptor modulators useful in treating diseases.
References Berry, C., et al.: PCT Int. Appl., WO 2016176460 A1 20161103 (2016)

Applications N,N'-Diisopropylthiourea is a reagent for the improved synthesis of cefathiamidine. Studies on the chemical nature of the thyroid inhibiting actions of compounds. Design and testing of antithyroid agents with decreased antioxidant activity.
References Wang, H., et al.: Zhongguo Xiandai Yingyong Yaoxue, 27, 126 (2010); Astwood, E. B., et al.: Endocrinology, 37, 456 (1945); Abou-Shaaban, R. R. A., et al.: Pharm. Res., 13, 129 (1996)

Applications 3,3'-Bis(methylthio)-2,2'-bithiophene is a useful reagent for organic synthesis and other chemical processes.
References Smie, A., et al.: J. Electroanal. Chem., 452, 87 (1998), Di C. N., et al.: Chem. Phys. Lett., 275, 533 (1997),

Stability Moisture Sensitive
Applications 2-Acetamido-5-nitrophenylboronic acid, pinacol ester

Applications 2’,3’-Isopropylidene Adenosine (cas# 362-75-4) is a compound useful in organic synthesis.

Applications 4-Aminobenzoic-​2,​3,​5,​6-​d4 Acid Methyl Ester is an intermediate in the synthesis of DMABA-d4 NHS Ester (D678402), which is a labelled DMABA NHS ester (D678400). DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids. DMABA NHS ester has been used in combination with DMABA NHS ester-d4, -d6, and -d10 to study relative changes in PE lipid abundance before and after radical oxidation.
References Wester, H., et al.: Nucl. Med. Bio., 23, 365 (1996), Frees, D., et al.: Mol. Microbiol., 48, 1565 (2003), Michel, A., et al.: J. Bacteriol., 188, 5783 (2006), Voelker, T., et al.: Bioorg. Med. Chem., 17, 2047 (2009),

Applications Butyric acid derivative. Displays some anti-inflammatory activity.

Applications 5'-Chloro-5'-deoxy-2',3'-O-isopropylideneadenosine is an intermediate in the synthesis of S-(5'-Adenosyl)-L-homocysteine which is a novel biomarker for predicting susceptibility of a subject to a mental or neurodegenerative disorder.

Impurity Voriconazole EP Impurity A; Voriconazole USP Related Compound C
Applications 2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone (Voriconazole EP Impurity A; Voriconazole USP Related Compound C) is an antifungal activity, particularly toward Candida albicans and Candida parapsilosis
References Upadhayaya, R., et al.: Eur. J. Med. Chem., 39, 579 (2004), Sheng, C., et al.: J. Med. Chem., 49, 2512 (2006),

Applications Cholesterol-3,4-13C2 (CAS# 78887-48-6) is a useful isotopically labeled research compound.

Applications 3,3'-Dithiobisbenzoic Acid, Technical Grade (cas# 1227-49-2) is a compound useful in organic synthesis.

Stability Light Sensitive, Temperature Sensitive
Applications A fatty acid ester of Retinol isomer, found mainly in the retina.

Applications 5-Aminomethyl-salicylic Acid Methyl Ester Hydrochloride (cas# 90610-24-5) is a useful research chemical.

Applications 4-(chloromethyl)-2-(4-nitrophenyl)-1,3-oxazole (cas# 39867-96-4) is a useful research chemical.

Applications Polygalacturonic Acid is found in ripe fruits and some vegetables and is a degradation product of pectin in plants.
References Aspinall, G., et al.: J. Chem. Soc., 4020 (1958);

Applications 6-Amino-2-chloro-5-nitropyridine (cas# 27048-04-0) is a compound useful in organic synthesis.

Applications 3β,17,21-trihydroxy-5α-Pregnane-11,20-dione 21-Acetate can be used to synthesize 5α-pregnane-3β, 17α,21-triol-11,20-dione (Reichstein's substance D) and 5α-pregnane-3β, 11β,17α,21-tetrol-20-one (Reichstein's substance V).
References Chamberlin, E., et al.: J. Amer. Chem. Soc., 77, 1221 (1955);

Applications 3’-Chloro-4’-hydroxyacetophenone (cas# 2892-29-7) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications N-Methyl-N-1-naphthalenylacetamide is a useful compound for organic synthesis.

Applications 3,3'-Dimethoxy-2,2'-bithiophene is a useful research chemical for organic synthesis and other chemical processes.
References Heinze, J., et al.: DECHEMA Monographien, 121, 125 (1990), Miller, L. L., et al.: J. Org. Chem., 60, 6813 (1995)

Applications N-(Phenyl)-2-naphthylamine is a reagent in the preparation of unsymmetrical triaryldiamines as thermally stable hole transport layers for various organic LEDs.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Koene, B. et al.: Chem. Mat., 10, 2235 (1998);

Applications Alpha-hydroxy-gamma-butyrolactone (cas# 19444-84-9) is a useful research chemical.

Applications Cholera Autoinducer 1: (3S)-3-Hydroxy-4-tridecanone is an extracellular quorum-sensing molecule which is responsible for the virulence production factor and biofilm development of Vibrio cholerae.
References Kelly, R. et al.: Nat. Chem. Biol., 12, 891 (2009);

Applications 2-Aminopyrazine-5-carboxylic Acid Methyl Ester (cas# 13924-94-2) is a compound useful in organic synthesis.

