Estándares farmacéuticos

Stability Light Sensitive
Applications (1R,​3S)​-3-​(2,​2-​Dichloroethenyl)​-​2,​2-​dimethylcyclopropanecarboxam​ide is a useful research chemical.

Applications rac cis-Paroxetine N-Methyl is an impurity formed in the synthesis Paroxetine (P205750) related compounds.
References Gangula, S., et al.: Syn. Commun., 42, 3344 (2012);

Applications N-Methyl(p-tosyl)carbamic Acid Methyl Ester is a methyl ester derivative of N-[(arylsulfonyl)methyl]carbamates that display intramolecular shielding.
References Van der Werf, S. et al.: Rec. Trav. Chim. Pays-Bas, 89, 423 (1970);

Applications 2,4,5-Trichlorophenoxyacetic Acid Isobutyl Ester is a component in herbicide formulation used in the protection of crops.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Noble, A. et al.: Pest. Sci., 28, 203 (1990);

Applications 1,1'-[Dithiobis(methylene)]biscyclopropaneacetic Acid is an intermediate in the synthesis of Montelukast (M568000), a selective leukotriene D4-receptor antagonist used as an antiasthmatic agent.

Stability Hygroscopic
Applications 3,3',5-triiodo-β-hydroxy-D/L-thyronine is an impurity or analog of 3,3’,5-Triiodo-D-thyronine (T795375), which is a structural analogue of the thyroid hormone Thyroxine (T425600). 3,3’,5-Triiodo-D-thyronine has been shown to reduce cholesterol in blood serum.
References Mintz, D.O., et. al.: New Engl. J. Med., 266, 808 (1962)

Applications A thienopyrimidine derivative as herbicides.
References Kourounakis, A., et al.: Drug Dev. Res., 2000, 49(4), 227 (2000),

Applications 21-Di[methylenebis(oxy)] 5α-Dihydrocortisol is an intermediate in the synthesis of Allo-3α-tetrahydro Cortisol 3-O-β-D-Glucuronide Sodium Salt-d7 (A548512), which is a metabolite of Cortisol (H714615) in human plasma.
References Ikegawa, S. et al.: Anal. Chem., 81, 10124 (2009); Kornel, L. et al.: J. Steroid. Biochem., 13, 751 (1980); Kornel, L. et al.: J. Steroid Biochem., 6, 1267 (1975);

Stability Moisture Sensitive, Temperature Sensitive
Applications A metabolite of Lumiracoxib.
References Fu, J., et al.: J. Biol. Chem., 265, 16737 (1990), Goldstein, J., et al.: Am. J. Gastroenterol., 96, 1019 (2001), Flower, R., et al.: Nat. Rev. Drug Discov., 2, 179 (2003), Grillo, M., et al.: Drug Metab. Dispos., 31, 1327 (2003),

Applications (S)-Metalaxyl is the S-enantiomer of Metalaxyl (M258740(P)), an agricultural fungicide. Metalaxyl is a contaminant of emerging concern (CECs). It is useful in cannabis testing kits as a component of pesticide mixes (P698235(M)).
References Boughalleb, N., et al.: Int. J. Agric. Res., 5, 1057 (2010), Lian, Y., et al.: J. Agric. Food Chem., 58, 9428 (2010)

Applications Prometon-d3 (methoxy-d3) (CAS# 1219803-43-6) is a useful isotopically labeled research compound.

Applications A prototypical BCRP inhibitor. Inhibits the Bcrp1-mediated transport.
References Neville, K., et al.: Clin. Cancer Res., 10, 2525 (2004), Reardon, D., et al.: J. Clin. Oncol. 23, 9359 (2005), Pan, G., et al.: Drug Metab. Dispos., 35, 1165 (2007),

Applications 25-Des(dimethylbutenyl) 25-(1,3-Dimethyl-2,3-epoxybutnyl) Moxidectin is a by-product during the synthesis of 3,4-Epoxy-moxidectin (E589045), which is derived from the parent compound Moxidectin (M744800), a macrocyclic lactone and semisynthetic derivative of nemadectin. Moxidectin is a parasiticide used for the prevention and control of heartworm and intestinal worms. Moxidectin is found in veterinary medicine used to treat animals such as dogs, cats, horses, cattle and sheep.Also, it is one of the impurities of Moxidectin under stress conditions.
References Bisset, S.A. et al.: New Zeal. Vet. J., 40, 97 (1992); Monahan, C.M. et al.: Vet. Parasitol., 63, 225 (1996); Glickman, L.T. et al.: Int. J. Appl. Res. Vet. Med., 3, 49 (2005); Awasthi, A., et al.: Anal. Bioanal. Chem., 404, 2203-2222 (2012)

Stability Hygroscopic
Applications Nicotine-N-(4-deoxy-4,5-didehydro)-β-D-glucuronide is a possible metabolite of Nicotine (N412420).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 4'-[(4,5-Dimethyl-3-isoxazolyl)sulfamoyl]acetanilide is an renal metabolite of Sulfatroxazole (S699265), is an component present in various veterinary drugs.
References Nouws, J. F. M., et al.: J. Vet. Pharmacol. Ther., 12, 50 (1989);

Applications Testosterone (T155000) derivative. Intermediate in the preparation of Epostane (E588850).