Derivados de Quinazolina y Quinolina
Las quinazolinas y quinolinas son compuestos heterocíclicos nitrogenados con estructuras aromáticas que desempeñan un papel clave en la síntesis de fármacos con actividad anticancerígena, antimicrobiana y antiinflamatoria. Sus derivados presentan modificaciones estructurales que optimizan su biodisponibilidad y selectividad, lo que permite el desarrollo de nuevos principios activos para diversas aplicaciones terapéuticas. Estos compuestos se utilizan en la fabricación de APIs destinados al tratamiento de cáncer, infecciones, enfermedades neurodegenerativas y cardiovasculares. Además, los derivados de quinazolina y quinolina son esenciales en la investigación de inhibidores enzimáticos y en el diseño de moléculas bioactivas innovadoras. En CymitQuimica disponemos de derivados de quinazolina y quinolina de alta pureza para aplicaciones en síntesis química, desarrollo farmacéutico y biotecnología.
Se han encontrado 65644 productos de "Derivados de Quinazolina y Quinolina"
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N-Nitroso-1-(2-methoxyphenyl)piperazine
CAS:Producto controlado<p>Applications N-Nitroso-1-(2-methoxyphenyl)piperazine is a reagent used in the preparation of 9-aminoacridine-based agents that impair bovine viral diarrhea virus replication.<br>References Loddo, R. et al.: Bio. & Med. Chem., 26(4), 855-868, (2018)<br></p>Fórmula:C11H15N3O2Forma y color:Off-White To Light BrownPeso molecular:221.266a-Naloxol
CAS:Producto controlado<p>Applications 6α-Naloxol is a metabolite of Naloxone (N285000), a specific opioid antagonist. Narcotic antagonist.<br>References Chatterjie, N., et al.: J. Med. Chem., 18, 490 (1975); Bilsky, E., et al.: J. Pharmacol. Exp. Ther., 277, 484 (1996); Blokhina, E., et al.: Eur. J, Pharmacol., 406, 227 (2000); Jasinski, D.R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967); McNicholas, L.F., et al.: Drugs, 27, 81 (1984); Hasson, M.M.A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985); Stowe, C., et al.: Ann. Pharmacother., 27, 447 (1993)<br></p>Fórmula:C19H23NO4Forma y color:NeatPeso molecular:329.394-{[(p-Fluorophenyl)imino]methyl}phenol
CAS:Producto controlado<p>Applications 4-{[(p-Fluorophenyl)imino]methyl}phenol is used in the preparation of benzylacetones which promote anti-fungal activity.<br>References Sandhar, R. et al.: J. Ind. Council Chem., 22, 32 (2005);<br></p>Fórmula:C13H10FNOForma y color:NeatPeso molecular:215.22Hydroxy Vildagliptin
<p>Applications Hydroxy Vildagliptin is an impurity of Vildagliptin (V305000). Vildagliptin is a DPP-4 enzyme inhibitor, has anti-oxidant properties and used as an apoptotic agent on pancreatic cancer . Vildagliptin is used to treat type 2 diabetes mellitus (T2DM) and improve the endothelial function of patients.<br>References Amritha, C.A., et al.: J. Clin. Diagn. Res., 9, FC14 (2015); Cosenso-Martin, L.N., et al.: Diabetol. Metab. Syndr., 7, 70/1 (2015)<br></p>Fórmula:C17H25N3O3Forma y color:NeatPeso molecular:319.40Indomethacin Acyl-β-D-glucuronide (>90%)
CAS:Producto controlado<p>Applications Indomethacin Acyl-β-D-glucuronide is a metabolite of Indomethacin (I641000). Acyl glucuronides have been implicated in the toxicity of many xenobiotics and marketed drugs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abid, A., et al.: Biochem. Pharmacol., 50, 557 (1995), Gamage, N., et al.: Toxicol. Sci., 90, 5 (2006), Cerveny, L., et al.: Drug Metab. Dispos., 35, 1032 (2007), Hayeshi, R., et al.: Eur. J. Pharm. Sci., 35, 383 (2008),<br></p>Fórmula:C25H24ClNO10Forma y color:NeatPeso molecular:533.914-(2-Nitrophenyl)morpholin-3-one
CAS:Producto controlado<p>Applications 4-(2-Nitrophenyl)morpholin-3-one is an intermediate in the synthesis of 4-(2-Aminophenyl)-3-morpholinone (A625985). 4-(2-Aminophenyl)-3-morpholinone is a reagent used in the preparation of various Morpholine based pharmaceuticals.<br>References Mederski, W., et al.: Bioorg. Med. Chem. Lett., 14, 3763 (2004); Roehrig, S., et al.: J. Med. Chem., 48, 5900 (2005)<br></p>Fórmula:C10H10N2O4Forma y color:NeatPeso molecular:222.2ZK 159222
CAS:Producto controlado<p>Stability Light Sensitive, Temperature Sensitive<br>Applications ZK 159222 is a vitamin D receptor antagonist. It is a derivative of Vitamin D3 (V676045).<br>References Mizwicki, M., et al.: J. Bio. Chem., 284, 36292 (2009); Ochiai, E., et al.: Mol. Endocrinol., 19, 1147 (2005)<br></p>Fórmula:C32H48O5Forma y color:NeatPeso molecular:512.72Cibenzoline
