Estándares farmacéuticos

Impurity Ambroxol EP Impurity B Hydrochloride
Stability Hygroscopic
Applications Ambroxol Cyclic Impurity is a metabolite as well as an impurity of the bronchosecretolytic drug, Ambroxol (A575900).
References Hammer, R. et al.: Arzneim.-Forsch., 28, 899 (1978); Nieder, M. et al.: HRC & CC, 9, 561 (1986); Huq, F. et al.: J. Pharmacol. Toxicol., 3, 147 (2008);

Applications Methyltriphenylphosphonium Bromide is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.
References Selassie, C.D. et al.: J. Med. Chem., 33, 1914 (1990); Venkatachalam, M.A et al.: Kidney Int., 49, 449 (1996);

Applications Zinc pentamethylenedithiocarbamate (cas# 13878-54-1) is a useful research chemical.

Stability Hygroscopic
Applications Mutagenic heterocyclic amines in cooked food.
References Stavric, B., et al.: Fd. Chem. Toxic., 31, 12, 981 (1993), Sugimura, T., et al.: Mutation Research, 290, 43 (1993), Eisenbrand & Tang: Toxicology, 84, 1 (1993)

Applications Labelled Torsemide (T548750). Used as a diuretic.
References Lesne, M., et al.: In. J. Clin. Pharmacol. Ther. Toxicol., 20, 382 (1982), Brater, D.C., et al.: Clin. Pharmacol. Ther., 42, 187 (1987),

Impurity Bupropion Des-t-Butylamino Impurity
Applications 3'-Chloropropiophenone is a reagent used in the vinylation, alkylation and dienylation of ketones. It is also used in the preparation of thizaine derivatives that show antibacterial activity.
References Li, H. et al.: J. Am. Chem. Soc., 127, 8355 (2005); Deepika, G. et al.: J. Pharm. Res., 5, 1105 (2012);

Applications Trestolone acetate is a derivative of Trestolone (T719600), a synthetic androgen used as a potential hormonal male contraceptive method that induces a state of temporary infertility.
References Garcia-Becerra, R., et al.: Reproduction., 143, 211 (2012); Attardi, B.J., et al.: J. Steroid. Biochem. Molec. Biol., 122, 212 (2010)

Applications 2,2':6',2''-Terpyridine (cas# 1148-79-4) is a useful research chemical.

Applications trans-Linalool Oxide is a derivative of Linalool (L465950), which is a terpene alcohol common in various flowers and spice plants. trans-Linalool Oxide is also an isomer of cis-Linalool Oxide, which has been employed to assess the effect of vine on the glycosylated flavour procurers in grapes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Baratta, M. T., et al.: J Essent Oil Res 10, 618 (1998); Bureau, S. M., et al.: J. Agric. Food Chem. 48, 1290 (2000)

Applications The major metabolite of Boldenone, an anabolic steroid.
References Fotsis, T., et al.: J. Steroid Biochem., 28, 203 (1987), Song, Y., et al.: Arch. Pharm. Res., 23, 599 (2000), Buiarelli, F., et al.: Anal. Chim. Acta, 526, 113 (2004), Poelmans, S., et al.: Food Addit. Contam., 22, 808 (2005),

Applications Inhibits the enzyme HMG-CoA reductase in vitro.
References Endo, A., et al.: J. Antibiot., 32, 852 (1979), Alberts, A.W., et al.: Drug Invest., 2 (Suppl. 2), 9 (1990), Kuroda, M., et al.: Biochim. Biophys. Acta, 486, 70 (1977),

Applications N,N,N-Trimethyl-2-oxo-1-propanaminium Chloride is an intermediate in the synthesis of 3-Carboxy-N.N,N-trimethyl-2-oxo-1-propanaminium Chloride (C183230), which is a derivative of L-Carnitine (C184110).
References Brewer, F. et al.: Arch. Biochem. Biophys., 276, 495 (1990);

Applications Cholesteryl Acetate Dibromide is an brominated intermediate in the synthesis of Cholesterol (C432501) derivatives.
References Kandutsch, A.A., et al.: J. Biol. Chem., 249, 6057 (1974);

Applications Lumichrome is a derivative of Riboflavin (R415000), a vitamin with a key role in maintaining cellular function and health in human and animals. Dyes and metabolites.
References Rajamani, S., et al.: Mol. Plant. Microbe. Interact., 21, 1184 (2008); Unna, K., et al.: J. Pharmacol. Exp. Ther., 76, 75 (1942), Rivlin, et al.: N. Engl. J. Med., 283, 463 (1970), Al-Shammary, F.J., et al.: Anal. Profiles Drug Subs., 19, 429 (1990),

Stability Reacts with DMSO
Applications A metabolite of Cyclophosphamide (C988580).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bohnenstengel, F., et al.: Eur. J. Clin. Pharmacol., 51, 297 (1996), Busse, D., et al.: J. Clin. Oncol., 15, 188 (1997), Roy, P., et al.: Drug Metab. Dispos., 27, 655 (1999),

Applications Surfactin is a lipopeptide antibiotic and biosurfactant.

