Vitaminas

Stability Light Sensitive, Temperature Sensitive, Toxic
Applications A labelled metabolite of Vitamin D2 (V676040).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Barnes, P., et al.: J. Clin. Invest., 83, 1527 (1989), Holick, M., et al.: J. Cell Biochem., 88(2), 296 (2003), Maunsell, Z., et al.: Clin. Chem., 51, 1683 (2005),

Applications 2-O-a-D-Glucopyranosyl-L-ascorbic Acid is a useful cosmetic gel and skin cleanser.
References Aizawa, K., et al.: PCT Int. Appl. (2020), WO 2020226147 A1

Applications Hydrocortisone 17-Valerate is a derivative of Hydrocortisone (H714615) which is a glucocorticoid that is produced by the zona fasciculata of the adrenal gland.
References Ponec, M. et. al.: J. Pharm. Sci., 75, 973 (1986); Vigore, L., et al.: Cancer Ther., 6, 699 (2008)

Stability Hygroscopic
Applications 4-Deoxypyridoxine is the deoxy analogue of Pyridoxine (P991735). 4-Deoxypyridoxine is a vitamin B6 antimetabolite; 4-Deoxypyridoxine can induce a deficient status that alters the function and ultrastructure of EC similar to vascular disease.
References La Pesa, M. et al.: Pathologia, 62, 907 (1970); Chang, S..: J. Nutrit. Sci. Vitaminol., 46, 149 (2000); Yamashita, J.: J. Nutrit. Sci. Vitaminol., 22, 1 (1976);

Stability Hygroscoipic, Light and Air Sensitive
Applications Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF).
References Andres, J., et al.: Bioorg. Chem., 24, 10 (1996), Benkovic, S., et al.: Science, 301, 1196 (2003), ,,,,Williams, D; J Mol Biol 2003, 329, 389,,,Krahn, J., et al.: Biochemistry, 46, 14878 (2007),

Impurity Cholecalciferol EP Impurity D
Stability Light Sensitive, Temperature Sensitive
Applications Isotachysterol3 (Cholecalciferol EP Impurity D) is a degradation product of Vitamin D3 (V676045). Isotachysterol3 has been shown to stimulate intestinal Ca transport and bone Ca mobilization in anephric rats.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bolos, J. et al.: Cien. Indust. Farm., 6, 259 (1987); Holick, M.F. et al.: Science, 180, 964 (1973);

Stability Light Sensitive, Temperature Sensitive
Applications A metabolite of Vitamin A (R252000(M)).
References Touma, S., et al.: Biochem. Pharmacol., 78, 1127 (2009), Muniz, A., et al.: Biochem., 48, 6854 (2009), Guignard, T., et al.: J. Biol. Chem., 285, 18759 (2010),

Stability Light Sensitive
Applications alpha-Tocotrienol is an antioxidant.

Stability Hygroscopic
Applications Hydroxocobalamin is an intermediate in the synthesis of Nitritocobalamin(N490240) is a useful synthetic intermediate in the synthesis of Hydroxocobalamin Acetate (H826800); a physiological analog of vitamin B12 where the CN group is replaced with OH. Exists in aqueous solution as an equilibrium mixture of the hydroxy isomer and the ionic aqua isomer (aquacobalamin). Precursor of the coenzymes methylcobalamin and cobamamide. Coordination Compound. Vitamin (hematopoietic).
References Kaczka, E.A., et al.: Science, 112, 354 (1950); Friedrich, W., et al.: Vitamins, 837 (1988); Forsyth, J.C., et al.: Clin. Toxicol., 31, 277 (1993)

Stability Light Sensitive
Applications δ-Tocotrienol is a natural substance with vitamin E activity. It can work as an antioxidant. It inhibits the growth of human breast cancer cells.
References Sen, C., et al.: Life Sci., 78, 2088 (2006); Yoshida, Y., et al.: Chem. Phys. Lipids, 123, 63 (2005)

Applications SR 9011 is a synthetic REV-ERBα/β agonist with activity in vivo. It is a lead compound for a new class of cancer drugs associated with the body’s circadian clock.
References Solt, L.A., et. al.: Nature, 485, 7396 (2012); Chem. and Eng. News. p.8, Jan. 15, 2018

Stability Moisture Sensitive
Applications Succinimidyl-6-(biotinamido) Hexanoate is a biotinylation reagent incorporating an aminocaproyl “spacer”. This can reduce the steric hindrance in binding avidin to some biotinylated compounds when used to biotinylate both the antibody and the carrier in the Protein Avidin-Biotin Capture System. This system avoids the direct interaction of a captured antibody with solid surfaces, such as plastics, which may reduce antigenicity. It has also been used to enhance the detection of DNA on nitrocellulose. Has also been used as a cell surface labelling reagent
References Hofmann, K., et al.: Biochemistry, 21, 978 (1982); Leary, J.J., et al.: P. Natl. Acad. Sci. USA, 80, 4045, (1983); Suter, M., et al.: Immunology Letters, 13, 313 (1986); Gretch, D.R., et al.: Anal. Biochem., 163, 270 (1987), Burgess, T.L., et al.: J. Biol. Chem., 269 (32), 19188 (1995), Schumacher, T.N.M., et al.: Science, 271, 1854 (1996)

Stability Hygroscopic
Applications One of the bioactive forms of Riboflavin. Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor).
References Unna, K., et al.: J. Pharmacol. Exp. Ther., 76, 75 (1942), Rivlin, et al.: N. Engl. J. Med., 283, 463 (1970), Al-Shammary, F.J., et al.: Anal. Profiles Drug Subs., 19, 429 (1990),

Stability Hygroscopic
Applications Corotenoid component of the visual pigments. All-trans retinal is converted to retinoic acid in vivo by the action of retinal dehydrogenase.
References Ball, et al.: Biochem. J., 42, 516 (1948), O’Brien, D.F., et al.: Science, 218, 961 (1982),

Applications (+)-Biotin 4-Amidobenzoic Acid, Sodium Salt is a fluorigenic substrate for the determination of Biotinidase activity.

Applications The labelled aglucon of Daidzin.
References Am. J. Respir. Cell Mol. Biol., 7, 637 (1992), Biochim. Biophys. Acta 1221, 29 (1994), Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)