Glycoscience

N-Acetyl D-mannosamine (ManNAc) is an aldohexose (2-acetamido-2-deoxymannose) in which the axial hydroxyl group at position 2 is replaced by a N-acetyl group (Collins, 2006). It has been reported that N-acetyl D-mannosamine supplementation, may provide novel means to break the link between obesity and hypertension (Peng, 2019). N-Acetyl-D-mannosamine and N-acetyl-D-glucosamine are the essential precursors of sialic acid, the specific monomer of polysialic acid, a bacterial pathogenic determinant, for example, Escherichia coli K1 uses both amino sugars as carbon sources. It has been reported that ManNAc can be used as a treatment for hereditary inclusion body myopathy, an adult-onset, progressive neuromuscular disorder and also for renal disorders involving proteinuria and hematuria due to podocytopathy and/or segmental splitting of the glomerular basement membrane (Galeano, 2007).

Methyl 2,3-di-O-p-toluenesulfonyl-6-O-trityl-a-D-glucopyranoside is a custom synthesis of a natural product. It is an analogue of the disaccharide sucrose (CAS No. 69649-64-5). Methyl 2,3-di-O-p-toluenesulfonyl 6-[(trityloxy)methyl]-a-(1,2:4,5)-D glucopyranoside reacts with fluoride ion to form methyl 2,3 di -O - p - toluenesulfonyl 6-[(trityloxy)methyl]-a-(1,2:4,5)-D glucopyranoside fluoride ion. The monosaccharides are linked by glycosyl bonds and can be modified by different reactions such as oxidation or reduction. The saccharide can be modified

Allyl 4-O-benzyl-2,3-di-O-levulinyl-a-L-rhamnopyranoside is a custom synthesis of an oligosaccharide with a complex carbohydrate backbone. It is modified by methylation and glycosylation and fluorinated to give it high purity.

Allosamizoline is a potent inhibitor of bacterial enzyme that is produced by the bacteria. It inhibits viral replication and has been shown to inhibit the biosynthesis of other bioactive molecules, such as cyclohexane ring, nitrogen atoms, and growth regulators. Allosamizoline is a bicyclic compound with an acetylation at the carbon atom and a cyclohexane ring. This compound also has two nitrogen atoms in its structure that are important for inhibiting bacterial enzymes. In addition, allosamizoline can be conjugated to fluorescein via an ester linkage. The fluorescein-allosamizoline conjugate can be used as a fluorescent probe for the detection of bacterial enzymes in live cells and tissues.

Ethyl 3-O-benzyl-4,6-O-benzylidene-2-deoxy-2-N-phthalimido-b-D-thioglucopyranoside is a synthetically modified sugar. It is a monosaccharide that has been fluorinated and methylated. This modification has been shown to increase the stability of the sugar in the presence of water. The sugar also has an oligosaccharide and polysaccharide moiety attached to it. These saccharides are glycosylated and have a complex carbohydrate structure.

Methyl α-D- glucopyranoside is a methylated sugar used as an inhibitor of lectin-conjugate binding. Methyl α-D- glucopyranoside is commonly used in protein purification for eluting glycoproteins and other glycoconjugates from affinity chromatography columns of agarose lectin. Methyl α-D- glucopyranoside is also known as Methyl alpha-D-glucoside or alpha-Methyl-glucoside.

1-O-Methyl-β-D-glucuronic acid is a β-glucuronidase inducer.

(2R, 3S, 4R, 5S) -2- Butyl-3, 4, 5- piperidinetriol is a custom synthesis of a fluorinated saccharide. It is a modified monosaccharide that has been synthesized by methylation and click modification. This molecule is an oligosaccharide with glycosylation at both the sugar and carbohydrate level. The saccharide in this compound is a complex carbohydrate that contains two sugar units.

4-Acetamido-4-deoxy-D-glucose is a custom synthesis of a monosaccharide that is modified with fluorine and methyl groups. It is synthesized by the Click modification, which involves the addition of an azide to an alkyne in a copper catalyzed reaction. 4-Acetamido-4-deoxy-D-glucose can be used as a building block for complex carbohydrate synthesis. 4-Acetamido-4-deoxy-D-glucose has shown effectiveness against fluoroquinolone resistance, as well as activity against methicillin resistant Staphylococcus aureus (MRSA) and Clostridium perfringens.

Methyl 3,5-O-isopropylidene-b-D-xylofuranoside is a methylated saccharide. It is an intermediate in the synthesis of glycosides and can be used for modifying proteins and polysaccharides. This compound is also useful for investigating carbohydrate metabolism and for determining the structure of complex carbohydrates.

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1-Deoxy-L-allitol is a naturally occurring compound found in human urine. It has been shown to have a role in the regulation of glucose metabolism, as it is catalysed by liver enzymes and can affect the synthesis of glycogen. 1-Deoxy-L-allitol also has been found to be an activator of t-cells, which are immune cells that help regulate the body's response to infection.