CAS:Producto controlado<p>Applications Cibenzoline acts as a highly active class I antiarrhythmic agent.<br>References Xie, C. et al.: Handbook. Metab. Pathway. Xenobio., 3, 1110 (2014);<br></p>Fórmula:C18H18N2Forma y color:NeatPeso molecular:262.354-Cyano Loratadine
CAS:Producto controlado<p>Applications Intermediate for the synthesis of 4-Hydroxymethyl Loratadine.<br>References Cerrada, V., et al.: ARKIVOC, 9, 200 (2005).<br></p>Fórmula:C23H22ClN3O2Forma y color:NeatPeso molecular:407.89(1S,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl
CAS:Producto controlado<p>Applications Tadalafil (T004500) derivative. Used in the preparation of pyrazinopyridoindole derivatives for their PDE5 inhibitory activity.<br>References Beghyn, T. et al.: Bioorgan. Med. Chem. Lett. 17, 789(2007)<br></p>Fórmula:C20H18N2O4Forma y color:Off White SolidPeso molecular:350.37Desthiazolylmethyloxycarbonyl Ritonavir
CAS:Producto controladoFórmula:C32H45N5O3SPureza:>85%Forma y color:NeatPeso molecular:579.80rac-trans-7-Hydroxy Pramipexole
CAS:Producto controlado<p>Impurity Pramipexole Related Compound F<br>Applications Pramipexole derivative used for the preparation of (S)-Pramipexole via resolution of 2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole derivatives.<br>References Validation of a column liquid chromatographic method for the analysis of pramipexole and its 5 impurities. Journal of AOAC International (2010), 93(4), 1102-1112. Gegoe, Csaba Lehel; Fejes, Imre; Garaczi, Sandor; Kovacs, Imre; Lukacs, Ferenc; Majercsik, Orsolya; Schneider, Geza. Process for preparation of (S)-pramipexole via resolution of 2,6-diamino-7-hydroxy-4,5,6,7-tetrahydrobenzothiazole derivatives. Eur. Pat. Appl. (2008), 26pp. CODEN: EPXXDW EP 1878731<br></p>Fórmula:C10H17N3OSForma y color:NeatPeso molecular:227.332-(1-Amino-1-methylethyl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide
CAS:Producto controlado<p>Applications An intermediate in the preparation of HIV-integrase inhibitors<br>References Summa, V., et al.: J. Med. Chem., 51, 5843 (2008),<br></p>Fórmula:C16H19FN4O3Forma y color:NeatPeso molecular:334.354-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
CAS:Producto controlado<p>Applications 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine is a reagent in the synthesis of (+)-tofacitinib, a selective Janus kinase 3 inhibitor (JAK3) and an immunosuppressant drug.<br>References Liao, H., et al.: Tetrahedron: Asymmetry, 28, 105, (2017)<br></p>Fórmula:C13H10ClN3O2SForma y color:NeatPeso molecular:307.76Vortioxetine Hydrobromide (1 mg/mL in Methanol)
CAS:Fórmula:C18H22N2S·BrHForma y color:Single SolutionPeso molecular:379.3581H-1-Ethyl-d5 Candesartan
CAS:Producto controlado<p>Applications Labelled Candesartan (C175575) impurity.<br></p>Fórmula:C26H19D5N6O3Forma y color:Off-White To Light YellowPeso molecular:473.54Cilostazol-d4
CAS:Producto controlado<p>Applications Cilostazol-d4 is the labeled analogue of Cilostazol (C441500), a potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Has antimitogeni, antithrombotic, vasodilatory and cardiotonic properties in vivo. Also affects lipid levels in vivo.<br>References Suri, A., et al.: J. Clin. Pharmacol., 38, 144 (1998); Park, S.-W., et al.: Am. J. Cardiol., 84, 511 (1999); Tsuchikane, E., et al.: Circulation, 100, 21 (1999)<br></p>Fórmula:C20H23D4N5O2Forma y color:NeatPeso molecular:373.493,3'-Disulfanediylbis[(2S)-2-methylpropanoic] Acid
CAS:Producto controladoFórmula:C8H14O4S2Forma y color:NeatPeso molecular:238.32Lisinopril (8R,S)-Diketopiperazine (Mixture of Diastereomers)Mps1-IN-1 dihydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Lisinopril (L468985) impurity.<br>References Drummer, O., et al.: Arzneim.-Forsch. Drug Res., 38, 647 (1988), Simpson, K., et al.: Drugs, 59, 1149 (2000),<br></p>Fórmula:C21H29N3O4Forma y color:NeatPeso molecular:387.47trans-Hydroxy Praziquantel-d5
CAS:Producto controlado<p>Applications Labelled trans-Hydroxy Praziquantel (H952405). The main cis-monohydroxylated metabolite of Praziquantel (P702095).<br>References Buehring, K., et al.: Eur. J. Drug Metab. Pharm., 3, 179 (1978), Moldeus, P., et al.: Methods Enzymol., 52, 60 (1978), Cioli, D., et al.: Pharmacol. Ther., 68, 35 (1995),<br></p>Fórmula:C19H19D5N2O3Forma y color:NeatPeso molecular:333.44Indigo Carmine 5,7'-Isomer (~90%)
