Otros

<p>Applications A labelled metabolite of Toluene.<br>References Gargas, M., et al.: Toxicol. Appl. Pharmacol., 98, 87 (1989), Commandeur, J., et al.: Pharmacol. Rev., 47(2), 271 (1995), Campo, P., et al.: Neurotoxicol. Teratol., 21, 427 (1999), Lohse, C., et al.: J. Agr. Food Chem., 48, 5913 (2000),<br></p>

<p>Impurity Fulvestrant EP Impurity B<br>Applications A metabolite of Fulvestrant (F862500).<br>References Rao, P., et al.: J. Steroid Biochem., 25, 417 (1986), Wakeling, A., et al.: J. Steroid Biochem. Mol. Biol., 43, 173 (1992), DeFriend, D., et al.: Cancer Res., 54, 408 (1994),<br></p>

<p>Applications Salicylic Acid β-D-O-Glucuronide is a metabolite of Acetylsalicylic Acid (Aspirin) (A187780).<br>References Grootveld, M., et al.: Biochem. Pharmacol., 37, 271 (1988), Subbegowda, R., et al.: Cancer Res., 58, 2772 (1998), Yoshida, Y., et al.: Eur. J. Pharmacol., 349, 49 (1998),<br></p>

<p>Applications An impurity in the synthesis of Silodosin (S465000), an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertophy.<br>References Barve, I. et al.: Tetra., 69, 2834 (2013); Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995), Murata, S., et al.: J. Urol., 164, 578 (2000),<br></p>

<p>Applications Cyancobalamin-b-carboxylic Acid is a Vitamin B12 (V676005) derivative, which is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.<br>References Rickes, et al.: Science, 107, 396 (1948); Kirschbaum, J., et al.: Anal. Profiles Drug Subs., 10, 183 (1981); Grasbeck, R., et al.: Clin. Biochem., 17, 99 (1984)<br></p>

<p>Applications β-Hydroxyisobutanol is used as a reagent in the synthesis of pyrazolo[1,5-a]pyridinecarbonyl-substituted spirocyclic piperidine ketals as inhibitors of HCV protein NS4B and of hepatitis C viral replication and their lack of cytotoxicity in human cells.<br>References Tai, V.W.-F., et al.: Bioorg. Med. Chem. Lett., 24, 2288 (2014);<br></p>

<p>Impurity Diazepam<br>Applications 7-Chloro-2-methoxy-5-phenyl-3H-1,4-benzodiazepine is an impurity of Diazepam (D416855), which is an anxiolytic, muscle relaxant, and anticonvulsant medication.<br>References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 79 (1972); Mandelli, M., et al.: Clin. Pharmacokinet., 3, 72 (1978); Bertilsson, L., et al.: Pharmacol. Ther., 45, 85 (1990); Murray, J.B., et al.: J. Psychol., 124, 655 (1990); Pellock, J.M., et al.: Drug Saf., 27, 383 (2004);<br></p>

<p>Applications Labelled MDV 3100. MDV 3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.<br>References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011);<br></p>

<p>Applications Gimeracil is an antitumor agent. Gimeracil is a potent inhibitor of dihydropyrimidine dehydrogenase (DPD).<br>References Shirasaka, T., et al.: Cancer Res., 56, 2602 (1996), Patt, Y., et al.: J. Clin. Oncol., 22, 271 (2004), Shirao, K., et al.: Cancer, 100, 2355 (2004), Kelly, H., et al.: J. Clin. Oncol., 23, 4553 (2005),<br></p>

<p>Applications 7-Ethyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine is known to show antihistiminic and anaphylactic compounds. Maintains potential anti-inflammatory compounds.<br>References Valhondo, M. et al.: J. Med. Chem., 56, 7851 (2013); Ozcan, S. et al.: J. Med. Chem., 56, 3783 (2013); Tozzi, S. et al.: J. Med. Chem., 18, 1 (1975);<br></p>

<p>Applications An alkyladamantane derivative that are biotransformed via strains of Pseudomonas. It is used to study alkyladamantane adsorption on graphitized thermal carbon black.<br>References Yashkin, S.N. et al.: Rus. Che,. Bull., 57, 2472 (2008); Slepen’kin, A. et al.: Nefeckhim., 33, 406 (1993);<br></p>

<p>Stability Light Sensitive<br>Applications Rhodamine B is used in biological studies for an anti-reactive oxygen species/hepatic fibrosis drug delivery system based on salvianolic acid B loaded mesoporous silica nanoparticles. Dyes and metabolites, Environmental Testing.<br>References He, Q., et al.: Biomaterials, 31, 7785 (2010)<br></p>

<p>Applications Pranoprofen is an anti-inflammatory used in ophthalmology.<br>References Ayaki, M., et al.: Biocont. Sci., 15, 97 (2010); Lee, X., et al.: For. Toxicol., 28, 96 (2010);<br></p>

<p>Applications N-Boc-piperazine (cas# 57260-71-6) is a compound useful in organic synthesis.<br></p>