3-Deoxy-D-gluconic acid is a chemical compound that has the chemical structure of C6H12O6. It is a white crystalline solid that can be found in nature as a reaction product of glucose and oxygen. 3-Deoxy-D-gluconic acid can also be synthesized by reacting D-glucose with nitrous acid or sulfur dioxide. 3-Deoxy-D-gluconic acid is an organic acid and has been shown to inhibit the growth of filamentous fungi by acting on their glycosidic bonds. This chemical compound has not been shown to have any adverse health effects in humans, although it may cause irritation if it comes into contact with skin or eyes.

Ribulose 5-phosphate sodium is a chemical that can be used to inhibit the enzyme ribulose phosphate reductase. Ribulose 5-phosphate sodium has been shown to inhibit glycolaldehyde production in the chloroplasts of plants, effectively reducing the amount of carbon dioxide produced. This chemical has also been shown to have an inhibitory effect on other enzymes involved in carbon fixation and assimilation. The effectiveness of this chemical is dependent on the specific plant species and environmental conditions.

Reference compound for metabolites of the pentosephosphate pathway

Chondroitin disaccharide 6S sodium salt is a synthetic, fluorinated, oligosaccharide that has been custom synthesized and glycosylated. It is a sugar-based compound with a high purity and excellent solubility in water. It was synthesized by click modification of the sugar monomer with an amine group at the reducing end. The chondroitin disaccharide 6S sodium salt was further modified with methylation to yield a product with a higher purity.

Applications N,N-[Iminobis(trimethylene)]bis-D-gluconamide (cas# 86303-20-0) is a compound useful in organic synthesis.

α-6⁴-6³-Di-galactosyl-mannopentaose is a specialized oligosaccharide, which is a type of complex carbohydrate. This compound is derived from natural plant sources and its structure comprises a mannopentaose core linked with two galactose units. The mode of action involves specific interactions with gut microbiota, where it selectively enriches beneficial bacterial populations, such as Bifidobacteria and Lactobacilli. These interactions occur by serving as a fermentation substrate, promoting the growth of microbes that confer beneficial effects on host health.

Heptadecyl 2-acetamido-2-deoxy-b-D-glucopyranoside is a solubilized ion pair that can be catalysed by amines and immobilized lipase. It is also a hydrophobic fatty acid ester. Heptadecyl 2-acetamido-2-deoxy-b-D-glucopyranoside is catalyzed by an enzyme, lipase, to form the corresponding amide. This reaction yield is increased in the presence of hexane, which aids in hydrolysis of the ester linkage between heptadecyl and 2,2′-diacetylidenebis(3,4,6,-trimethylphenol). Heptadecyl 2-acetamido-2-deoxyglucopyranoside is used as a substrate for lipases to produce amides from amines. This product has been used in the production of

4-Glucopyranosylmannose is a disaccharide compound, which is a synthetic carbohydrate derived from the enzymatic or chemical glycosylation processes. It consists of glucose and mannose units linked through a glycosidic bond. The compound is sourced through advanced synthetic methodologies involving specific glycosyltransferases or chemical catalysts that facilitate the precise attachment of these sugar moieties.

2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-a-D-galactopyranose is a fluorinated complex carbohydrate that has been modified by methylation and acetylation. This product is a custom synthesis that has not been previously described in the scientific literature. It is synthesized from 2, 3, 4, 6 tetraacetyl alpha D galactopyranoside and 2 deoxy alpha D galactopyranose. The chemical properties of this compound are similar to those of other complex carbohydrates such as glycogen and heparin.

Methyl D-arabinofuranoside is an antimycobacterial agent that inhibits the synthesis of mycolic acids, which are important components of the cell wall of Mycobacterium tuberculosis. Methyl D-arabinofuranoside has been shown to be active against drug-resistant strains and has been well tolerated by animals. This compound can be synthesized from 2,4-dichlorophenylacetic acid and arabinose in two steps. The first step involves a three-component condensation reaction with sodium hydroxide, hydrochloric acid, and 2,4-dichlorophenylacetic acid. The second step is a nucleophilic attack on the pyran ring of methyl D-arabinofuranoside with hypophosphorous acid. Methyl D-arabinofuranoside can also be prepared by reacting sodium nitrosobenzene with sodium benzene sulfinate in alcoholic solution

1,5-α-L-Arabinohexaose is a carbohydrate. It is a nonreducing sugar that can be found in plants. 1,5-α-L-Arabinohexaose has an optimum pH of 5 and an ethanol concentration of 0.02%. The enzyme form of 1,5-α-L-Arabinohexaose is α-(1→6)-glycosidase. This enzyme hydrolyzes the α-(1→6) glycosidic bond between two glucose residues in a polysaccharide chain to produce β-(1→4) bonds. It also hydrolyzes the β-(1→4) glycosidic bond between two galactose residues to produce β-(1→2) bonds and oxidizes the terminal carbon atom to produce aldehyde products.
A structural analysis of this carbohydrate was conducted using marine microorganisms and it was found that they contain galacturonic acid and sugar residues

4-Deoxy-D-glucose is a sugar that is synthesized by the condensation of two molecules of erythrose. It has been shown to be an efficient donor substrate for nucleophilic attack, which can lead to the synthesis of glycosides and other natural products. 4-Deoxy-D-glucose is also a competitive inhibitor of uridine diphosphate (UDP) glucose, which is an enzyme involved in the biosynthesis of UDP sugars and glycoproteins. The concentration of 4-deoxy-D-glucose affects its catalytic mechanism, as it acts as a competitive inhibitor at high concentrations. Molecular modeling has revealed that this molecule adopts a chair conformation with significant solvent exposure.