CAS:<p>Applications Indigo Carmine 5,7’-Isomer is an analog of 5,5’-Indigodisulfonic Acid Disodium Salt (I521300) and synthesized from Indigo (I512250). Indigo is a chemical compound used as a dye in industrial clothing and textile processes. Also used in the synthesis of organic semiconductors.<br>References He, B. et al.: J. Am. Chem. Soc., 136, 15093 (2014); Pitayatanakul, O. et al.: J. mat. Chem. C., Mat. Op. Elec. Dev., 9311 (2014);<br></p>Fórmula:C16H8N2Na2O8S2Pureza:~90%Forma y color:Dark Blue SolidPeso molecular:466.35(R)-(+)-Verapamil-d6 Hydrochloride
CAS:Producto controladoFórmula:C27H32D6N2O4•HClForma y color:Off-WhitePeso molecular:460.653646Anastrozole Diacid
CAS:Producto controlado<p>Impurity Anastrozole Diacid Impurity<br>Applications Anastroloze Diacid is a derivative of Anastrozole (A637425), an aromatase inhibitor. Used as an antineoplastic. Anastrozole Diacid Imp<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>Fórmula:C17H21N3O4Forma y color:WhitePeso molecular:331.373-Hydroxy Anagrelide-13C3 (~80%)
CAS:Producto controlado<p>Applications 3-Hydroxy Anagrelide-13C3 is a major labelled metabolite of Anagrelide, an antithrombotic.<br>References Fleming, J., et al.: Thromb. Res., 15, 373 (1979), Gillespie, E., et al.: Biochem. Pharmacol., 37, 2866 (1988), Mazur, E., et al.: Blood, 79, 1931 (1992), Wang, G., et al.: Br. J. Pharmacol., 146, 324 (2005), Wagstaff, A., et al.: Drugs, 66, 111 (2006),<br></p>Fórmula:C713C3H7Cl2N3O2Pureza:~80%Forma y color:NeatPeso molecular:275.071-(2,5-Dimethylphenyl)ethanol
CAS:Producto controlado<p>Applications 1-(2,5-Dimethylphenyl)ethanol can be used as a reagent in reactions or as a aroma compound<br>References Zhou, J., et al.: Yuanyi Xuebao., 37, 1621-1628 (2010)<br></p>Fórmula:C10H14OForma y color:NeatPeso molecular:150.229-Desmethyl endo-Granisetron Hydrochloride
CAS:Producto controlado<p>Impurity Granisetron USP Related Compound C<br>Stability Hygroscopic<br>Applications 9-Desmethyl endo-Granisetron hydrochloride (Granisetron USP Related Compound C) is an impurity in the synthesis of Granisetron HCl (G780000), a specific serotonin (5HT3) receptor antagonist. Used as an antiemetic.<br>References Kilpatrick, G.J., et al.: Nature, 330, 746 (1987), Durig, T., et al.: J. Pharm. Sci., 86, 1092 (1997), Yuasa, H., et al.: Chem. Pharm. Bull., 44, 1361 (1996),<br></p>Fórmula:C17H22N4O·ClHForma y color:NeatPeso molecular:334.84Fingolimod Stearoate Amide
CAS:Producto controlado<p>Applications Fingolimod Stearoate Amide is an impurity of Fingolimod (F805000, HCl salt), a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Fórmula:C37H67NO3Forma y color:NeatPeso molecular:573.93N’-[2-[2,4-(Dimethylphenyl)thio]phenyl] Vortioxetine
Producto controlado<p>Applications N’-[2-[2,4-Dimethylphenyl)thio]phenyl] Vortioxetine is an impurity of Vortioxetine (V766000, HBr salt) which is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT.<br>References Bang-Andersen, B., et al.: J. Med. Chem., 54, 3206 (2011); Mørk, A., et al.: J. Pharmacol. Exp. Ther., 340, 666 (2012); Mørk, A., et al.: Pharmacol. Biochem. Behav. 105C, 41 (2013)<br></p>Fórmula:C32H34N2S2Forma y color:NeatPeso molecular:510.763-(tert-Butyldimethylsilyl)morphinone
CAS:Producto controlado<p>Applications Protected Morphinone (M652350), a toxic metabolite of Morphine.<br>References James, R., et al.: J. Pharmacol. Exp. Ther., 221, 708 (1982), Yamano, S., et al.: J. Biol. Chem., 260, 5259(1985), Ishida, T., et al.: Drug Metab. Dispos., 17, 77 (1989), Yamano, S., et al.: Xenobiotica, 27, 645 (1997),<br></p>Fórmula:C23H31NO3SiForma y color:NeatPeso molecular:397.58Desacetyl Diltiazem-d4
CAS:Producto controlado<p>Applications A labelled metabolite of Diltiazem (D460620).<br></p>Fórmula:C20H20D4N2O3SForma y color:NeatPeso molecular:376.51Oxo-MDV 3100 (Oxo-enzalutamide)
CAS:Producto controlado<p>Applications Oxo-MDV 3100 (Oxo-enzalutamide) is an impurity of Enzalutamide (M199800), which is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. Enzalutamide has been shown to induce tumor cell apoptosis, and is used for the treatment of castration-resistant prostate cancer.<br>References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011); Ma, X., et al.: J. Pharm. Biomed. Anal., 131, 436 (2016);<br></p>Fórmula:C21H16F4N4O3Forma y color:NeatPeso molecular:448.374-Amino-2-fluoro-N-methylbenzamide
