Sistema complementario
El sistema complementario es una parte crucial de la respuesta inmune, compuesto por una serie de pequeñas proteínas que mejoran la capacidad de los anticuerpos y las células fagocíticas para eliminar patógenos de un organismo. Estas proteínas trabajan juntas para opsonizar patógenos, inducir respuestas inflamatorias y lisar directamente las membranas de los patógenos, desempeñando un papel vital en la inmunidad innata y la función inmunitaria general. En CymitQuimica, ofrecemos proteínas del sistema del complemento de alta calidad para apoyar sus estudios inmunológicos e investigaciones clínicas.
Se han encontrado 172 productos de "Sistema complementario"
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PMX 205 acetate(514814-49-4 free base)
PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).Fórmula:C47H66N10O8Pureza:99.4%Forma y color:SolidPeso molecular:899.09Ref: TM-T12506L1
1mg105,00€5mg266,00€10mg350,00€25mg745,00€50mg1.189,00€100mg1.735,00€1mL*10mM (DMSO)374,00€Sutimlimab
CAS:Sutimlimab: monoclonal antibody, inhibits complement protein C1, treats cold agglutinin-induced hemolysis.Pureza:> 95%Forma y color:LiquidPeso molecular:144.8 kDaDexamethasone
CAS:Dexamethasone: a glucocorticoid agonist; modulates IL receptors; reduces inflammatory miRNA-155 exosomes in macrophage responses.Fórmula:C22H29FO5Pureza:98% - 99.91%Forma y color:Crystals From Ether (Ntp 1992)Peso molecular:392.46Ravulizumab
CAS:Ravulizumab (ALXN1210) is a humanized antibody for blocking complement activation, treating PNH, aHUS, and myasthenia gravis.Pureza:> 95%Forma y color:LiquidPeso molecular:145.80 kDaCyclosporin A
CAS:Cyclosporin A is a Calcineurin Inhibitor Immunosuppressant, and a Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.Fórmula:C62H111N11O12Pureza:99.00% - 99.92%Forma y color:White PowderPeso molecular:1202.61Vilobelimab
CAS:Vilobelimab (CaCP-29, IFX-1), a monoclonal antibody, inhibits C5a to reduce inflammation and is researched in sepsis and COVID-19 studies.Pureza:99% (SDS-PAGE); 98.9% (SEC-HPLC) - 99% (SDS-PAGE); 98.9% (SEC-HPLC)Forma y color:LiquidPeso molecular:145.86 kDaTesidolumab
CAS:Tesidolumab, a fully human IgG1/λ anti-C5 monoclonal antibody, inhibits crovalimab and C5, preventing membrane attack complex formation.Pureza:99.72% (SEC-HPLC) - > 95%Forma y color:LiquidPeso molecular:142 kDa (average)SB290157 trifluoroacetate
CAS:SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM).Fórmula:C24H29F3N4O6Pureza:98.93% - 99.89%Forma y color:SolidPeso molecular:526.51PIC1 PA
CAS:PIC1 PA, a peptide consisting of 15 amino acids, serves as an effective analog of PIC1 that inhibits complement activation mediated by the classical pathway. Functionally, PIC1 PA interferes with the interaction between the C1s-C1r-C1r-C1s/MASPs and the collagen-like region (CLR) of C1q/MBL. It specifically binds to the CLR of C1q, with an average equilibrium dissociation constant (KD) of 33.3 nM when binding purified C1q.Fórmula:C71H123N19O21S2Forma y color:SolidPeso molecular:1642.98C5a Anaphylatoxin (human)
CAS:C5a Anaphylatoxin (human) is a pro-inflammatory peptide that functions as a leukocyte chemoattractant, utilized in researching inflammation and immune responsesFórmula:C350H578N108O107S8Pureza:98%Forma y color:SolidPeso molecular:8267.51Factor B-IN-5
CAS:Factor B-IN-5 is a complement factor B inhibitor, which can be used to study immune-related diseases.Fórmula:C27H32N2O4Pureza:98.19%Forma y color:SoildPeso molecular:448.55POT-4 acetate
POT-4 acetate inhibits Complement C3 activation. POT-4 acetate can be used for studies about age-related macular degeneration.Fórmula:C74H106N22O20S2Pureza:98%Forma y color:SolidPeso molecular:1687.9ASP-1948
ASP-1948 is a human monoclonal antibody targeting NRP1/VEGF165R/CD34. It is capable of reversing the inhibitory effects of regulatory T cells and can be applied in the study of solid tumors.Forma y color:Odour LiquidZilucoplan (PEG2)
Zilucoplan(PEG2) is a derivative of Zilucoplan where the linker component has been substituted with PEG2 instead of PEG24. This compound acts as an effective inhibitor of complement component 5 (C5).Fórmula:C128H190N24O33Forma y color:SolidPeso molecular:2593.02C1s-IN-1 trihydrochloride
