Glycoscience

Agarose is a polysaccharide found in red algae, typically Gelidium and Gracilaria. It is a strictly alternating polysaccharide of α-1,3 linked D-galactose and β-1,4 linked L-3,6 anhydrogalactose with occasional sulfation at position 6 of the anhydrogalactose residue. Agaro-oligosaccharides result from cleavage at galactose residues and neoagaro-oligosaccharides from cleavage at 3,6-anhydro residues. Reports have suggested that agaropentaose has neuroprotective properties.

2-Azidoethyl N-acetyl-D-lactosamine is a custom synthesis that is a complex carbohydrate. It has been modified to include methylation and glycosylation. The saccharide is composed of several sugar molecules, including glucose and galactose, which are linked by alpha (1→4) or beta (1→3) bonds. The carbohydrate can be fluorinated, which increases its stability in the presence of oxygen. This compound has CAS number 338971-38-3. 2-Azidoethyl N-acetyl-D-lactosamine is a high purity product that can be used in the modification of other carbohydrates with click chemistry.

The product is a custom synthesis of the amino acid azetidine-2-carboxylic acid. It is synthesized from 2-acetamido-3,4-dihydroxybenzoic acid and 1,1'-dimethylethyl dimethylsilyl ether as starting materials. The product is used in glycosylation reactions to form complex carbohydrates with sugars. The product has been shown to be useful in Click chemistry, which is a type of chemical reaction where biotinylated molecules are used to attach other molecules in lab experiments. The CAS number for the product is 1992035-15-0.

Levan is a (2,6)-linked fructan produced by Erwinia herbicola. The polysaccharide contains branches every 10-12 fructose residues linked (1,2) and is reported to have a molecular weight in excess of 1000 KDa.  Potential industrial applications of levan have been proposed as an emulsifier, formulation aid, stabilizer and thickener, surface-finishing agent, encapsulating agent, and carrier for flavor and fragrances. In addition, levan is promising in medicine as a plasma substitute, drug activity prolongator and antihyperlipidemic agent.

Methyl 4,6-O-benzylidene-2,3-di-O-pivaloyl-a-D-mannopyranoside is a synthetic carbohydrate. It is a methylated saccharide that has been modified with a click modification and an Oligosaccharide. This product is also fluorinated and complexed with other sugars.

D-glucosyl-β-1,1'-N-nervonoyl-D-erythro-sphingosine is a mouse metabolite that was found to be an acyl group. This metabolite was shown to be a mouse metabolite.

2,3,4,6-Tetra-O-acetyl-5-thio-D-galactopyranosyl trichloroacetimidate is a carbohydrate that is modified with acetylation at the 2' and 3' positions of the 5'-hydroxyl group of the sugar. This modification can be used for oligosaccharides, complex carbohydrates, and synthetic carbohydrates. The CAS number for this product is 4862-90-8.

(1R) -1- [(2S, 3R,4R) -4-(Acetylamino)methyl-N-butyl-3- hydroxy- 1- azetidinyl] -1, 2- ethanediol is a Glycosylation that is synthesized by the Click modification of a polysaccharide. It is custom synthesis with high purity and CAS No.

N-Acetyl D-mannosamine (ManNAc) is an aldohexose (2-acetamido-2-deoxymannose) in which the axial hydroxyl group at position 2 is replaced by a N-acetyl group (Collins, 2006). It has been reported that N-acetyl D-mannosamine supplementation, may provide novel means to break the link between obesity and hypertension (Peng, 2019). N-Acetyl-D-mannosamine and N-acetyl-D-glucosamine are the essential precursors of sialic acid, the specific monomer of polysialic acid, a bacterial pathogenic determinant, for example, Escherichia coli K1 uses both amino sugars as carbon sources. Glycoproteins normally have some level of glycan sialylation, but incomplete sialylation can reduce their therapeutic effect when produced recombinantly. To improve performance, cell lines and culture media can be adjusted. The GNE enzyme controls the efficiency of sialylation in human cell lines, making it crucial for producing effective recombinant glycoprotein drugs. Adding ManNAc and other supplements to culture media improves sialylation, which boosts drug yield, increases stability and half-life, and lowers immune reactions by reducing antibody formation.It has also been reported that ManNAc can be used as a treatment for hereditary inclusion body myopathy, an adult-onset, progressive neuromuscular disorder and also for renal disorders involving proteinuria and hematuria due to podocytopathy and/or segmental splitting of the glomerular basement membrane (Galeano, 2007).