CAS:Producto controlado<p>Stability Moisture Sensitive<br>Applications 4-Amino-2-fluoro-N-methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors<br>References Ivachtchenko, A. V., et al.: Eur. J. Med. Chem., 99, 51 (2015); Zhang, D., et al.: Bioorg. Med. Chem. Lett., 23, 2408 (2013)<br></p>Fórmula:C8H9FN2OForma y color:NeatPeso molecular:168.17Pamapimod
CAS:Producto controlado<p>Applications A selective inhibitor of the α-isoform of p38 MAP kinase. It is used in in treatment of patient with rheumatoid arthritis. Pamapimod was tolerable but not effective as Methotrexate.<br>References Guan, Z., et al.: J. Biol. Chem., 273, 12901 (1998), Lee, J., et al.: Pharmacol. Ther., 82, 389 (1999), Korb, A., et al.: Arthritis Rheum., 54, 2745 (2006),<br></p>Fórmula:C19H20F2N4O4Forma y color:WhitePeso molecular:406.385-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic Acid
CAS:Producto controlado<p>Applications Sunitinib intermediate.<br></p>Fórmula:C16H13FN2O3Forma y color:NeatPeso molecular:300.28Desmethoxy Apixaban
CAS:<p>Applications Desmethoxy Apixaban is an impurity of Apixaban; an anticoagulant drug.<br>References Landge, S. B., et al.: Am. J. Anal. Chem., 6, 539 (2015); Arous, B., et al.: Pharm. Chem. J. 52, 573 (2018)<br></p>Fórmula:C24H23N5O3Forma y color:NeatPeso molecular:429.471N-Methyl-2-[[3-[(1Z)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide
CAS:Producto controlado<p>Applications N-Methyl-2-[[3-[(1Z)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide is an impurity of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.<br>References Wasser, K., et al.: Eur. Radiol., 13, 80 (2003), Park, J., et al.: Clin. Cancer Res., 8, 1172 (2002), Bergers, G., et al.: J. Clin. Invest., 111, 1287 (2003),<br></p>Fórmula:C22H18N4OSForma y color:NeatPeso molecular:386.4695N-[(1S,2S,4S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]carbamic Acid 5-Thiazolylmethyl Ester
CAS:Producto controlado<p>Impurity Ritonavir EP Impurity J<br>Applications N-[(1S,2S,4S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]carbamic Acid 5-Thiazolylmethyl Ester (Ritonavir EP Impurity J) is an intermediate in the synthesis of Ritonavir (R535000), a selective HIV protease inhibitor used for the treatment of HIV infections and AIDS.<br>References Hamada, Y., et al.: Bioorg. Med. Chem., 10, 4155 (2002);<br></p>Fórmula:C28H35N3O5SForma y color:White To Off-WhitePeso molecular:525.664-(Trifluoromethoxy)aniline
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications 4-(Trifluoromethoxy)aniline is used in the synthesis of anticancer agents and antitumor medicaments. Also, its an intermediate in the production of labelled Riluzole (R510000), a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cilibrizzi, A., et al.: J. Med. Chem., 52, 5044 (2009), Verhaeghe, P., et al.: Bioorg. Med. Chem., 17, 4313 (2009), Chandregowda, V., et al.: Eur. J. Med. Chem., 44, 3046 (2009), Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993) Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994); Piras, S. et al.: Eur. j. Med. Chem., 75, 169 (2014); Vyas, V. et al.: Eur. J. Med. Chem., 82, 385 (2014);<br></p>Fórmula:C7H6F3NOForma y color:NeatPeso molecular:177.12N-Isopropyl Carvedilol
CAS:Producto controlado<p>Applications Carvedilol (C184625) derivative.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C27H32N2O4Forma y color:White To Off-WhitePeso molecular:448.55Anastrozole EP Impurity E (2-[3-(Cyanodimethylmethyl)-5-hydroxymethylphenyl]-2-methylpropionitrile)
CAS:Producto controlado<p>Impurity Anastrozole EP Impurity E<br>Applications 2-[3-(Cyanodimethylmethyl)-5-hydroxymethylphenyl]-2-methylpropionitrile (Anastrozole EP Impurity E ) is an impurity of Anastrozole (A637425), an aromatase inhibitor which functions as an antineoplastic (1,2). Anastrozole is used in post-menopausal women with advanced breast cancer.<br>References 1. Plourde, P. et al.: Breast Cancer Res Treat. 1994;30(1):103-112. Buzdar, A. et al.: Cancer. 1997 Feb 15;79(4):730-9.<br></p>Fórmula:C15H18N2OForma y color:NeatPeso molecular:242.32N-[4-Cyano-3-(trifluoromethyl)phenyl]-2,3-dihydroxy-2-methylpropanamide
