Azúcares troncales y bases nucleicas

Applications A guanine derivative that acts as modulators of GTPases and modulator-resistant enzymes; used in drug design and target validation.
References Goth-Goldstein, R., et al.: Cancer Res., 40, 2623 (1980), Nakabeppu, Y., et al.: J. Biol. Chem., 259, 13723 (1984), Modrich, P., et al.: Science, 266, 1959 (1994),

Applications 2'-Deoxy-N3-methyluridine (cas# 24514-32-7) is a useful research chemical.

Applications Guanidinoacetic Acid is an important marker for renal failure, in kidney transplantation, and for the renal metabolic activity.
References Zugno, A., et al.: Neurochem. Res., 33, 1804 (2008), Debray, F., et al.: Neurol., 71, 44 (2008), da Silva, R., et al.: Am. J. Physiol., 296, E256 (2009),

Applications 6-Amino-5-1,3-dimethyl-5-(formamido)uracil is a substitued uracilic metabolite of methylxanthine and is also a metabolite of Theophylline (T343850). 6-Amino-5-1,3-dimethyl-5-(formamido)uracil has been used for the synthesis of 8-arylaminotheophyllines.
References Peri, G., et. al.: Toxicol. Lett., 18, 133 (1983); Celardo, A., et. al.: Eur. J. Drug Metab. Ph., 10, 279 (1985); Senga, K., et. al.: J. Heterocyclic Chem., 15, 641 (1978)

Applications 6-Benzyl-2-thiouracil (cas# 6336-50-1) is a useful research chemical.

Applications 5,6-Dihydrothymine is a derivative of Thymine, a nucleobase in the nucleic acid of DNA . 5,6-Dihydrothymine is a radiolysis product of DNA.
References Hubbard, K. et al.: Biochemistry, 28, 4382 (1989); Cadet, J. et al.: Int. J. Rad. Biol. Rel. Stud. Phys. Chem. Med., 39, 119 (1981);

Applications 1,3-Diethyl-6-aminouracil (cas# 41740-15-2) is a compound useful in organic synthesis.

Applications 5-Hydroxymethyluracil (cas# 4433-40-3) is a compound useful in organic synthesis.

Applications N-Succinyl-5-aminoimidazole-4-carboxamide Ribose 5’-Phosphate is a metabolite of Purine. Since adenosine is a potent inhibitor of neuronal function, depressing the release of several excitatory transmitters and causing direct hyperpolarization of neurons, it was possible that the symptoms seen in adenylosuccinate lyase (ASase) deficient patients could reflect an interference of succinylpurines with neurotransmission.
References Gollub, E.G., et al.: J. Bacteriol., 78, 320 (1959), Srivastava, P.C., et al.: J. Med. Chem., 17, 1207 (1974),

Applications 1,3-Diethyl-5-nitroso-6-aminouracil (cas# 89073-60-9) is a compound useful in organic synthesis.

Applications A useful intermediate in the synthesis of 1-substituted adenines.
References Laufer, S., et al.: J. Med. Chem., 48, 710 (2005), Lambertucci, C., et al.: Bioorg. Med. Chem., 17, 2812 (2009),

Applications N6-(2-Isopentenyl)adenine can be used in biological study for cytokinins stimulated expression of stress-related proteins and transcripts in Arabidopsis thaliana with isopentenyltransferase overexpression.
References Skalak, J., et al.: J. Exp. Bot., 67, 2861-2873 (2016)