CAS:C1s-IN-1 trihydrochloride (Compound A1) is a selective inhibitor of C1s protease with a Ki of 5.8 μM. This compound inhibits the cleavage of C2 by C1s with an IC50 of 85 μM and prevents activation of the classical pathway, with an IC50 of 22 μM. Additionally, C1s-IN-1 trihydrochloride acts as a competitive inhibitor of thrombin, exhibiting a Ki of 51.2 μM.Fórmula:C16H22Cl3N5Forma y color:SolidPeso molecular:390.74ATWLPPR Peptide TFA
ATWLPPR Peptide TFA inhibits neuropilin-1 and VEGF165-NRP-1 binding; may reduce diabetic retinal damage.Fórmula:C42H62F3N11O11Pureza:98%Forma y color:SolidPeso molecular:954ARC186
ARC186 is a highly potent aptamer that serves as a complement inhibitor by blocking the convertase-catalyzed activation of C5.Forma y color:SolidPeso molecular:120702.76Zilucoplan TFA
Zilucoplan TFA (RA101495), a 15-amino acid macrocyclic peptide, serves as a potent inhibitor of complement component 5 (C5).Fórmula:(C2H4O)nC126H186N24O32·C2HF3O2Pureza:98%Forma y color:SolidPeso molecular:3562.18 (free base)Pozelimab
CAS:Pozelimab (REGN 3918) is a humanized antibody targeting component 5 (C5), used for research on Pozelimab disease.Pureza:98.94% (SEC-HPLC) - 98.94% (SEC-HPLC)Forma y color:LiquidPeso molecular:144.78 kDaPIC1 PA TFA
PIC1 PATFA is the trifluoroacetate form of PIC1 PA. PIC1 PA TFA is a peptide composed of 15 amino acids and serves as an effective PIC1 analog capable of inhibiting complement activation mediated by the classical pathway.Fórmula:C71H123N19O21S2·xC2HF3O2Forma y color:SolidtLyP-1 peptide
CAS:tLyP-1 peptide is an NRP-1 targeting peptide with an IC50 of 4 μM, and its amino acid sequence is CGNKRTR. It can specifically bind to NRP-1 to target tumor cells.Fórmula:C31H59N15O10SForma y color:SolidPeso molecular:833.96PMX 205
CAS:PMX 205 is an effective complement antagonist of the C5a receptor.Fórmula:C45H62N10O6Pureza:98%Forma y color:SolidPeso molecular:839.04C5a Receptor agonist, mouse, human
CAS:C5a Receptor Agonist (mouse, human) is a bioactive peptide derived from the C-terminus of the complement fragment 5 anaphylatoxin (C5a), functioning as anFórmula:C44H72N10O7Pureza:98%Forma y color:SolidPeso molecular:853.11C1q Protein (rat)
C1qProtein (Rat) is a subunit of the complement system. It can recognize various ligands and plays a role in maintaining immune system balance, promoting tissue repair, and defending against pathogens.Forma y color:Odour SolidC3 Protein (human)
C3 Protein (human) is an intrinsically glycosylated polypeptide composed of two disulfide-linked chains. Complement protein C3 is a pivotal molecule within the complement system, and its activation is fundamental to all essential functions of this system.Forma y color:Odour SolidAnti-CD88/C5AR1 Antibody (G2_anti-C5aR)
Anti-CD88/C5AR1 Antibody (G2_anti-C5aR) is a human monoclonal antibody (mAb) targeting C5AR1.Forma y color:Odour Liquid3-O-(2'E,4'Z-Decadienoyl)ingenol
3-O-(2'E,4'Z-Decadienoyl)ingenol is a useful organic compound for research related to life sciences and the catalog number is T124104.Fórmula:C30H42O6Forma y color:SolidPeso molecular:498.66L-156,602
CAS:L-156,602 has a wide range of applications in life science related research.Fórmula:C38H64N8O13Forma y color:SolidPeso molecular:840.973Vemircopan
CAS:Vemircopan is a complement factor D inhibitor.Fórmula:C29H28BrN7O3Forma y color:SolidPeso molecular:602.493PMX 205 Trifluoroacetate
PMX 205 Trifluoroacetate is a potent complement C5a receptor ( C5aR ; CD88 ) antagonist.Fórmula:C47H63F3N10O8Forma y color:SolidPeso molecular:953.06Campneoside II
CAS:Campneoside II, a compound extracted from the wood of Paulownia tomentosa var. tomentosa, demonstrates remarkable anti-complement activity [1].Fórmula:C29H36O16Forma y color:SolidPeso molecular:640.59Certepetide
CAS:Certepetide, or iRGD, is a cyclic peptide that enhances tumor penetration and researches solid cancers.Fórmula:C37H60N14O14S2Forma y color:SolidPeso molecular:989.09AMY-101
CAS:AMY-101 TFA is a C3 complement inhibitor with high affinity (KD: 0.5 nM) and promising anti-inflammatory effects in severe COVID-19.Fórmula:C83H117N23O18S2Pureza:98%Forma y color:SolidPeso molecular:1789.11C3a (70-77) (TFA)
C3a (70-77) (TFA) (Complement 3a (70-77) TFA) is an octapeptide derived from the COOH-terminus of Complement 3a, exhibiting 1–2% C3a biological activity.Fórmula:C37H62F3N13O12Forma y color:SolidPeso molecular:937.96TLQP-21