CAS:Producto controlado<p>Applications N-[4-Cyano-3-(trifluoromethyl)phenyl]-2,3-dihydroxy-2-methylpropanamide is used as a reagent in the preparation of bicalutamide by coupling with sodium p-fluorobenzenesulfinate.<br>References Thijs, L., et al.: U.S. Pat. Appl. Publ. 23pp. (2004)<br></p>Fórmula:C12H11F3N2O3Forma y color:NeatPeso molecular:288.22t-Butyl 4-Bromobutanoate
CAS:Producto controlado<p>Applications t-Butyl 4-bromobutanoate is a useful research chemical for organic synthesis and other chemical and pharmaceutical processes.<br>References Brudeli, B., et al.: Bioorg. Med. Chem., 18, 8600 (2010); Colak, S., et al.: Macromolecules, 41, 8436 (2008)<br></p>Fórmula:C8H15BrO2Forma y color:NeatPeso molecular:223.113-Deschloro-3,4-difluoro Gefitinib
CAS:<p>Applications 3-Deschloro-3,4-difluoro gefitinib, is an impurity of Gefitinib (G304000), an antineoplastic.<br>References Anderson, N.G., et al.: Int. J. Cancer, 94, 774 (2001), Hirata, A., et al.: Cancer Res., 62, 2554 (2002), Kris, M.G., et al.: J. Am. Med. Assoc., 290, 2149 (2003), Tamura, K., et al.: Expert Opin. Pharmacother., 6, 985 (2005),<br></p>Fórmula:C22H24F2N4O3Forma y color:Off-White To Light YellowPeso molecular:430.448N-Aminocarbonyl Felbamate
CAS:Producto controlado<p>Applications N-Aminocarbonyl Felbamate is an impurity of Felbamate (F231000), an antiepileptic, structurally similar to meprobamate.<br></p>Fórmula:C12H15N3O5Forma y color:NeatPeso molecular:281.262-(Chloromethyl)-3,5-dimethylpyridine Hydrochloride
CAS:Producto controlado<p>Applications Intermediate in the preparation of Omeprazole metabolites<br></p>Fórmula:C8H10ClN·ClHForma y color:NeatPeso molecular:192.091-Benzo[b]thien-4-yl-piperazine Monohydrochloride
CAS:Producto controlado<p>Applications 1-Benzo[b]thien-4-yl-piperazine is the starting material to prepare piperazine-substituted benzothiophenes useful in treatment and prevention of mental disorders including CNS disorders.<br>References Yamashita, H., et al.: PCT Int. Appl., WO 2006112464 A1 20061026 (2006)<br></p>Fórmula:C12H14N2S·ClHForma y color:NeatPeso molecular:254.78Agomelatine-d3 (acetamide-2,2,2-d3)
CAS:Producto controlado<p>Applications Agomelatine-d3 (acetamide-2,2,2-d3) (CAS# 1079389-38-0) is a useful isotopically labeled research compound.<br></p>Fórmula:C15D3H14NO2Forma y color:NeatPeso molecular:246.326-(4-Phenylbutoxy)-1-hexanamine
CAS:<p>Applications 6-(4-Phenylbutoxy)-1-hexanamine is an intermediate in the synthesis of salmeterol (S090100), a structural analog of Albuterol (A514500).<br>References Goswami, J., et al.: Tetrahedron. Asym., 12, 3343 (2002);<br></p>Fórmula:C16H27NOForma y color:Off White SolidPeso molecular:249.39(E)-Thiothixene
CAS:Producto controlado<p>Applications (E)-Thiothixene is an antipsychotic agent used in the treatment of psychological disorders.<br>References Andorn, A. et al.: Brain Res., 971, 66 (2003); Seeman, P. et al.: Mol. Pharmacol. 28, 391 (1985);<br></p>Fórmula:C23H29N3O2S2Forma y color:NeatPeso molecular:443.637,8-Dihydro-1-naphthalenol
CAS:<p>Stability Light Sensitive, Air (oxygen) Sensitive<br>Applications 7,8-Dihydro-1-naphthalenol can be used as reagent/reactant in stereoselective preparation of indanes via chiral hypervalent iodine - mediated ring contraction of dihydronaphthalenes<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahmed, A., & Silva, L. F,: J. Org. Chem., 81, 2174-2181 (2016)<br></p>Fórmula:C10H10OForma y color:White To Light YellowPeso molecular:146.19MRX-2843
CAS:Producto controlado<p>Applications MRX-2843, is an orally available small-molecule inhibitor of both MERTK and FLT3.<br>References Minson, K. A. et al.: JCI Insight. 2016 Mar;1(3):e85630.;<br></p>Fórmula:C29H40N6OForma y color:NeatPeso molecular:488.67Trazodone 1,4-Di-N-Oxide
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications A possible metabolite of Trazodone-HCl (T718500).<br></p>Fórmula:C19H22ClN5O3Forma y color:NeatPeso molecular:403.869-Acridinecarboxylic acid
CAS:Producto controlado<p>Applications 9-Acridinecarboxylic acid is used in the synthesis of short DNA-binding peptides.<br></p>Fórmula:C14H9NO2Forma y color:YellowPeso molecular:223.23Nifekalant Hydrochloride
