Derivados de Purinas y Pirimidinas
Las purinas tienen una estructura bicíclica, formada por un anillo de seis miembros fusionado con un anillo de cinco, ambos con átomos de nitrógeno en posiciones clave. Los derivados de purinas, como la adenina y la guanina, son fundamentales en la formación del ADN y ARN. Estos compuestos tienen aplicaciones terapéuticas en tratamientos contra el cáncer y enfermedades virales, al inhibir la replicación celular. Las pirimidinas, por otro lado, tienen una estructura monocíclica de seis miembros con dos átomos de nitrógeno. Sus derivados, como la citosina, timina y uracilo, también son componentes esenciales del ADN y ARN y se utilizan en la quimioterapia y tratamientos antivirales.
En CymitQuimica disponemos de derivados de purinas y pirimidinas para investigación en biología molecular, genómica y desarrollo de terapias innovadoras.
Se han encontrado 8888 productos de "Derivados de Purinas y Pirimidinas"
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(S)-Tenofovir Disoproxil Fumarate
CAS:Producto controlado<p>Impurity Tenofovir Disoproxil USP Related Compound A<br>Applications The S-enantiomeric impurity of the antiviral Tenofovir Disoproxil Fumarate (T018505(P)), which is an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor and used as an anti-HIV agent.Tenofovir Disoproxil USP Related Compound A.<br>References Shaw, J. P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)<br></p>Fórmula:C19H30N5O10P·C4H4O4Forma y color:White SolidPeso molecular:635.524-(2H-1,3-benzodioxol-5-yl)-6-(3,4-dimethylphenyl)pyrimidin-2-amine
CAS:Pureza:95.0%Peso molecular:319.364013671875Phenylhydrazine
CAS:Producto controlado<p>Applications An aryl hydrazine used in the preparation of various dyes and pharmaceutical compounds. It is used in the investigation of oligosaccharides as well as the structure of photosystem II.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lattova, E. et al.: Meth. Mol. Biol., 534, 65 (2009); Anderson, L.B. et al.: J. Biol. Chem., 275, 4920 (2000);<br></p>Fórmula:C6H8N2Forma y color:Yellowish LiquidPeso molecular:108.14Acetaldehyde 2,4-Dinitrophenylhydrazone
CAS:<p>Stability Hygroscopic<br>Applications Acetaldehyde 2,4-Dinitrophenylhydrazone is a dinitrophenylhydrazone (DNPH) derivative of an aliphatic alldehyde found in mainstream cigarette smoke. Dyes and metabolites.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zwiener, C. et al.: Anal. Bioanal. Chem., 372, 615 (2002); Delgado, B. et al.: J. Liq. Chrom. Rel. Technol., 31, 361 (2008); Miller, J.H. et al.: J. Chrom. Sci., 48, 12 (2010);<br></p>Fórmula:C8H8N4O4Forma y color:YellowPeso molecular:224.173-Nitro-L-tyrosine-d3
CAS:Producto controlado<p>Applications A labelled marker for peroxynitrite. Oxidant and cytotoxic agent.<br>References Sekiguchi, M., et al.: Brain Res., 978, 228 (2003), van den Tweel, E., et al.: J. Neurobiol., 167, 64 (2005), Shirakura, T., et al.: Biol. Pharm. Bull., 28, 1658 (2005),<br></p>Fórmula:C9D3H7N2O5Forma y color:NeatPeso molecular:229.2trans-Zeatin
