Sistema complementario
El sistema complementario es una parte crucial de la respuesta inmune, compuesto por una serie de pequeñas proteínas que mejoran la capacidad de los anticuerpos y las células fagocíticas para eliminar patógenos de un organismo. Estas proteínas trabajan juntas para opsonizar patógenos, inducir respuestas inflamatorias y lisar directamente las membranas de los patógenos, desempeñando un papel vital en la inmunidad innata y la función inmunitaria general. En CymitQuimica, ofrecemos proteínas del sistema del complemento de alta calidad para apoyar sus estudios inmunológicos e investigaciones clínicas.
Se han encontrado 156 productos de "Sistema complementario"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Avdoralimab
CAS:<p>Avdoralimab (IPH 5401) is a humanized monoclonal antibody targeting complement C5a receptor 1 (C5aR1).</p>Pureza:>95%Forma y color:LiquidTesidolumab
CAS:<p>Tesidolumab, a fully human IgG1/λ anti-C5 monoclonal antibody, inhibits crovalimab and C5, preventing membrane attack complex formation.</p>Pureza:99.72% (SEC-HPLC) - > 95%Forma y color:LiquidPeso molecular:142 kDa (average)Lampalizumab
CAS:<p>Lampalizumab (RG 7417) is a humanized monoclonal antibody targeting Factor D, which can be used in cardiovascular disease research.</p>Pureza:>95%Forma y color:LiquidPeso molecular:46.96 (kDa)Sutimlimab
CAS:<p>Sutimlimab: monoclonal antibody, inhibits complement protein C1, treats cold agglutinin-induced hemolysis.</p>Pureza:> 95%Forma y color:LiquidPeso molecular:144.8 kDaVesencumab
CAS:<p>Vesencumab (MNRP-1685A) is an IG1 antibody targeting NRP-1 with anti-angiogenic and anti-tumor activity. Vesencumab can be used to study solid tumors.</p>Pureza:99.2% (SDS-PAGE); 96.6% (SEC-HPLC) - 99.2% (SDS-PAGE); 96.6% (SEC-HPLC)Forma y color:LiquidCyclosporin A
CAS:<p>Cyclosporin A is a Calcineurin Inhibitor Immunosuppressant, and a Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.</p>Fórmula:C62H111N11O12Pureza:99.00% - 99.92%Forma y color:White PowderPeso molecular:1202.61Vilobelimab
CAS:<p>Vilobelimab (CaCP-29, IFX-1), a monoclonal antibody, inhibits C5a to reduce inflammation and is researched in sepsis and COVID-19 studies.</p>Pureza:99% (SDS-PAGE); 98.9% (SEC-HPLC) - 99% (SDS-PAGE); 98.9% (SEC-HPLC)Forma y color:LiquidDexamethasone
CAS:<p>Dexamethasone: a glucocorticoid agonist; modulates IL receptors; reduces inflammatory miRNA-155 exosomes in macrophage responses.</p>Fórmula:C22H29FO5Pureza:98% - 99.91%Forma y color:Crystals From Ether (Ntp 1992)Peso molecular:392.46SB290157 trifluoroacetate
CAS:<p>SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM).</p>Fórmula:C24H29F3N4O6Pureza:98.93% - 99.89%Forma y color:SolidPeso molecular:526.51Ravulizumab
CAS:<p>Ravulizumab (ALXN1210) is a humanized antibody for blocking complement activation, treating PNH, aHUS, and myasthenia gravis.</p>Pureza:> 95%Forma y color:LiquidPeso molecular:145.80 kDaC3a (70-77)
CAS:<p>C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a.</p>Fórmula:C35H61N13O10Pureza:98%Forma y color:SolidPeso molecular:823.94Greziprubart
<p>Greziprubart is a humanized IgG1κ monoclonal antibody that targets C5a, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Forma y color:Odour LiquidCK3 peptide
CAS:<p>CK3 peptide is an NRP-1-targeting peptide with the amino acid sequence CLKADKAKC. It specifically binds to NRP-1 to target breast cancer cells. Single-photon emission computed tomography (SPECT) and near-infrared fluorescence (NIRF) imaging demonstrate that CK3 peptide significantly accumulates in xenograft tumors in nude mice. CK3 peptide is applicable for molecular imaging studies of breast cancer.</p>Fórmula:C40H72N12O12S2Forma y color:SolidPeso molecular:977.203Zilucoplan (PEG2)
<p>Zilucoplan(PEG2) is a derivative of Zilucoplan where the linker component has been substituted with PEG2 instead of PEG24. This compound acts as an effective inhibitor of complement component 5 (C5).</p>Fórmula:C128H190N24O33Forma y color:SolidPeso molecular:2593.02Claseprubart
CAS:<p>Claseprubart is a monoclonal antibody that targets human complement C1s. It specifically binds to complement C1s, inhibiting the activation of the complement system and exerting immunosuppressive effects. Claseprubart shows potential for research in autoimmune diseases and inflammation-related conditions.</p>Forma y color:LiquidPMX 205