CAS:<p>Applications Nifekalant Hydrochloride is a class III antiarrhythmic agent. Nifekalant Hydrochloride is used in the treatment of patients with extensive anterior infarction and severe ventricular dysfunction.<br>References Takenaka, K. Jap. Circ. J., 65, 60 (2001); Igawa, M. et al.: J. Cardio. Pharmacol., 40, 735 (2002); Washizuka, T. et al.: Circ. J., 69, 1508 (2005);<br></p>Fórmula:C19H27N5O5·ClHForma y color:Light Yellow SolidPeso molecular:441.9091N-Desmethyl 4-Benzyloxy Toremifene Hydrochloride
CAS:Producto controlado<p>Applications Toremifene (T547500) derivative. A triphenylalkene derivative with anti-estrogenic, and anti-tumor properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C32H33Cl2NO2Forma y color:NeatPeso molecular:534.52rac-7-Oxo-pramipexole Dihydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications An impurity of Pramipexole production.<br>References Jancic, B., et al.: Acta Chim. Slov., 54, 49 (2007),<br></p>Fórmula:C10H17Cl2N3OSForma y color:NeatPeso molecular:225.31 + 2(36.46)Niclosamide Piperazinesalt
CAS:Producto controladoFórmula:C13H8Cl2N2O4·C4H10N2Forma y color:NeatPeso molecular:413.265’-Oxo Amisulpride
CAS:Producto controlado<p>Applications 5’-Oxo Amisulpride is an impurity of the dopamine receptor antagonist Amisulpride (A633250).<br></p>Fórmula:C17H25N3O5SForma y color:Off-WhitePeso molecular:383.46N-(4-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
CAS:Producto controlado<p>Applications Intermediate in the preparation of Imatinib impurities. It is a COVID19-related research product.<br></p>Fórmula:C16H15N5Forma y color:NeatPeso molecular:277.32Haloperidol Decanoate N-Oxide
Producto controladoFórmula:C31H41ClFNO4Forma y color:NeatPeso molecular:546.114-Methyl Irinotecan
Producto controlado<p>Applications 4-Methyl Irinotecan, is an impurity of Irinotecan (I767500), a DNA topoisomerase inhibitor.<br>References Kunimoto, T., et al.: Cancer Res., 47, 5944 (1987), Shimada, Y., et al.: J. Clin. Oncol., 11, 909 (1993)<br></p>Fórmula:C34H40N4O6Forma y color:NeatPeso molecular:600.70Tipelukast
CAS:Producto controlado<p>Applications Tipelukast a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model.<br>References Rajasekaran, M., et. al.: BJU Int., 98, 430 (2006)<br></p>Fórmula:C29H38O7SForma y color:NeatPeso molecular:530.673-[2-[4-(6-Fluoro-2-benzoxazolyl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (Risperidone Impurity)
CAS:Producto controladoFórmula:C23H27FN4O2Forma y color:NeatPeso molecular:410.48N-Desmesthyl N-Nitroso-Telmisartan
Producto controladoFórmula:C32H27N5O3Forma y color:NeatPeso molecular:529.6N-Desethyl N-Methyl Rivastigmine
CAS:Producto controlado<p>Impurity Rivastigmine EP Impurity B<br>Applications N-Desethyl N-Methyl Rivastigmine (Rivastigmine EP Impurity B) is an impurity of Rivastigmine (R541000), a brain selective acetylcholinesterase inhibitor. Nootropic.<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999), Enz, A., et al.: Prog. Brain Res., 98, 431 (1993),<br></p>Fórmula:C13H20N2O2Forma y color:NeatPeso molecular:236.32Triciribine
CAS:Producto controlado<p>Applications Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is also a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.<br>References Garrett, C.R. et al.: Invest. New Drugs, 29, 1381 (2011); Ptak, R.G. et al.: AIDS Res. Human Retrovir., 14, 1315 (1998); Bennett, L.L. et al.: BIochem. Pharmacol., 27, 233 (1978);<br></p>Fórmula:C13H16N6O4Forma y color:NeatPeso molecular:320.30Paliperidone N-Oxide
CAS:Producto controlado<p>Impurity Paliperidone USP Related Compound D<br>Applications One of the major degradation product of Risperidone in bulk drug and pharmaceutical dosage forms. Paliperidone USP Related Compound D.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Leysen, J., et al.: J. Pharmacol. Exp. Ther., 247, 661 (1988), Huang, M., et al.: Pharm. Drug Dispos., 54, 257 (1993), Smyth, W., et al.: Anal. Bioanal. Chem., 378, 1305 (2004),<br></p>Fórmula:C23H27FN4O4Forma y color:NeatPeso molecular:442.484-Fluoro-2-(hydroxymethyl)phenol
CAS:Producto controlado<p>Applications 4-Fluoro-2-(hydroxymethyl)phenol can be used in preparation of naphthyridine derivatives as chemokine receptor antagonists useful in the treatment of pain.<br>References Wang, X., et al.: PCT Int. Appl., WO 2013010453 A1 20130124 (2013)<br></p>Fórmula:C7H7FO2Forma y color:NeatPeso molecular:142.128N-(1-Carboxy-3-phenylpropyl)-S-lisinopril (Mixture of diastereomers)
