Flavonoides

<p>8-Hydroxygenistein-7,8,4'-trimethyl ether is a phytochemical derivative, which is sourced from plant metabolites, specifically isoflavonoids. This compound is modified through methylation processes to enhance its stability and lipophilicity, making it a subject of interest in various biochemical studies. Its mode of action primarily involves interaction with cellular signaling pathways, influencing antioxidant mechanisms and potentially affecting gene expression related to oxidative stress.</p>

<p>Enhances TRAIL-induced apoptosis in MOLT-4- cells</p>

Cinnamtannin B-1 (LDN 0022358) is an A-type proanthocyanidin contained in several plant species such as Vaccinium vitis-idaea, Laurus nobilis L., Cinnamomum

<p>Isoscutellarein is a flavonoid compound, which is naturally derived from various plant sources, including herbs and certain vegetables. It functions primarily as an antioxidant, scavenging free radicals and reducing oxidative stress within biological systems. This activity is attributed to its ability to donate hydrogen atoms or electrons, thus stabilizing reactive oxygen species (ROS).</p>

<p>Myricetin-3-galactoside is a flavonoid glycoside, which is a type of secondary metabolite originating from various plant sources, including fruits, vegetables, and certain herbs. This compound forms when the flavonol, myricetin, is glycosylated with a galactose molecule. Its structure enhances the stability and solubility of myricetin, thereby modulating its bioavailability and biological activity.</p>

<p>Naringenin-7-rutinoside is a flavonoid glycoside, which is naturally sourced from citrus fruits, such as grapefruits and oranges. This compound is characterized by its unique molecular structure where the flavonoid naringenin is bound to the disaccharide rutinose. The mode of action of naringenin-7-rutinoside primarily involves its antioxidant properties, which allow it to scavenge free radicals and reduce oxidative stress in biological systems.</p>

<p>(+)-Pinocembrin is a flavonoid compound, which is a naturally occurring phytochemical. It is predominantly sourced from propolis, a resinous substance produced by bees, and also found in various plants such as honey and ginger root. The mode of action of (+)-Pinocembrin involves its potent antioxidant and antimicrobial properties. It acts by scavenging free radicals, thereby protecting cells from oxidative stress, and it also interferes with microbial cell membranes, leading to antimicrobial effects.</p>

Jamaicin (AnCoA4), an isoflavone derived from the chickweed plant, is an inhibitor of the STIM1-Orai1 channel that blocks calcium ion influx.

<p>Kaempferol-7,4'-dimethyl ether is a flavonoid derivative, which is a naturally occurring compound predominantly found in certain plant species. As a derivative of kaempferol, it is an O-methylated flavonoid, often isolated from various members of the Leguminosae family. Its mode of action involves interacting with multiple biological pathways, typically exhibiting antioxidant and anti-inflammatory properties. This potent flavonoid modulates signaling pathways and can influence cellular energy metabolism, often impacting reactive oxygen species (ROS) levels.</p>

<p>Quercetin 3,4'-diglucoside is a flavonoid glycoside, which is a compound naturally derived from various plant sources, including certain fruits and vegetables. This compound is known for its significant role as an antioxidant. It operates by scavenging free radicals, thereby mitigating oxidative stress at the cellular level. This mode of action makes it a compound of interest in studies related to inflammation, aging, and chronic diseases.</p>

<p>Velutin is a natural flavonoid, which is derived from the leaves of certain plant species, specifically from the Asteraceae family. This compound demonstrates a unique mode of action by modulating various signaling pathways involved in inflammation and oxidative stress. Velutin effectively inhibits the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and reduces the expression of pro-inflammatory cytokines, contributing to its anti-inflammatory properties.</p>

<p>Dimoxystrobin is a fungicidal compound, which is a synthetic chemical derived from the strobilurin class of fungicides. It is sourced from natural antifungal compounds originally discovered in certain mushroom species. Dimoxystrobin's mode of action involves inhibiting mitochondrial respiration in fungi by binding to the Qo site of the cytochrome bc1 complex. This interference disrupts energy production in fungal cells, leading to their effective control and eventual death.</p>

