Azúcares troncales y bases nucleicas

Applications 6-Amino-5-1,3-dimethyl-5-(formamido)uracil is a substitued uracilic metabolite of methylxanthine and is also a metabolite of Theophylline (T343850). 6-Amino-5-1,3-dimethyl-5-(formamido)uracil has been used for the synthesis of 8-arylaminotheophyllines.
References Peri, G., et. al.: Toxicol. Lett., 18, 133 (1983); Celardo, A., et. al.: Eur. J. Drug Metab. Ph., 10, 279 (1985); Senga, K., et. al.: J. Heterocyclic Chem., 15, 641 (1978)

Applications 1,3-Diethyl-5-nitroso-6-aminouracil (cas# 89073-60-9) is a compound useful in organic synthesis.

Applications 9-(2-Propenyl)adenine is an N-substituted purine used in the preparation of mesityl dihydroisoxazolyl homo-N-nucleosides.
References Thalassitis, A. et al.: Bioorg. Med. Chem. Lett., 19, 6433 (2009); Chiacchio, U. et al.: Tetrahedron, 60, 441 (2004)

Applications Nucleoside derivatives of 5-substituted uracil have been explored for their potential application as anti-viral agents and in the treatment of tumors.
References Ressner, E.C., et al.: J. Med. Chem., 19, 1, 194 (1976)

Applications Reagent used in the preparation of Antithyroid agents.
References Toropov, A., et al.: Eur. J. Med. Chem., 45, 3581 (2010), Daniels, C., et al>.: J. Bacteriol., 192, 2169 (2010), Castillo-Garit, J., et al.: Eur. J. Pharm. Sci., 39, 30 (2010),

Applications 5,6-Dihydrothymine is a derivative of Thymine, a nucleobase in the nucleic acid of DNA . 5,6-Dihydrothymine is a radiolysis product of DNA.
References Hubbard, K. et al.: Biochemistry, 28, 4382 (1989); Cadet, J. et al.: Int. J. Rad. Biol. Rel. Stud. Phys. Chem. Med., 39, 119 (1981);

Impurity Zidovudine EP Impurity C
Applications Thymine (Zidovudine EP Impurity C) is a nitrogenous base component in the nucleic acid of DNA.
References Keum, Y., et al.: App. Microbiol. Biotechnol., 80, 863 (2008); Redzic, Z., et al.: Neurochem. Res., 34, 566 (2009); Lanevskij, K., et al.: J. Pharm. Sci., 98, 122 (2009); Rajendar, B., et al.: Bioorg. Med. Chem., 17, 351 (2009);

Applications 6-​Phenyl-​2-​thiouracil is a reagent used in the synthesis of antifungal agents.
References Gullapelli, K. et al.: Int. J. Pharm. Biol. Sci., 4, 59 (2014);

Applications Protected guanine
References Tretyakova, N., et al.: Chem. Res. Toxicol., 20, 284 (2007), Rana, S., et al.: Bioorg. Med. Chem. Lett., 19, 670 (2009),

Applications An intermediate in the preparation of thymidine derivatives
References el Kouni, M., et al.: Biochem. Pharmacol., 51, 1687 (1996),

Applications 6-Benzyl-2-thiouracil (cas# 6336-50-1) is a useful research chemical.

Stability Hygroscopic
Applications Adenine Hemisulfate can be one of the factors that influence in vitro growth and shoot multiplication of pomegranate. It can be used in biological study along with varied levels of sucrose, light intensity, and MS medium hydrogen ion concentration where those factors can all significantly influence multiplication and growth of Punica granatum shoots.
References Singh, P., & Patel, R., M.: Bioscan, 9, 1031-1035 (2014)

Impurity Aciclovir EP Impurity B
Applications Guanine is one of the five nucleobases incorporated into biological nucleic acids. Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA. Aciclovir EP Impurity B.
References Geslain, R., et al.: J. Biol. Chem., 284, 27760 (2009); Manini, P., et al.: Toxicol. Lett., 190, 41 (2009); Gong, B., et al.: Biochem., 48, 11961 (2009); Sugimoto, M., et al.: J. Agric. Food Chem., 58, 374 (2010);

Applications 4-Thiouracil is a derivative of Uracil (U801000), which is a nitrogenous base in RNA nucleic acid. 4-Thiouracil is used for tagging in cell type-specific RNA isolation from intact complex tissues.
References Miller, M., et al.: Nat. Methods, 6, 439 (2009); Seth, P., et al.: J. Med. Chem., 53, 8309 (2010); Cui, H., et al.: Eur. J. Med. Chem., 45, 5140 (2010);

Stability Hygroscopic
Applications 5-Hydroxymethyl-2’-deoxyuridine acts as a biomarker for the diagnosis for oxidative stress in humans. Used as a diagnostic to for propensitiy for the development of breast cancer.
References McAnulty, L. et al.: App. Physiol. Nutr. Metab., 36, 976 (2011); Djuric Z. et al.: Cancer Epidemiol. Biomarkers. Prev., 10, 147 (2001); Frenkel, K. et al.: 7, 49, (1998);

5-Hydroxymethyluridine is a nucleoside that is synthesized from uridine. It has shown to be effective in the treatment of inflammatory diseases, such as rheumatoid arthritis, and also has antiviral activity against herpes simplex virus. 5-Hydroxymethyluridine has been shown to have a high affinity for hydrophilic interaction chromatography (HIC) and can be used to purify glycosylases. This compound can also inhibit the formation of cancer cells by inhibiting the transcriptional activity of RNA polymerase II. 5-Hydroxymethyluridine has been found to demethylate DNA while maintaining its ability to bind with DNA-dependent RNA polymerase II. This process is catalyzed by glycosylases and hydroxylases that are found in the body.