D-ribulose-5-phosphate sodium is a nucleotide sugar that is one of the ribonucleotides, which are fundamental components of RNA. D-ribulose 5-phosphate sodium has been shown to be an intermediate in the metabolism of ribulose and catalyzes the oxidation of d-arabinose. This enzyme also catalyses the synthesis of fatty acids and participates in reactions involving glycerolipids and phospholipids. The reaction mechanism involves a double displacement with simultaneous attack by a water molecule on C2' and C3'. When deuterium is present, it affects the rate of these reactions in a way that depends on the orientation of the substrate to the enzyme.

Allyl 2-acetamido-4,6-O-benzylidene-2-deoxy-b-D-glucopyranoside is a synthetic compound that belongs to the class of carbohydrates. It is used as a reagent in sugar chemistry and glycosylation reactions. Allyl 2-acetamido-4,6-O-benzylidene-2-deoxy-b-D-glucopyranoside is also used for the modification of polysaccharides and fluorination reactions. This product has been shown to be effective as a substrate for site specific methylation reactions. Allyl 2 acetamido 4,6 O benzylidene 2 deoxy b D glucopyranoside has been tested in vitro against methicillin resistant Staphylococcus aureus (MRSA) with promising results.

4-O-Acetyl-3,6-di-O-benzyl-D-glucal is a custom synthesized compound with high purity. This product is a complex carbohydrate that can be used as a monosaccharide or sugar. It has been modified with fluorination and methylation to produce a compound that is resistant to degradation by enzymes and oxidation. The CAS number for this product is 165524-87-8.

D-Xylulose 5-phosphate sodium salt is a synthetic monosaccharide that can be used in the synthesis of oligosaccharides, polysaccharides, and complex carbohydrates. It is also used in glycosylation reactions. D-Xylulose 5-phosphate sodium salt has been fluorinated to provide better stability and solubility. The compound has a molecular weight of 206.06 g/mol and a CAS number of 105931-44-0. This product is available for custom synthesis upon request.

2-Amino-2,3,5-trideoxy-3-methyl-L-arabinonic acid-gamma-lactone hydrochloride is a lipid biosynthesis inhibitor that blocks the first step of this pathway by inhibiting the enzyme d-arabinose 4,5-diphosphate aldolase. This compound inhibits bacterial growth and leads to cell lysis. It has been shown to be active against cryptococcus neoformans and Candida neopformans. 2AADL has also been shown to inhibit the production of cell wall polysaccharides in C. neoformans and other fungi. 2AADL is thought to bind to the cell membrane through its alcohol group, which may lead to changes in the redox potential of the cells.

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3'-a-Sialyl-N-acetyllactosamine sodium salt is a high purity, custom synthesis sugar. It has been modified with fluorination, glycosylation, and methylation to provide the desired properties. This product is also available in other forms such as monosaccharide and saccharide. 3'-a-Sialyl-N-acetyllactosamine sodium salt can be used in various applications including Click modification, fluoroamination, glycosylation, carbonylation and methylation. CAS No. 350697-53-9

3-Fucosyllactose is a high purity synthetic sugar that is custom synthesized to order. It has a click modification, fluorination and glycosylation. 3-Fucosyllactose is a monosaccharide with CAS No. 160159-69-2. 3-Fucosyllactose has the ability to be modified for glycoengineering and glycobiology studies. It can be used in the synthesis of complex carbohydrates, such as oligosaccharides and monosaccharides.

b-D-Thioglucose sodium salt hydrate is a complex carbohydrate that is used as an intermediate for the synthesis of oligosaccharides and polysaccharides. It is also used in the modification of saccharide chains, such as glycosylation, and for the preparation of fluorinated carbohydrates. b-D-Thioglucose sodium salt hydrate is high purity, with no detectable impurities or degradation products. It has been modified with fluorine to form a new chemical entity that has not been previously described in the literature.

Decyl D-glucopyranoside is a sodium salt of decyl D-glucopyranoside that is used as a detergent additive in cleaning compositions. Decyl D-glucopyranoside has shown antimicrobial activity against both Gram-positive and Gram-negative bacteria, including methicillin resistant Staphylococcus aureus (MRSA) and Clostridium perfringens. Decyl D-glucopyranoside has also been shown to have chemical stability at high temperatures, making it useful in the manufacture of lacrimal gland preparations and cationic surfactants.

ADP-L-glycero-b-D-manno-heptose is a synthetic, fluorinated oligosaccharide that is custom synthesized and modified. It has a high purity level and CAS No., as well as being a complex carbohydrate that can be modified with methylation or click modification to generate desired properties. ADP-L-glycero-b-D-manno-heptose is an Oligosaccharide with a glycosylation and methylation. This compound can be used in the synthesis of saccharides, polysaccharides, or other complex carbohydrates.