Impurity Clonidine EP Impurity A
Applications 1-Acetyl-2-imidazolidinone (Clonidine EP Impurity A) is a synthetic reagent used in the preparation of triple [14C]-labelled moxonidine which is an antihypertensive compound.
References Czeskis, B., et al.: J. Labelled Comp. Radiopharm., 47, 699 (2004)

Applications DL-Indole-3-lactic Acid Methyl Ester-D5 is an intermediate used in the synthesis of DL-Indole-3-lactic Acid-d5 (I627102), which is the isotope labelled analog of DL-Indole-3-lactic Acid (I627100); a reagent in the synthesis of 2-hydroxy-1-(1H-indol-3-yl)-4-methylpentan-3-one which has weak antibacterial activity against 16 bacterial strains, including Escherichia coli, Bacillus subtilis and Staphylococcus aureus. DL-Indole-3-lactic Acid is also used in the preparation of Monatin, a natural sweet peptidomimetic.
References Nguyen, S.T., et al.: Bioorg. Med. Chem. Lett., 20, 5739 (2010); Nakamura, K., et al.: Peptide Sci., 40, 61 (2003)

Applications A bile acid derivative as anti-inflammatory and antitumor agent.
References Yasukawa, K., et al.: Chem. Pharm. Bull, 19, 573 (1996), Yasukawa, K., et al.: J. Pharm. Pharmacol., 52, 119 (2000), Iida, T., et al.: Lipids, 38, 281 (2003),

Stability Hygroscopic
Applications Perfluorodecane Sulfonic Acid, is a micropollutant found in marine organisms and waste water sludge.
References Wille, K., et. al.: Anal. Bioanal. Chem., 400, 1459 (2011); Arvaniti, O.S., et. al.: J. Hazard. Mater., 239, 24 (2012)

Stability Moisture Sensitive
Applications Oxyfedrine acts as a vasodilator affecting the coronary base flow.
References Baraka, Y. et al.: J. Drug Res., 12, 161 (1980);

Applications (2R,3S)-N-Benzoyl-3-phenyl Isoserine Methyl Ester is an intermediate in the preparation of potent anticancer drug Paclitaxel (P132500) used to study the location of the binding sites.
References Paal, K. et al.: Bioorg. Med. Chem., 15, 1323 (2007); Krawczyk, E. et al.: J. Pharm. Pharmacol., 57, 791 (2005);

Stability Hygroscopic
Applications An active metabolite of Glimepiride (G410150).
References Groop, L., et al.: Diabetes Care, 15, 737 (1992), Muller, G., et al.: Diabetes, 42, 1852 (1993), Kramer, W., et al.: Biochem. Biophys. Acta, 119, 278 (1994),

Applications Ruthenium, is a rare transition metal belonging to the platinum group of the periodic table with various applications. It can be used in platinum and palladium alloys to make wear-resistant electrical contacts.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hunt, L. B., et al.: Platinum Metals Rev., 49 (2), 74 (2003);

Applications 4-Hydroxy Flecainide is an analogue of Flecainide (F390000).
References Blom, Y., et al.: J. Chromatogr., 653, 138 (1993),

Applications Syringic-d6 acid is deuterium labelled syringic acid (S920027), which is used in biological studies for electron transfer from plant phenolates to carotenoid radical cations with antioxidant interaction entering the Marcus theory inverted region.
References Cheng, H., et al.: J. Agric. Food Chem., 62, 942 (2014)

Impurity Rosuvastatin EP Impurity C (Calcium Salt)
Stability Hygroscopic
Applications 5-Oxo Rosuvastatin (Rosuvastatin EP Impurity C (Calcium Salt)) is a Rosuvastatin (R700500) impurity.
References Endo, A., et al.: J. Antibiot., 32, 852 (1979), Beck, G., et al.: J. Med. Chem., 33, 52 (1990), Koga, T., et al.: Lipids, 30, 775 (1995),

Stability Hygroscopic
Applications A metabolite of Diphenhydramine (D486900) in humans.
References Breyer-Pfaff, U., et al.: Drug Metab. Dispos., 25, 340 (1997),

Applications Cyclizine is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. Antiemetic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kuntzman, R., et al.: J. Pharmacol. Exp. Ther., 158, 332 (1967), Walker, R., et al.: Eur. J. Pharm. Sci., 4, 301 (1996), Dumasia, M., et al.: Xenobiotica, 32, 795 (2002),

Applications 2-Phenyl-4’-trifluoromethylacetophenone, is used in the preparation of arylketones via palladium-tedicyp-catalyzed Heck reaction.
References Battace, A., et al.: Eur. J. Org. Chem., 19, 3122 (2007)

Applications Triamcinolone Acetonide (T767165) impurity.
References Laurent, H., et al.: J. Steroid Biochem., 6, 185 (1975),

Applications 1-Nitronaphthalene as a nitroaromatic compound is studied for mutagenicity, as nitroaromatics are used in everyday products from polmers, dyes to drugs.
References Tawari, N., et al.: Int J Pharm Pharm Sci., 6, 149-157 (2014)

Applications 1-(1-phenylpropan-2-yl)-1H-pyrrole-2-carboxylic acid (cas# 1432680-68-6) is a useful research chemical.

Applications Roflumilast-N-oxide is the active metabolite of Roflumilast (R639700).
References Chiba, M., et al.: Drug Metab. Dispos., 25, 1022 (1997), Jarvis, B., et al.: Drugs, 59, 891 (2000),

Applications Sodium Chlorite is used as a bleaching agent for cotton textiles.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Shenai, V.A., Pai, S.M.: Textile Dyer Printer, 3, 153 (1969)

Applications (1R)-(+)-α-Pinene is used in hydroboration reactions and the reduction of ketones.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Brown, H. et al.: J. Org. Chem., 50, 1384 (1985);

Applications Forsythoside A is used as an antiinflammatory agent in traditional Chinese medicine.
References Li, H. et al.: Phytother. Res., 25, 338 (2011);

Applications 1-​[3-​(Dimethylamino)​propyl]​-​3-​ethylurea is a reagent used in the preparation of water soluble, multifunctional antibody-porphyrin gold nanoparticles.
References Penon, O. et al.: J. Colloid. Inter. Sci., 496, 100 (2017);