CAS:TLQP 21, a VGF-derived peptide, guards CGCs against apoptosis and combats early diet-induced diabetes by boosting energy spend.Fórmula:C107H170N40O26Pureza:98%Forma y color:SolidPeso molecular:2432.75Compstatin TFA
Compstatin TFA: 13-residue cyclic peptide, inhibits primate complement C3, species-specific, protease-resistant, IC50=63μM (classical), 12μM (alternative).Fórmula:C68H100F3N23O19S2Forma y color:SolidPeso molecular:1664.79Pegcetacoplan acetate
Pegcetacoplan acetate is a pegylated complement C3 inhibitory peptide that functions by binding to complement component 3 (C3) and its activation fragment C3b. This compound is utilized in the study of complement-mediated diseases, including age-related macular degeneration, C3 glomerulopathy, geographic atrophy (GA), and autoimmune hemolytic anemia.Forma y color:Odour SolidComplement C1s-IN-1
CAS:Complement C1s-IN-1 is a selective inhibitor of complement C1s，oral and brain penetrable, inhibit human serum-induced formation of membrane attack complexesFórmula:C22H20F2N6OPureza:97.77%Forma y color:SoildPeso molecular:422.43JPE-1375
CAS:JPE-1375: a C5aR1 antagonist, blocks leukocyte mobilization (EC50=6.9 µM), lowers TNF in mice (EC50=4.5 µM), useful for autoimmune/inflammation research.Fórmula:C49H63FN10O9Forma y color:SolidPeso molecular:955.08Factor B-IN-1
CAS:Factor B-IN-1 is a Factor B inhibitor.Fórmula:C19H16N4O2Forma y color:SolidPeso molecular:332.3559PMX-53
CAS:PMX-53: MrgX2 agonist; C5aR antagonist; lessens atherosclerotic lesions & metastasis in mice; blocks rat hypernociception.Fórmula:C47H65N11O7Pureza:98%Forma y color:SolidPeso molecular:896.09C2 Protein (human)
C2 Protein (human) is a naturally glycosylated peptide with a 20-amino acid signal sequence. It plays a critical regulatory role in the early activation stages of the classical pathway and is involved in the formation of the classical pathway C3 convertase, C4b2a.Forma y color:Odour SolidHuman Immunoglobulin M
Human Immunoglobulin M (IgM) is an antibody secreted by the adaptive immune system in response to foreign antigens. It is a primary type of immunoglobulin released into circulation during the early stages of the primary antibody response. Human Immunoglobulin M forms a pentamer comprising five IgG equivalents, with 10 Fab fragments, allowing for 10 antigen binding sites. Additionally, Human Immunoglobulin M acts as a complement (complement) activator.Forma y color:Odour SolidCK3 peptide
CAS:CK3 peptide is an NRP-1-targeting peptide with the amino acid sequence CLKADKAKC. It specifically binds to NRP-1 to target breast cancer cells. Single-photon emission computed tomography (SPECT) and near-infrared fluorescence (NIRF) imaging demonstrate that CK3 peptide significantly accumulates in xenograft tumors in nude mice. CK3 peptide is applicable for molecular imaging studies of breast cancer.
Fórmula:C40H72N12O12S2Forma y color:SolidPeso molecular:977.203BCX 1470 hydrochloride
BCX 1470 hydrochloride is a serine protease inhibitor with anti-inflammatory activity that inhibits factor D hemolytic activity and may be used to study edema.Fórmula:C14H11ClN2O2S2Pureza:99.71%Forma y color:SoildPeso molecular:338.83Vensobafusp alfa
CAS:Vensobafusp alfa (KP-104) is a fusion protein composed of an IgG4 monoclonal antibody targeting complement protein C5, combined with the domains 1-5 of complement factor H (FH1-5). It exhibits anti-inflammatory and immunomodulatory properties. The isotype control for Vensobafusp alfa can be referred to as human IgG4(S228P) kappa.Forma y color:LiquidC1q Protein (Rabbit)
C1qProtein (Rabbit) is a subunit of the complement system. It recognizes various ligands, playing a role in maintaining immune system balance, promoting tissue repair, and defending against pathogens.Forma y color:Odour SolidC1q Protein (Cyno)
C1qProtein (Cyno) is a subunit of the complement system. It recognizes various ligands and is involved in maintaining immune system balance, promoting tissue repair, and defending against pathogens.Forma y color:Odour SolidPOT-4 TFA
POT-4 TFA, a Compstatin derivative, inhibits C3 activation, for macular degeneration research.Fórmula:C74H103F3N22O20S2Forma y color:SolidPeso molecular:1741.87BM213
CAS:BM213 is a useful organic compound for research related to life sciences and the catalog number is T35399.Fórmula:C43H70N12O10Pureza:98%Forma y color:SoildPeso molecular:915.09
