Otros

<p>Applications Fulvestrant (F862500) impurity D.<br></p>

<p>Impurity Atenolol EP Impurity D<br>Applications 4-(3-Chloro-2-hydroxypropoxy)benzeneacetamide is an impurity of Atenolol (A790075), a cardioselective β-adrenergic blocker. Atenolol EP Impurity D<br>References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984); Pai, N.R., et al.: J. Chem. Pharma. Rsch., 4, 375 (2012);<br></p>

<p>Applications Enzalutamide Carboxylic Acid is used as hormone therapies to prevent androgen-fuled growth of castrate-resistant prostate cancer.<br>References Tomasz, M.B., et al.: New Engl, J. Med., 424, 371 (2014);<br></p>

<p>Folinic acid (Leucovorin) is a biofolic acid that can be used in the treatment of methotrexate, often in combination with Methotrexate (MTX) to reduce MTX-</p>

<p>Impurity Abiraterone Impurity 5<br>Applications 17-Iodo-androsta-5,16-diene-3β-ol is an analog of Abiraterone (A108490) and is used as a reagent in the synthesis of C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens which exhibit antitumor activity. Abiraterone Impurity 5<br>References Handratta, V.D., et al.: J. Med. Chem., 48, 2972 (2005)<br></p>

<p>Applications A metabolite of Zopiclone (Z700500).<br>References Fernandez, C., et al.: Clin. Pharmacokinet., 29, 431 (1995), Nordgren, H., et al.: Ther. Drug Monit., 24, 410 (2002),<br></p>

<p>Applications An intermediate in the production of Bimatoprost (B386800).<br></p>

<p>M04074 - 5-Bromo-6-chloro-3-indolyl beta-D-glucuronide cyclohexylammonium salt</p>

<p>Applications N-Formyl Memantine is an impurity of Memantine (M218000). Memantine impurity E per USP.<br>References Gerzon, K., et al.: J. Med. Chem., 6, 760 (1963),<br></p>

<p>Applications 1,1,1-Tris(hydroxymethyl)propane is a building block often used to make polymers. 1,1,1-Tris(hydroxymethyl)propane has been used as a precursor to prepatre alkyd resins for linseed oil based paint.<br>References Wang, X., et. al.: J. Polym. Res., 18, 721 (2011); Isiri-Caglar, D., et. al.: Rog. Org. Coat., 77, 81 (2014); Heiskanen,N., et. al.: J. Appl. Polym. Sci., 119, 209 (2011)<br></p>

<p>Applications Phenylboronic Acid is a compound used in organic synthesis of various pharmaceutical goods.<br>References Ainley, A.D., et al.: J. Chem. Soc., 2171 (1930);<br></p>

<p>Applications 5-9-Leuprolide is a metabolite of Leuprolide (L330590), a gonadotropin-releasing hormone (GnRH) analogue acting as an agonist at pituitary GnRH receptors.<br>References Handelsman, David J., et al.: J. of Steroid Biochem. and Mol. Bio., 141, 113-120 (2014);Okada, Hiroaki, et al.: Pharma. Res., 8(6), 787-91 (1991)<br></p>

<p>Applications Cyclopropanecarboxylic Acid is used as a reagent in the synthesis of substituted 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors. Also used as a reagent in the synthesis of 2-alkyloxazoles as potent and selective PI4KIIIβ inhibitors demonstrating inhibition of HCV replication.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, L., et al.: Bioorg. Med. Chem. Lett., 24, 3739 (2014); Keaney, E.P., et al.: Bioorg. Med. Chem. Lett., 24, 3714 (2014)<br></p>

<p>Impurity Diazepam EP Impurity B<br>Applications N-(2-Benzoyl-4-chlorophenyl)-2-chloro-N-methylacetamide (Diazepam EP Impurity B) is the impurity of Temazepam (T017200), which is a pharmacologically active metabolite of Diazepam. It is used as a sedative and hypnotic drug.<br>References Sarteschi, P., et al.: Arzneim.-Forsch., 22, 93 (1972), Schwandt, H.J., et al.: Xenobiotica, 4, 733 (1974), Curry, S.H., et al.: Br. J. Pharmacol., 57, 427 (1976), Heel, R.C., et al.: Drugs, 21, 321 (1981)<br></p>