CAS:Producto controlado<p>Applications N-(1-Carboxy-3-phenylpropyl)-S-lisinopril (Mixture of diastereomers) is an impurity of lisinopril (L468985), an orally active angiotensin-converting enzyme (ACE) inhibitor.<br>References Shinde, V., et. al.: J. Pharm. Biomed. Anal., 43, 381 (2007); Goa, K.L., et al.: Drugs, 52, 564 (1996), Chaturvedi, N., et al.: Lancet, 351, 28 (1998)<br></p>Fórmula:C31H41N3O7Forma y color:NeatPeso molecular:567.67cis-Hydroxy Solifenacin (Mixture of Diastereomers)
CAS:Producto controlado<p>Applications Solifenacin (S676700) metabolite.<br>References Naito, R., et al.: J. Med. Chem., 48, 6597 (2005), Krauwinkel, W., et al.: Int. J. Clin. Pharmacol. Ther., 43, 227 (2005),<br></p>Fórmula:C23H26N2O3Forma y color:NeatPeso molecular:378.464-Hydroxy Ramelteon
CAS:<p>Applications A metabolite of Ramelteon (R110051)<br></p>Fórmula:C16H21NO3Forma y color:Off White SolidPeso molecular:275.34Loratadine-d5
CAS:Producto controlado<p>Applications Loratadine-d5 is the labeled analogue of Loratadine (L469575), a nonsedating-type histamine H1-receptor.<br>References Bruttmann, G., et al.: J. Allergy Clin. Immunol., 83, 411 (1989); Haria, M., et al.: Drugs, 48, 617 (1994)<br></p>Fórmula:C22H18D5ClN2O2Forma y color:NeatPeso molecular:387.912-Acetylbenzothiophene
CAS:Producto controlado<p>Applications A novel anti-osteoporosis agent, by enhansing expression of the BMP-2 gene.<br>References Horiguchi, Y., et al.: Chem. Pharm. Bull., 52, 214 (2004), Joshi, E., et al.: Chem. Res. Toxicol., 17, 137 (2004), Liu, Z., et al.: Bioorg. Med. Chem. Lett., 19, 4167 (2009),<br></p>Fórmula:C10H8OSForma y color:NeatPeso molecular:176.234-[3-(Methylamino)-1-(2-thienyl)propyl]-1-naphthalenol Hydrochloride (Duloxetine Impurity)
CAS:Producto controlado<p>Impurity D721000<br>Applications Duloxetine impurity; also a related compound of Duloxetine metabolite.<br></p>Fórmula:C18H19NOS·ClHForma y color:NeatPeso molecular:333.887,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
CAS:Producto controlado<p>Applications 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is a substituted benzazepinonee derivative used in the preparation of bradycardic agents as well as isoform-selective f-current blockers.<br>References Liang, H.-Y. et al.: Arch. Pharm., 343, 114 (2010); Reiffen, M. et al.: J. Med. Chem., 33, 1496 (1990); Melchiorre, M. et al.: J. Med. Chem., 53, 6773 (2010);<br></p>Fórmula:C12H13NO3Forma y color:Off-WhitePeso molecular:219.243,5-Bis(chloromethyl)pyridine Hydrochloride
CAS:Producto controlado<p>Stability Unstable in Aqueous Solution<br>Applications 3,5-BIS(CHLOROMETHYL)PYRIDINE HCL (cas# 1210824-61-5) is a useful research chemical.<br></p>Fórmula:C7H7Cl2N•HClForma y color:NeatPeso molecular:212.55-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications An intermediate of 5-Fluoro Risperidone (F595925).<br>References Strupczewski, J.T., et al.: J. Med. Chem., 28, 761 (1985),<br></p>Fórmula:C12H13FN2O·ClHForma y color:NeatPeso molecular:256.70N-Ethyl-N-nitroso-2-propanamine (100 μg/mL in Methanol)
CAS:Producto controladoFórmula:C5H12N2OForma y color:ColourlessPeso molecular:116.1616Chlorpromazine-d6 Hydrochloride
CAS:Producto controlado<p>Applications Labelled Chlorpromazine (C424750). Used as an antiemetic; antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anden, N.-E., et al.: Eur. J. Pharmacol., 11, 303 (1970), Curzon, G., et al.: Trends Pharmacol. Sci., 11, 61 (1990),<br></p>Fórmula:C172H6H13ClN2S·ClHForma y color:White To Light YellowPeso molecular:361.36N,N'-bis(2,6-Dimethylphenyl)-1,4-piperazinediacetamide
CAS:Producto controlado<p>Impurity Ranolazine USP Related Compound D<br>Applications N,N'-bis(2,6-Dimethylphenyl)-1,4-piperazinediacetamide is an intermediate of Ranolazine (R122500), an anti-ischemic agent which modulates myocardial metabolism. Ranolazine is also known to exert antianginal activities.<br>References Sampath, A., et al.: Org. Proc. Rsch. Dev., 16, 748 (2012); Chaitman, B.R., et al.: J. Am. Coll. Cardial., 43, 1375 (2004); McCormack, J.G., et al.: Gen. Pharmacol., 30, 639 (1998); Schofield, J.A.H., et al.: Expert Opin. Invest. Drugs, 11, 117 (2002)<br></p>Fórmula:C24H32N4O2Forma y color:NeatPeso molecular:408.54Fenbutrazate
