Vitaminas

Applications Arotinoid ethyl ester is a retinoid with a similar structure to vitamin A (R252000), and inhibits human epidermal keratinocyte RNase P activity, as well as tRNA biogenesis.
References Liao, W.; et al.: Zhongguo Linchuang Yaolixue Yu Zhiliaoxue, 19, 112 (2014); Papadimou, E.; et al.: Biol. Chem., 384, 457 (2003); Papadimou, E.; et al.: Skin Pharmacol. Physiol., 13, 345 (2000).

Stability Light and Temperature Sensitive
Applications 9-cis-13,14-Dihydroretinoic Acid, is a derivative of Retinal (R240000), corotenoid component of the visual pigments.
References Ball, et al.: Biochem. J., 42, 516 (1948), O’Brien, D.F., et al.: Science, 218, 961 (1982),

Applications MRL-871 is a novel RORγt inhibitor, binding to a previously unidentified allosteric pocket in the RORγt LBD.
References Scheepstra, Marcel., et al.:Nat. Commun., 6, 8833/1 (2015); Fauber, Benjamin P., et al.: Bioorganic Med. Chem. Lett., 25, 2907 (2015);

Applications Α hydroxylated metabolite of Vitamin D2 (V676040); a synthetic analog of Vitamin D.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Matsuoka, M. et al.: J. Nutrit. Sci. Vitaminol., 35, 253 (1989); Jones, G. et al.: Arch. Biochem. Biophys., 202, 450 (1980); Goff, J. et al.: J. Nutrit., 112, 1387 (1982);

Applications SR 1078 is a selective agonist of RORα and RORγ that stimulates ROR transcriptional activity in HEK293 cell reporter assays.
References Wang, Y., et al.: ACS Chem. Biol., 5, 1029 (2010); Wang, Y., et al.: PLoS One, 7, 1 (2012)

Applications SC-58236 is a highly selective and potent cyclooxygenase-2 inhibitor which has been shown to induce apoptosis in gastric cells via down-regulation of Akt and then release of cytochrome c. Its anti-inflammatory effects allows for potential use in therapy for inflammatory allergic diseases.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Fan, X.M. et al.: Digestion, 2, 75 (2006); Kim, S. et al.: Life Sci., 81, 863 (2007); Kim, S. et al.: J. Pharmacol. Exp. Therap., 313, 27 (2005);

Applications Antagonizes Wnt/β-catenin/Tcf-mediated transcription as well as PPARγ and δ activity. Able to inhibit the recruitment of the co-activators β-catenin and GRIP1, both of which are activators for both pathways.
References Handeli, S., et al.: Mol. Cancer Ther., 7, 521 (2008),

Applications 17beta-Estradiol-16,16-d2 (CAS# 3188-46-3) is a useful isotopically labeled research compound.

Stability Hygroscopic! Store Under Inert Atmosphere.
Applications An active Biotinylation reagent.
References Giubellino, A., et al.: J. Med. Chem., 51, 7459 (2008), Wang, Z., et al.: Nat. Chem. Biol., 4, 557 (2008),

Applications SR 8278 is a synthetic antagonist of the nuclear heme receptor REV-ERB.
References Kojetin, D., et al.: ACS. Chem. Biol., 6, 131 (2011);

Applications Coenzyme Q2 is a redox carrier in the mitochondrial respiratory chain in eukaryotic cells. It has been used to investigate interaction of coenzyme Q with phosphatidylethanolamine membranes.
References Do, T., et al.: J. Biol Chem. 276, 18161 (2001); Gomez-Fernandez, J. C., et al.: Eur. J. Biochem. 259, 739 (1999);

Applications A metabolite of Budesonide (B689490), an antiinflammatory agent.
References Cserhati, T., et al.: J. Pharm. Biomed. Anal., 22, 25 (2000), Dilger, K., et al.: J. Clin. Pharmacol., 47, 1532 (2007), Buchwald, P., et al.: Steroids, 73, 193 (2008),

Applications Vitamin K1 2,3-Epoxide is a metabolite of Vitamin K1 (V676080), which is occurs widely in green plants, algae, and photosynthetic bacteria.
References Smee, D.F., et al.: Antimicrob. Agents Chemother., 23, 676 (1983), Miyamoto, T., et al.: Biochem. Pharmacol., 35, 839 (1986); Hassan, M.M.A., et al.: Anal. Profiles Drug Subs., 17, 449 (1988), Breton, J., et al.: Biochemistry, 33, 12405 (1994), Dowd, P., et al.: Science, 269, 1684 (1995);

Applications The active labelled metabolite of Vitamin D2 (V676040).
References Lam, H., et al.: Science, 186, 1038 (1974), Dilworth, F., et al.: J. Biol. Chem., 270, 16766 (1995), Horst, R., et al.: Biochem. Pharmacol. 60, 701 (2000), Horst, R., et al.: J. Cell Biochem., 88, 282 (2003),

Applications 13-cis-Retinyl Acetate is a derivative of 13-Cis-Retinol (R252110), an active metabolite of vitamin A.
References Shantz, E., et al.: J. Biol. Chem., 183, A61 (1950), Barua, A., et al.: Biochem. J., 164, 133 (1977), Brouwer, I., et al.: Nutr. Res. Rev., 14, 267 (2001), Grillenberger, M., et al.: Br. J. Nutr., 95, 379 (2006),

Applications Vitamin D5 is used in the synthetic preparation of 1α-Hydroxyvitamin D5 a promising chemopreventive agent for breast cancer.
References Moriarty, R.M., Albinescu, D.: J. Org. Chem., 70, 7624 (2005)

Applications GW3965 Hydrochloride, is a potent, selective liver X receptor (LXR) agonist for hLXRα and hLXR. GW3965 has shown potent anti-inflammatory activity in both irritant and allergic contact models of dermatitis, requiring the participation of both LXRα and LXRβ.
References Fowler, A.J., et. al.: J. Invest. Dermatol., 120, 246 (2003)

Stability Light Sensitive, Temperature Sensitive
Applications Echinenone is a protective carotenoid. Echinenone is an analogue of β-Carotene (C184250), the most important of the provitamins A. Widely distributed in the plant and animal kingdom. In plants it occurs almost always together with chlorophyll. Vitamin A precursor. Ultraviolet screen.
References Karrer, et al.: Helv. Chim. Acta, 12, 1142 (1929); Fischli, M., et al.: Helv. Chim. Acta, 58, 1584 (1975); Desmet, J., et al.: Biochem. Biophys. Acta, 912, 211 (1987); Tan, C., et al.: Food Chem., 92, 661 (2005); Chu, B., et al.: J. Agric. Food Chem., 55, 6754 (2007)

Vitamin D3 is a fat-soluble vitamin that can be obtained from some fish, mushrooms, and dairy products. The most common form of the vitamin is cholecalciferol (vitamin D3) which can be converted in the liver to calcidiol (25-hydroxycholecalciferol) and in the kidneys to calcitriol (1,25-dihydroxycholecalciferol). Vitamin D3 has been shown to have a positive effect on calcium absorption and bone mineralization. It also has important physiological functions such as regulation of cell growth and differentiation. The solubility of vitamin D3 is dependent on the presence of a hydroxy group at position 3' or 25'. This liquid chromatography method uses an experimental solubility data set for the determination of solubility data for compounds with a hydroxy group at position 3'.