<p>Stability Hygroscopic<br>Applications d-Cloprostenol Sodium Salt is the d-enantiomer of Cloprostenol (C587300), an aryl-oxymethyl analog of prostaglandin F2α.<br>References Gumen, A., et al.: J. Animal. Sci., 56, 279 (2011); Leterlier, C.A., et al.: Reproduct. Domestic. Animals., 46, 481 (2011); Martins, J.P.N., et al.: J. Diary. Sci., 94, 2815 (2011);<br></p>

<p>Applications Pyrene occurs in coal tar. Also obtained by the destructive hydrogenation of hard coal. Found in wastewater in aquatic environments, and possesses genotoxic characteristics relating to estrogenic/androgenic, antiestrogenic and antiandrogenic activity. This compound is a contaminant of emerging concern (CECs).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Winterstein, et al.: Z. Physiol. Chem., 230, 162 (1934), Fang, Y. et al.: Env. Toxicol. Chem., 31, 1273 (2012);<br></p>

<p>Applications Labelled MDV 3100. MDV 3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.<br>References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011);<br></p>

<p>Applications Lindane is an insecticide that is used as a treatment for scabies and lice. Lindane has been used as a broad-spectrum insecticide for seed and soil treatment, foliar applications, tree and wood treatment and against ectoparasites in both veterinary and human applications. Lindane is persistent, bioaccumulates easily in the food chain and bioconcentrates rapidly. There is evidence for long-range transport and toxic effects (immunotoxic, reproductive and developmental effects) in laboratory animals and aquatic organisms. One of the new POPs under the Stockholm Convention.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bist, R., et al.: Int. J. Pharm. Pharma. Sci., 4, 117 (2012); Heinz, M., et al.: Human. Health. Handbook., 1, 355 (2012); Bay, S.M., et al.: Enviro. Toxciol. Chem., 31, 2711 (2012);<br></p>

<p>Applications Bimatoprost 13,14-Epoxide is the impurity of Bimatoprost (B386800), which is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.<br>References Brandt, J.D., et al.: Ophthalmology, 108, 1023 (2001), Woodward, D.F., et al.: J. Pharmacol. Exp. Ther., 305, 772 (2003), Quinones, R., et al.: J. Ocul. Pharmacol. Ther., 20, 115 (2004)<br></p>

<p>Impurity Diazepam EP Impurity E<br>Applications 6-Chloro-1-methyl-4-phenyl-2(1H)-quinazolinone (Diazepam EP Impurity E) is an impurity of Temazepam (T017200), which is a pharmacologically active metabolite. It is used as a sedative and hypnotic drug.<br>References Sarteschi, P., et al.: Arzneim.-Forsch., 22, 93 (1972), Schwandt, H.J., et al.: Xenobiotica, 4, 733 (1974), Curry, S.H., et al.: Br. J. Pharmacol., 57, 427 (1976), Heel, R.C., et al.: Drugs, 21, 321 (1981)<br></p>

<p>Impurity Fulvestrant EP Impurity A<br>Applications Fulvestrant (F862500) impurity A. The S-isomer of Fulvestrant.<br>References Sharman, G.J., et al.: Mag. Resonance Chem., 39, 549 (2001),<br></p>

<p>Applications (15R)-Bimatoprost Acid is an impurity of the antiglaucoma agent Bimatoprost (B386820). (15R)-Bimatoprost Acid is a metabolically stable analog of PGF2α (P838625) and is a potent agonist for the FP receptor.<br>References Balapure, A.K. et al.: Biochem. Pharmacol., 38, 2375 (1989); Hellberg, M.R. et al.: J. Ocular Pharmacol. Ther., 19, 97 (2003); Krishna, P.M. et al.: J. Pharm. res., 4, 2381 (2011); Resul, B., et al.: J. Med. Chem., 36, 243 (1993)<br></p>

<p>Stability Hygroscopic<br>Applications Used in the synthesis of cyanogen glycoside. A component of antiperspirants, deodorants, body soaps, shampoos, hair rinses, and hair; it inhibits volatile steroid formation by resident bacteria.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Marouf, A., et al.: Pharm. Biol., 39, 263 (2001), Fukuda, T., et al.: Biol. Pharm. Bull., 26, 271 (2003), Butler, M., et al.: J. Nat. Prod., 67, 2141 (2004), He, J., et al.: J. Nat. Prod., 69, 121 (2006),<br></p>

