Estándares farmacéuticos

Stability Hygroscopic
Applications 3,3'-Oxydipropanol is an intermediate in the synthesis of 3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol] (O870290). 3,3'-[Oxybis(3,1-propanediyloxy)]bis[1-propanol] is derived from 3-(Benzyloxy)propyl 4-Toluenesulfonate (B288830), which is used as a reagent in the synthesis of Silodosin (S465000); an antidysuria drug. 3-(Benzyloxy)propyl 4-Toluenesulfonate is also used as a reagent in the preparation of aryloxyalkyl derivatives of adenine which have antiviral activity.
References Calogero, F., et al.: Eur. J. Org. Chem., 2015, 6011 (2015); Petrov, V.I., et al.: Chem. Heterocyc. Compd., 39, 1218 (2003)

Applications 3-Nitrophenol is a chemical reagent used in various organic syntheses. Used in the synthesis of RAGE inhibitors via the etherification of phenols. Also used in the synthesis of kinase inhibitors against epidermal growth factor receptor T790M mutation.
References Zhou, W. et al: Nature. 462, 4887 (2009); McKillop, A. et al.: Tetrahedron, 30, 1379 (1974);

Applications 2-Naphthylamine Hydrochloride is listed as a known human carcinogen used in the manufacturing of dyes and as antioxidant in rubber.
References IARC Monographs, 4, 97 (1974),

Applications 6,6'-Dimethoxy-2,2'-binaphthalene, can be used for the synthesis of novel classes of non-steroidal substrate mimetics, as inhibitors of human CYP17. It is also an impurity of Nabumetone (N200500), a non-steroidal anti-inflammatory drug, acting as anti-inflammatory agent.
References Kumpulainen, H., et al.: J. Med. Chem., 49, 1207 (2006); Pinto-Bazurco, M. A. E., et al.: Bioorg. Med. Chem. Lett., 18, 267 (2008);

Applications Cyclobutanecarboxylic Acid, can be used as an organic building block in the chemical synthesis. It is also an Antiinflammatory agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Grassy, G. et al.: Euro. J. Med. Chem., 14, 493, (1979);

Applications 5-Chloro-m-salicylic Acid was studied as a potential selective lactate receptor (GPR81) agonists with antilipolytic effects.
References Dvorak, C.A., et al.: ACS. Med. Chem. Lett., 3, 637 (2012);

Applications Palladium (II) chloride is used to catalyze the carbonylation of organotellurium compounds with carbon monoxide. Palladium (II) chloride is also sometimes used in carbon monoxide detectors where it undergoes a redox reaction and changes colour, causing the alarm to be triggered.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ohe, K., et al.: J. Org. Chem., 52, 4859 (1987)

Applications The major metabolite of Mosapride (M731000).
References Somogyi, A., et al.: Clin. Pharmacokinet., 8, 463 (1983), Cashman, J., et al.: Drug Metab. Dispos., 21, 587 (1993), Berkman, C., et al.: Biochem. Pharmacol., 50, 565(1995), Blake, B., et al.: Xenobiotica, 25, 377 (1995),

Applications 3-Amino-5-nitrophenylboronic acid

Impurity Levonorgestrel EP Impurity D
Applications 13-Ethyl-18,19-dinor-17α-pregn-4-en-20-yn-17-ol (Levonorgestrel EP Impurity D) is an impurity of Levonorgestrel.
References McGinty, D., et al.: Endocrinology, 24, 829 (1939), Belanger, A., et al.: Steroids, 37, 361 (1981), Nieman, L., et al.: J. Clin. Endocrinol. Metab., 61, 536 (1985), Klebe, G., et al.: J. Med. Chem., 37, 4130 (1994),