<p>Impurity Atenolol USP Related Compound D; Atenolol EP Impurity F<br>Applications 4,4'-[[(1-methylethyl)imino]bis[(2-hydroxy-3,1-propanediyl)oxy]]bis-benzeneacetamide (Atenolol USP Related Compound D; Atenolol EP Impurity F) is an impurity of Atenolol (A790075), a cardioselective β-adrenergic blocker.<br>References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984); Caplar, V., et al.: Acta. Pharma. Jugoslavica., 33, 71 (1983);<br></p>

<p>Applications Lindane-d6 is very toxic. It was an effective insecticide on mosquitoes, house flies, and on German and American cockroaches.<br>References Tanaka, K., et al.: Pestic. Biochem. Physiol., 6, 386-391 (1976)<br></p>

<p>Applications 2-CHLOROTOLUENE (cas# 95-49-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Lindane is an insecticide that is used as a treatment for scabies and lice. Lindane has been used as a broad-spectrum insecticide for seed and soil treatment, foliar applications, tree and wood treatment and against ectoparasites in both veterinary and human applications. Lindane is persistent, bioaccumulates easily in the food chain and bioconcentrates rapidly. There is evidence for long-range transport and toxic effects (immunotoxic, reproductive and developmental effects) in laboratory animals and aquatic organisms. One of the new POPs under the Stockholm Convention.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bist, R., et al.: Int. J. Pharm. Pharma. Sci., 4, 117 (2012); Heinz, M., et al.: Human. Health. Handbook., 1, 355 (2012); Bay, S.M., et al.: Enviro. Toxciol. Chem., 31, 2711 (2012);<br></p>

<p>Applications Perfluorophenol is used in the synthesis of PGA-films as biodegradable polymers. It also participates in the synthesis of tripod macrocyclic Gd(III) chelates for cancer molecular MRI.<br>References Lee, K. et al.: Langmuir., 20, 2531 (2004); Zhou, Z. et al.: Biomater., 34, 7683 (2013);<br></p>

<p>Applications The main metabolite of Chlordiazepoxide (C327050).<br>References Barbone, F., et al.: Lancet, 352, 1331 (1998); Miki, A., et al.: J. Anal. Toxicol., 26, 87 (2002);<br></p>

<p>Impurity Fulvestrant EP Impurity A<br>Applications Fulvestrant (F862500) impurity A. The S-isomer of Fulvestrant.<br>References Sharman, G.J., et al.: Mag. Resonance Chem., 39, 549 (2001),<br></p>

<p>Impurity Memantine Related Compound A (1,3-Dimethyladamantane)<br>Applications 1,3-Dimethyladamantane is a dimethylated adamantane derivative. Memantine impurity A. Memantine Related Compound A (1,3-Dimethyladamantane).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Diazepam N-Oxide is a derivative of Diazepam (D416855), an anxiolytic.<br>References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 79 (1972); Mandelli, M., et al.: Clin. Pharmacokinet., 3, 72 (1978); Bertilsson, L., et al.: Pharmacol. Ther., 45, 85 (1990); Murray, J.B., et al.: J. Psychol., 124, 655 (1990); Pellock, J.M., et al.: Drug Saf., 27, 383 (2004)<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Memantine (M218000), used for the treatment of neurological disorders.<br>References Eiichi, K., et al.: Chem. Pharm. Bull., 33, 4680 (1985),<br></p>

<p>Applications N-(3-(3-Cyano-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidin-5-yl)phenyl)-N-ethylacetamide is an impurity of Zaleplon (Z145000), Selective non-benzodiazepine GABAA receptor agonist.<br>References Allen, D., et al.: Eur. J. Clin. Pharmacol., 45, 313 (1993), Beer, B., et al.: J. Clin. Pharmacol., 34, 335 (1994), Rosen, A.S., et al.: Biopharm. Drug Dispos., 20, 171 (1999), Elie, R., et al.: J. Clin. Psychiatry, 60, 536 (1999), Heydorn, W.E., et al.: Expert Opin. Invest. Drugs, 9, 841 (2000)<br></p>

<p>Applications Isotope labelled MDV 3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.<br></p>

<p>Stability Hygroscopic<br>Applications Cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. This is a controlled substance (depressant) in the US but not in Canada. Sedative, hypnotic.<br>References Noble, S., et al.: Drugs, 55, 277 (1998), Musch, B., et al.: Int. J. Clin. Psychopharmacol., 5, 147 (1990),<br></p>

<p>Stability Hygroscopic<br>Applications 7-Methyl Memantine is an impurity of Memantine (HCl salt, M218000) which is used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>

<p>Applications A potent, selective and orally active cysteinyl leukotriene type 1 receptor antagonist. Used as an antiasthmatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Matassa, V.G., et al.: J. Med. Chem., 33, 1781 (1990), Findlay, S.R., et al.: J. Allergy Clin. Immunol., 89, 1040 (1992), Krell, R.D., et al.: Am. Rev. Respir. Dis., 141, 978 (1990), Dunn, C.J., Drugs, 61, 285 (2001),<br></p>