CAS:Producto controlado<p>Applications Fenbutrazate is a derivative of Phenmetrazine (P314500). Fenbutrazate is a psychostimulant used as an anorexigen (appetite suppressant).<br>References Betbeder, A. et al.: Bull. Soc. Pharm. Bord., 121, 125 (1982); Hengen, O.: Arzneim.-Forsch., 7, 524 (1957);<br></p>Fórmula:C23H29NO3Forma y color:NeatPeso molecular:367.48(R)-Afatinib
CAS:Producto controlado<p>Applications (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide, is an impurity of Afatinib (A355300) an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.<br></p>Fórmula:C24H25ClFN5O3Forma y color:NeatPeso molecular:485.94N-Des(4-Fluorophenyl)-N-(3-chlorophenyl)-ezetimibe
CAS:Producto controladoFórmula:C24H21ClFNO3Forma y color:NeatPeso molecular:425.88Montelukast Cyclized Ether impurity
CAS:Producto controlado<p>Applications A cyclic ether impurity of antiasthmatic Montelukast (M568000).<br>References Egekeze, J.O. et al.: Anal. Chem., 67, 2292 (1995);<br></p>Fórmula:C29H26ClNOForma y color:NeatPeso molecular:439.98R-Amisulpride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications R-Amisulpride is an isomer of the antipsychotic Amisulpride (A633250). R-Amisulprideis a potential antidiabetic agent.<br>References Roix, J.J., et. al.: Diabetes Obesity Metab., 14, 329 (2012)<br></p>Fórmula:C17H27N3O4SForma y color:NeatPeso molecular:369.482,2’-Methylene Bis[Ranitidine]
CAS:Producto controlado<p>Impurity Ranitidine EP Impurity I<br>Stability Light Sensitive, Temperature Sensitive<br>Applications 2,2’-Methylene Bis[Ranitidine] (Ranitidine EP Impurity I) is an impurity of histamine H2-receptor antagonist Ranitidine (R120000).<br>References Jones, M.D. et al.: J. Sep. Sci., 29, 2409 (2006); Kelly, M.A. et al.: J. Chrom. A, 798, 297 (1998);<br></p>Fórmula:C27H44N8O6S2Forma y color:NeatPeso molecular:640.821,3-Bis(bromomethyl)-5-methylbenzene
CAS:Producto controlado<p>Impurity Anastrozole 1,3-Dibromomethyl Impurity<br>Applications 1,3-Bis(bromomethyl)-5-methylbenzene is a reagent used in the synthesis of sphingosine kinase 2 inhibitors. Anastrozole 1,3-Dibromomethyl Impurity<br>References Congdon, M. et al.: Bioorg. Med. Chem. Lett., 25, 4956 (2015);<br></p>Fórmula:C9H10Br2Forma y color:NeatPeso molecular:277.982-(2-Methoxyethyl)phenol
CAS:Producto controlado<p>Applications 2-(2-Methoxyethyl)phenol is used as a stabilizer in the preparation of polysiloxane based coating compounds with good stability.<br></p>Fórmula:C9H12O2Forma y color:NeatPeso molecular:152.195-Dehydro Tolvaptan
CAS:Producto controlado<p>Applications 5-Dehydro Tolvaptan is an impurity of Tolvaptan (T536650), a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH g<br>References Yin, L., et al.: Tetrahedron, Asym., 21, 2390 (2010); Torisawa, Y., et al.: Bioorg. Med. Chem. Lett., 17, 6455 (2007); Kondo, K., et al.: Bioorg. Med. Chem., 7, 1743 (1999);<br></p>Fórmula:C26H23ClN2O3Forma y color:NeatPeso molecular:446.93rac 4-(3-Aminobutyl)phenol
CAS:Producto controlado<p>Applications A metabolite of the antihypertensive agent, Labetalol (L096500).<br>References Gal, J., et al.: Res. Comm. Chem. Pathol. Pharmacol., 62, 3 (1988),<br></p>Fórmula:C10H15NOForma y color:NeatPeso molecular:165.23N-Nitroso-(1S,2R)-ephedrine
CAS:Producto controladoFórmula:C10H14N2O2Forma y color:NeatPeso molecular:194.232-(Trifluoroacetyl)-4-chloroaniline, Hydrochloride Hydrate
CAS:Producto controlado<p>Applications HIV reverse transcriptase inhibitor.<br></p>Fórmula:C8H5ClF3NO·ClHForma y color:NeatPeso molecular:260.04m-Salicylic Acid
CAS:Producto controlado<p>Applications m-Salicylic Acid is widely used in organic synthesis. It is also an important active metabolite of aspirin (A187780).<br>References Haynes, M., et al.: CRC H.b Chem. Phys., 92, 306 (2011)<br></p>Fórmula:C7H6O3Forma y color:Off-WhitePeso molecular:138.12Selexipag D-Mannitol Ester (>80%)
Producto controladoFórmula:C31H41N3O8Pureza:>80%Forma y color:NeatPeso molecular:583.6810-Acetyloxy Oxcarbazepine
CAS:Producto controlado<p>Applications An intermediate in the preparation of Carbamazepine metabolites.<br>References Heckendorn, R., et al.: Helv. Chimica Acta, 70, 1955 (1987),<br></p>Fórmula:C17H14N2O4Forma y color:NeatPeso molecular:310.30
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