CAS:Producto controlado<p>Applications Zeatin, purified from Zea mays, is a member of the cytokinin group of plant growth factors, the activity of which is attributed to its more stable trans form. Trans-Zeatin inhibits UVB-induced matrix metalloproteinase-1 expression via MAP kinase signaling in human skin fibroblasts. Trans-Zeatin is a potential agent for the management of skin photoaging.<br>References Murashige, T., et al.: Physiol. Plant, 15, 473 (1962), Brenneisen, P., et al.: J. Biol. Chem., 273, 5279 (1998), Choi, M., et al.: J. Dermatol. Sci., 46, 127 (2007), Bae, J., et al.: Food Chem. Toxicol., 46, 1298 (2008),<br></p>Fórmula:C10H13N5OForma y color:NeatPeso molecular:219.243-[(Dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one Hydrochloride
CAS:Producto controlado<p>Impurity Ondansetron EP Impurity A/ Ondansetron USP Related Compound A<br>Applications 3-[(Dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron EP Impurity A) is an impurity of Ondansetron (O655000), an antiemetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mackinnon, J.W.M., et al.: Eur. J. Cancer Clin. Oncol., 25, 61 (1989);<br></p>Fórmula:C16H20N2O·ClHForma y color:NeatPeso molecular:292.804-Chloro Kynurenine-13C2,15N
CAS:Producto controlado<p>Applications 7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.<br>References Leeson, P., et al.: J. Med. Chem., 37, 4053 (1994), Hilmas, C., et al.: J. Neurosci., 2001, 21, 7463 (2001), Palmer, G., et al.: Curr. Drug Targets, 2, 241 (2001), Wu, H., et al.: Exp. Neurol., 177, 222 (2002),<br></p>Fórmula:C813C2H11ClN15NO3Forma y color:NeatPeso molecular:245.64N-Hydroxymethyl Sumatriptan
CAS:Producto controlado<p>Applications Hydroxymethyl Sumatriptan is an analog of Sumatriptan (S810000), a serotonin 5HT1-receptor agonist.<br>References Humphrey, P.P.A., et al.: Brit. J. Pharmacol., 94, 1123 (1988), Doenicke, A., et al.: Lancet 1, 1309 (1988),<br></p>Fórmula:C15H23N3O3SForma y color:NeatPeso molecular:325.43Pemetrexed Sodium Methyl Ester
Producto controlado<p>Applications Pemetrexed Sodium Methyl Ester is an impurity of Pemetrexed(P219550). Pemetrexed Disodium Heptahydrate is an chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed Disodium Heptahydrate exhibit inhibitory activities towards thymidylate synthase as well as other folate dependent enzymes.<br>References Vogelzang, N.J., et al.: J. Clin. Oncol., 21,2636 (2003); Paz-Ares, L., et al.: Lancet. Oncol., 13, 247 (2012);<br></p>Fórmula:C21H22N5NaO6Forma y color:NeatPeso molecular:463.4193-Des[2-(Dimethylamino)ethyl] Zolmitriptan 3-Acetic Acid
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications The indole acetic acid metabolite of Zolmitriptan (Z639000) formed by human hepatocytes.<br>References Wild, M.J. et al.: Xenobiotica, 29, 847 (1999);<br></p>Fórmula:C14H14N2O4Forma y color:NeatPeso molecular:274.27(S)-4-(4-Aminobenzyl)-2-(1H)-oxazolidinone
CAS:Producto controlado<p>Impurity Zolmitriptan USP Related Compound G<br>Applications An intermediate of Zolmitriptan, as a novel inhibitor of the cytochrome P-450 enzyme aromatase. Zolmitriptan USP Related Compound G.<br>References Ahmed, S., et al.: Bioorg. Med. Chem. Lett., 5, 2789(1995), Ahmed, S., et al.: Drug. Des. Discov., 15, 239 (1998), Brodie, A., et al.: Steroids, 65, 171 (2000),<br></p>Fórmula:C10H12N2O2Forma y color:NeatPeso molecular:192.21Methotrexate (1 mg/mL in Methanol with 0.1N NaOH)
CAS:Fórmula:C20H22N8O5Forma y color:Single SolutionPeso molecular:454.442-[5-amino-3-(2-furyl)-1H-pyrazol-1-yl]-6-isopropylpyrimidin-4(3H)-one
CAS:Pureza:95.0%Peso molecular:285.3070068359375
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