CAS:<p>PMX 205 is an effective complement antagonist of the C5a receptor.</p>Fórmula:C45H62N10O6Pureza:98%Forma y color:SolidPeso molecular:839.04ATWLPPR Peptide TFA
<p>ATWLPPR Peptide TFA inhibits neuropilin-1 and VEGF165-NRP-1 binding; may reduce diabetic retinal damage.</p>Fórmula:C42H62F3N11O11Pureza:98%Forma y color:SolidPeso molecular:954EG01377 2HCl
CAS:<p>EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377</p>Fórmula:C26H32Cl2N6O6S2Pureza:98.91%Forma y color:SoildPeso molecular:659.6ARC186
<p>ARC186 is a highly potent aptamer that serves as a complement inhibitor by blocking the convertase-catalyzed activation of C5.</p>Forma y color:SolidPeso molecular:120702.76AMY-101
CAS:<p>AMY-101 TFA is a C3 complement inhibitor with high affinity (KD: 0.5 nM) and promising anti-inflammatory effects in severe COVID-19.</p>Fórmula:C83H117N23O18S2Pureza:98%Forma y color:SolidPeso molecular:1789.11PIC1 PA TFA
<p>PIC1 PATFA is the trifluoroacetate form of PIC1 PA. PIC1 PA TFA is a peptide composed of 15 amino acids and serves as an effective PIC1 analog capable of inhibiting complement activation mediated by the classical pathway.</p>Fórmula:C71H123N19O21S2·xC2HF3O2Forma y color:SolidPozelimab
CAS:<p>Pozelimab (REGN 3918) is a humanized antibody targeting component 5 (C5), used for research on Pozelimab disease.</p>Pureza:98.94% (SEC-HPLC) - 98.94% (SEC-HPLC)Forma y color:Liquid3-Phenoxybenzaldehyde
CAS:<p>3-Phenoxybenzaldehyde is a complement (classical pathway) inhibitor with IC50 of 1388μM.</p>Fórmula:C13H10O2Pureza:99.01%Forma y color:SolidPeso molecular:198.22CP-289
CAS:<p>CP-289 is a potent C5a receptor antagonist with IC50 of 1 μM.</p>Fórmula:C30H35ClN2O2Pureza:99.97%Forma y color:SoildPeso molecular:491.06tLyP-1 peptide
CAS:<p>tLyP-1 peptide is an NRP-1 targeting peptide with an IC50 of 4 μM, and its amino acid sequence is CGNKRTR. It can specifically bind to NRP-1 to target tumor cells.</p>Fórmula:C31H59N15O10SForma y color:SolidPeso molecular:833.96AMY-101 TFA
CAS:<p>AMY-101 TFA is an inhibitor of complement C3 and an immunomodulator, gingivitis and periodontitis. reduces inflammation and lowers levels of MMP-8 and MMP-9</p>Fórmula:C85H118F3N23O20S2Forma y color:SolidPeso molecular:1903.11C5aR2 agonist P32 acetate
<p>C5aR2 agonist P32 acetate (Ac-RHYPYWR-OH), a selective agonist for C5aR2, has been shown to induce various immunomodulatory activities both in vitro and in vivo. It modulates cell signaling via the downregulation of C5aR1-mediated pathways and can also function independently of C5aR1.</p>Fórmula:C54H70N16O11·xC2H4O2Forma y color:SolidPeso molecular:1119.23 (free base)Olendalizumab
CAS:<p>Olendalizumab (ALXN1007) is a humanized antibody targeting C5a for research on COVID-19-related inflammation.</p>Forma y color:LiquidFactor B-IN-5
CAS:<p>Factor B-IN-5 is a complement factor B inhibitor, which can be used to study immune-related diseases.</p>Fórmula:C27H32N2O4Pureza:98.19%Forma y color:SoildPeso molecular:448.553-O-(2'E,4'Z-Decadienoyl)ingenol
<p>3-O-(2'E,4'Z-Decadienoyl)ingenol is a useful organic compound for research related to life sciences and the catalog number is T124104.</p>Fórmula:C30H42O6Forma y color:SolidPeso molecular:498.66NH2-C6-ARC186
<p>NH2-C6-ARC186 is a derivative of the aptamer ARC186, featuring an NH2-C6 moiety that enables coupling to various peptides or molecules.</p>Pureza:98%Forma y color:SolidPeso molecular:12881Human Immunoglobulin M
<p>Human Immunoglobulin M (IgM) is an antibody secreted by the adaptive immune system in response to foreign antigens. It is a primary type of immunoglobulin released into circulation during the early stages of the primary antibody response. Human Immunoglobulin M forms a pentamer comprising five IgG equivalents, with 10 Fab fragments, allowing for 10 antigen binding sites. Additionally, Human Immunoglobulin M acts as a complement (complement) activator.</p>Forma y color:Odour SolidPMX 205 Trifluoroacetate
<p>PMX 205 Trifluoroacetate is a potent complement C5a receptor ( C5aR ; CD88 ) antagonist.</p>Fórmula:C47H63F3N10O8Forma y color:SolidPeso molecular:953.06Vemircopan