<p>Applications Labelled Diazepam, an anxiolytic; muscle relaxant (skeletal); anticonvulsant.Diazepam is a Controlled substance (depressant).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 79 (1972), Mandelli, M., et al.: Clin. Pharmacokinet., 3, 72 (1978), Bertilsson, L., et al.: Pharmacol. Ther., 45, 85 (1990), Murray, J.B., et al.: J. Psychol., 124, 655 (1990), Pellock, J.M., et al.: Drug Saf., 27, 383 (2004),<br></p>

<p>Applications Palbociclib-d4 is an isotope labelled compound of Palbociclib (P139900). Palbociclib (P139900) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>

<p>Stability Hygroscopic<br>Applications Cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. This is a controlled substance (depressant) in the US but not in Canada. Sedative, hypnotic.<br>References Noble, S., et al.: Drugs, 55, 277 (1998), Musch, B., et al.: Int. J. Clin. Psychopharmacol., 5, 147 (1990),<br></p>

<p>Impurity Entacapone EP Impurity A<br>Applications cis-Entacapone (Entacapone EP Impurity A) is the (Z)-Isomer of Entacapone polymorphic form B. Antiparkinsonian.<br>References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),<br></p>

<p>Stability Hygroscopic<br>Applications 7-Methyl Memantine is an impurity of Memantine (HCl salt, M218000) which is used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>

<p>Impurity Atenolol 2-Hydroxy Impurity<br>Applications Hydroxyatenolol is a metabolite of Atenolol (A790075); a cardioselective β-adrenergic blocker, antihypertensive, antianginal, and antiarrhythmic (class II). Atenolol 2-Hydroxy Impurity<br>References Escher, B., et al.: Environ. Sci. Technol., 40, 7402 (2006); Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984)<br></p>

<p>Applications An impurity of labelled Salicylic Acid synthesis<br>References Kovacik, J., et al.: J. Agric. Food Chem., 57, 9848 (2009), Gao, X., et al.: Anal. Biochem., 393, 163 (2009), Rocher, F., et al.: Plant Physiol., 150, 2081 (2009),<br></p>

<p>Impurity Atenolol EP Impurity C<br>Applications 4-(2,3-Epoxypropoxy)phenylacetamide (Atenolol EP Impurity C) is an impurity of Atenolol, a cardioselective β-adrenergic blocker.<br>References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984)<br></p>

<p>Applications The trans-isomer used in the improved process for the production and purification of Bimatoprost (B386800).<br></p>

<p>Applications Desmethyl 5-Methoxycarbonyl Nintedanib is an impurity of Intedanib (I666650), which is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases. it is an indolinone as triple angiokinase inhibitors and an antitumor agent.<br>References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)<br></p>

<p>Bestatin (Ubenimex) competitively inhibits many aminopeptidases. Bestatin is a microbial metabolite and dipeptide with immunomodulatory and antitumor effects.</p>

<p>Applications Silodosin is an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertrophy.<br>References (1) Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995) (2) Murata, S., et al.: J. Urol., 164, 578 (2000)<br></p>

<p>Applications A β-adrenergic agonist, related to Clenbuterol and Mabuterol. A repartitioning agent.<br>References Engelhardt, G., et al.: Arzneim.-Forsch., 34, 1625 (1984),<br></p>

<p>Applications Tetramethylurea is an excellent solvent for organic substances, in particular aromatic compounds.<br>References Lüttringhaus, A., et al.: Angew. Chem. Int. Ed. Engl., 3, 260 (1964)<br></p>

<p>Impurity Atenolol Desmethyl Impurity<br>Applications Cis-Desmethyl Atenolol is an impurity of Atenolol (A790075), a cardioselective β-adrenergic blocker and antihypertensive agent. Atenolol Desmethyl Impurity<br>References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984);<br></p>

<p>Applications Lindane-d6 is very toxic. It was an effective insecticide on mosquitoes, house flies, and on German and American cockroaches.<br>References Tanaka, K., et al.: Pestic. Biochem. Physiol., 6, 386-391 (1976)<br></p>

<p>Applications Tert-butyl Acetate is a common solvent used in the production of various industrial cleansers, thinners and adhesives and is also known as a VOC.Environmental contaminants; Food contaminants<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mackay, D., et al.: SAR. QSAR. Enviro. Res., 23, 205 (2012); Yang, Y.S., et al.: Toxicol. Res., 26, 293 (2010);<br></p>