Applications 5-(3'-Hydroxybenzyl)hydantoin (cas# 216956-20-6) is a compound useful in organic synthesis.

Applications (1,2,5,6-Tetramethyl-d6)naphthalene is the labeled analogue of 1,2,5,6-Tetramethylnaphthalene (T303675), a polycyclic aromatic hydrocarbon that has been found in petroleum.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Forster, P.G., et. al.: J. Chromatogr., 483, 384 (1989)

Applications Testosterone Heptanoate-6,6,7,7,7-d5 (CAS# 1263095-31-3) is a useful isotopically labeled research compound.

Applications 3-Hydroxy-2-naphthoic Acid-d6 is an intermediate used in the synthesis of Pamoic Acid-d10 (P173502), which is a labelled Pamoic Acid. Agonist of the orphan G protein-coupled receptor GPR35: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Used as an inhibitor in the real-time fluorescence enzymatic characterization study of specialized human DNA polymerases. Enzyme replacement therapy in pancreatic enzyme deficiency.
References Fonge H., et al.: Bioconjugate Chem., 18, 1924 (2007), Mayr, G.W., et al.: J. Biol. Chem., 282, 35424 (2007); Zhao, P. et al.: Mol. Pharmacol., 78, 560 (2010); Dorjsujen, D. et al.: Nuc. Acids Res., 37, e128 (2009);

Applications Perchlorate salt derivative of Adenosine (A280400), nucleotide. It is also used in the synthesis of 2’-deoxy-7-methyladenosine.
References Fujii, T. et al.: Chem. Pharm. Bull., 42, 495 (1994);

Applications 5,6-Dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylic Acid is an intermediate used to prepare benzothienoazepine compounds as respiratory syncytial virus (RSV) RNA polymerase inhibitors.
References Xiong, H., et al.: Bioorg. Med. Chem. Lett., 23, 6789 (2013)

Applications N-[1-(1-Naphthalenyl)ethyl]formamide is derived from 1-Acetylnaphthalene (A186940), which is used in the preparation of S(-)-1-(1'-naphthyl) ethanol, an important synthetic intermediate of mevinic acid analog;Also, it is used in the preparation of (R)-(+)-1-(1-naphthyl)ethylamine as an intermediate of cinacalcet.
References Kamble, A.L. et al.: J. Mol. Catal. B Enzym., 35, 1 (2005); Bhattacharyya, M. et al.: Biores. Technol., 98, 1958 (2007); Xu, Y., et al.: Faming Zhuanli Shenquig (2013), CN 103420845 A 20131204

Applications 4-(1,1-Dimethylethyl)-α-methyl-benzenepropanoic-d3 Acid Methyl Ester is an intermediate in synthesizing Fenpropimorph-d3 (F249502), which is a labelled analogue of Fenpropimorph (F249500), a systemic fungicide for control of powdery mildew, rust in cereal crops.
References Baloch, R.I., et al.: Phytochemistry, 23, 2219 (1984); Pommer, E.-H., et al.: Pestic. Sci., 15, 285 (1984);

Applications 2-Bromo-3'-nitroacetophenone is a reagent used the preparation of arylthiazolidinone derivatives which have BRD4 bromodomain inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zhao, L., et al.: J. Med. Chem., 56, 3833 (2013);

Applications 1,2,3,4-Tetrahydro-1,2,5-naphthalenetriol is a a reagent used in pharmaceutical synthesis.

Applications 2,2'-Dithiobisbenzanilide has biological applications. It has been used as peptizing agent for rubber.
References Garner, C. E., et al.: Toxicol. Rep., 7, 883 (2020)

Applications 4-BROMO-1,8-NAPHTHYRIDINE (cas# 54569-28-7) is a useful research chemical.

Applications 5-Amino-1-naphthol is a reagent in the preparation of 5-hydroxy duloxetine. It is also used in the preparation of tetrahydronaphthol-, naphthol-, sulfonamide-, phenyl-, and heterocyclic-TRPV1 antagonists.
References Urbahns, K., et al.: Bioorg. Med. Chem. Lett., 22, 3408 (2012);

Applications 4-(Dimethylamino)pyridin-1-ium ((2-Nitrophenyl)sulfonyl)(phenoxycarbonyl)amide is an intermediate used in the synthesis of Monosulfuron (M567185), which is a sulfonylurea herbicide that inhibits Acetohydroxyacid synthase enzyme.
References Wang, J., et al.: J. Comput. Aided Mol. Des., 19, 801 (2005);

Applications An intermediate of synergistic pesticide Boscalid. Also, used in the preparation of thieno[2.3-b]pyrrole derivatives as cannabinoid receptor agonists useful in mono- and combination therapy of diseases.
References Granger, D., et al.: Arthritis Rheum., 37, 1053 (1994), Robinson, R., et al.: J. Med. Chem., 39, 10 (1996),

Applications 5-Acetylsalicylic Acid Methyl Ester (cas# 16475-90-4) is a compound useful in organic synthesis.

Applications 3'-O-Levulinoyl-N-benzoyl-2'-deoxyadenosine is a protected nucleotide derivative/building block.
References Kiuru, E., et al.: Helvetica Chimica Acta, 96, 1997-2008 (2013);

Applications Labelled 1-Naphthol (N367990). Used in the manufacturing of dyes, intermediates, synthetic perfumes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package