The benzyl group is a type of organic group in which the hydrogen atom at the alpha position is replaced with a phenyl group. In this compound, the benzyl group is attached to a sugar molecule through an ether bond. The benzyl group can be modified to produce different compounds. For example, it can be fluorinated to produce fluoro-benzyl compounds that are used as anti-cancer agents.

(2R, 3S, 4S) -4- (Azidomethyl) - 3- fluoro- 1- (phenylmethyl) -2- azetidinecarboxylic acid methyl ester is a synthetic saccharide which is used in the synthesis of oligosaccharides and monosaccharides. It has been shown to be useful for glycosylation reactions and click chemistry. This compound is also fluorinated and has a purity of 98%.

Alpha-cyclodextrin (α-CD) derivative with a hydrophilic exterior and lipophilic cavity (smaller than β-CDs and γ-CDs) to allocate certain guest molecules. This structural characteristic enables applications in molecular encapsulation, solubility enhancement, and stabilization across multiple industries. In pharmaceuticals, it serves as a drug delivery vehicle, enhancing the bioavailability and stability of active ingredients. The food industry utilizes it as a stabilizer for flavors, colors, and nutrients, as well as a functional ingredient for its effects on lipid metabolism. In cosmetics, it acts as a complex agent for fragrances and active components. Its applications extend to analytical chemistry for chiral separation and to materials science for developing smart materials and nanosystems.

Methyl 6-chloro-6-deoxy-a-D-altropyranoside is a custom synthesis that has been modified to have fluorination and methylation. This product is a monosaccharide that has been synthesized with the click modification and oligosaccharides. It is also polysaccharides and glycosylations, which are complex carbohydrates. These modifications can be found by CAS number.

Methyl 4,6-O-(4-methoxybenzylidene)-2,3-di-O-pivaloyl-a-D-galactopyranoside is a custom synthesis of a sugar that is Click modified with fluorine and glycosylated. Methyl 4,6-O-(4-methoxybenzylidene)-2,3-di-O-pivaloyl-a-D-galactopyranoside is an oligosaccharide that has saccharides and monosaccharides. This complex carbohydrate has been synthesized by methylation and modification. Methyl 4,6-O-(4-methoxybenzylidene)-2,3--di--pivaloyl--a--D--galactopyranoside belongs to the CAS No. of 689717–97–1.

6-Deoxy-D-gulono(L-mannono)-1.4-lactone is a custom synthesis of an oligosaccharide. It is a polysaccharide that is glycosylated with a sugar or carbohydrate. This molecule can be modified in the following ways: fluorination, methylation, and click modification. The CAS number for this compound is 73226-08-2.

(1S) -1- [(2S, 3R,4R) -N-Benzyl-3- benzyloxy- 4-hydroxymethyl-3-methyl-1- azetidinyl] -1, 2- ethanediol is a custom synthesis product that has been modified with methylation and fluorination. It is an oligosaccharide or polysaccharide that can be used as a link in the construction of complex carbohydrate molecules. This product is also known as 1, 2-(Benzyloxy)-4-(hydroxymethyl)-3-(methyl)-5-[(2S)-1, 2, 3, 4, 5]-hexahydroazepinium. This compound has been shown to have high purity and good stability. The chemical formula for this product is C12H22O7F2N2O5.

Hyaluronate fluorescein is a complex carbohydrate with the molecular weight of 500kDa. It is a Glycosylation, Methylation, Click modification, Polysaccharide, Fluorination, saccharide and Modification product. The CAS No. for this product is not available. This product can be Custom synthesized to order for high purity.

3'-Sulfated Lewis X sodium salt is a synthetic carbohydrate with a sulfate group on the 3' position of the sugar. It is a selective blocker of E-selectin, a type of selectin that plays an important role in inflammation and tissue injury. The binding site for 3'-sulfated Lewis X sodium salt is the cavity at the end of the selectin molecule, which has a hydrophobic region. This cavity can be blocked by hydrophobic moieties such as sulfates, fatty acids, or steroids. 3'-Sulfated Lewis X sodium salt has been shown to be effective in treating inflammatory conditions such as asthma and arthritis.