Estándares farmacéuticos

Applications 1-​(6-​Amino-​9H-​purin-​2-​yl)​-1H-​pyrazole-​4-​carboxylic Acid Ethyl Ester is an intermediate in synthesizing 1-(6-Amino-9H-purin-2-yl)-N-methyl-1H-pyrazole-4-carboxamide (A629440), it is used in the synthetic preparation of regadenoson and intermediates by using cyclocondensation, amidation and condensation as the key steps.
References Chai, J.; et al.: Faming Zhuanli Shenqing. 14pp.Patent 2015 CODEN:CNXXEV

Applications rac Isopropyl (±)-10-camphorsulfate-d7 is the isotope analog of rac Isopropyl (±)-10-camphorsulfate. rac Isopropyl (±)-10-camphorsulfate is an Impurity from the synthesis of Frovatriptan Succinate (F768500) and a chiral derivative of Camphor.
References Parsons, A.A., et al.: J. Cardiovasc. Pharmacol., 30, 136 (1997); Siow, C.H., et al.: Cephalalgia, 24, 1045 (2004); Poolsup, N., et al.: J. Clin. Pharm. Ther., 30, 521 (2005); Peng, R., et al.: Biochem. Pharmacol., 35, 1391 (1986), Tanaka, E., et al.: Biochem. Pharmacol., 41, 472 (1991),

Applications Labelled 3-(3,4-Dimethoxyphenyl)propanoic Acid (D460730), one of the novel circulating coffee metabolites in human plasma.
References Clifford, M., et al.: J. Sci. Food Agric., 80, 1033 (2000), Mateos, R., et al.: J. Agric. Food Chem., 54, 8724 (2006), Wong, C., et al.: J. Nutr. Biochem., 21, 1060 (2010),

Applications 9-Bromononanoic Acid is an intermediate in synthesizing Rumenic Acid (R701590), a trans fatty acid that may potentially reduce the risk of cancer and cardiovascular diseases. It may also prevent disease processes that lead to chronic inflammation, atherosclerosis, and diabetes.
References Baer, D. J.: Am J Clin Nutr 95, 267 (2012); Gebauer, S. K., et al.:  Adv Nutr 2, 332 (2011); Duffy, P. E., et al.: Tetrahedron 62, 4838 (2006)

Applications Droxicam is a non-steroidal anti-inflammatory drug.
References Lapeyre-Mestre, M., et. al.: Fundam. Clin. Pharm., 20, 391 (2006)

Applications [2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium Hydroxide is a reagent in the synthesis of PVA/SBMA crosslinked hydrogels used in tissue mimicking, vascular cell culturing and implanting. For use in soft-tissue surgery and keeping it minimally invasive.
References Jian, S. et al.: J. Mech. Bwhav. Biomed. Mat., 4, 1228 (2011); Xu, S. et al.: Ann. Tech. Conf. Soc. Plastics Emg., 71, 1032 (2013);

Applications Metopimazine (MPZ) is used to prevent emesis during chemotherapies. Antiemetic.
References Catz, P., et al.: Int. J. Pharm., 58, 93 (1990), Sato, K., et al.: J. Pharm. Sci., 80, 104 (1991), Herrstedt, J., et al.: Cancer Chemother. Pharmacol., 33, 53 (1996), Sigsgaard, T., et al.: J. Clin. Onc., 19, 2091 (2001),

Applications An optically active metabolite of Tramadol.
References Garrido, M., et al.: J. Pharmacol. Exp. Ther., 305, 710 (2003), Pedersen, R., et al.: Eur. J. Clin. Pharmacol., 62, 513 (2006),

Impurity Beclomethasone Dipropionate EP Impurity I
Applications (16β)-16-Methyl-17,21-bis(1-oxopropoxy)pregna-1,4,9(11)-triene-3,20-dione (Beclomethasone Dipropionate EP Impurity I) is an impurity of Beclomethasone (B131000), a glucocorticoid. Used in chronic asthma and allergic rhinitis. Antiallergic, antiasthmatic (inhalant). Anti-inflammatory (topical).
References Malfitan, V.A., et al.: Clin. Ther., 4, 472 (1982), Rao, M., et al.: J. Asthma, 19, 21 (1982), Small, P., et al.: Ann. Allergy, 49, 127 (1982), Brogden, R.N., et al.: Drugs, 28, 99 (1984),

Applications α-Cholesterol-d6 is labelled α-Cholesterol which is a stereoisomer of Cholesterol (C432501), a major component of all biological membranes and the principal sterol of the higher animals.
References Rosin, Z., et al.: Physiol. Chem., 124, 282 (1923), Schoenheimer, et al.: J. Biol. Chem., 105, 355 (1934), Gemant, et al.: Life Sci., 1, 233 (1962), Johnson, K., et al.: 4, 457 (1964),

Applications Benzyl N-(4-nitrophenyl)carbamate