<p>Isovitexin is a naturally occurring flavonoid compound, specifically a C-glycosyl flavone, which is found in a variety of plants, including green tea, passionflower, and barley leaves. Derived from these botanical sources, isovitexin is characterized by its structural complexity, contributing to its biological activity. The mode of action of isovitexin involves its ability to scavenge free radicals and inhibit oxidative stress. It exhibits strong antioxidant properties that allow it to stabilize reactive oxygen species (ROS), thereby preventing cellular damage. Additionally, isovitexin has been studied for its potential anti-inflammatory and neuroprotective effects, attributed to its influence on signaling pathways and enzyme activities related to inflammation and cell survival. Isovitexin is primarily utilized in the context of scientific research to explore its pharmacological potentials. Researchers study its application in fields such as neuroprotection, cardioprotection, and its role in mitigating the effects of metabolic disorders. Its broad spectrum of activity makes it a compound of interest in both the development of therapeutic agents and the enhancement of nutritional supplements.</p>

<p>Quercetin-7-O-β-D-glucopyranoside is a flavonoid glycoside, which is a specialized type of bioactive compound found predominantly in various plants. Structurally, it constitutes quercetin—a well-known flavonoid—conjugated with a glucose molecule, specifically at the 7th position of the quercetin structure. This compound is primarily sourced from fruits, vegetables, and various herbs.</p>

<p>Inhibitor of HSP70 and HSP27 expression</p>

<p>Flavanone hydrazone (FH) is a natural compound that has been found to have antiviral activity against a number of viruses, including the papilloma virus and picornavirus. The antiviral activity of FH is due to its ability to inhibit the shikimate pathway, which is required for the synthesis of aromatic amino acids from chorismate. This inhibition prevents the production of viral proteins, leading to cell death. FH also has an inhibitory effect on hepatitis C virus and leukoplakia by inhibiting fatty acid synthesis. It may also be used in the treatment of inflammatory diseases such as rheumatoid arthritis and ulcerative colitis.</p>

<p>3,7-Dimethoxy-3',4',5-Trihydroxyflavone is a flavonoid compound, which is derived from various plant sources known for their bioactive compounds. These plants are rich in polyphenolic substances, contributing to the compound's complex structure and functionality. The mode of action of 3,7-Dimethoxy-3',4',5-Trihydroxyflavone involves its ability to act as a potent antioxidant. It scavenges free radicals and reduces oxidative stress by neutralizing reactive oxygen species at the molecular level. Additionally, its molecular configuration allows for interactions with cellular signaling pathways, potentially influencing various biochemical processes.</p>

<p>Alpinumisoflavone is a naturally occurring isoflavone, which is derived from plants, particularly those in the Leguminosae family. Structurally, isoflavones are a class of phytoestrogens, plant-derived compounds with estrogenic activity. Alpinumisoflavone exerts its effects primarily through its antioxidant and anti-inflammatory activities. It modulates key signaling pathways by interacting with cellular components to reduce oxidative stress and inhibit inflammatory responses, making it a valuable compound in studying cellular protection mechanisms.</p>

<p>5-Hydroxy-7,8-dimethoxyflavanone is a naturally occurring flavanone, which is typically sourced from various plant species known for their bioactive compounds. This compound falls under the category of flavonoids and exhibits distinct structural features that contribute to its biochemical activities. The source plants for this flavanone are often part of traditional medicinal systems, owing to their rich profile of secondary metabolites.</p>

<p>Kaempferol-3-O-glucorhamnoside is a bioactive flavonoid glycoside, which is a naturally occurring compound found in a variety of plants. It serves as a significant molecule in the study of plant biochemistry and pharmacology. This compound is sourced from various plant species such as tea, broccoli, and other common vegetables and fruits, where it contributes to the plant's defense mechanisms against environmental stresses.</p>