Glycoscience

(3S, 4R) -3, 4-Dihydroxy-2-methyl-D-proline is a synthetic monosaccharide. It is an intermediate in the synthesis of (3S, 4R)-3,4-dihydroxy-2-methyl-D-proline and can be used for the production of glycosylated products. This carbohydrate has been synthesized by fluorination followed by methylation and glycosylation. This is a high purity product that can be custom synthesized to meet your needs.

D-Galactosamine (GalN) is an aldohexose (2-amino-2-deoxygalactose) in which the hydroxyl group at position 2 is replaced by an amino group (Collins, 2006). Galactosamine (as the N-acetyl derivative) forms a key part of both N- and O-linked glycoproteins, glycolipids and glycosaminoglycans. Treatment of experimental animals with D-galactosamine / lipopolysaccharide causes lethal liver injury characterized by apoptosis of the hepatocyte and it is used as a laboratory model to study the effect of therapeutic agents (Hirono, 2001).

L-Idose is an aqueous solution of dextrose and anhydrous dextrose. It is a carbohydrate that provides energy to the body. L-Idose can be used to minimize the effects of certain organisms, such as bacteria, yeast, and fungi. It also helps to maintain blood glucose levels in people with diabetes by providing a source of glucose for their metabolism. L-Idose can be found in fruits and other foods that contain carbohydrates, such as breads, cereals, pastas, rice, potatoes, pasta sauces, chips, and crackers.

Fucose is a 6-carbon sugar that is an essential component of the human diet. It is found in many vegetables and fruits, but it can also be produced by the body from glucose. Fucose is involved in a number of important biochemical processes, including calcium metabolism and the synthesis of galactose, l-glutamic acid, and other carbohydrates. Fucose has been shown to inhibit leukemia cells through programmed cell death and may also have a role in regulating cell proliferation.

This beta-cyclodextrin (β-CD) derivative is a functionalized cyclic oligosaccharide composed of seven glucose units, characterized by a hydrophilic exterior and a lipophilic cavity (bigger than α-CD and smaller than γ-CDs), which allows it to encapsulate various guest molecules. This structural feature facilitates its use in multiple applications, including pharmaceuticals, food enhancement, and cosmetics. In the pharmaceutical industry, it enhances the solubility and stability of poorly water-soluble drugs, improving their bioavailability and efficacy while also masking unpleasant tastes. The food sector utilizes it as a stabilizer for flavors, colors, and nutrients, extending shelf life by protecting sensitive ingredients from degradation. In cosmetics, it serves as a complexing agent for fragrances and active components, ensuring their stability and controlled release. Its use expands to many other fields, including nanotechnology for drug delivery systems, environmental remediation for extracting organic pollutants, textiles for slow-release fragrances, and analytical chemistry for chiral separation.

5-Thio-a-D-mannose is a disaccharide that contains a sulfhydryl group. It has been shown to be a cellular and trackable molecule, which can be acetylated by mercuric chloride. The glycosidases of this molecule are mannosidases, which cleave the 5th carbon from the glycosidic linkage of the sugar. This is an important process for a variety of biological functions, such as the synthesis of DNA and proteins. In addition, this disaccharide is involved in various metabolic pathways, including glycolysis and gluconeogenesis.

1,2,3,4,6-Penta-O-acetyl-α-D-mannopyranose is an acetylated sugar which is used as an intermediate in the mannosylation of glycoproteins or glycoconjugates. It can be used in the production of mannosylated glycoconjugate vaccines or lipid nanoparticles (LNPs) which have been investigated for improving antigen up-take mediated, via the mannose receptor (MR) of human antigen presenting cells (APCs).  1,2,3,4,6-Penta-O-acetyl-a-D-mannopyranose, also known as α-D-Mannose pentaacetate, has also been used in the study of isolated rat pancreatic islets where it stimulates insulin release.

D-Glucose-6-phosphate barium salt is a custom synthesis of the saccharide, which is a component of the carbohydrates. It has been modified by fluorination, methylation, and monosaccharide modification. The synthesis of this compound can be done in a single reaction, and it is an example of glycosylation. This product has been shown to have high purity.

Methyl β-D-fructopyranoside is a glycoside that is made up of a pyranose ring and the sugar d-fructose. This molecule is stable because of its hydrogen bonds, which are formed between the oxygen atom of the hydroxyl group and the hydrogen atom of the methyl group. Methyl β-D-fructopyranoside has two chiral centers, so it can exist as two enantiomers. The most common form is D-(+)-methyl β-d-fructopyranoside, which has a configuration of R (right) and S (left).

2-Deoxy-1,3,4,6-tetra-O-pivaloyl-D-glucopyranose is a glycosylation sugar that belongs to the category of complex carbohydrates. It is a methylated sugar that can be fluorinated or modified with other saccharides. This product can be custom synthesized and has high purity.

Dextran sulphate is a dextran derivative whose ulcer (colitis) -causing properties were first reported in hamsters and extrapolated a few years later to mice and rats. The exact mechanisms through which dextran sulphate induces intestinal inflammation are unclear but may be the result of direct damage of the monolayer of epithelial cells in the colon, leading to the crossing of intestinal contents (for e.g. commensal bacteria and their products) into underlying tissue and therefore induction of inflammation.  The dextran sulphate sodium induced ulceration model in laboratory animals has some advantages, when compared to other animal models of colitis, due to its simplicity and similarities to human inflammatory bowel disease.

Glycyl-Oligosaccharidesmannose 3(a) (GL3(a)) is a complex carbohydrate that is composed of mannose and glycyl chains. It has been modified with methyl, click, fluorination, and saccharide modifications. GL3(a) has been synthesized using custom synthesis methods that yield high purity.

Methyl α-L-rhamnopyranoside is a conjugate molecule made via a Fisher glycosylation with MeOH. It has been shown to have pesticidal activities and can be used in the production of pesticides or glycoconjugates. Methyl α-L-rhamnopyranoside is of interest as a vaccine adjuvant, due to its ability to activate the immune system. This compound also has anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.