CAS:<p>Vemircopan is a complement factor D inhibitor.</p>Fórmula:C29H28BrN7O3Forma y color:SolidPeso molecular:602.493PMX-53
CAS:<p>PMX-53: MrgX2 agonist; C5aR antagonist; lessens atherosclerotic lesions & metastasis in mice; blocks rat hypernociception.</p>Fórmula:C47H65N11O7Pureza:98%Forma y color:SolidPeso molecular:896.09Factor B-IN-1
CAS:<p>Factor B-IN-1 is a Factor B inhibitor.</p>Fórmula:C19H16N4O2Forma y color:SolidPeso molecular:332.3559JPE-1375
CAS:<p>JPE-1375: a C5aR1 antagonist, blocks leukocyte mobilization (EC50=6.9 µM), lowers TNF in mice (EC50=4.5 µM), useful for autoimmune/inflammation research.</p>Fórmula:C49H63FN10O9Forma y color:SolidPeso molecular:955.08TLQP-21
CAS:<p>TLQP 21, a VGF-derived peptide, guards CGCs against apoptosis and combats early diet-induced diabetes by boosting energy spend.</p>Fórmula:C107H170N40O26Pureza:98%Forma y color:SolidPeso molecular:2432.75L-156,602
CAS:<p>L-156,602 has a wide range of applications in life science related research.</p>Fórmula:C38H64N8O13Forma y color:SolidPeso molecular:840.973Certepetide
CAS:<p>Certepetide, or iRGD, is a cyclic peptide that enhances tumor penetration and researches solid cancers.</p>Fórmula:C37H60N14O14S2Forma y color:SolidPeso molecular:989.09Compstatin TFA
<p>Compstatin TFA: 13-residue cyclic peptide, inhibits primate complement C3, species-specific, protease-resistant, IC50=63μM (classical), 12μM (alternative).</p>Fórmula:C68H100F3N23O19S2Forma y color:SolidPeso molecular:1664.79Pegcetacoplan acetate
<p>Pegcetacoplan acetate is a pegylated complement C3 inhibitory peptide that functions by binding to complement component 3 (C3) and its activation fragment C3b. This compound is utilized in the study of complement-mediated diseases, including age-related macular degeneration, C3 glomerulopathy, geographic atrophy (GA), and autoimmune hemolytic anemia.</p>Forma y color:Odour SolidComplement C1s-IN-1
CAS:<p>Complement C1s-IN-1 is a selective inhibitor of complement C1s，oral and brain penetrable, inhibit human serum-induced formation of membrane attack complexes</p>Fórmula:C22H20F2N6OPureza:97.77%Forma y color:SoildPeso molecular:422.43Vensobafusp alfa
CAS:<p>Vensobafusp alfa (KP-104) is a fusion protein composed of an IgG4 monoclonal antibody targeting complement protein C5, combined with the domains 1-5 of complement factor H (FH1-5). It exhibits anti-inflammatory and immunomodulatory properties. The isotype control for Vensobafusp alfa can be referred to as human IgG4(S228P) kappa.</p>Forma y color:LiquidC1s-IN-1 trihydrochloride
CAS:<p>C1s-IN-1 trihydrochloride (Compound A1) is a selective inhibitor of C1s protease with a Ki of 5.8 μM. This compound inhibits the cleavage of C2 by C1s with an IC50 of 85 μM and prevents activation of the classical pathway, with an IC50 of 22 μM. Additionally, C1s-IN-1 trihydrochloride acts as a competitive inhibitor of thrombin, exhibiting a Ki of 51.2 μM.</p>Fórmula:C16H22Cl3N5Forma y color:SolidPeso molecular:390.74CP-447697
CAS:<p>CP-447697, a lipophilic C5a receptor antagonist, exhibits an IC50 of 31 nM. It is utilized in inflammation research.</p>Fórmula:C29H26ClF2N3O2SPureza:99.90%Forma y color:SoildPeso molecular:554.05Complement C5 Protein, Cynomolgus, Recombinant (His)
<p>Complement C5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>Forma y color:Lyophilized PowderPeso molecular:188.1 kDa (predicted); 106.3 and 75.8 kDa (reducing conditions)Complement C2 Protein, Cynomolgus, Recombinant (His)
<p>Single nucleotide polymorphism (SNP) of complement component 2 (C2) has been found to be significantly associated with hepatocellular carcinoma (HCC).</p>Forma y color:Lyophilized PowderPeso molecular:82.18 kDa (predicted). Due to glycosylation, the protein migrates to 90-110 kDa based on Tris-Bis PAGE result.Complement factor I Protein, Human, Recombinant (His)
<p>Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for</p>Forma y color:Lyophilized PowderPeso molecular:64.58 kDa (predicted). Due to enzyme lysis and glycosylation, the protein migrates to 75-95 kDa based on Tris-Bis PAGE result.Complement Factor MASP3 Protein, Human, Recombinant (His)
<p>MASP3 is a member of the MASPs involved in mannan-binding lectin (MBL) complement pathway.</p>Forma y color:Lyophilized PowderPeso molecular:95-120 KDa (reducing condition)
